iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117596

Ensembl Protein ID

ENSTRUP00000008303.1

UniProt Accession

H2S7D1; H2S7D1_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

fynb; fyn

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000003538.1	ENSTRUT00000008352.1	ENSTRUP00000008303.1
ENSTRUG00000003538.1	ENSTRUT00000008353.1	ENSTRUP00000008304.1
ENSTRUG00000003538.1	ENSTRUT00000008354.1	ENSTRUP00000008305.1
ENSTRUG00000003538.1	ENSTRUT00000008355.1	ENSTRUP00000008306.1
ENSTRUG00000003538.1	ENSTRUT00000008356.1	ENSTRUP00000008307.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.10e-15	56.7	91	147

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++ +lydyea ++d+L+++kG++ ++i  ++ +++W+++ + ++g +G +P+n+v+ ++
   Q: 91   LFVALYDYEARTEDDLSFRKGEKFQII--NSSEGDWWEARSLTTGGNGYIPSNYVAPVD 147
           6789***********************..89999*********************9987 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGCVQCKDKK ATKLTDNRET NHSLGAARYH YGADPMPQHY PSFGVTAIPN YNNFHTPVGQ 60
GMAVFGGVST SSHSGTLRTH SGTGLAKRVT LFVALYDYEA RTEDDLSFRK GEKFQIINSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGTG TGCAATGCAA GGATAAGAAA GCAACCAAAC TGACAGACAA CAGAGAGACC 60
AACCACTCCC TCGGAGCTGC CCGCTACCAT TATGGGGCAG ACCCCATGCC TCAGCACTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0060027--P:convergent extension involved in gastrulation
GO:0031101--P:fin regeneration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005712	Arabidopsis lyrata	33.33	1.00e-19	92.00
IUUC-Bol-016049	Brassica oleracea	32.37	4.00e-18	87.00
IUUC-Cel-018594	Caenorhabditis elegans	51.77	3.00e-147	515.00
IUUC-Ont-071783	Oreochromis niloticus	92.80	0.00e+00	1035.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence