iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013066

Ensembl Protein ID

ENSBTAP00000008019.5

UniProt Accession

Q58DA0; Q0V8P5; PSMD4_BOVIN

Genbank Protein ID

AAX46402.1; AAX46544.1; AAX46604.1; ABG67012.1; AAI19965.1

Protein Name

26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10

Genbank Nucleotide ID

BT021555; BT021697; BT021757; BT026173; BC119964

Gene Name

PSMD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000006101.5	ENSBTAT00000008019.5	ENSBTAP00000008019.5
ENSBTAG00000006101.5	ENSBTAT00000046341.2	ENSBTAP00000043651.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UIM	43.30	4.00e-66	248.00	IUUC-Ath-007436
UBD/Alpha-Helix/UIM	56.84	1.00e-104	376.00	IUUC-Dme-032000
UBD/Alpha-Helix/UIM	99.18	0.00e+00	634.00	IUUC-Hsa-045850

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains.

Protein Sequence
(Fasta)

MVLESTMVCV DNSEYMRNGD FLPTRLQAQQ DAVNIVCHSK TRSNPENNVG LITLANDCEV 60
LTTLTPDTGR ILSKLHTVQP KGKITFCTGI RVAHLALKHR QGKNHKMRII AFVGSPVEDN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGTCGGGG AGGGAGGAAG GAGGCACGAT GGTGTTGGAA AGCACTATGG TTTGGTGAGG 60
AGCCACCTCG GGCCCCCTTG GGGAGCGGGA CTGGGTCGGG GGCGCCTGTA GCTCGGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR027040--Proteasome_su_Rpn10
IPR003903--UIM_dom
IPR002035--VWF_A

PROSITE

PS50330--UIM
PS50234--VWFA

Pfam

PF02809--UIM
PF13519--VWA_2

SMART

SM00726--UIM
SM00327--VWA

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0022624--C:proteasome accessory complex
GO:0008540--C:proteasome regulatory particle, base subcomplex
GO:0031593--F:polyubiquitin binding
GO:0043248--P:proteasome assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

bta:282016

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001241	Ailuropoda melanoleuca	99.17	0.00e+00	639.00
IUUC-Atr-002938	Amborella trichopoda	41.71	8.00e-65	240.00
IUUC-Apl-003881	Anas platyrhynchos	97.13	2.00e-110	390.00
IUUC-Aca-004397	Anolis carolinensis	97.32	1.00e-120	425.00
IUUC-Aly-005564	Arabidopsis lyrata	42.04	2.00e-56	213.00
IUUC-Ath-007436	Arabidopsis thaliana	42.22	1.00e-55	210.00
IUUC-Ago-007858	Ashbya gossypii	51.30	1.00e-58	219.00
IUUC-Acl-008094	Aspergillus clavatus	45.45	2.00e-38	152.00
IUUC-Afl-008689	Aspergillus flavus	46.75	5.00e-39	154.00
IUUC-Afu-008959	Aspergillus fumigatus	46.29	6.00e-39	154.00
IUUC-Ani-009344	Aspergillus nidulans	43.01	2.00e-23	102.00
IUUC-Ang-009602	Aspergillus niger	45.45	3.00e-37	148.00
IUUC-Aor-009906	Aspergillus oryzae	44.74	1.00e-24	106.00
IUUC-Ate-010267	Aspergillus terreus	44.50	2.00e-30	125.00
IUUC-Ame-011018	Astyanax mexicanus	87.88	6.00e-176	609.00
IUUC-Bgr-012200	Blumeria graminis	50.00	4.00e-49	188.00
IUUC-Bci-013904	Botrytis cinerea	51.90	1.00e-49	189.00
IUUC-Bdi-014537	Brachypodium distachyon	49.58	5.00e-53	201.00
IUUC-Bol-015474	Brassica oleracea	50.42	2.00e-52	199.00
IUUC-Bra-018039	Brassica rapa	50.42	9.00e-53	200.00
IUUC-Cel-018187	Caenorhabditis elegans	45.35	1.00e-67	250.00
IUUC-Cja-019738	Callithrix jacchus	92.64	0.00e+00	636.00
IUUC-Cfa-020362	Canis familiaris	98.90	0.00e+00	638.00
IUUC-Cpo-021297	Cavia porcellus	98.87	2.00e-176	612.00
IUUC-Cre-022783	Chlamydomonas reinhardtii	49.58	4.00e-46	177.00
IUUC-Cho-024800	Choloepus hoffmanni	97.25	4.00e-57	214.00
IUUC-Cin-025469	Ciona intestinalis	56.46	7.00e-92	330.00
IUUC-Csv-026297	Ciona savignyi	56.39	3.00e-102	365.00
IUUC-Cgl-026657	Colletotrichum gloeosporioides	48.95	2.00e-39	155.00
IUUC-Cne-027027	Cryptococcus neoformans	47.14	3.00e-49	188.00
IUUC-Cme-027212	Cyanidioschyzon merolae	41.03	6.00e-47	181.00
IUUC-Dre-027759	Danio rerio	87.05	1.00e-173	602.00
IUUC-Dno-029528	Dasypus novemcinctus	92.64	0.00e+00	636.00
IUUC-Dor-030255	Dipodomys ordii	91.34	2.00e-176	611.00
IUUC-Dse-031464	Dothistroma septosporum	49.79	1.00e-53	203.00
IUUC-Dme-032000	Drosophila melanogaster	68.44	1.00e-87	316.00
IUUC-Ete-032762	Echinops telfairi	92.10	0.00e+00	633.00
IUUC-Eca-034399	Equus caballus	97.24	0.00e+00	636.00
IUUC-Eeu-035072	Erinaceus europaeus	97.43	1.00e-144	505.00
IUUC-Fca-035993	Felis catus	91.32	3.00e-176	610.00
IUUC-Fal-037623	Ficedula albicollis	66.11	4.00e-120	424.00
IUUC-Fox-037746	Fusarium oxysporum	47.03	2.00e-49	189.00
IUUC-Fso-038431	Fusarium solani	49.15	3.00e-50	191.00
IUUC-Gmo-039290	Gadus morhua	83.15	5.00e-145	507.00
IUUC-Ggr-039821	Gaeumannomyces graminis	48.70	3.00e-41	162.00
IUUC-Gga-040288	Gallus gallus	95.33	4.00e-176	610.00
IUUC-Gac-042587	Gasterosteus aculeatus	84.40	2.00e-165	575.00
IUUC-Gma-044042	Glycine max	52.17	1.00e-57	216.00
IUUC-Ggo-044628	Gorilla gorilla	92.64	0.00e+00	636.00
IUUC-Hsa-045850	Homo sapiens	99.18	0.00e+00	658.00
IUUC-Hvu-047715	Hordeum vulgare	49.58	2.00e-52	199.00
IUUC-Itr-048388	Ictidomys tridecemlineatus	98.06	2.00e-179	621.00
IUUC-Kpa-049158	Komagataella pastoris	54.59	3.00e-56	211.00
IUUC-Lch-050472	Latimeria chalumnae	91.24	8.00e-167	580.00
IUUC-Lpe-051233	Leersia perrieri	48.73	3.00e-49	191.00
IUUC-Loc-052437	Lepisosteus oculatus	76.59	1.00e-90	327.00
IUUC-Lma-053295	Leptosphaeria maculans	52.50	3.00e-48	185.00
IUUC-Laf-053504	Loxodonta africana	92.10	0.00e+00	633.00
IUUC-Mcc-054877	Macaca mulatta	92.64	0.00e+00	634.00
IUUC-Meu-056114	Macropus eugenii	97.27	0.00e+00	645.00
IUUC-Mor-057212	Magnaporthe oryzae	45.99	3.00e-44	171.00
IUUC-Mpo-057587	Magnaporthe poae	49.74	3.00e-42	165.00
IUUC-Mtr-058520	Medicago truncatula	40.10	6.00e-56	211.00
IUUC-Mla-059105	Melampsora laricipopulina	41.84	6.00e-19	88.20
IUUC-Mga-059537	Meleagris gallopavo	94.23	2.00e-180	624.00
IUUC-Mvi-060277	Microbotryum violaceum	37.15	2.00e-39	156.00
IUUC-Mmr-061736	Microcebus murinus	98.63	4.00e-180	623.00
IUUC-Mdo-062403	Monodelphis domestica	97.74	0.00e+00	629.00
IUUC-Mmu-063937	Mus musculus	95.91	3.00e-173	600.00
IUUC-Mac-065456	Musa acuminata	39.90	1.00e-58	220.00
IUUC-Mpu-065901	Mustela putorius furo	99.17	0.00e+00	639.00
IUUC-Mlu-067994	Myotis lucifugus	98.08	0.00e+00	651.00
IUUC-Nfi-068540	Neosartorya fischeri	46.29	9.00e-39	153.00
IUUC-Ncr-068760	Neurospora crassa	49.58	8.00e-53	200.00
IUUC-Nle-069463	Nomascus leucogenys	92.64	0.00e+00	636.00
IUUC-Opr-070298	Ochotona princeps	91.83	0.00e+00	633.00
IUUC-Ont-072615	Oreochromis niloticus	88.12	1.00e-175	608.00
IUUC-Ocu-074141	Oryctolagus cuniculus	91.55	0.00e+00	633.00
IUUC-Oba-075955	Oryza barthii	48.73	7.00e-50	191.00
IUUC-Obr-076545	Oryza brachyantha	48.31	2.00e-48	186.00
IUUC-Ogl-077252	Oryza glaberrima	48.31	1.00e-47	183.00
IUUC-Ogu-078986	Oryza glumaepatula	48.73	9.00e-50	190.00
IUUC-Oin-080166	Oryza indica	47.64	7.00e-48	185.00
IUUC-Olo-080390	Oryza longistaminata	48.05	9.00e-47	182.00
IUUC-Ome-082015	Oryza meridionalis	48.73	5.00e-50	191.00
IUUC-Oni-082397	Oryza nivara	48.73	6.00e-50	191.00
IUUC-Opu-083674	Oryza punctata	48.73	4.00e-50	191.00
IUUC-Oru-085199	Oryza rufipogon	48.73	6.00e-50	191.00
IUUC-Osa-085911	Oryza sativa	48.73	6.00e-50	191.00
IUUC-Ola-087383	Oryzias latipes	87.32	6.00e-169	587.00
IUUC-Olu-087857	Ostreococcus lucimarinus	48.42	1.00e-45	176.00
IUUC-Oga-088882	Otolemur garnettii	98.03	3.00e-180	624.00
IUUC-Oar-089311	Ovis aries	99.73	0.00e+00	636.00
IUUC-Ptr-090931	Pan troglodytes	99.18	0.00e+00	658.00
IUUC-Pan-092286	Papio anubis	99.18	0.00e+00	657.00
IUUC-Psi-093908	Pelodiscus sinensis	88.64	3.00e-169	587.00
IUUC-Pma-094737	Petromyzon marinus	79.19	2.00e-142	498.00
IUUC-Pno-094807	Phaeosphaeria nodorum	52.10	6.00e-54	204.00
IUUC-Ppa-095749	Physcomitrella patens	48.35	2.00e-52	199.00
IUUC-Pfo-097212	Poecilia formosa	86.46	3.00e-173	600.00
IUUC-Pab-097708	Pongo abelii	99.15	0.00e+00	638.00
IUUC-Pop-099138	Populus trichocarpa	40.93	4.00e-64	238.00
IUUC-Pca-100722	Procavia capensis	100.00	2.00e-63	236.00
IUUC-Ppe-101877	Prunus persica	41.73	1.00e-70	260.00
IUUC-Pva-103185	Pteropus vampyrus	91.83	0.00e+00	629.00
IUUC-Pgr-103361	Puccinia graminis	39.83	3.00e-31	129.00
IUUC-Ptt-103848	Puccinia triticina	35.54	6.00e-15	74.30
IUUC-Pte-104114	Pyrenophora teres	50.43	3.00e-49	188.00
IUUC-Pyt-104662	Pyrenophora triticirepentis	51.05	1.00e-52	199.00
IUUC-Rno-104906	Rattus norvegicus	97.82	0.00e+00	647.00
IUUC-Sce-106427	Saccharomyces cerevisiae	48.73	2.00e-55	208.00
IUUC-Sha-106574	Sarcophilus harrisii	96.45	0.00e+00	637.00
IUUC-Sja-107706	Schizosaccharomyces japonicus	48.85	4.00e-49	187.00
IUUC-Spo-108378	Schizosaccharomyces pombe	46.51	1.00e-51	195.00
IUUC-Smo-109639	Selaginella moellendorffii	48.98	7.00e-53	201.00
IUUC-Sit-110284	Setaria italica	50.85	7.00e-50	191.00
IUUC-Sly-111246	Solanum lycopersicum	40.86	8.00e-62	231.00
IUUC-Stu-112695	Solanum tuberosum	40.41	5.00e-62	231.00
IUUC-Sar-113015	Sorex araneus	98.81	3.00e-98	351.00
IUUC-Sbi-114495	Sorghum bicolor	50.85	3.00e-50	192.00
IUUC-Sre-114891	Sporisorium reilianum	53.88	1.00e-58	219.00
IUUC-Ssc-116142	Sus scrofa	98.90	0.00e+00	656.00
IUUC-Tgu-116946	Taeniopygia guttata	90.88	5.00e-129	453.00
IUUC-Tru-118485	Takifugu rubripes	86.97	7.00e-168	584.00
IUUC-Tsy-119004	Tarsius syrichta	95.50	2.00e-147	514.00
IUUC-Tni-120074	Tetraodon nigroviridis	87.85	5.00e-174	603.00
IUUC-Tca-121251	Theobroma cacao	39.61	3.00e-55	209.00
IUUC-Tre-122168	Trichoderma reesei	49.79	6.00e-54	204.00
IUUC-Tvi-122655	Trichoderma virens	49.36	3.00e-50	191.00
IUUC-Tae-124568	Triticum aestivum	49.58	3.00e-52	198.00
IUUC-Tur-126420	Triticum urartu	49.58	4.00e-52	198.00
IUUC-Tme-126937	Tuber melanosporum	54.01	3.00e-55	208.00
IUUC-Tbe-128080	Tupaia belangeri	90.46	5.00e-179	619.00
IUUC-Ttr-128811	Tursiops truncatus	92.64	0.00e+00	636.00
IUUC-Uma-129436	Ustilago maydis	54.31	2.00e-59	223.00
IUUC-Vda-129920	Verticillium dahliae	48.35	3.00e-43	168.00
IUUC-Vpa-130762	Vicugna pacos	100.00	3.00e-65	242.00
IUUC-Vvi-130840	Vitis vinifera	50.21	1.00e-55	210.00
IUUC-Xtr-131967	Xenopus tropicalis	91.11	7.00e-117	412.00
IUUC-Xma-134224	Xiphophorus maculatus	85.91	3.00e-171	594.00
IUUC-Yli-134643	Yarrowia lipolytica	54.04	2.00e-53	202.00
IUUC-Zma-135870	Zea mays	41.04	2.00e-53	203.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence