iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092253

Ensembl Protein ID

ENSPANP00000000892.1

UniProt Accession

A0A096MMQ7; A0A096MMQ7_PAPAN

Genbank Protein ID

ENSPANP00000000892

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHZZ01046110

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000008411.1	ENSPANT00000003986.1	ENSPANP00000000892.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.70e-91	304.5	156	498

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 156  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 240
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 241  DAHEFLIAALDVLHRHCKG----------------DDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 313
           *****************22................2344668899999****************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 314  CTSFWPmspgressvngeshipgitTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF--EHSAKQRRKI 400
           98766699*********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           +++++fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl   
   Q: 401  TTYISFPLELDMTPFMASskesrmngqlqlPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD-- 487
           ******************5555555555554444444**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 488  -SEGYLLFYHKQ 498
           .********985 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

ELRVIYQCFV WCGTPETRKS KAKSCICHVC GTHLNRLHSC LSCVFFGCFT EKHIHEHAET 60
KQHNLAVDLY YGGIYCFMCK DYVYDKDIEQ IAKEEQGEAL KLQASTSTEV SHQQCSVPGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACTGCGGG TTATCTACCA GTGCTTCGTG TGGTGTGGAA CCCCAGAGAC CAGGAAAAGC 60
AAGGCAAAGT CGTGCATCTG CCATGTGTGT GGCACCCATC TGAACAGACT CCACTCTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002084	Ailuropoda melanoleuca	97.42	0.00e+00	1021.00
IUUC-Aly-006565	Arabidopsis lyrata	36.15	2.00e-73	270.00
IUUC-Ath-007536	Arabidopsis thaliana	36.15	1.00e-73	270.00
IUUC-Bta-012659	Bos taurus	98.17	0.00e+00	902.00
IUUC-Bol-016509	Brassica oleracea	37.11	4.00e-74	272.00
IUUC-Cja-019954	Callithrix jacchus	91.25	0.00e+00	952.00
IUUC-Cfa-020956	Canis familiaris	98.83	0.00e+00	1066.00
IUUC-Cpo-022014	Cavia porcellus	97.61	0.00e+00	1026.00
IUUC-Csa-023350	Chlorocebus sabaeus	99.77	0.00e+00	914.00
IUUC-Dno-029905	Dasypus novemcinctus	98.40	0.00e+00	902.00
IUUC-Dor-030832	Dipodomys ordii	97.93	6.00e-113	400.00
IUUC-Eca-033957	Equus caballus	96.62	0.00e+00	1012.00
IUUC-Fca-035768	Felis catus	97.02	0.00e+00	1019.00
IUUC-Ggo-044925	Gorilla gorilla	98.01	0.00e+00	1026.00
IUUC-Hsa-045775	Homo sapiens	100.00	0.00e+00	916.00
IUUC-Itr-048775	Ictidomys tridecemlineatus	99.54	0.00e+00	914.00
IUUC-Laf-053947	Loxodonta africana	96.22	0.00e+00	1014.00
IUUC-Mmr-061013	Microcebus murinus	98.40	0.00e+00	905.00
IUUC-Mmu-064287	Mus musculus	96.34	0.00e+00	885.00
IUUC-Mpu-066433	Mustela putorius furo	97.02	0.00e+00	1020.00
IUUC-Mlu-067330	Myotis lucifugus	96.41	0.00e+00	1009.00
IUUC-Nle-069084	Nomascus leucogenys	100.00	0.00e+00	916.00
IUUC-Ocu-074951	Oryctolagus cuniculus	95.23	0.00e+00	1004.00
IUUC-Oga-088771	Otolemur garnettii	99.03	0.00e+00	1068.00
IUUC-Oar-089610	Ovis aries	98.25	0.00e+00	1063.00
IUUC-Ppa-095413	Physcomitrella patens	34.24	8.00e-82	298.00
IUUC-Pab-098324	Pongo abelii	98.01	0.00e+00	1026.00
IUUC-Pca-100329	Procavia capensis	96.62	0.00e+00	1014.00
IUUC-Pva-102721	Pteropus vampyrus	91.85	0.00e+00	943.00
IUUC-Rno-105081	Rattus norvegicus	96.57	0.00e+00	890.00
IUUC-Smo-109310	Selaginella moellendorffii	36.21	4.00e-87	315.00
IUUC-Stu-112203	Solanum tuberosum	38.98	5.00e-76	278.00
IUUC-Sar-113174	Sorex araneus	93.36	0.00e+00	923.00
IUUC-Sre-115195	Sporisorium reilianum	27.46	1.00e-52	201.00
IUUC-Ssc-115315	Sus scrofa	99.20	0.00e+00	1048.00
IUUC-Tca-121154	Theobroma cacao	39.34	7.00e-93	334.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence