iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004300

UUCD1 version

UUC-AnC-00556

Ensembl Protein ID

ENSACAP00000005145.3

UniProt Accession

G1KDV1; G1KDV1_ANOCA

Protein Name

Uncharacterized protein

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000005186.3	ENSACAT00000005262.3	ENSACAP00000005145.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-86	289.0	4469	4798

Active Site

Position(s)	Description	Evidence
4767	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4469 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakslLHMNMFRFLGVLLGIAIRTGSPL 4555
           4566*********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++  ++t +N+ eYv+
   Q: 4556 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPNASGQDIQLSSKYAHITLDNRAEYVR 4637
           ***************************************99999999999*999.....7889999999****************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFwev+e+fs++er+
   Q: 4638 LAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPTASLIQWFWEVMESFSNTERS 4722
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4723 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4798
           *************.8*************999988888***********************************99875 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSSESFCLEA QTRFDSKWLK TDLQLAFTRD GLCGLWNEMV KDGEIVYTGT ELSQNSEASP 60
RKDDTTEGQT GSKKDDQNDK ERKDEEDTPS PTYRAKSIVE SWVWGKQPDV SELKECLYVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCACCGA GCTCCGATTG GGCGCCTCCT CAGTCCCTCC GCTTCCCTGG CGTAAGTGGG 60
TGGGGCGAAG AAGGTGGAGC AGCAGTAGCA GGAGGATTAG TTGGGAGCTT GTGTAGTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR016186--C-type_lectin-like/link
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	90.43	0.00e+00	6809.00
IUUC-Atr-003065	Amborella trichopoda	34.73	1.00e-50	194.00
IUUC-Apl-003983	Anas platyrhynchos	95.07	0.00e+00	8754.00
IUUC-Aly-006441	Arabidopsis lyrata	33.61	3.00e-44	173.00
IUUC-Ame-010621	Astyanax mexicanus	87.28	0.00e+00	7135.00
IUUC-Bta-013067	Bos taurus	89.73	0.00e+00	8210.00
IUUC-Bdi-014093	Brachypodium distachyon	33.25	7.00e-49	189.00
IUUC-Cja-019687	Callithrix jacchus	88.82	0.00e+00	8033.00
IUUC-Cfa-020672	Canis familiaris	90.46	0.00e+00	8301.00
IUUC-Cpo-021819	Cavia porcellus	87.58	0.00e+00	8012.00
IUUC-Csa-023817	Chlorocebus sabaeus	90.25	0.00e+00	8260.00
IUUC-Cho-024387	Choloepus hoffmanni	91.05	0.00e+00	1823.00
IUUC-Cin-025709	Ciona intestinalis	55.00	0.00e+00	2239.00
IUUC-Csv-026336	Ciona savignyi	42.34	0.00e+00	3041.00
IUUC-Dre-027717	Danio rerio	84.16	0.00e+00	7484.00
IUUC-Dno-029296	Dasypus novemcinctus	90.61	0.00e+00	8267.00
IUUC-Dor-030979	Dipodomys ordii	83.97	0.00e+00	2736.00
IUUC-Dme-032171	Drosophila melanogaster	60.89	0.00e+00	1545.00
IUUC-Ete-032687	Echinops telfairi	80.45	0.00e+00	2718.00
IUUC-Eca-034046	Equus caballus	89.86	0.00e+00	8229.00
IUUC-Eeu-034859	Erinaceus europaeus	90.93	0.00e+00	1897.00
IUUC-Fca-036262	Felis catus	90.42	0.00e+00	8311.00
IUUC-Fal-037562	Ficedula albicollis	94.79	0.00e+00	8663.00
IUUC-Gmo-039054	Gadus morhua	88.52	0.00e+00	1116.00
IUUC-Gga-040359	Gallus gallus	95.10	0.00e+00	8718.00
IUUC-Gac-041879	Gasterosteus aculeatus	92.53	0.00e+00	1059.00
IUUC-Ggo-044692	Gorilla gorilla	93.56	0.00e+00	4203.00
IUUC-Hsa-045995	Homo sapiens	90.52	0.00e+00	8312.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	85.85	0.00e+00	2231.00
IUUC-Lch-049808	Latimeria chalumnae	88.64	0.00e+00	3418.00
IUUC-Lpe-051482	Leersia perrieri	33.68	4.00e-46	179.00
IUUC-Loc-052685	Lepisosteus oculatus	87.06	0.00e+00	7810.00
IUUC-Laf-053372	Loxodonta africana	89.94	0.00e+00	8225.00
IUUC-Mcc-054693	Macaca mulatta	90.33	0.00e+00	8299.00
IUUC-Meu-056660	Macropus eugenii	97.57	0.00e+00	1953.00
IUUC-Mga-059371	Meleagris gallopavo	95.31	0.00e+00	7511.00
IUUC-Mmr-060787	Microcebus murinus	90.91	0.00e+00	8372.00
IUUC-Mdo-062518	Monodelphis domestica	91.60	0.00e+00	8268.00
IUUC-Mmu-063690	Mus musculus	89.82	0.00e+00	8213.00
IUUC-Mpu-066478	Mustela putorius furo	89.95	0.00e+00	8234.00
IUUC-Mlu-067596	Myotis lucifugus	85.47	0.00e+00	4196.00
IUUC-Nle-069445	Nomascus leucogenys	88.25	0.00e+00	2027.00
IUUC-Opr-070990	Ochotona princeps	85.91	0.00e+00	2944.00
IUUC-Ont-072285	Oreochromis niloticus	85.52	0.00e+00	7613.00
IUUC-Oan-072721	Ornithorhynchus anatinus	87.10	0.00e+00	3482.00
IUUC-Ocu-074273	Oryctolagus cuniculus	89.72	0.00e+00	8231.00
IUUC-Oba-075573	Oryza barthii	32.90	8.00e-45	175.00
IUUC-Obr-076107	Oryza brachyantha	33.25	3.00e-49	190.00
IUUC-Ogl-077193	Oryza glaberrima	32.90	8.00e-45	175.00
IUUC-Ogu-078817	Oryza glumaepatula	32.90	8.00e-45	175.00
IUUC-Oin-079609	Oryza indica	31.99	9.00e-48	185.00
IUUC-Olo-080629	Oryza longistaminata	32.90	8.00e-45	175.00
IUUC-Ome-081686	Oryza meridionalis	32.90	3.00e-45	177.00
IUUC-Opu-084137	Oryza punctata	33.16	2.00e-45	177.00
IUUC-Oru-085013	Oryza rufipogon	32.90	8.00e-45	175.00
IUUC-Osa-085597	Oryza sativa	32.90	9.00e-45	175.00
IUUC-Ola-087346	Oryzias latipes	93.98	0.00e+00	1212.00
IUUC-Oga-088742	Otolemur garnettii	89.97	0.00e+00	8163.00
IUUC-Oar-090093	Ovis aries	89.94	0.00e+00	8222.00
IUUC-Ptr-091034	Pan troglodytes	85.67	0.00e+00	5467.00
IUUC-Pan-092783	Papio anubis	88.28	0.00e+00	8079.00
IUUC-Psi-094027	Pelodiscus sinensis	95.24	0.00e+00	8348.00
IUUC-Pfo-096208	Poecilia formosa	82.57	0.00e+00	6210.00
IUUC-Pab-097681	Pongo abelii	85.28	0.00e+00	2406.00
IUUC-Pca-100705	Procavia capensis	91.80	0.00e+00	1127.00
IUUC-Pva-103147	Pteropus vampyrus	80.89	0.00e+00	2354.00
IUUC-Rno-105458	Rattus norvegicus	89.73	0.00e+00	8196.00
IUUC-Sha-106959	Sarcophilus harrisii	83.77	0.00e+00	7210.00
IUUC-Sit-109917	Setaria italica	35.74	1.00e-47	184.00
IUUC-Sly-110961	Solanum lycopersicum	34.51	2.00e-52	201.00
IUUC-Sar-113532	Sorex araneus	82.49	0.00e+00	1788.00
IUUC-Sbi-114352	Sorghum bicolor	31.88	7.00e-49	189.00
IUUC-Ssc-115337	Sus scrofa	84.58	0.00e+00	2785.00
IUUC-Tgu-116789	Taeniopygia guttata	94.67	0.00e+00	8685.00
IUUC-Tru-118129	Takifugu rubripes	84.50	0.00e+00	7622.00
IUUC-Tsy-119302	Tarsius syrichta	79.31	0.00e+00	1198.00
IUUC-Tni-120374	Tetraodon nigroviridis	83.19	0.00e+00	7476.00
IUUC-Tca-121094	Theobroma cacao	35.03	1.00e-53	205.00
IUUC-Tae-124157	Triticum aestivum	33.33	1.00e-48	188.00
IUUC-Tbe-128137	Tupaia belangeri	82.43	0.00e+00	2190.00
IUUC-Ttr-128273	Tursiops truncatus	85.89	0.00e+00	2691.00
IUUC-Vpa-130471	Vicugna pacos	79.90	0.00e+00	1441.00
IUUC-Xtr-132185	Xenopus tropicalis	88.01	0.00e+00	7995.00
IUUC-Xma-133233	Xiphophorus maculatus	84.67	0.00e+00	7562.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence