iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093833

Ensembl Protein ID

ENSPSIP00000006306.1

UniProt Accession

K7FE46; K7FE46_PELSI

Genbank Protein ID

ENSPSIP00000006306

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01110652

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000005773.1	ENSPSIT00000006343.1	ENSPSIP00000006306.1
ENSPSIG00000005773.1	ENSPSIT00000006357.1	ENSPSIP00000006320.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.70e-93	312.6	2811	3145
E3 adaptor/Cullin RING/DCX/DWD	5.60e-21	73.8	1724	1754

Active Site

Position(s)	Description	Evidence
3114	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l n      ehl  F+flG+l+g+a+++++
   Q: 2811 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNATAEVGYNRDRFLFNSsacldEHLMQFKFLGILMGVAIRTKK 2897
           466666****************************************************9999************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+  +l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 2898 PLDLHLAPMVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHIEDSGITEENFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 2984
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e i++qv+a+reG+++++p  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 2985 EYVERAIEYRLHE-IDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 3069
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ i+ e+L+yAi++++++++
   Q: 3070 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLIMAERLRYAINNCRSIDM 3145
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 1724 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 1754
           55416677.*9778****************97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

QDGIRSAKRN IQIEIQVAVH KIYQQLSATL ERALQANKHH IEAQQRLLLV TVFALSVHYQ 60
PVDVSLAIST GLLNVLSQLC GTDTMLGQPL QLLPKTGISQ LSTALKVAST RLLQILAITT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGATGGTA TCAGATCAGC CAAGAGAAAT ATTCAGATTG AAATCCAAGT GGCTGTGCAC 60
AAGATTTACC AGCAATTATC TGCTACACTG GAGAGAGCTC TGCAAGCAAA CAAGCACCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	92.13	0.00e+00	5464.00
IUUC-Apl-003461	Anas platyrhynchos	94.31	0.00e+00	5540.00
IUUC-Aca-004452	Anolis carolinensis	85.43	0.00e+00	4799.00
IUUC-Aly-006545	Arabidopsis lyrata	36.36	3.00e-49	190.00
IUUC-Ame-011268	Astyanax mexicanus	60.24	0.00e+00	2216.00
IUUC-Bta-013213	Bos taurus	92.45	0.00e+00	5418.00
IUUC-Bra-017584	Brassica rapa	33.68	4.00e-49	190.00
IUUC-Cja-019298	Callithrix jacchus	92.29	0.00e+00	5435.00
IUUC-Cfa-021213	Canis familiaris	92.58	0.00e+00	5494.00
IUUC-Cpo-021674	Cavia porcellus	91.97	0.00e+00	5417.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.11	2.00e-50	192.00
IUUC-Csa-023341	Chlorocebus sabaeus	91.97	0.00e+00	5407.00
IUUC-Cho-024567	Choloepus hoffmanni	91.54	0.00e+00	1726.00
IUUC-Dre-028289	Danio rerio	78.44	0.00e+00	4625.00
IUUC-Dno-029988	Dasypus novemcinctus	91.76	0.00e+00	5420.00
IUUC-Dor-030636	Dipodomys ordii	89.99	0.00e+00	2058.00
IUUC-Ete-032598	Echinops telfairi	82.78	0.00e+00	1348.00
IUUC-Eca-033754	Equus caballus	92.49	0.00e+00	5447.00
IUUC-Eeu-034702	Erinaceus europaeus	88.27	0.00e+00	1458.00
IUUC-Fca-035900	Felis catus	92.79	0.00e+00	5474.00
IUUC-Fal-037034	Ficedula albicollis	90.97	0.00e+00	4417.00
IUUC-Gmo-039260	Gadus morhua	75.68	0.00e+00	1264.00
IUUC-Gga-040321	Gallus gallus	94.09	0.00e+00	5589.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.13	0.00e+00	2210.00
IUUC-Gma-043808	Glycine max	32.38	1.00e-45	178.00
IUUC-Ggo-045134	Gorilla gorilla	92.37	0.00e+00	3274.00
IUUC-Hsa-046516	Homo sapiens	92.26	0.00e+00	5446.00
IUUC-Hvu-047529	Hordeum vulgare	35.09	2.00e-49	191.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	93.13	0.00e+00	2471.00
IUUC-Lch-049903	Latimeria chalumnae	87.62	0.00e+00	5168.00
IUUC-Lpe-051165	Leersia perrieri	33.41	8.00e-51	194.00
IUUC-Loc-052149	Lepisosteus oculatus	82.95	0.00e+00	4836.00
IUUC-Laf-053426	Loxodonta africana	92.45	0.00e+00	5477.00
IUUC-Mcc-055826	Macaca mulatta	92.48	0.00e+00	5462.00
IUUC-Meu-056521	Macropus eugenii	88.88	0.00e+00	2097.00
IUUC-Mga-059964	Meleagris gallopavo	84.18	0.00e+00	861.00
IUUC-Mmr-061512	Microcebus murinus	92.67	0.00e+00	5457.00
IUUC-Mdo-062177	Monodelphis domestica	92.35	0.00e+00	5374.00
IUUC-Mmu-064373	Mus musculus	92.51	0.00e+00	5443.00
IUUC-Mpu-066148	Mustela putorius furo	91.97	0.00e+00	5444.00
IUUC-Mlu-067680	Myotis lucifugus	91.97	0.00e+00	5407.00
IUUC-Nle-069633	Nomascus leucogenys	91.81	0.00e+00	5387.00
IUUC-Opr-070609	Ochotona princeps	86.95	0.00e+00	1334.00
IUUC-Ont-071249	Oreochromis niloticus	80.30	0.00e+00	4868.00
IUUC-Oan-073157	Ornithorhynchus anatinus	92.11	0.00e+00	5369.00
IUUC-Ocu-074841	Oryctolagus cuniculus	92.00	0.00e+00	5475.00
IUUC-Oba-075262	Oryza barthii	33.58	4.00e-50	191.00
IUUC-Obr-076115	Oryza brachyantha	34.07	5.00e-49	188.00
IUUC-Ogl-077586	Oryza glaberrima	33.58	4.00e-50	192.00
IUUC-Ogu-078796	Oryza glumaepatula	33.33	2.00e-49	189.00
IUUC-Oin-079298	Oryza indica	33.33	2.00e-49	189.00
IUUC-Olo-080768	Oryza longistaminata	35.07	7.00e-54	204.00
IUUC-Ome-081908	Oryza meridionalis	33.00	1.00e-48	187.00
IUUC-Oni-082049	Oryza nivara	33.33	2.00e-49	189.00
IUUC-Opu-083608	Oryza punctata	33.01	3.00e-50	192.00
IUUC-Oru-084712	Oryza rufipogon	33.33	2.00e-49	189.00
IUUC-Osa-086078	Oryza sativa	33.33	2.00e-49	189.00
IUUC-Ola-086889	Oryzias latipes	79.34	0.00e+00	4806.00
IUUC-Oga-088459	Otolemur garnettii	92.73	0.00e+00	5439.00
IUUC-Oar-089888	Ovis aries	92.48	0.00e+00	5418.00
IUUC-Ptr-091114	Pan troglodytes	92.26	0.00e+00	5437.00
IUUC-Pan-092442	Papio anubis	92.29	0.00e+00	5437.00
IUUC-Pma-094275	Petromyzon marinus	46.34	2.00e-83	304.00
IUUC-Ppa-095790	Physcomitrella patens	36.17	9.00e-55	207.00
IUUC-Pfo-097262	Poecilia formosa	79.38	0.00e+00	4711.00
IUUC-Pab-097760	Pongo abelii	91.82	0.00e+00	4721.00
IUUC-Pop-099121	Populus trichocarpa	36.63	6.00e-53	202.00
IUUC-Pca-100465	Procavia capensis	91.51	0.00e+00	4391.00
IUUC-Ppe-101345	Prunus persica	33.76	6.00e-52	199.00
IUUC-Pva-102950	Pteropus vampyrus	91.70	0.00e+00	2949.00
IUUC-Rno-104892	Rattus norvegicus	92.13	0.00e+00	5381.00
IUUC-Sha-106633	Sarcophilus harrisii	92.21	0.00e+00	5287.00
IUUC-Smo-108827	Selaginella moellendorffii	34.88	5.00e-52	199.00
IUUC-Sit-110415	Setaria italica	34.96	2.00e-53	202.00
IUUC-Sly-111155	Solanum lycopersicum	37.10	3.00e-54	206.00
IUUC-Stu-112166	Solanum tuberosum	31.46	3.00e-48	187.00
IUUC-Sar-113251	Sorex araneus	85.31	0.00e+00	1924.00
IUUC-Ssc-116391	Sus scrofa	92.23	0.00e+00	5444.00
IUUC-Tgu-116554	Taeniopygia guttata	93.62	0.00e+00	5581.00
IUUC-Tru-118695	Takifugu rubripes	79.49	0.00e+00	4837.00
IUUC-Tsy-119647	Tarsius syrichta	86.90	0.00e+00	4075.00
IUUC-Tni-120707	Tetraodon nigroviridis	79.61	0.00e+00	4803.00
IUUC-Tbe-127346	Tupaia belangeri	84.67	0.00e+00	1835.00
IUUC-Ttr-128542	Tursiops truncatus	89.22	0.00e+00	4357.00
IUUC-Vpa-130611	Vicugna pacos	89.61	0.00e+00	2607.00
IUUC-Xtr-131933	Xenopus tropicalis	84.76	0.00e+00	4928.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence