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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046992
Ensembl Protein ID ENSP00000351947.4
UniProt Accession Q9H4L7; B7Z799; Q05D56; Q96SX1; Q9H017; Q9H860; Q9NPU9; Q9ULU7; SMRCD_HUMAN
Genbank Protein ID AAG16639.1; BAA86436.2; BAB14759.1; BAB55150.1; BAH13535.1; AAH17953.1; AAH45534.1; CAB95769.1; CAC21685.1
Protein Name SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; ATP-dependent helicase 1
Genbank Nucleotide ID AY008271; AB032948; AK023990; AK027490; AK301668; AC096746; BC045534; AL359929; AL512768
Gene Name SMARCAD1; KIAA1122
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163104.17 ENST00000359052.8 ENSP00000351947.4
ENSG00000163104.17 ENST00000510105.5 ENSP00000424624.1
ENSG00000163104.17 ENST00000354268.8 ENSP00000346217.4
ENSG00000163104.17 ENST00000394961.6 ENSP00000378413.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/CUE 44.84 9.00e-125 442.00 IUUC-Sce-106399
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.
 DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing.
Protein Sequence
(Fasta)
MNLFNLDRFR FEKRNKIEEA PEATPQPSQP GPSSPISLSA EEENAEGEVS RANTPDSDIT 60
EKTEDSSVPE TPDNERKASI SYFKNQRGIQ YIDLSSDSED VVSPNCSNTV QEKTFNKDTV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046992|UBD,CUE|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATTACGCGCT CTTAAGGTTT CTCCGTGGTG TTTTGGAAGG TCCCGGCACG GCTACCGTCG 60
CCCCACGCTA GGAAATTTTT TTTTTATTTT CAACCTTTGT TACATAGCAC TGAGGCTACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046992|UBD,CUE|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR003892--CUE
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
PROSITE

PS51140--CUE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
Pfam

PF00271--Helicase_C
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00490--HELICc
Gene Ontology

GO:0000792--C:heterochromatin
GO:0016363--C:nuclear matrix
GO:0043596--C:nuclear replication fork
GO:0005654--C:nucleoplasm
GO:0035861--C:site of double-strand break
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0003676--F:nucleic acid binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0006325--P:chromatin organization
GO:0006338--P:chromatin remodeling
GO:0051304--P:chromosome separation
GO:0000729--P:DNA double-strand break processing
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0009117--P:nucleotide metabolic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051260--P:protein homooligomerization
GO:0000018--P:regulation of DNA recombination
KEGG hsa:56916
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000567 Aegilops tauschii 37.85 2.00e-99 357.00
IUUC-Aml-002063 Ailuropoda melanoleuca 95.83 0.00e+00 1911.00
IUUC-Atr-003078 Amborella trichopoda 35.53 2.00e-104 374.00
IUUC-Apl-003860 Anas platyrhynchos 71.60 0.00e+00 1375.00
IUUC-Aca-004485 Anolis carolinensis 69.18 0.00e+00 1382.00
IUUC-Aly-006561 Arabidopsis lyrata 39.50 2.00e-105 376.00
IUUC-Ath-006832 Arabidopsis thaliana 39.86 1.00e-106 380.00
IUUC-Ago-007758 Ashbya gossypii 45.88 8.00e-135 474.00
IUUC-Acl-008226 Aspergillus clavatus 45.08 1.00e-134 474.00
IUUC-Afl-008556 Aspergillus flavus 46.17 3.00e-132 466.00
IUUC-Afu-008799 Aspergillus fumigatus 44.90 2.00e-134 473.00
IUUC-Ani-009127 Aspergillus nidulans 46.14 1.00e-132 467.00
IUUC-Ang-009676 Aspergillus niger 44.57 4.00e-133 469.00
IUUC-Aor-010184 Aspergillus oryzae 45.45 3.00e-133 469.00
IUUC-Ate-010559 Aspergillus terreus 37.68 3.00e-131 463.00
IUUC-Ame-011933 Astyanax mexicanus 59.82 0.00e+00 883.00
IUUC-Bta-012963 Bos taurus 94.18 0.00e+00 1874.00
IUUC-Bci-013670 Botrytis cinerea 41.44 1.00e-118 421.00
IUUC-Bdi-014286 Brachypodium distachyon 37.34 1.00e-101 364.00
IUUC-Bol-016519 Brassica oleracea 39.71 4.00e-107 382.00
IUUC-Bra-017239 Brassica rapa 39.71 8.00e-107 381.00
IUUC-Cel-018253 Caenorhabditis elegans 43.16 4.00e-139 489.00
IUUC-Cja-019465 Callithrix jacchus 97.08 0.00e+00 1931.00
IUUC-Cfa-020637 Canis familiaris 94.27 0.00e+00 1908.00
IUUC-Cpo-021822 Cavia porcellus 95.24 0.00e+00 1799.00
IUUC-Csa-023315 Chlorocebus sabaeus 99.52 0.00e+00 1678.00
IUUC-Cin-025444 Ciona intestinalis 50.00 3.00e-176 612.00
IUUC-Cgl-026383 Colletotrichum gloeosporioides 40.04 1.00e-104 374.00
IUUC-Cne-027090 Cryptococcus neoformans 36.22 3.00e-114 406.00
IUUC-Dre-028385 Danio rerio 58.52 0.00e+00 869.00
IUUC-Dno-028932 Dasypus novemcinctus 96.21 0.00e+00 1951.00
IUUC-Dse-031394 Dothistroma septosporum 36.90 3.00e-104 373.00
IUUC-Dme-031640 Drosophila melanogaster 45.38 2.00e-157 550.00
IUUC-Eca-033276 Equus caballus 97.18 0.00e+00 1982.00
IUUC-Fca-035936 Felis catus 93.69 0.00e+00 1884.00
IUUC-Fal-037636 Ficedula albicollis 66.92 0.00e+00 1324.00
IUUC-Fso-038229 Fusarium solani 35.40 9.00e-111 395.00
IUUC-Gmo-039654 Gadus morhua 57.32 0.00e+00 892.00
IUUC-Ggr-039922 Gaeumannomyces graminis 33.72 2.00e-94 341.00
IUUC-Gga-040646 Gallus gallus 67.05 0.00e+00 1382.00
IUUC-Gac-042320 Gasterosteus aculeatus 66.15 0.00e+00 802.00
IUUC-Gma-042832 Glycine max 38.92 1.00e-105 377.00
IUUC-Ggo-044875 Gorilla gorilla 90.26 0.00e+00 1822.00
IUUC-Hvu-047408 Hordeum vulgare 37.34 1.00e-101 364.00
IUUC-Itr-047881 Ictidomys tridecemlineatus 98.38 0.00e+00 1110.00
IUUC-Kpa-049212 Komagataella pastoris 43.56 2.00e-126 447.00
IUUC-Lpe-050987 Leersia perrieri 35.07 3.00e-100 360.00
IUUC-Loc-052272 Lepisosteus oculatus 52.57 0.00e+00 1009.00
IUUC-Lma-053118 Leptosphaeria maculans 42.56 6.00e-122 432.00
IUUC-Laf-053436 Loxodonta africana 94.36 0.00e+00 1873.00
IUUC-Mcc-055209 Macaca mulatta 99.21 0.00e+00 1734.00
IUUC-Mor-056994 Magnaporthe oryzae 34.65 3.00e-95 343.00
IUUC-Mpo-057305 Magnaporthe poae 34.14 3.00e-99 357.00
IUUC-Mtr-058432 Medicago truncatula 39.60 1.00e-104 374.00
IUUC-Mla-058972 Melampsora laricipopulina 39.17 2.00e-123 436.00
IUUC-Mga-059572 Meleagris gallopavo 64.85 0.00e+00 1233.00
IUUC-Mvi-060209 Microbotryum violaceum 40.53 3.00e-141 496.00
IUUC-Mmr-061416 Microcebus murinus 93.65 0.00e+00 1132.00
IUUC-Mdo-062869 Monodelphis domestica 81.41 0.00e+00 1639.00
IUUC-Mmu-064272 Mus musculus 90.57 0.00e+00 1679.00
IUUC-Mac-064963 Musa acuminata 34.23 1.00e-94 341.00
IUUC-Mpu-065755 Mustela putorius furo 95.63 0.00e+00 1944.00
IUUC-Mlu-067604 Myotis lucifugus 93.48 0.00e+00 1883.00
IUUC-Nfi-068310 Neosartorya fischeri 44.71 9.00e-134 471.00
IUUC-Ncr-068841 Neurospora crassa 33.93 2.00e-108 387.00
IUUC-Nle-069227 Nomascus leucogenys 99.90 0.00e+00 1995.00
IUUC-Opr-071088 Ochotona princeps 87.79 0.00e+00 1365.00
IUUC-Ont-072291 Oreochromis niloticus 66.30 0.00e+00 827.00
IUUC-Oan-073460 Ornithorhynchus anatinus 85.02 0.00e+00 1384.00
IUUC-Ocu-074811 Oryctolagus cuniculus 95.53 0.00e+00 1884.00
IUUC-Oba-075463 Oryza barthii 37.89 3.00e-99 355.00
IUUC-Obr-076342 Oryza brachyantha 37.57 4.00e-102 366.00
IUUC-Ogu-078837 Oryza glumaepatula 37.89 1.00e-99 357.00
IUUC-Oin-079623 Oryza indica 37.89 7.00e-100 358.00
IUUC-Ome-081105 Oryza meridionalis 37.89 6.00e-100 358.00
IUUC-Oni-082598 Oryza nivara 37.89 1.00e-99 357.00
IUUC-Opu-084040 Oryza punctata 37.89 4.00e-100 359.00
IUUC-Oru-084219 Oryza rufipogon 37.89 6.00e-100 358.00
IUUC-Osa-085461 Oryza sativa 37.89 8.00e-100 358.00
IUUC-Ola-087307 Oryzias latipes 56.68 0.00e+00 874.00
IUUC-Olu-087812 Ostreococcus lucimarinus 39.11 2.00e-100 359.00
IUUC-Oga-089064 Otolemur garnettii 95.43 0.00e+00 1929.00
IUUC-Oar-090054 Ovis aries 96.80 0.00e+00 1907.00
IUUC-Ptr-091228 Pan troglodytes 99.71 0.00e+00 1985.00
IUUC-Pan-092769 Papio anubis 98.85 0.00e+00 1842.00
IUUC-Psi-093202 Pelodiscus sinensis 71.80 0.00e+00 1403.00
IUUC-Pma-094725 Petromyzon marinus 46.55 0.00e+00 876.00
IUUC-Pno-095130 Phaeosphaeria nodorum 41.75 7.00e-111 395.00
IUUC-Ppa-095559 Physcomitrella patens 40.77 4.00e-109 389.00
IUUC-Pfo-096546 Poecilia formosa 66.41 0.00e+00 835.00
IUUC-Pab-097698 Pongo abelii 99.32 0.00e+00 1980.00
IUUC-Pop-099986 Populus trichocarpa 39.36 3.00e-106 379.00
IUUC-Ppe-101649 Prunus persica 39.41 9.00e-104 371.00
IUUC-Pva-102138 Pteropus vampyrus 94.07 0.00e+00 1883.00
IUUC-Pgr-103272 Puccinia graminis 35.21 4.00e-121 429.00
IUUC-Ptt-103880 Puccinia triticina 35.96 4.00e-129 456.00
IUUC-Pte-104260 Pyrenophora teres 43.02 2.00e-118 421.00
IUUC-Pyt-104532 Pyrenophora triticirepentis 34.16 3.00e-79 290.00
IUUC-Rno-105903 Rattus norvegicus 92.91 0.00e+00 1733.00
IUUC-Sce-106399 Saccharomyces cerevisiae 44.84 1.00e-126 447.00
IUUC-Sha-106783 Sarcophilus harrisii 79.90 0.00e+00 1567.00
IUUC-Sja-107887 Schizosaccharomyces japonicus 41.46 7.00e-143 502.00
IUUC-Spo-108154 Schizosaccharomyces pombe 42.50 1.00e-147 518.00
IUUC-Smo-108759 Selaginella moellendorffii 39.78 9.00e-105 374.00
IUUC-Sit-110023 Setaria italica 36.60 3.00e-100 360.00
IUUC-Sly-111423 Solanum lycopersicum 39.10 1.00e-105 377.00
IUUC-Sbi-114688 Sorghum bicolor 36.98 5.00e-101 362.00
IUUC-Sre-114983 Sporisorium reilianum 35.90 8.00e-110 392.00
IUUC-Ssc-116030 Sus scrofa 94.37 0.00e+00 1915.00
IUUC-Tgu-117451 Taeniopygia guttata 76.84 0.00e+00 1196.00
IUUC-Tru-118600 Takifugu rubripes 66.10 0.00e+00 794.00
IUUC-Tsy-119130 Tarsius syrichta 87.45 0.00e+00 1619.00
IUUC-Tni-119758 Tetraodon nigroviridis 56.90 0.00e+00 878.00
IUUC-Tca-121797 Theobroma cacao 39.82 2.00e-107 383.00
IUUC-Tre-121883 Trichoderma reesei 40.67 2.00e-101 363.00
IUUC-Tvi-122333 Trichoderma virens 40.33 8.00e-110 392.00
IUUC-Tae-122848 Triticum aestivum 37.85 1.00e-99 357.00
IUUC-Tur-126594 Triticum urartu 37.85 5.00e-99 355.00
IUUC-Tme-127106 Tuber melanosporum 42.15 2.00e-123 437.00
IUUC-Tbe-127911 Tupaia belangeri 98.21 0.00e+00 1008.00
IUUC-Ttr-128597 Tursiops truncatus 95.93 0.00e+00 1860.00
IUUC-Uma-129321 Ustilago maydis 36.47 7.00e-111 395.00
IUUC-Vpa-130686 Vicugna pacos 89.12 0.00e+00 1696.00
IUUC-Vvi-131046 Vitis vinifera 39.23 1.00e-105 377.00
IUUC-Xtr-132740 Xenopus tropicalis 65.15 0.00e+00 1139.00
IUUC-Xma-134260 Xiphophorus maculatus 56.22 0.00e+00 887.00
IUUC-Yli-134634 Yarrowia lipolytica 40.70 1.00e-138 487.00
IUUC-Zma-135493 Zea mays 36.68 2.00e-100 360.00
Created Date 25-Jun-2017

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