iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UIM	8.70e-06	25.6	224	242
UBD/Alpha-Helix/UIM	1.5e-05	15.9	244	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           d++++Lq+Ala+S+qE ++
   Q: 224  DDEDDLQRALAMSRQEIDM 242
           79**************886 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqE 16
           dE+++L++A++lS+q 
   Q: 244  DEEADLRRAIQLSMQG 259
           7*************97 PP

Organism

Rattus norvegicus

Functional Description
(View)

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity).

Protein Sequence
(Fasta)

MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERLRMAE GGVTSEDYRT 60
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACGTGGGTA GGGCGGGGCG GGCCGGGGCG GAGGGGTGGG GCCGGGGGCG GAGCTGCTGG 60
AGGGGGCTGC TCCGCGCCGG GGCCGTTGGC TCCAGACAAA TAAACATGGA GTCCATCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR033865--Ataxin-3
IPR006155--Josephin
IPR009068--S15_NS1_RNA-bd
IPR003903--UIM_dom

PROSITE

PS50957--JOSEPHIN
PS50330--UIM

Pfam

PF02099--Josephin
PF02809--UIM

SMART

SM01246--Josephin
SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005759--C:mitochondrial matrix
GO:0031966--C:mitochondrial membrane
GO:0042405--C:nuclear inclusion body
GO:0005634--C:nucleus
GO:0051117--F:ATPase binding
GO:0042802--F:identical protein binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0001012--F:RNA polymerase II regulatory region DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0030036--P:actin cytoskeleton organization
GO:0034605--P:cellular response to heat
GO:0071218--P:cellular response to misfolded protein
GO:0035640--P:exploration behavior
GO:0070932--P:histone H3 deacetylation
GO:0045104--P:intermediate filament cytoskeleton organization
GO:0000226--P:microtubule cytoskeleton organization
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0010810--P:regulation of cell-substrate adhesion
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

rno:60331

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002015	Ailuropoda melanoleuca	86.17	4.00e-174	603.00
IUUC-Atr-002735	Amborella trichopoda	50.00	2.00e-06	43.50
IUUC-Apl-003210	Anas platyrhynchos	72.70	2.00e-138	485.00
IUUC-Aca-005171	Anolis carolinensis	66.67	1.00e-120	426.00
IUUC-Aly-005625	Arabidopsis lyrata	44.64	2.00e-40	159.00
IUUC-Ath-007088	Arabidopsis thaliana	44.64	2.00e-40	159.00
IUUC-Ame-010715	Astyanax mexicanus	69.11	1.00e-120	425.00
IUUC-Bta-013538	Bos taurus	77.96	3.00e-166	577.00
IUUC-Bdi-015000	Brachypodium distachyon	42.01	7.00e-36	144.00
IUUC-Bol-015894	Brassica oleracea	44.05	1.00e-40	160.00
IUUC-Bra-018020	Brassica rapa	44.31	9.00e-41	161.00
IUUC-Cel-018121	Caenorhabditis elegans	37.88	2.00e-43	169.00
IUUC-Cja-018840	Callithrix jacchus	80.06	5.00e-167	580.00
IUUC-Cfa-021035	Canis familiaris	84.68	3.00e-175	607.00
IUUC-Cpo-021776	Cavia porcellus	79.73	1.00e-167	582.00
IUUC-Csa-023257	Chlorocebus sabaeus	66.30	9.00e-131	459.00
IUUC-Cho-024878	Choloepus hoffmanni	83.62	1.00e-167	582.00
IUUC-Cgl-026754	Colletotrichum gloeosporioides	32.79	3.50e-01	30.80
IUUC-Cme-027158	Cyanidioschyzon merolae	31.22	1.00e-12	66.20
IUUC-Dre-027506	Danio rerio	67.47	1.00e-88	319.00
IUUC-Dno-029172	Dasypus novemcinctus	82.92	4.00e-172	597.00
IUUC-Dor-030900	Dipodomys ordii	78.14	2.00e-146	511.00
IUUC-Ete-033000	Echinops telfairi	55.29	5.00e-84	304.00
IUUC-Eca-034338	Equus caballus	85.51	2.00e-171	594.00
IUUC-Eeu-034585	Erinaceus europaeus	97.14	6.00e-57	214.00
IUUC-Fca-035441	Felis catus	79.43	3.00e-62	230.00
IUUC-Fal-037525	Ficedula albicollis	71.51	9.00e-129	452.00
IUUC-Gmo-039718	Gadus morhua	71.77	8.00e-113	399.00
IUUC-Gga-040774	Gallus gallus	73.30	2.00e-147	515.00
IUUC-Gac-041671	Gasterosteus aculeatus	72.26	1.00e-107	382.00
IUUC-Gma-042801	Glycine max	41.32	4.00e-37	148.00
IUUC-Ggo-044759	Gorilla gorilla	79.93	1.00e-133	469.00
IUUC-Hsa-046591	Homo sapiens	84.24	9.00e-166	576.00
IUUC-Hvu-047492	Hordeum vulgare	43.20	2.00e-34	139.00
IUUC-Itr-048851	Ictidomys tridecemlineatus	68.98	5.00e-122	430.00
IUUC-Lch-049519	Latimeria chalumnae	71.88	4.00e-106	377.00
IUUC-Lpe-050819	Leersia perrieri	43.27	8.00e-36	144.00
IUUC-Loc-051816	Lepisosteus oculatus	64.99	1.00e-126	446.00
IUUC-Laf-053784	Loxodonta africana	83.66	3.00e-177	613.00
IUUC-Mcc-055283	Macaca mulatta	85.60	4.00e-177	613.00
IUUC-Meu-056589	Macropus eugenii	70.03	7.00e-138	483.00
IUUC-Mtr-058233	Medicago truncatula	41.92	1.00e-36	147.00
IUUC-Mla-059013	Melampsora laricipopulina	39.70	6.00e-31	128.00
IUUC-Mga-059301	Meleagris gallopavo	72.21	1.00e-150	525.00
IUUC-Mmr-061038	Microcebus murinus	84.15	3.00e-178	617.00
IUUC-Mdo-062927	Monodelphis domestica	87.87	5.00e-148	516.00
IUUC-Mmu-063600	Mus musculus	94.08	0.00e+00	633.00
IUUC-Mpu-065897	Mustela putorius furo	85.39	1.00e-152	532.00
IUUC-Mlu-067543	Myotis lucifugus	89.62	2.00e-154	538.00
IUUC-Nle-069847	Nomascus leucogenys	79.22	7.00e-161	559.00
IUUC-Opr-070550	Ochotona princeps	76.29	1.00e-147	515.00
IUUC-Ont-071723	Oreochromis niloticus	67.41	1.00e-110	392.00
IUUC-Oan-073569	Ornithorhynchus anatinus	73.99	4.00e-154	537.00
IUUC-Ocu-074632	Oryctolagus cuniculus	84.48	2.00e-175	607.00
IUUC-Oba-075288	Oryza barthii	43.27	5.00e-38	151.00
IUUC-Obr-076050	Oryza brachyantha	42.69	6.00e-34	138.00
IUUC-Ogl-077174	Oryza glaberrima	43.27	5.00e-38	151.00
IUUC-Ogu-078006	Oryza glumaepatula	43.27	5.00e-38	151.00
IUUC-Oin-079278	Oryza indica	40.88	1.00e-35	143.00
IUUC-Olo-080941	Oryza longistaminata	43.27	5.00e-38	151.00
IUUC-Ome-081172	Oryza meridionalis	43.27	5.00e-38	151.00
IUUC-Oni-082239	Oryza nivara	43.27	5.00e-38	151.00
IUUC-Opu-083939	Oryza punctata	42.69	2.00e-37	149.00
IUUC-Oru-084393	Oryza rufipogon	43.27	5.00e-38	151.00
IUUC-Osa-086080	Oryza sativa	43.27	4.00e-38	151.00
IUUC-Ola-087566	Oryzias latipes	72.95	9.00e-113	399.00
IUUC-Oga-088617	Otolemur garnettii	68.45	6.00e-125	439.00
IUUC-Oar-090052	Ovis aries	77.99	1.00e-165	575.00
IUUC-Ptr-091435	Pan troglodytes	85.64	4.00e-178	617.00
IUUC-Pan-092742	Papio anubis	65.46	9.00e-129	452.00
IUUC-Psi-093313	Pelodiscus sinensis	85.28	4.00e-126	443.00
IUUC-Pma-094374	Petromyzon marinus	61.36	4.00e-85	307.00
IUUC-Ppa-095601	Physcomitrella patens	44.64	1.00e-44	173.00
IUUC-Pfo-097327	Poecilia formosa	69.36	8.00e-113	399.00
IUUC-Pab-098611	Pongo abelii	82.26	9.00e-144	502.00
IUUC-Pca-101022	Procavia capensis	98.21	4.00e-65	241.00
IUUC-Ppe-101545	Prunus persica	42.86	2.00e-38	152.00
IUUC-Pva-102844	Pteropus vampyrus	84.25	1.00e-174	605.00
IUUC-Sha-107106	Sarcophilus harrisii	78.79	3.00e-161	560.00
IUUC-Sit-110477	Setaria italica	44.44	1.00e-37	150.00
IUUC-Sly-111416	Solanum lycopersicum	39.13	5.00e-18	84.30
IUUC-Stu-112227	Solanum tuberosum	40.86	4.00e-20	90.90
IUUC-Sar-113534	Sorex araneus	73.86	2.00e-142	498.00
IUUC-Sbi-114751	Sorghum bicolor	43.35	3.00e-36	145.00
IUUC-Ssc-115274	Sus scrofa	86.20	1.00e-177	615.00
IUUC-Tgu-117426	Taeniopygia guttata	73.22	5.00e-137	480.00
IUUC-Tru-118059	Takifugu rubripes	72.79	1.00e-110	392.00
IUUC-Tsy-119448	Tarsius syrichta	82.18	1.00e-87	316.00
IUUC-Tni-120681	Tetraodon nigroviridis	88.37	6.00e-62	228.00
IUUC-Tca-121442	Theobroma cacao	34.53	1.00e-39	156.00
IUUC-Tae-123969	Triticum aestivum	42.11	1.00e-32	133.00
IUUC-Tbe-127638	Tupaia belangeri	79.43	9.00e-158	549.00
IUUC-Ttr-129288	Tursiops truncatus	76.11	2.00e-151	528.00
IUUC-Uma-129359	Ustilago maydis	38.74	1.00e-34	141.00
IUUC-Vda-129976	Verticillium dahliae	40.38	1.20e-01	33.10
IUUC-Vpa-130788	Vicugna pacos	83.24	8.00e-171	592.00
IUUC-Vvi-131227	Vitis vinifera	42.51	4.00e-36	144.00
IUUC-Xtr-132147	Xenopus tropicalis	67.31	2.00e-129	454.00
IUUC-Xma-133144	Xiphophorus maculatus	69.02	1.00e-109	389.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence