iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.10e-30	104.2	805	949

Active Site

Position(s)	Description	Evidence
887	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk...ifhPnvyenGkvClsilk 87
           ++ke++ l+++ p+gi++k+ ++  ++ +++li Gp++tpYe+g++ ++i++p+ YP+ PP++++l++   +++Pn+y+nGkvC+s+l+
   Q: 805  VRKEMALLATSLPDGIMVKTFED-RMDLFSALIKGPTRTPYEDGLYLFDIQLPNIYPAVPPHFCYLSQcsgRLNPNLYDNGKVCVSLLG 892
           589********************.5*******************************************999*****************6 PP
   S: 88   .....eeekWspalsvesvllsiqsll..aepnpesplneeaa...ellkknreeykk 135
                 +e+W++++s+ +vl+siq l+  +ep+++++  ++ +   e ++++r+ y++
   Q: 893  twigkGTERWTSKSSLLQVLISIQGLIlvNEPYYNEAGFDSDRglqEGYENSRC-YNE 949
           6666699******************9999*******998887655466666665.666 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MRSTDSQCGT VIDVNIDCAV KLIGTNCIIY PVNSKDLQHI WPFMYGDYIA YDCWLGKVYD 60
LKNQIILKLS NGARCSMNTE DGAKLYDVCP HVSDSGLFFD DSYGFYPGQV LIGPAKIFSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCGGCCCC GAAGCGGGCT CGCAGCGCCT GCTGTTCTCT CACGACCTGG TGTCCGGCCG 60
TTACCGCGGC TCGGTGCACT TCGGGCTGGT GCGCCTCATC CACGGTGAGG ACTCGGACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0003723--F:RNA binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0030513--P:positive regulation of BMP signaling pathway
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042147--P:retrograde transport, endosome to Golgi

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000412	Aegilops tauschii	44.89	5.00e-46	179.00
IUUC-Aml-001463	Ailuropoda melanoleuca	94.38	0.00e+00	1918.00
IUUC-Atr-002469	Amborella trichopoda	43.56	7.00e-42	166.00
IUUC-Apl-004084	Anas platyrhynchos	77.70	0.00e+00	1561.00
IUUC-Aca-004435	Anolis carolinensis	73.15	0.00e+00	1487.00
IUUC-Aly-005970	Arabidopsis lyrata	28.96	2.00e-59	224.00
IUUC-Ath-007320	Arabidopsis thaliana	29.35	9.00e-60	225.00
IUUC-Acl-008031	Aspergillus clavatus	44.23	7.00e-33	136.00
IUUC-Afl-008480	Aspergillus flavus	37.31	2.00e-35	145.00
IUUC-Afu-009040	Aspergillus fumigatus	40.31	8.00e-34	139.00
IUUC-Ani-009341	Aspergillus nidulans	41.77	2.00e-23	105.00
IUUC-Ang-009816	Aspergillus niger	39.51	4.00e-32	134.00
IUUC-Aor-010121	Aspergillus oryzae	38.95	1.00e-30	128.00
IUUC-Ate-010487	Aspergillus terreus	36.06	7.00e-35	142.00
IUUC-Ame-010604	Astyanax mexicanus	67.43	0.00e+00	878.00
IUUC-Bta-013234	Bos taurus	93.59	0.00e+00	1909.00
IUUC-Bdi-015067	Brachypodium distachyon	39.73	1.00e-42	169.00
IUUC-Bol-016468	Brassica oleracea	45.16	1.00e-46	182.00
IUUC-Bra-016796	Brassica rapa	41.70	3.00e-47	184.00
IUUC-Cel-018661	Caenorhabditis elegans	40.00	3.00e-40	160.00
IUUC-Cja-018812	Callithrix jacchus	93.85	0.00e+00	1855.00
IUUC-Cfa-020448	Canis familiaris	93.68	0.00e+00	1904.00
IUUC-Cpo-021316	Cavia porcellus	95.00	0.00e+00	1937.00
IUUC-Cre-022768	Chlamydomonas reinhardtii	39.23	1.00e-29	123.00
IUUC-Csa-023869	Chlorocebus sabaeus	94.12	0.00e+00	1854.00
IUUC-Cin-025614	Ciona intestinalis	34.43	3.00e-32	132.00
IUUC-Cne-026812	Cryptococcus neoformans	45.07	8.00e-45	175.00
IUUC-Dre-028814	Danio rerio	66.27	0.00e+00	884.00
IUUC-Dno-029590	Dasypus novemcinctus	94.18	0.00e+00	1431.00
IUUC-Dor-030644	Dipodomys ordii	82.44	0.00e+00	1119.00
IUUC-Dse-031508	Dothistroma septosporum	36.89	3.00e-34	140.00
IUUC-Dme-032211	Drosophila melanogaster	48.23	3.00e-65	244.00
IUUC-Eca-033413	Equus caballus	89.94	0.00e+00	1779.00
IUUC-Eeu-035035	Erinaceus europaeus	89.44	0.00e+00	1386.00
IUUC-Fca-035610	Felis catus	93.59	0.00e+00	1894.00
IUUC-Fal-036879	Ficedula albicollis	76.08	0.00e+00	1568.00
IUUC-Gmo-039262	Gadus morhua	65.12	0.00e+00	959.00
IUUC-Ggr-040040	Gaeumannomyces graminis	44.30	9.00e-28	119.00
IUUC-Gga-040958	Gallus gallus	76.50	0.00e+00	1554.00
IUUC-Gac-041730	Gasterosteus aculeatus	63.59	0.00e+00	1288.00
IUUC-Gma-043359	Glycine max	28.51	5.00e-56	213.00
IUUC-Ggo-045316	Gorilla gorilla	94.29	0.00e+00	1861.00
IUUC-Hsa-046126	Homo sapiens	94.03	0.00e+00	1856.00
IUUC-Hvu-047713	Hordeum vulgare	40.62	4.00e-43	170.00
IUUC-Itr-048048	Ictidomys tridecemlineatus	94.65	0.00e+00	1919.00
IUUC-Lch-050531	Latimeria chalumnae	64.25	0.00e+00	1320.00
IUUC-Lpe-051268	Leersia perrieri	47.60	2.00e-39	157.00
IUUC-Loc-052209	Lepisosteus oculatus	67.64	0.00e+00	1328.00
IUUC-Lma-053064	Leptosphaeria maculans	44.14	4.00e-35	143.00
IUUC-Laf-053567	Loxodonta africana	92.00	8.00e-124	436.00
IUUC-Mcc-055722	Macaca mulatta	94.21	0.00e+00	1857.00
IUUC-Meu-056834	Macropus eugenii	88.48	7.00e-178	618.00
IUUC-Mpo-057396	Magnaporthe poae	38.76	5.00e-28	120.00
IUUC-Mtr-057804	Medicago truncatula	44.78	4.00e-42	167.00
IUUC-Mla-059114	Melampsora laricipopulina	30.00	1.00e-18	89.00
IUUC-Mga-059571	Meleagris gallopavo	77.98	0.00e+00	1548.00
IUUC-Mvi-060389	Microbotryum violaceum	43.33	8.00e-44	172.00
IUUC-Mmr-061535	Microcebus murinus	94.29	0.00e+00	1815.00
IUUC-Mdo-062111	Monodelphis domestica	86.13	0.00e+00	1716.00
IUUC-Mmu-064171	Mus musculus	97.63	0.00e+00	2011.00
IUUC-Mac-065585	Musa acuminata	40.76	8.00e-42	166.00
IUUC-Mpu-065697	Mustela putorius furo	94.12	0.00e+00	1860.00
IUUC-Mlu-068177	Myotis lucifugus	92.11	0.00e+00	1813.00
IUUC-Nfi-068366	Neosartorya fischeri	46.30	9.00e-34	139.00
IUUC-Nle-069704	Nomascus leucogenys	94.47	0.00e+00	1871.00
IUUC-Opr-070982	Ochotona princeps	91.48	0.00e+00	1820.00
IUUC-Ont-072115	Oreochromis niloticus	60.35	0.00e+00	1237.00
IUUC-Oan-072991	Ornithorhynchus anatinus	85.32	0.00e+00	794.00
IUUC-Ocu-073994	Oryctolagus cuniculus	92.45	0.00e+00	1746.00
IUUC-Oba-075236	Oryza barthii	40.18	5.00e-42	166.00
IUUC-Obr-076363	Oryza brachyantha	40.18	8.00e-43	169.00
IUUC-Ogl-077340	Oryza glaberrima	40.18	5.00e-42	166.00
IUUC-Ogu-078661	Oryza glumaepatula	43.44	2.00e-42	168.00
IUUC-Oin-079331	Oryza indica	44.28	1.00e-44	174.00
IUUC-Olo-080524	Oryza longistaminata	46.15	1.00e-44	173.00
IUUC-Ome-081767	Oryza meridionalis	40.18	3.00e-42	167.00
IUUC-Oni-082897	Oryza nivara	40.18	5.00e-42	166.00
IUUC-Opu-083143	Oryza punctata	28.37	3.00e-55	210.00
IUUC-Oru-084813	Oryza rufipogon	40.18	5.00e-42	166.00
IUUC-Osa-085536	Oryza sativa	40.18	5.00e-42	166.00
IUUC-Ola-087200	Oryzias latipes	64.49	0.00e+00	1235.00
IUUC-Oga-088737	Otolemur garnettii	93.77	0.00e+00	1833.00
IUUC-Oar-090259	Ovis aries	88.18	0.00e+00	1804.00
IUUC-Ptr-091146	Pan troglodytes	95.39	0.00e+00	1612.00
IUUC-Pan-091743	Papio anubis	94.21	0.00e+00	1857.00
IUUC-Psi-093231	Pelodiscus sinensis	77.85	0.00e+00	1569.00
IUUC-Pma-094499	Petromyzon marinus	65.84	4.00e-136	479.00
IUUC-Pno-095065	Phaeosphaeria nodorum	45.71	4.00e-31	130.00
IUUC-Ppa-095324	Physcomitrella patens	46.95	3.00e-54	207.00
IUUC-Pfo-096799	Poecilia formosa	63.74	0.00e+00	911.00
IUUC-Pab-098220	Pongo abelii	94.12	0.00e+00	1846.00
IUUC-Pop-099156	Populus trichocarpa	43.52	5.00e-43	170.00
IUUC-Pca-100963	Procavia capensis	87.88	0.00e+00	1653.00
IUUC-Ppe-101372	Prunus persica	29.97	1.00e-59	225.00
IUUC-Pva-102384	Pteropus vampyrus	92.89	0.00e+00	1835.00
IUUC-Pte-104381	Pyrenophora teres	42.93	5.00e-37	149.00
IUUC-Pyt-104607	Pyrenophora triticirepentis	42.42	8.00e-37	149.00
IUUC-Sha-106642	Sarcophilus harrisii	86.65	0.00e+00	1722.00
IUUC-Smo-108758	Selaginella moellendorffii	39.68	5.00e-54	206.00
IUUC-Sit-110041	Setaria italica	41.07	3.00e-44	174.00
IUUC-Sly-111922	Solanum lycopersicum	43.78	1.00e-44	175.00
IUUC-Stu-112339	Solanum tuberosum	39.63	7.00e-45	176.00
IUUC-Sbi-114493	Sorghum bicolor	28.75	6.00e-64	239.00
IUUC-Sre-114954	Sporisorium reilianum	44.71	9.00e-46	178.00
IUUC-Ssc-115901	Sus scrofa	91.23	0.00e+00	1829.00
IUUC-Tgu-116873	Taeniopygia guttata	78.94	0.00e+00	1580.00
IUUC-Tru-118710	Takifugu rubripes	55.84	0.00e+00	787.00
IUUC-Tsy-119256	Tarsius syrichta	83.41	0.00e+00	649.00
IUUC-Tni-120839	Tetraodon nigroviridis	61.26	0.00e+00	1176.00
IUUC-Tca-121665	Theobroma cacao	43.78	2.00e-44	175.00
IUUC-Tae-125159	Triticum aestivum	40.59	3.00e-52	200.00
IUUC-Tur-126696	Triticum urartu	38.50	9.00e-43	168.00
IUUC-Tme-127207	Tuber melanosporum	42.79	4.00e-35	144.00
IUUC-Ttr-128990	Tursiops truncatus	94.03	0.00e+00	1902.00
IUUC-Uma-129323	Ustilago maydis	43.48	4.00e-47	183.00
IUUC-Vvi-131411	Vitis vinifera	28.81	2.00e-58	221.00
IUUC-Xtr-132000	Xenopus tropicalis	66.67	0.00e+00	653.00
IUUC-Xma-133380	Xiphophorus maculatus	72.02	0.00e+00	872.00
IUUC-Zma-135755	Zea mays	28.88	8.00e-65	242.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence