iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012469

Ensembl Protein ID

ENSBTAP00000040793.2

UniProt Accession

Q3B7M5; LASP1_BOVIN

Genbank Protein ID

AAI07543.1

Protein Name

LIM and SH3 domain protein 1

Genbank Nucleotide ID

BC107542

Gene Name

LASP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000030587.3	ENSBTAT00000043205.2	ENSBTAP00000040793.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-14	53.9	205	260

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           + ++ ydy+a+++de +++ Gd++  +  ++ d gW++g+ e +g  G++P+n+ve +
   Q: 205  RYRAVYDYSAADEDEVSFQDGDTIVNV--QQIDDGWMYGTVERTGDTGMLPANYVEAI 260
           56899*******************999..99************************975 PP

Organism

Bos taurus

Functional Description
(View)

Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).

Protein Sequence
(Fasta)

MNPNCARCCK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 60
SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTCCCTAG CTCAAGCCGC CGTCGCTGTC GCCTGTGCAG TTGAGGCCGC GGCCGTCTCC 60
CGCCAGCTCG TTCCGGGGAA AGAGAACGCG CGCGAGCTCG GGCGTCCTCG CCCCAGCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0406--Ion transport
KW-0440--LIM domain
KW-0479--Metal-binding
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0813--Transport
KW-0862--Zinc

Interpro

IPR000900--Nebulin_repeat
IPR001452--SH3_domain
IPR001781--Znf_LIM

PROSITE

PS00478--LIM_DOMAIN_1
PS50023--LIM_DOMAIN_2
PS51216--NEBULIN
PS50002--SH3

Pfam

PF00412--LIM
PF00880--Nebulin
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00132--LIM
SM00227--NEBU
SM00326--SH3

Gene Ontology

GO:0005938--C:cell cortex
GO:0005856--C:cytoskeleton
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0008270--F:zinc ion binding
GO:0006811--P:ion transport

KEGG

bta:532851

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000663	Aegilops tauschii	29.63	1.00e-03	38.10
IUUC-Aml-001609	Ailuropoda melanoleuca	91.15	4.00e-109	387.00
IUUC-Apl-003494	Anas platyrhynchos	79.42	5.00e-95	340.00
IUUC-Aca-004462	Anolis carolinensis	84.59	1.00e-115	409.00
IUUC-Ath-007530	Arabidopsis thaliana	29.79	3.40e-01	30.00
IUUC-Ame-011113	Astyanax mexicanus	63.85	2.00e-76	278.00
IUUC-Cel-018413	Caenorhabditis elegans	52.00	3.00e-35	142.00
IUUC-Cja-019344	Callithrix jacchus	85.42	7.00e-64	236.00
IUUC-Cfa-020384	Canis familiaris	90.84	1.00e-110	392.00
IUUC-Cpo-022244	Cavia porcellus	85.89	1.00e-108	385.00
IUUC-Csa-023039	Chlorocebus sabaeus	95.79	2.00e-117	414.00
IUUC-Cin-025236	Ciona intestinalis	51.39	7.00e-36	143.00
IUUC-Csv-026002	Ciona savignyi	45.59	5.00e-52	197.00
IUUC-Dre-028335	Danio rerio	65.77	3.00e-85	307.00
IUUC-Dno-029377	Dasypus novemcinctus	91.63	8.00e-98	349.00
IUUC-Dor-031101	Dipodomys ordii	98.96	9.00e-46	176.00
IUUC-Dme-031598	Drosophila melanogaster	57.03	8.00e-41	161.00
IUUC-Eca-033966	Equus caballus	93.33	3.00e-110	390.00
IUUC-Fca-035699	Felis catus	92.34	7.00e-118	416.00
IUUC-Gmo-039493	Gadus morhua	84.40	5.00e-45	174.00
IUUC-Gga-040316	Gallus gallus	85.82	1.00e-115	408.00
IUUC-Gac-042632	Gasterosteus aculeatus	62.45	8.00e-78	283.00
IUUC-Gma-042981	Glycine max	28.33	3.00e-03	36.60
IUUC-Ggo-044835	Gorilla gorilla	90.42	5.00e-114	403.00
IUUC-Hsa-046825	Homo sapiens	95.79	3.00e-119	420.00
IUUC-Hvu-047551	Hordeum vulgare	29.63	1.00e-03	38.10
IUUC-Itr-048498	Ictidomys tridecemlineatus	92.50	2.00e-111	394.00
IUUC-Loc-052082	Lepisosteus oculatus	68.44	6.00e-88	316.00
IUUC-Laf-053578	Loxodonta africana	89.35	6.00e-114	403.00
IUUC-Mcc-055650	Macaca mulatta	95.79	2.00e-119	421.00
IUUC-Meu-056479	Macropus eugenii	90.50	1.00e-110	392.00
IUUC-Mga-059763	Meleagris gallopavo	85.95	2.00e-104	371.00
IUUC-Mmr-061164	Microcebus murinus	95.02	1.00e-114	405.00
IUUC-Mdo-061979	Monodelphis domestica	89.47	2.00e-125	441.00
IUUC-Mmu-063302	Mus musculus	93.16	3.00e-132	464.00
IUUC-Mac-065516	Musa acuminata	30.56	5.00e-03	33.50
IUUC-Mpu-066114	Mustela putorius furo	91.92	2.00e-120	424.00
IUUC-Mlu-068217	Myotis lucifugus	93.87	4.00e-121	427.00
IUUC-Nle-069636	Nomascus leucogenys	83.97	3.00e-92	331.00
IUUC-Opr-070892	Ochotona princeps	93.10	4.00e-127	446.00
IUUC-Ont-072280	Oreochromis niloticus	67.69	4.00e-86	310.00
IUUC-Oan-073220	Ornithorhynchus anatinus	89.33	4.00e-32	129.00
IUUC-Ocu-073804	Oryctolagus cuniculus	91.29	1.00e-127	448.00
IUUC-Oba-075638	Oryza barthii	27.78	5.00e-03	35.80
IUUC-Obr-076045	Oryza brachyantha	27.54	3.00e-03	36.60
IUUC-Ogl-077659	Oryza glaberrima	28.57	5.00e-03	35.80
IUUC-Ogu-078055	Oryza glumaepatula	28.12	1.30e-01	31.20
IUUC-Oin-079541	Oryza indica	27.94	7.00e-03	35.40
IUUC-Oni-082309	Oryza nivara	28.12	9.50e-02	31.60
IUUC-Opu-083412	Oryza punctata	27.54	4.00e-03	36.60
IUUC-Oru-085213	Oryza rufipogon	28.12	9.50e-02	31.60
IUUC-Osa-085312	Oryza sativa	28.57	5.00e-03	35.80
IUUC-Ola-086514	Oryzias latipes	59.32	8.00e-91	326.00
IUUC-Oga-088707	Otolemur garnettii	92.72	1.00e-120	425.00
IUUC-Oar-089771	Ovis aries	98.46	9.00e-139	485.00
IUUC-Ptr-091237	Pan troglodytes	95.79	3.00e-119	420.00
IUUC-Pan-092656	Papio anubis	95.79	2.00e-119	421.00
IUUC-Pma-094377	Petromyzon marinus	57.71	9.00e-65	239.00
IUUC-Pfo-097079	Poecilia formosa	57.69	4.00e-82	297.00
IUUC-Pab-097833	Pongo abelii	90.42	3.00e-114	404.00
IUUC-Pop-099698	Populus trichocarpa	31.25	5.00e-04	39.30
IUUC-Pca-100691	Procavia capensis	89.02	1.00e-113	402.00
IUUC-Pva-102270	Pteropus vampyrus	89.66	5.00e-118	416.00
IUUC-Rno-105362	Rattus norvegicus	93.54	2.00e-132	464.00
IUUC-Sce-106228	Saccharomyces cerevisiae	40.00	7.00e-07	48.90
IUUC-Sha-107134	Sarcophilus harrisii	86.06	2.00e-111	394.00
IUUC-Smo-108841	Selaginella moellendorffii	28.33	1.40e-02	33.90
IUUC-Sly-111106	Solanum lycopersicum	28.33	1.60e-02	34.30
IUUC-Stu-112570	Solanum tuberosum	28.33	1.70e-02	34.30
IUUC-Sbi-114441	Sorghum bicolor	27.08	4.90e-02	32.70
IUUC-Sre-115023	Sporisorium reilianum	55.77	4.00e-11	63.20
IUUC-Tru-118693	Takifugu rubripes	53.96	7.00e-75	273.00
IUUC-Tni-120393	Tetraodon nigroviridis	60.08	5.00e-77	280.00
IUUC-Tca-121863	Theobroma cacao	26.67	3.60e-02	33.10
IUUC-Tae-125394	Triticum aestivum	27.94	1.00e-03	38.10
IUUC-Tur-126326	Triticum urartu	29.63	1.00e-03	38.10
IUUC-Ttr-128639	Tursiops truncatus	93.46	4.00e-128	450.00
IUUC-Uma-129649	Ustilago maydis	53.85	5.00e-11	62.80
IUUC-Vpa-130114	Vicugna pacos	93.79	4.00e-72	263.00
IUUC-Vvi-131569	Vitis vinifera	27.59	8.70e-02	31.60
IUUC-Xtr-131827	Xenopus tropicalis	76.25	1.00e-108	385.00
IUUC-Xma-134054	Xiphophorus maculatus	64.09	4.00e-85	307.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence