iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066612

Ensembl Protein ID

ENSMPUP00000004860.1

UniProt Accession

M3Y0K9; M3Y0K9_MUSPF

Genbank Protein ID

ENSMPUP00000004860

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01054557

Gene Name

RFWD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000004900.1	ENSMPUT00000004944.1	ENSMPUP00000004860.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.60e-06	26.4	1	38
E3 adaptor/Cullin RING/DCX/DWD	8.90e-23	79.5	334	363

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 2    aiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           +iC++++++  + + CgH f+ +C+++          + rCP C+
   Q: 1    PICFDMIEE-AYMTKCGHSFCYKCIHQS------LEDNNRCPKCN 38
           8******99.888***********9555......999999****6 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tdsvtclaf..sd.tllvsGsdDgtikvWD 29
           +++++c+++     +ll+s+ + gt+ +WD
   Q: 334  NSKISCISWssYHkNLLASSDYEGTVILWD 363
           689******9622599************** PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

PICFDMIEEA YMTKCGHSFC YKCIHQSLED NNRCPKCNYV VDNIDHLYPN FLVNELILKQ 60
KQRFEEKRFK LDHSVSSTNG HRWQIFQDLL GTDQDNLDLA NVNLMLELLV QKKKQLEAES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNCGGCTC AGCTGCGCGG CCAGGCCCAG CGCCGGCGTG GGAGGGAGCA GCTCCAGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00400--WD40

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000885	Aegilops tauschii	39.65	9.00e-122	430.00
IUUC-Aml-001265	Ailuropoda melanoleuca	98.97	0.00e+00	1169.00
IUUC-Atr-002460	Amborella trichopoda	38.10	4.00e-117	415.00
IUUC-Apl-003796	Anas platyrhynchos	97.93	0.00e+00	1155.00
IUUC-Aca-005078	Anolis carolinensis	96.91	0.00e+00	1128.00
IUUC-Aly-006014	Arabidopsis lyrata	39.68	3.00e-123	435.00
IUUC-Ath-007636	Arabidopsis thaliana	39.35	9.00e-123	434.00
IUUC-Ame-011176	Astyanax mexicanus	95.87	8.00e-69	254.00
IUUC-Bta-012595	Bos taurus	98.97	0.00e+00	1167.00
IUUC-Bdi-014152	Brachypodium distachyon	38.59	5.00e-122	431.00
IUUC-Bol-016380	Brassica oleracea	40.00	7.00e-124	437.00
IUUC-Bra-017690	Brassica rapa	38.81	3.00e-118	419.00
IUUC-Cja-018926	Callithrix jacchus	98.63	0.00e+00	1162.00
IUUC-Cfa-021088	Canis familiaris	98.63	0.00e+00	1165.00
IUUC-Cpo-022442	Cavia porcellus	96.66	0.00e+00	1160.00
IUUC-Cre-022579	Chlamydomonas reinhardtii	33.45	2.00e-33	135.00
IUUC-Csa-024119	Chlorocebus sabaeus	98.97	0.00e+00	1168.00
IUUC-Cho-024883	Choloepus hoffmanni	63.48	2.00e-96	346.00
IUUC-Cin-025375	Ciona intestinalis	56.19	0.00e+00	642.00
IUUC-Cme-027350	Cyanidioschyzon merolae	45.45	1.00e-74	275.00
IUUC-Dre-028453	Danio rerio	87.10	0.00e+00	1016.00
IUUC-Dno-029887	Dasypus novemcinctus	98.11	0.00e+00	1158.00
IUUC-Dor-031110	Dipodomys ordii	79.04	0.00e+00	892.00
IUUC-Ete-033016	Echinops telfairi	83.36	0.00e+00	951.00
IUUC-Eca-034403	Equus caballus	99.13	0.00e+00	1159.00
IUUC-Eeu-034690	Erinaceus europaeus	84.35	0.00e+00	960.00
IUUC-Fca-036475	Felis catus	99.30	0.00e+00	1160.00
IUUC-Fal-037189	Ficedula albicollis	97.77	0.00e+00	1157.00
IUUC-Gmo-039245	Gadus morhua	86.18	0.00e+00	1003.00
IUUC-Gga-040806	Gallus gallus	97.77	0.00e+00	1156.00
IUUC-Gac-042177	Gasterosteus aculeatus	87.71	0.00e+00	1033.00
IUUC-Gma-044187	Glycine max	40.45	5.00e-120	424.00
IUUC-Ggo-044430	Gorilla gorilla	98.43	0.00e+00	876.00
IUUC-Hsa-045853	Homo sapiens	98.63	0.00e+00	1162.00
IUUC-Hvu-047750	Hordeum vulgare	37.88	3.00e-87	317.00
IUUC-Itr-048238	Ictidomys tridecemlineatus	99.58	2.00e-143	500.00
IUUC-Lch-050420	Latimeria chalumnae	91.19	0.00e+00	1068.00
IUUC-Lpe-051219	Leersia perrieri	38.78	2.00e-120	426.00
IUUC-Loc-052728	Lepisosteus oculatus	90.31	0.00e+00	1034.00
IUUC-Laf-053775	Loxodonta africana	97.94	0.00e+00	1167.00
IUUC-Meu-056595	Macropus eugenii	77.70	3.00e-177	615.00
IUUC-Mtr-058555	Medicago truncatula	40.51	5.00e-127	448.00
IUUC-Mga-059646	Meleagris gallopavo	98.44	0.00e+00	1153.00
IUUC-Mmr-060990	Microcebus murinus	98.97	0.00e+00	1168.00
IUUC-Mdo-062287	Monodelphis domestica	98.28	0.00e+00	1164.00
IUUC-Mmu-064097	Mus musculus	98.63	0.00e+00	1165.00
IUUC-Mac-065240	Musa acuminata	40.96	3.00e-128	452.00
IUUC-Mlu-067967	Myotis lucifugus	98.46	0.00e+00	1162.00
IUUC-Nle-069543	Nomascus leucogenys	98.80	0.00e+00	1167.00
IUUC-Opr-070366	Ochotona princeps	84.33	0.00e+00	674.00
IUUC-Ont-071522	Oreochromis niloticus	87.20	0.00e+00	1022.00
IUUC-Oan-073409	Ornithorhynchus anatinus	98.96	0.00e+00	1159.00
IUUC-Ocu-073756	Oryctolagus cuniculus	99.30	0.00e+00	1164.00
IUUC-Oba-075149	Oryza barthii	38.84	5.00e-120	426.00
IUUC-Obr-076563	Oryza brachyantha	38.91	3.00e-120	425.00
IUUC-Ogl-077701	Oryza glaberrima	38.52	2.00e-120	426.00
IUUC-Ogu-078383	Oryza glumaepatula	38.52	2.00e-120	426.00
IUUC-Oin-079965	Oryza indica	36.69	1.00e-108	387.00
IUUC-Olo-080639	Oryza longistaminata	38.36	4.00e-118	418.00
IUUC-Ome-081821	Oryza meridionalis	38.37	4.00e-110	392.00
IUUC-Oni-082622	Oryza nivara	38.52	2.00e-120	426.00
IUUC-Opu-083295	Oryza punctata	38.52	4.00e-120	425.00
IUUC-Oru-084661	Oryza rufipogon	38.52	2.00e-120	426.00
IUUC-Osa-085766	Oryza sativa	38.52	2.00e-120	426.00
IUUC-Ola-086727	Oryzias latipes	87.37	0.00e+00	1041.00
IUUC-Olu-087702	Ostreococcus lucimarinus	43.10	1.00e-65	243.00
IUUC-Oga-088215	Otolemur garnettii	97.80	0.00e+00	1164.00
IUUC-Oar-089880	Ovis aries	99.65	0.00e+00	1164.00
IUUC-Ptr-090597	Pan troglodytes	98.63	0.00e+00	1162.00
IUUC-Pan-091987	Papio anubis	98.97	0.00e+00	1167.00
IUUC-Psi-094033	Pelodiscus sinensis	97.23	0.00e+00	1136.00
IUUC-Pma-094587	Petromyzon marinus	70.30	0.00e+00	766.00
IUUC-Ppa-095256	Physcomitrella patens	38.96	9.00e-125	441.00
IUUC-Pfo-097388	Poecilia formosa	86.30	0.00e+00	1001.00
IUUC-Pab-098029	Pongo abelii	98.63	0.00e+00	1162.00
IUUC-Pop-099319	Populus trichocarpa	38.52	4.00e-123	435.00
IUUC-Pca-100846	Procavia capensis	89.71	0.00e+00	1055.00
IUUC-Ppe-101250	Prunus persica	38.60	4.00e-114	405.00
IUUC-Pva-102407	Pteropus vampyrus	98.63	0.00e+00	1154.00
IUUC-Rno-105312	Rattus norvegicus	98.63	0.00e+00	1162.00
IUUC-Sha-106514	Sarcophilus harrisii	98.65	0.00e+00	769.00
IUUC-Smo-109418	Selaginella moellendorffii	39.10	7.00e-123	434.00
IUUC-Sit-110248	Setaria italica	38.33	2.00e-121	429.00
IUUC-Sly-110964	Solanum lycopersicum	40.54	1.00e-126	447.00
IUUC-Stu-112882	Solanum tuberosum	40.54	7.00e-127	447.00
IUUC-Sar-113230	Sorex araneus	70.65	0.00e+00	779.00
IUUC-Sbi-113962	Sorghum bicolor	36.43	3.00e-116	412.00
IUUC-Ssc-115987	Sus scrofa	99.31	2.00e-161	561.00
IUUC-Tgu-116471	Taeniopygia guttata	97.60	0.00e+00	1153.00
IUUC-Tru-118231	Takifugu rubripes	86.50	0.00e+00	988.00
IUUC-Tsy-119415	Tarsius syrichta	97.94	0.00e+00	1140.00
IUUC-Tni-120893	Tetraodon nigroviridis	86.67	0.00e+00	994.00
IUUC-Tca-121703	Theobroma cacao	41.22	5.00e-124	438.00
IUUC-Tae-125317	Triticum aestivum	40.68	6.00e-128	451.00
IUUC-Tur-126557	Triticum urartu	40.36	8.00e-125	441.00
IUUC-Tbe-127253	Tupaia belangeri	69.13	0.00e+00	769.00
IUUC-Ttr-129100	Tursiops truncatus	96.57	0.00e+00	1109.00
IUUC-Vpa-130613	Vicugna pacos	91.77	0.00e+00	1066.00
IUUC-Vvi-130880	Vitis vinifera	40.54	2.00e-118	419.00
IUUC-Xtr-132033	Xenopus tropicalis	94.85	0.00e+00	1153.00
IUUC-Xma-133421	Xiphophorus maculatus	86.13	0.00e+00	998.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence