iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021648

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02027832

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000000686.3	ENSCPOT00000000691.2	ENSCPOP00000000608.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-134	449.0	565	894

Active Site

Position(s)	Description	Evidence
864	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+n +sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 565  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINANSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 653
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv+++r
   Q: 654  IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWR 737
           *********************************99...6666..7******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++i++q++af+eGf e+ip++l++lF+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++LqFvTg
   Q: 738  FVNRIQKQMAAFKEGFFELIPQDLIKLFDENELELLMCGLGDVDVSDWREHTKYKNGYSASHQVIQWFWKAVLMMDSEKRIRLLQFVTG 826
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 827  TSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 894
           *******************************************************************8 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MYQCFVNVLK EKDCEMENSR IVRVKVIAGI GLAKKDILGS SDPYVRVTLY DPMNGVFTSV 60
QTKTIKKSLN PKWNEEILFR VHPQQHRLLF EVFDENRLTR DDFLGQVDVP LYPLPTENPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTATCAGT GTTTTGTAAA TGTTCTGAAG GAGAAGGACT GTGAGATCTA AGGATATAGC 60
ACAGAAATTT CATCTTGTCT GATGAGGCAG AGGGCGTGGG GAGTTGAAGA AGTCACATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	89.17	0.00e+00	1432.00
IUUC-Apl-003886	Anas platyrhynchos	73.65	0.00e+00	1353.00
IUUC-Ame-011138	Astyanax mexicanus	82.29	0.00e+00	834.00
IUUC-Bta-012453	Bos taurus	87.38	0.00e+00	1380.00
IUUC-Cja-019034	Callithrix jacchus	88.10	0.00e+00	1327.00
IUUC-Cfa-020258	Canis familiaris	87.58	0.00e+00	1381.00
IUUC-Csa-023334	Chlorocebus sabaeus	89.90	0.00e+00	1587.00
IUUC-Dre-027924	Danio rerio	67.01	0.00e+00	997.00
IUUC-Dno-029159	Dasypus novemcinctus	84.22	0.00e+00	1233.00
IUUC-Ete-032409	Echinops telfairi	79.54	0.00e+00	1110.00
IUUC-Eca-033441	Equus caballus	88.16	0.00e+00	1514.00
IUUC-Eeu-034546	Erinaceus europaeus	72.59	0.00e+00	1100.00
IUUC-Fca-036384	Felis catus	88.57	0.00e+00	1418.00
IUUC-Fal-037547	Ficedula albicollis	79.05	0.00e+00	1403.00
IUUC-Gmo-039679	Gadus morhua	68.46	0.00e+00	1195.00
IUUC-Gga-040524	Gallus gallus	78.73	0.00e+00	1404.00
IUUC-Gac-042607	Gasterosteus aculeatus	65.76	0.00e+00	1199.00
IUUC-Hsa-046479	Homo sapiens	90.16	0.00e+00	1447.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	80.19	0.00e+00	1140.00
IUUC-Lch-050445	Latimeria chalumnae	72.00	0.00e+00	1176.00
IUUC-Loc-052645	Lepisosteus oculatus	71.92	0.00e+00	1309.00
IUUC-Laf-053638	Loxodonta africana	80.40	0.00e+00	1279.00
IUUC-Mcc-055585	Macaca mulatta	90.41	0.00e+00	1443.00
IUUC-Meu-056897	Macropus eugenii	94.77	1.00e-168	587.00
IUUC-Mga-059362	Meleagris gallopavo	72.79	0.00e+00	1373.00
IUUC-Mmr-061061	Microcebus murinus	88.83	0.00e+00	1442.00
IUUC-Mmu-063318	Mus musculus	78.73	0.00e+00	1347.00
IUUC-Mpu-066567	Mustela putorius furo	88.51	0.00e+00	1595.00
IUUC-Mlu-068148	Myotis lucifugus	88.68	0.00e+00	1404.00
IUUC-Nle-069225	Nomascus leucogenys	90.91	0.00e+00	1473.00
IUUC-Ont-071664	Oreochromis niloticus	66.95	0.00e+00	1162.00
IUUC-Oan-073019	Ornithorhynchus anatinus	82.34	0.00e+00	1404.00
IUUC-Ocu-074409	Oryctolagus cuniculus	89.68	0.00e+00	1446.00
IUUC-Oga-088241	Otolemur garnettii	81.39	0.00e+00	1243.00
IUUC-Oar-089797	Ovis aries	89.18	0.00e+00	1492.00
IUUC-Ptr-091629	Pan troglodytes	87.83	0.00e+00	1303.00
IUUC-Psi-093618	Pelodiscus sinensis	79.13	0.00e+00	1276.00
IUUC-Pfo-097145	Poecilia formosa	66.38	0.00e+00	1176.00
IUUC-Pab-098394	Pongo abelii	90.63	0.00e+00	1591.00
IUUC-Pca-100568	Procavia capensis	75.75	0.00e+00	1102.00
IUUC-Rno-106095	Rattus norvegicus	79.52	0.00e+00	1365.00
IUUC-Sha-107370	Sarcophilus harrisii	76.15	0.00e+00	1274.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.51	1.00e-153	537.00
IUUC-Sre-114929	Sporisorium reilianum	47.01	1.00e-150	527.00
IUUC-Tgu-117474	Taeniopygia guttata	78.76	0.00e+00	1407.00
IUUC-Tru-117675	Takifugu rubripes	64.45	0.00e+00	1169.00
IUUC-Tni-119993	Tetraodon nigroviridis	63.24	0.00e+00	1157.00
IUUC-Tbe-127408	Tupaia belangeri	82.04	0.00e+00	1082.00
IUUC-Ttr-128437	Tursiops truncatus	79.43	0.00e+00	1095.00
IUUC-Vpa-130503	Vicugna pacos	84.55	0.00e+00	1229.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence