iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059368

Ensembl Protein ID

ENSMGAP00000006995.1

UniProt Accession

G1N518; G1N518_MELGA

Protein Name

Phosphoinositide phospholipase C

Gene Name

PLCG2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000006882.1	ENSMGAT00000007760.1	ENSMGAP00000006995.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.60e-11	42.0	772	828

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++lydy a+ +deL++ +G  ++ +  +++ +gW+kg    e+ +  fP+n+ve l+
   Q: 772  RTVKALYDYRAKRSDELSFCRGALIHNV--TKETGGWWKGD-YGEKVQHYFPSNYVEDLS 828
           689************************9..8899******5.8889999*******9986 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MPRKSIDYGE LPEYEKSQIK RTLELGTVMT VFSIKKSSPE RRTIQVIMET RQVAWSKTAD 60
KIEGFLDLME IKEIRPGKNS KDFERCKAKH REEHCFTIFY GTQFVLNTLS LAADSKDDAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCCAGAA AGAGTATAGA TTATGGAGAG CTGCCGGAGT ATGAGAAAAG CCAGATCAAA 60
AGGACATTGG AGCTGGGAAC TGTTATGACT GTATTCAGTA TTAAGAAGAG TAGTCCAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028381--PLC-gamma2
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0032237--P:activation of store-operated calcium channel activity
GO:0050853--P:B cell receptor signaling pathway
GO:0002316--P:follicular B cell differentiation
GO:0032959--P:inositol trisphosphate biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0043069--P:negative regulation of programmed cell death
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0009395--P:phospholipid catabolic process
GO:0002092--P:positive regulation of receptor internalization
GO:0032481--P:positive regulation of type I interferon production
GO:0010468--P:regulation of gene expression
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0032496--P:response to lipopolysaccharide
GO:0050852--P:T cell receptor signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003345	Anas platyrhynchos	95.92	0.00e+00	2338.00
IUUC-Aca-004266	Anolis carolinensis	85.70	0.00e+00	2232.00
IUUC-Ame-011540	Astyanax mexicanus	60.20	0.00e+00	1457.00
IUUC-Bta-013196	Bos taurus	83.19	0.00e+00	2091.00
IUUC-Cpo-021890	Cavia porcellus	82.16	0.00e+00	2167.00
IUUC-Csa-024233	Chlorocebus sabaeus	83.20	0.00e+00	2184.00
IUUC-Dre-028650	Danio rerio	60.42	0.00e+00	1478.00
IUUC-Dno-028871	Dasypus novemcinctus	83.44	0.00e+00	2133.00
IUUC-Eca-033458	Equus caballus	83.60	0.00e+00	2204.00
IUUC-Eeu-035329	Erinaceus europaeus	79.83	0.00e+00	2080.00
IUUC-Fal-037390	Ficedula albicollis	94.70	0.00e+00	2488.00
IUUC-Gga-040918	Gallus gallus	98.89	0.00e+00	2568.00
IUUC-Ggo-045625	Gorilla gorilla	82.19	0.00e+00	2170.00
IUUC-Hsa-046129	Homo sapiens	83.14	0.00e+00	2205.00
IUUC-Loc-052025	Lepisosteus oculatus	64.65	0.00e+00	1624.00
IUUC-Mcc-054831	Macaca mulatta	83.27	0.00e+00	2125.00
IUUC-Mmr-060898	Microcebus murinus	80.90	0.00e+00	1977.00
IUUC-Mmu-064334	Mus musculus	82.49	0.00e+00	2155.00
IUUC-Mlu-067230	Myotis lucifugus	82.98	0.00e+00	2185.00
IUUC-Nle-069318	Nomascus leucogenys	78.45	0.00e+00	2010.00
IUUC-Opr-070718	Ochotona princeps	71.89	0.00e+00	960.00
IUUC-Ocu-073814	Oryctolagus cuniculus	81.77	0.00e+00	2157.00
IUUC-Ola-086501	Oryzias latipes	58.62	0.00e+00	1468.00
IUUC-Oga-088036	Otolemur garnettii	82.64	0.00e+00	1570.00
IUUC-Oar-089556	Ovis aries	82.85	0.00e+00	2084.00
IUUC-Ptr-091001	Pan troglodytes	83.21	0.00e+00	2207.00
IUUC-Pan-092744	Papio anubis	83.28	0.00e+00	2182.00
IUUC-Psi-093987	Pelodiscus sinensis	90.67	0.00e+00	2355.00
IUUC-Pfo-096249	Poecilia formosa	58.92	0.00e+00	1502.00
IUUC-Pab-098268	Pongo abelii	80.82	0.00e+00	2131.00
IUUC-Pva-102939	Pteropus vampyrus	81.02	0.00e+00	2016.00
IUUC-Sre-115229	Sporisorium reilianum	47.62	2.00e-10	61.60
IUUC-Ssc-115308	Sus scrofa	79.07	0.00e+00	1919.00
IUUC-Tgu-116811	Taeniopygia guttata	94.31	0.00e+00	2481.00
IUUC-Tru-117536	Takifugu rubripes	58.80	0.00e+00	1464.00
IUUC-Tsy-119139	Tarsius syrichta	75.26	0.00e+00	838.00
IUUC-Ttr-128392	Tursiops truncatus	80.68	0.00e+00	2080.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence