iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066172

Ensembl Protein ID

ENSMPUP00000013216.1

UniProt Accession

M3YPF8; M3YPF8_MUSPF

Genbank Protein ID

ENSMPUP00000013216

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AEYP01074286

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000013314.1	ENSMPUT00000013427.1	ENSMPUP00000013216.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.90e-51	174.1	81	271

Active Site

Position(s)	Description	Evidence
88	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
91	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
265		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 81   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSD 169
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 170  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-E 254
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 255  PKVYLLYRPGHYDILYK 271
           ***************96 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE 60
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG AGGAACCTCA GCAGCAGAAG CAGGAGCCGC TCGGCAGCGA CTCCGAAGGT 60
ACTGACCCGG GGAGGACCAC CCGGCCCGGG CTAACAGGGG CGATGCCGGG TCGCCGGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	98.17	6.00e-156	542.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	5.00e-19	85.10
IUUC-Aca-004648	Anolis carolinensis	85.40	2.00e-137	481.00
IUUC-Aly-005710	Arabidopsis lyrata	42.12	5.00e-52	197.00
IUUC-Ath-007112	Arabidopsis thaliana	41.97	5.00e-51	194.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.80
IUUC-Ame-010662	Astyanax mexicanus	82.89	4.00e-130	457.00
IUUC-Bta-013533	Bos taurus	98.89	7.00e-153	532.00
IUUC-Bol-016100	Brassica oleracea	42.05	2.00e-50	192.00
IUUC-Bra-017705	Brassica rapa	39.15	2.00e-45	175.00
IUUC-Cel-018295	Caenorhabditis elegans	34.42	8.00e-42	163.00
IUUC-Cja-019190	Callithrix jacchus	100.00	3.00e-154	537.00
IUUC-Cfa-020430	Canis familiaris	100.00	1.00e-149	521.00
IUUC-Cpo-022355	Cavia porcellus	99.63	4.00e-154	536.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.80	1.00e-46	179.00
IUUC-Csa-023286	Chlorocebus sabaeus	96.79	8.00e-152	529.00
IUUC-Cin-025507	Ciona intestinalis	43.33	1.00e-44	172.00
IUUC-Csv-026273	Ciona savignyi	49.80	4.00e-69	254.00
IUUC-Dre-027843	Danio rerio	79.32	7.00e-127	446.00
IUUC-Dno-029165	Dasypus novemcinctus	99.00	7.00e-118	415.00
IUUC-Dor-030943	Dipodomys ordii	99.63	4.00e-154	536.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	2.00e-78	285.00
IUUC-Ete-032296	Echinops telfairi	96.23	1.00e-89	323.00
IUUC-Eca-033695	Equus caballus	98.81	3.00e-148	516.00
IUUC-Fca-036441	Felis catus	100.00	1.00e-149	522.00
IUUC-Gmo-038908	Gadus morhua	80.30	1.00e-126	445.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.41	1.00e-32	134.00
IUUC-Gga-040460	Gallus gallus	81.55	7.00e-134	469.00
IUUC-Gac-042417	Gasterosteus aculeatus	81.20	1.00e-122	432.00
IUUC-Gma-043712	Glycine max	41.13	1.00e-51	196.00
IUUC-Ggo-044552	Gorilla gorilla	100.00	1.00e-92	332.00
IUUC-Hsa-046766	Homo sapiens	100.00	3.00e-154	536.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	99.63	4.00e-154	536.00
IUUC-Lch-050602	Latimeria chalumnae	81.35	3.00e-119	421.00
IUUC-Laf-053705	Loxodonta africana	99.63	4.00e-154	536.00
IUUC-Mcc-055745	Macaca mulatta	93.77	1.00e-150	525.00
IUUC-Meu-056569	Macropus eugenii	85.61	2.00e-135	474.00
IUUC-Mtr-057712	Medicago truncatula	43.49	9.00e-47	180.00
IUUC-Mvi-060358	Microbotryum violaceum	33.94	2.00e-15	75.90
IUUC-Mmr-061123	Microcebus murinus	99.57	6.00e-128	449.00
IUUC-Mdo-062613	Monodelphis domestica	87.08	1.00e-123	435.00
IUUC-Mmu-063658	Mus musculus	99.63	4.00e-154	536.00
IUUC-Mac-065274	Musa acuminata	37.60	2.00e-39	155.00
IUUC-Mlu-066966	Myotis lucifugus	99.26	2.00e-153	534.00
IUUC-Nle-069519	Nomascus leucogenys	88.17	2.00e-93	335.00
IUUC-Ont-071901	Oreochromis niloticus	82.47	4.00e-125	440.00
IUUC-Ola-087331	Oryzias latipes	80.90	4.00e-86	310.00
IUUC-Oga-088064	Otolemur garnettii	100.00	3.00e-154	536.00
IUUC-Oar-089251	Ovis aries	98.03	1.00e-147	515.00
IUUC-Ptr-091430	Pan troglodytes	100.00	5.00e-154	536.00
IUUC-Psi-093823	Pelodiscus sinensis	87.74	4.00e-134	470.00
IUUC-Pma-094366	Petromyzon marinus	72.01	2.00e-103	368.00
IUUC-Pfo-096734	Poecilia formosa	80.88	4.00e-114	404.00
IUUC-Pab-097919	Pongo abelii	100.00	3.00e-127	447.00
IUUC-Pop-099401	Populus trichocarpa	41.24	1.00e-48	186.00
IUUC-Ppe-101977	Prunus persica	42.38	1.00e-51	196.00
IUUC-Pva-102499	Pteropus vampyrus	100.00	3.00e-149	520.00
IUUC-Rno-105233	Rattus norvegicus	99.63	4.00e-154	536.00
IUUC-Sha-107081	Sarcophilus harrisii	96.51	1.00e-148	518.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	3.00e-49	188.00
IUUC-Ssc-116202	Sus scrofa	100.00	3.00e-154	536.00
IUUC-Tru-117664	Takifugu rubripes	77.32	7.00e-123	432.00
IUUC-Tca-121467	Theobroma cacao	41.54	2.00e-50	192.00
IUUC-Tbe-128116	Tupaia belangeri	98.76	2.00e-93	335.00
IUUC-Ttr-128622	Tursiops truncatus	99.26	1.00e-151	528.00
IUUC-Vvi-131389	Vitis vinifera	43.75	5.00e-53	201.00
IUUC-Xma-134191	Xiphophorus maculatus	81.27	4.00e-115	407.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence