iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038695.13	ENSMUST00000035844.10	ENSMUSP00000048415.4
ENSMUSG00000038695.13	ENSMUST00000206887.1	ENSMUSP00000145582.1
ENSMUSG00000038695.13	ENSMUST00000134398.2	ENSMUSP00000145857.1
ENSMUSG00000038695.13	ENSMUST00000136609.7	ENSMUSP00000123205.1
ENSMUSG00000038695.13	ENSMUST00000136679.7	ENSMUSP00000114900.1
ENSMUSG00000038695.13	ENSMUST00000121922.2	ENSMUSP00000112796.1
ENSMUSG00000038695.13	ENSMUST00000139097.1	ENSMUSP00000147171.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/Josephin	3.00e-92	308.4	1	187

Active Site

Position(s)	Description	Evidence
24	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU00331}
125	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00331}

Domain Profile

DUB/Josephin

   S: 1    msqvpgaqaapesiyhekqrrelCalhalnnvlqdelfsreeldeiakrldeeerlqPskslldtGnydvnvisaalkvlGleavwfdk 89
           msq+p a+++p+s+yhe+qr+elCa+halnnvlq++lfs+e++dei+krl++++rl+P++sll+tGnydvnvi+aal++lGl+avw+d+
   Q: 1    MSQAPEARPSPPSVYHERQRLELCAVHALNNVLQEQLFSQEAADEICKRLAPDSRLNPHRSLLGTGNYDVNVIMAALQGLGLAAVWWDR 89
           8**************************************************************************************** PP
   S: 90   rrelqklaldnvlgfilnlpsslslgllklplkkqhWvtvrkvgkayynldsklkaPeligdetelrkflakllqqkyselllvvkeev 178
           rr+l++lal++vlg+ilnlps++slgll+lpl+++hWv++r+v++ yynldskl+aPe++gde+ +r+fla++l+q+++e+llvv++ev
   Q: 90   RRPLSQLALPQVLGLILNLPSPVSLGLLSLPLRRRHWVALRQVDGIYYNLDSKLRAPEALGDEDGVRTFLAAALAQGLCEVLLVVTKEV 178
           ***************************************************************************************** PP
   S: 179  edkesdqrl 187
           e+ ++++ +
   Q: 179  EEAGCWLNT 187
           ******876 PP

Organism

Mus musculus

Functional Description
(View)

Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (By similarity).

Protein Sequence
(Fasta)

MSQAPEARPS PPSVYHERQR LELCAVHALN NVLQEQLFSQ EAADEICKRL APDSRLNPHR 60
SLLGTGNYDV NVIMAALQGL GLAAVWWDRR RPLSQLALPQ VLGLILNLPS PVSLGLLSLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGTCCCAC GCGGCAGAGC AGCCCCGGAG GACTTCCGGA CTGCGCGTCC TATTTAGACG 60
CCCTACGGAG GCCTTCGGGA ATCGCAGTTC GGCGCGCGCA AGTCGCCGGG AGCTGTAGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR006155--Josephin

PROSITE

PS50957--JOSEPHIN

Pfam

PF02099--Josephin

SMART

SM01246--Josephin

Gene Ontology

GO:0005829--C:cytosol
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination

KEGG

mmu:66124

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000785	Aegilops tauschii	37.43	2.00e-25	108.00
IUUC-Aml-001650	Ailuropoda melanoleuca	93.62	3.00e-80	290.00
IUUC-Atr-002584	Amborella trichopoda	42.01	1.00e-26	113.00
IUUC-Aca-004833	Anolis carolinensis	71.43	2.00e-72	264.00
IUUC-Aly-005621	Arabidopsis lyrata	41.24	2.00e-30	126.00
IUUC-Ath-007306	Arabidopsis thaliana	38.82	2.00e-29	123.00
IUUC-Ame-010835	Astyanax mexicanus	66.48	4.00e-68	250.00
IUUC-Bta-012918	Bos taurus	93.71	3.00e-70	257.00
IUUC-Bdi-014128	Brachypodium distachyon	37.99	3.00e-27	114.00
IUUC-Bol-015647	Brassica oleracea	41.34	5.00e-32	130.00
IUUC-Bra-017811	Brassica rapa	38.51	9.00e-29	119.00
IUUC-Cel-018568	Caenorhabditis elegans	41.28	1.00e-39	155.00
IUUC-Cja-019837	Callithrix jacchus	96.57	4.00e-75	273.00
IUUC-Cfa-021001	Canis familiaris	94.12	2.00e-79	288.00
IUUC-Cpo-021340	Cavia porcellus	93.71	6.00e-72	263.00
IUUC-Csa-023069	Chlorocebus sabaeus	96.00	2.00e-74	271.00
IUUC-Cme-027180	Cyanidioschyzon merolae	30.47	5.00e-08	51.20
IUUC-Dre-028459	Danio rerio	64.41	4.00e-67	246.00
IUUC-Dno-029569	Dasypus novemcinctus	93.62	4.00e-79	286.00
IUUC-Dor-030570	Dipodomys ordii	95.19	1.00e-77	281.00
IUUC-Dme-032124	Drosophila melanogaster	50.88	2.00e-42	165.00
IUUC-Fca-036089	Felis catus	93.62	9.00e-80	289.00
IUUC-Gmo-038493	Gadus morhua	64.74	9.00e-63	232.00
IUUC-Gac-041579	Gasterosteus aculeatus	66.67	1.00e-68	252.00
IUUC-Gma-043620	Glycine max	41.67	2.00e-32	132.00
IUUC-Ggo-045508	Gorilla gorilla	94.68	2.00e-80	291.00
IUUC-Hsa-046522	Homo sapiens	94.68	2.00e-80	291.00
IUUC-Hvu-047184	Hordeum vulgare	38.55	8.00e-26	109.00
IUUC-Itr-048074	Ictidomys tridecemlineatus	96.00	1.00e-74	271.00
IUUC-Lch-050506	Latimeria chalumnae	65.52	1.00e-68	252.00
IUUC-Lpe-051421	Leersia perrieri	38.55	1.00e-27	115.00
IUUC-Mcc-054840	Macaca mulatta	96.57	6.00e-75	273.00
IUUC-Meu-056539	Macropus eugenii	87.71	4.00e-76	276.00
IUUC-Mtr-058745	Medicago truncatula	39.01	4.00e-32	130.00
IUUC-Mac-065631	Musa acuminata	39.38	1.00e-25	111.00
IUUC-Mpu-066337	Mustela putorius furo	93.09	1.00e-79	288.00
IUUC-Nle-069739	Nomascus leucogenys	95.43	2.00e-74	271.00
IUUC-Ont-072050	Oreochromis niloticus	66.10	6.00e-63	233.00
IUUC-Oba-075401	Oryza barthii	37.43	2.00e-27	115.00
IUUC-Obr-076916	Oryza brachyantha	36.87	5.00e-26	110.00
IUUC-Ogl-077194	Oryza glaberrima	37.43	2.00e-27	115.00
IUUC-Ogu-078532	Oryza glumaepatula	37.43	2.00e-27	115.00
IUUC-Oin-079562	Oryza indica	36.25	3.00e-23	100.00
IUUC-Olo-080503	Oryza longistaminata	37.43	2.00e-27	115.00
IUUC-Ome-081997	Oryza meridionalis	37.99	1.00e-27	115.00
IUUC-Oni-082854	Oryza nivara	35.60	3.00e-27	114.00
IUUC-Opu-083984	Oryza punctata	36.87	5.00e-27	114.00
IUUC-Oru-084655	Oryza rufipogon	37.36	2.00e-26	112.00
IUUC-Osa-085854	Oryza sativa	37.43	2.00e-27	115.00
IUUC-Ola-086805	Oryzias latipes	64.61	4.00e-66	243.00
IUUC-Oga-088741	Otolemur garnettii	89.95	3.00e-67	248.00
IUUC-Oar-089548	Ovis aries	93.71	2.00e-70	258.00
IUUC-Ptr-091101	Pan troglodytes	83.51	1.00e-78	285.00
IUUC-Pan-092144	Papio anubis	96.57	6.00e-75	273.00
IUUC-Ppa-095444	Physcomitrella patens	32.00	2.00e-23	102.00
IUUC-Pfo-097459	Poecilia formosa	65.90	1.00e-66	245.00
IUUC-Pca-100200	Procavia capensis	83.60	8.00e-79	285.00
IUUC-Ppe-102087	Prunus persica	40.64	6.00e-33	133.00
IUUC-Pva-102585	Pteropus vampyrus	94.41	3.00e-75	273.00
IUUC-Rno-105654	Rattus norvegicus	96.81	2.00e-80	291.00
IUUC-Smo-109138	Selaginella moellendorffii	48.76	6.00e-21	93.60
IUUC-Sit-110826	Setaria italica	39.66	2.00e-28	118.00
IUUC-Sly-111452	Solanum lycopersicum	38.42	3.00e-28	117.00
IUUC-Stu-112215	Solanum tuberosum	37.57	4.00e-28	117.00
IUUC-Sbi-114786	Sorghum bicolor	39.66	2.00e-29	121.00
IUUC-Ssc-115298	Sus scrofa	93.14	5.00e-71	259.00
IUUC-Tru-118437	Takifugu rubripes	64.61	2.00e-67	248.00
IUUC-Tni-120715	Tetraodon nigroviridis	65.00	1.00e-62	231.00
IUUC-Tae-123012	Triticum aestivum	37.43	2.00e-25	108.00
IUUC-Tur-126618	Triticum urartu	38.21	1.00e-16	79.00
IUUC-Ttr-128359	Tursiops truncatus	69.14	3.00e-40	157.00
IUUC-Vvi-131246	Vitis vinifera	35.68	1.00e-29	122.00
IUUC-Xtr-132462	Xenopus tropicalis	63.43	1.00e-66	245.00
IUUC-Xma-134148	Xiphophorus maculatus	64.41	2.00e-66	244.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence