iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-56	185.8	111	149
UBD/Beta-Prp	3.60e-79	266.9	19	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt+  +c++f +  +++vsGs D t+++WD++tg++lk
   Q: 111  GHTNYAFCVNFnPQsNMIVSGSFDETVRIWDVTTGKCLK 149
           8***********666**********************97 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgheds 96
           tl +h+   +++vkfs d++lla++s+d+ti+ + + t +      ++++ ghe+++++v fs+d+ ++v++s+D+t+k+wd++tg+ + tl gh+++
   Q: 19   TLTSHNR-AVSSVKFSSDGRLLASASADKTIRTYTINTINDpiaepVQEFTGHENGISDVAFSSDARFIVSASDDKTLKLWDVETGSLIKTLIGHTNY 115
           5555555.5556*************************988899******************************************************* PP
   S: 97   vlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngke 194
           + +++f+p+++ +vsGs d+t+r+wd+ tg+cl+ +l  h++ v+ v ++ dg+l+vs+s+D+ +r+Wd+ tg +++tl  + +++v  + f++ngk+
   Q: 116  AFCVNFNPQSNMIVSGSFDETVRIWDVTTGKCLK-VLPAHSDPVTAVDFNRDGSLIVSSSYDGLCRIWDSGTGHCVKTLIDDENPPVSFVRFSPNGKF 212
           **********************************.********************************************999**************** PP
   S: 195  lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs...pnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskv 289
           ++ g ld+t++lw++++ + ++t++gh +  +++       n++r+vsgs+D+ + +W l s++ll++l++h ++v+ va+ ++++n +++gs d++v
   Q: 213  ILVGTLDNTLRLWNISSAKFLKTYTGHVNAQYCISSAfsvTNGKRIVSGSEDNCVHMWELNSKKLLQKLEGHTETVMNVAC-HPTENLIASGSLDKTV 309
           ****************************9999987655699****************************************.**************** PP
   S: 290  niwklkk 296
           +iw +kk
   Q: 310  RIWTQKK 316
           ***9876 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Forms multiple COMPASS-like complexes involved in histone methylation by interacting with different histone H3 'Lys-4' methyltransferases such as ATX1, SDG14 or SDG16 (PubMed:21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed:19567704). Upregulates FLC and MAF4 expression to delay flowering (PubMed:19567704).

Protein Sequence
(Fasta)

MAEEIPATAS FTPYVHSQTL TSHNRAVSSV KFSSDGRLLA SASADKTIRT YTINTINDPI 60
AEPVQEFTGH ENGISDVAFS SDARFIVSAS DDKTLKLWDV ETGSLIKTLI GHTNYAFCVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTATTTAA AAGAGTCGGG GTTTTTCCAA GAACACTGGA TCGTCGTCTC TCTCCTTTAG 60
TTAGACAAAG CCTCCTTTCC CAAAACCCTA AAATCAGCCA AATTCAAATT CCGCTAACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0042393--F:histone binding
GO:0008168--F:methyltransferase activity
GO:0010228--P:vegetative to reproductive phase transition of meristem

KEGG

ath:AT3G49660

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002420	Ailuropoda melanoleuca	65.45	6.00e-117	412.00
IUUC-Atr-002439	Amborella trichopoda	71.47	1.00e-136	478.00
IUUC-Apl-003436	Anas platyrhynchos	60.13	7.00e-106	376.00
IUUC-Aca-004259	Anolis carolinensis	65.12	2.00e-116	411.00
IUUC-Aly-005723	Arabidopsis lyrata	95.58	0.00e+00	635.00
IUUC-Ago-007915	Ashbya gossypii	34.23	1.00e-39	155.00
IUUC-Acl-008045	Aspergillus clavatus	43.13	1.00e-72	266.00
IUUC-Afl-008596	Aspergillus flavus	44.27	6.00e-73	267.00
IUUC-Afu-009074	Aspergillus fumigatus	44.48	3.00e-74	271.00
IUUC-Ani-009318	Aspergillus nidulans	44.16	1.00e-71	263.00
IUUC-Ang-009775	Aspergillus niger	43.87	2.00e-73	269.00
IUUC-Aor-010222	Aspergillus oryzae	44.27	4.00e-73	268.00
IUUC-Ate-010583	Aspergillus terreus	44.41	2.00e-72	266.00
IUUC-Ame-011349	Astyanax mexicanus	65.45	2.00e-116	411.00
IUUC-Bgr-011968	Blumeria graminis	44.93	3.00e-71	261.00
IUUC-Bta-013016	Bos taurus	65.45	1.00e-116	412.00
IUUC-Bci-013948	Botrytis cinerea	45.61	2.00e-68	252.00
IUUC-Bdi-014263	Brachypodium distachyon	66.02	6.00e-127	446.00
IUUC-Bol-015900	Brassica oleracea	86.98	9.00e-166	575.00
IUUC-Bra-017143	Brassica rapa	86.75	7.00e-168	582.00
IUUC-Cel-018355	Caenorhabditis elegans	57.77	5.00e-104	370.00
IUUC-Cja-019936	Callithrix jacchus	65.45	6.00e-117	412.00
IUUC-Cfa-020596	Canis familiaris	65.45	6.00e-117	412.00
IUUC-Cpo-021318	Cavia porcellus	65.45	6.00e-117	412.00
IUUC-Cre-022935	Chlamydomonas reinhardtii	41.25	3.00e-72	265.00
IUUC-Csa-023053	Chlorocebus sabaeus	65.45	6.00e-117	412.00
IUUC-Cho-024642	Choloepus hoffmanni	60.13	1.00e-100	358.00
IUUC-Cin-025495	Ciona intestinalis	62.46	1.00e-113	402.00
IUUC-Csv-025988	Ciona savignyi	63.51	1.00e-113	402.00
IUUC-Cgl-026771	Colletotrichum gloeosporioides	33.65	4.00e-46	179.00
IUUC-Cne-027025	Cryptococcus neoformans	31.12	5.00e-50	191.00
IUUC-Cme-027119	Cyanidioschyzon merolae	49.85	9.00e-89	319.00
IUUC-Dre-027521	Danio rerio	65.45	1.00e-116	412.00
IUUC-Dno-029739	Dasypus novemcinctus	65.45	1.00e-116	412.00
IUUC-Dor-030966	Dipodomys ordii	65.45	1.00e-116	411.00
IUUC-Dse-031189	Dothistroma septosporum	44.79	8.00e-75	273.00
IUUC-Dme-031613	Drosophila melanogaster	65.45	2.00e-116	411.00
IUUC-Ete-033098	Echinops telfairi	58.80	7.00e-105	372.00
IUUC-Eca-033790	Equus caballus	65.45	6.00e-117	412.00
IUUC-Eeu-034805	Erinaceus europaeus	60.80	8.00e-102	362.00
IUUC-Fca-035901	Felis catus	65.45	6.00e-117	412.00
IUUC-Fal-037413	Ficedula albicollis	65.45	7.00e-117	412.00
IUUC-Fox-037876	Fusarium oxysporum	45.71	3.00e-55	207.00
IUUC-Fso-038186	Fusarium solani	37.22	5.00e-49	187.00
IUUC-Gmo-039131	Gadus morhua	65.88	4.00e-116	410.00
IUUC-Ggr-040071	Gaeumannomyces graminis	36.11	2.00e-51	196.00
IUUC-Gga-040789	Gallus gallus	65.45	7.00e-117	412.00
IUUC-Gac-042634	Gasterosteus aculeatus	65.88	2.00e-115	408.00
IUUC-Gma-043987	Glycine max	73.07	6.00e-144	502.00
IUUC-Ggo-044443	Gorilla gorilla	65.45	6.00e-117	412.00
IUUC-Hsa-046290	Homo sapiens	65.45	6.00e-117	412.00
IUUC-Hvu-047077	Hordeum vulgare	61.61	3.00e-82	296.00
IUUC-Itr-048954	Ictidomys tridecemlineatus	65.45	6.00e-117	412.00
IUUC-Kpa-049404	Komagataella pastoris	43.01	1.00e-60	225.00
IUUC-Lch-049539	Latimeria chalumnae	65.45	8.00e-117	412.00
IUUC-Lpe-051082	Leersia perrieri	65.91	1.00e-126	445.00
IUUC-Loc-051743	Lepisosteus oculatus	65.45	2.00e-116	411.00
IUUC-Lma-053188	Leptosphaeria maculans	43.73	7.00e-77	280.00
IUUC-Laf-054432	Loxodonta africana	62.15	1.00e-113	402.00
IUUC-Mcc-055603	Macaca mulatta	65.45	6.00e-117	412.00
IUUC-Meu-056440	Macropus eugenii	61.79	1.00e-99	355.00
IUUC-Mor-056965	Magnaporthe oryzae	32.78	7.00e-55	207.00
IUUC-Mpo-057333	Magnaporthe poae	36.88	1.00e-51	197.00
IUUC-Mtr-057951	Medicago truncatula	71.17	1.00e-143	501.00
IUUC-Mla-058896	Melampsora laricipopulina	38.41	1.00e-62	233.00
IUUC-Mga-060046	Meleagris gallopavo	65.12	1.00e-116	411.00
IUUC-Mvi-060453	Microbotryum violaceum	43.50	4.00e-78	285.00
IUUC-Mmr-061020	Microcebus murinus	61.08	7.00e-110	389.00
IUUC-Mdo-062204	Monodelphis domestica	63.79	1.00e-113	402.00
IUUC-Mmu-063917	Mus musculus	65.45	6.00e-117	412.00
IUUC-Mac-065310	Musa acuminata	66.67	4.00e-127	446.00
IUUC-Mpu-066072	Mustela putorius furo	65.45	6.00e-117	412.00
IUUC-Mlu-068209	Myotis lucifugus	65.45	6.00e-117	412.00
IUUC-Nfi-068538	Neosartorya fischeri	44.16	1.00e-73	270.00
IUUC-Ncr-068651	Neurospora crassa	34.77	8.00e-57	214.00
IUUC-Nle-069383	Nomascus leucogenys	61.74	7.00e-103	366.00
IUUC-Opr-070937	Ochotona princeps	60.81	1.00e-100	358.00
IUUC-Ont-071458	Oreochromis niloticus	66.22	1.00e-116	411.00
IUUC-Oan-073597	Ornithorhynchus anatinus	65.45	1.00e-116	412.00
IUUC-Ocu-074180	Oryctolagus cuniculus	30.13	2.00e-40	159.00
IUUC-Oba-075082	Oryza barthii	59.59	3.00e-105	374.00
IUUC-Obr-076318	Oryza brachyantha	72.90	3.00e-100	356.00
IUUC-Ogl-077251	Oryza glaberrima	65.08	1.00e-126	444.00
IUUC-Oin-079601	Oryza indica	58.91	9.00e-122	429.00
IUUC-Olo-080976	Oryza longistaminata	68.85	4.00e-114	403.00
IUUC-Ome-081430	Oryza meridionalis	65.50	8.00e-127	445.00
IUUC-Opu-083880	Oryza punctata	65.18	1.00e-125	442.00
IUUC-Osa-085706	Oryza sativa	65.08	1.00e-126	444.00
IUUC-Ola-087134	Oryzias latipes	66.22	1.00e-116	411.00
IUUC-Olu-087660	Ostreococcus lucimarinus	43.75	9.00e-41	158.00
IUUC-Oga-088672	Otolemur garnettii	65.45	5.00e-117	413.00
IUUC-Oar-089860	Ovis aries	60.83	9.00e-104	369.00
IUUC-Ptr-091513	Pan troglodytes	65.45	6.00e-117	412.00
IUUC-Pan-092046	Papio anubis	65.45	6.00e-117	412.00
IUUC-Psi-093192	Pelodiscus sinensis	65.45	7.00e-117	412.00
IUUC-Pma-094319	Petromyzon marinus	28.75	3.00e-38	151.00
IUUC-Pno-094881	Phaeosphaeria nodorum	47.40	2.00e-82	299.00
IUUC-Ppa-095367	Physcomitrella patens	67.52	5.00e-130	456.00
IUUC-Pfo-097434	Poecilia formosa	66.22	1.00e-116	411.00
IUUC-Pab-098758	Pongo abelii	61.74	5.00e-103	366.00
IUUC-Pop-099778	Populus trichocarpa	76.04	2.00e-144	504.00
IUUC-Pca-100281	Procavia capensis	52.57	3.00e-72	264.00
IUUC-Ppe-101341	Prunus persica	72.84	8.00e-136	475.00
IUUC-Pva-103020	Pteropus vampyrus	65.12	3.00e-116	410.00
IUUC-Pgr-103589	Puccinia graminis	34.68	2.00e-59	222.00
IUUC-Pte-104153	Pyrenophora teres	48.29	8.00e-85	306.00
IUUC-Pyt-104712	Pyrenophora triticirepentis	48.13	1.00e-67	249.00
IUUC-Rno-105858	Rattus norvegicus	65.45	6.00e-117	412.00
IUUC-Sce-106243	Saccharomyces cerevisiae	31.31	4.00e-37	147.00
IUUC-Sha-107101	Sarcophilus harrisii	65.45	6.00e-117	412.00
IUUC-Sja-107858	Schizosaccharomyces japonicus	43.58	2.00e-55	209.00
IUUC-Spo-108117	Schizosaccharomyces pombe	40.17	2.00e-53	202.00
IUUC-Ssl-108631	Sclerotinia sclerotiorum	42.71	2.00e-62	233.00
IUUC-Smo-109155	Selaginella moellendorffii	67.09	4.00e-128	450.00
IUUC-Sit-110688	Setaria italica	65.70	2.00e-127	447.00
IUUC-Sly-110891	Solanum lycopersicum	73.10	9.00e-140	488.00
IUUC-Stu-112365	Solanum tuberosum	72.47	6.00e-139	485.00
IUUC-Sar-113309	Sorex araneus	29.81	3.00e-40	158.00
IUUC-Sbi-114284	Sorghum bicolor	66.34	3.00e-127	447.00
IUUC-Sre-115180	Sporisorium reilianum	40.73	1.00e-59	222.00
IUUC-Ssc-116204	Sus scrofa	65.45	1.00e-116	412.00
IUUC-Tgu-117172	Taeniopygia guttata	65.45	7.00e-117	412.00
IUUC-Tru-118320	Takifugu rubripes	65.88	2.00e-116	411.00
IUUC-Tsy-119493	Tarsius syrichta	29.81	5.00e-39	154.00
IUUC-Tni-120660	Tetraodon nigroviridis	67.55	1.00e-72	265.00
IUUC-Tca-121051	Theobroma cacao	77.42	8.00e-148	515.00
IUUC-Tre-122237	Trichoderma reesei	41.94	5.00e-69	254.00
IUUC-Tvi-122635	Trichoderma virens	40.92	3.00e-69	254.00
IUUC-Tae-125819	Triticum aestivum	64.26	1.00e-125	442.00
IUUC-Tur-126217	Triticum urartu	59.83	6.00e-83	299.00
IUUC-Tme-127061	Tuber melanosporum	48.09	2.00e-87	314.00
IUUC-Tbe-127488	Tupaia belangeri	58.79	5.00e-103	366.00
IUUC-Ttr-129309	Tursiops truncatus	61.46	2.00e-107	381.00
IUUC-Uma-129585	Ustilago maydis	38.44	3.00e-67	248.00
IUUC-Vda-129907	Verticillium dahliae	39.80	3.00e-61	229.00
IUUC-Vpa-130384	Vicugna pacos	60.83	1.00e-102	365.00
IUUC-Vvi-131269	Vitis vinifera	76.62	4.00e-137	479.00
IUUC-Xtr-131945	Xenopus tropicalis	65.12	8.00e-116	409.00
IUUC-Xma-132997	Xiphophorus maculatus	66.22	1.00e-116	411.00
IUUC-Yli-134418	Yarrowia lipolytica	37.67	2.00e-66	245.00
IUUC-Zma-135765	Zea mays	65.37	7.00e-126	442.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence