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Tag Content
iUUCD ID IUUC-Ani-009248
Ensembl Protein ID CADANIAP00008406
UniProt Accession Q5BCH0; C8VP62; ATG12_EMENI
Genbank Protein ID EAA64046.1; CBF85511.1
Protein Name Ubiquitin-like protein ATG12; Autophagy-related protein 12
Genbank Nucleotide ID AACD01000027; BN001307
Gene Name ANIA_01760; atg12; AN1760
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADANIAG00008406 CADANIAT00008406 CADANIAP00008406
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UBL/ATG12 27.59 5.00e-10 61.60 IUUC-Hsa-046903
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Aspergillus nidulans
Functional Description
(View)

Functional Description


     Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
 Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes (By similarity).
Protein Sequence
(Fasta)
MSSPSSRISS INNSPNPNLR KPSSRRESLD QPSNAQNAPI PDDEHGADLP LTMSASVVLT 60
SLPRDAHQAL ADAEAIDTGK VTVRFQPLAS APILKNRVFK ISASQKFETV VNFLRKKLNC 120
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Protein Fasta Sequence


>IUUC-Ani-009248|ULD,ATG12|Aspergillus nidulans
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Nucleotide Sequence
(Fasta)
ATGAGCTCTC CTTCTTCACG TATTTCCTCA ATTAATAACT CTCCGAACCC AAACTTGCGA 60
AAACCATCGA GCCGGAGGGA AAGTTTAGAC CAGCCATCCA ACGCACAGAA TGCGCCTATA 120
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Nucleotide Fasta Sequence


>IUUC-Ani-009248|ULD,ATG12|Aspergillus nidulans
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Sequence Source Ensembl
Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom
Pfam

PF04110--APG12
Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0034045--C:pre-autophagosomal structure membrane
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006501--P:C-terminal protein lipidation
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy
GO:0015031--P:protein transport
KEGG ani:AN1760.2
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001177 Aegilops tauschii 41.38 2.00e-14 68.20
IUUC-Aml-002116 Ailuropoda melanoleuca 28.74 4.00e-12 62.00
IUUC-Atr-002615 Amborella trichopoda 40.23 1.00e-13 66.20
IUUC-Apl-003753 Anas platyrhynchos 47.37 8.00e-07 42.70
IUUC-Aca-005231 Anolis carolinensis 28.74 1.00e-08 50.10
IUUC-Aly-006172 Arabidopsis lyrata 42.53 1.00e-14 69.30
IUUC-Ath-006953 Arabidopsis thaliana 42.53 9.00e-16 72.80
IUUC-Ago-007970 Ashbya gossypii 43.68 2.00e-13 67.40
IUUC-Acl-008072 Aspergillus clavatus 91.23 3.00e-59 217.00
IUUC-Afl-008725 Aspergillus flavus 85.71 4.00e-74 268.00
IUUC-Afu-008967 Aspergillus fumigatus 85.14 4.00e-71 258.00
IUUC-Ang-009684 Aspergillus niger 79.74 6.00e-69 251.00
IUUC-Aor-009947 Aspergillus oryzae 85.71 4.00e-74 268.00
IUUC-Ame-011656 Astyanax mexicanus 27.17 2.00e-10 56.20
IUUC-Bgr-012174 Blumeria graminis 57.30 1.00e-24 103.00
IUUC-Bta-012483 Bos taurus 27.59 8.00e-12 60.80
IUUC-Bci-013755 Botrytis cinerea 55.74 2.00e-31 125.00
IUUC-Bdi-014156 Brachypodium distachyon 41.84 2.00e-15 72.00
IUUC-Bol-015683 Brassica oleracea 42.53 6.00e-16 73.60
IUUC-Bra-016802 Brassica rapa 41.38 8.00e-15 69.70
IUUC-Cel-018242 Caenorhabditis elegans 36.26 3.00e-12 61.60
IUUC-Cja-019514 Callithrix jacchus 27.59 1.00e-11 60.80
IUUC-Cfa-020748 Canis familiaris 28.74 4.00e-12 62.00
IUUC-Cpo-021965 Cavia porcellus 28.74 6.00e-12 61.60
IUUC-Cre-023009 Chlamydomonas reinhardtii 36.96 3.00e-12 61.20
IUUC-Csa-023494 Chlorocebus sabaeus 27.59 5.00e-12 61.60
IUUC-Cho-024631 Choloepus hoffmanni 27.59 9.00e-12 61.60
IUUC-Cin-025609 Ciona intestinalis 43.68 4.00e-20 87.40
IUUC-Cgl-026722 Colletotrichum gloeosporioides 50.00 2.00e-33 132.00
IUUC-Dre-027479 Danio rerio 28.57 6.00e-12 60.80
IUUC-Dno-029693 Dasypus novemcinctus 44.74 7.00e-06 41.20
IUUC-Dse-031440 Dothistroma septosporum 54.61 9.00e-42 160.00
IUUC-Dme-031892 Drosophila melanogaster 25.56 1.00e-09 53.10
IUUC-Ete-032550 Echinops telfairi 27.38 3.00e-11 58.50
IUUC-Eca-033553 Equus caballus 27.59 5.00e-12 61.60
IUUC-Fca-036524 Felis catus 28.74 1.00e-10 57.00
IUUC-Fal-036942 Ficedula albicollis 30.23 6.00e-12 60.10
IUUC-Fox-037753 Fusarium oxysporum 65.00 1.00e-38 150.00
IUUC-Gmo-039498 Gadus morhua 27.59 3.00e-10 55.50
IUUC-Ggr-039852 Gaeumannomyces graminis 60.33 3.00e-30 122.00
IUUC-Gga-041263 Gallus gallus 28.74 5.00e-12 61.60
IUUC-Gac-042346 Gasterosteus aculeatus 29.76 2.00e-10 55.80
IUUC-Gma-042896 Glycine max 40.23 2.00e-13 65.10
IUUC-Ggo-045601 Gorilla gorilla 27.59 1.00e-11 60.80
IUUC-Hsa-046903 Homo sapiens 27.59 6.00e-12 61.20
IUUC-Hvu-047239 Hordeum vulgare 41.24 2.00e-14 68.90
IUUC-Itr-048445 Ictidomys tridecemlineatus 27.59 7.00e-12 61.20
IUUC-Kpa-049355 Komagataella pastoris 31.75 2.00e-14 69.30
IUUC-Lch-050619 Latimeria chalumnae 31.03 9.00e-13 63.90
IUUC-Loc-052102 Lepisosteus oculatus 25.45 4.00e-03 30.80
IUUC-Lma-053299 Leptosphaeria maculans 55.65 3.00e-32 128.00
IUUC-Laf-054205 Loxodonta africana 27.59 4.00e-12 62.00
IUUC-Meu-056804 Macropus eugenii 28.74 6.00e-12 61.20
IUUC-Mor-057052 Magnaporthe oryzae 58.12 8.00e-30 121.00
IUUC-Mtr-057961 Medicago truncatula 41.38 5.00e-14 67.00
IUUC-Mla-059045 Melampsora laricipopulina 49.02 2.00e-24 102.00
IUUC-Mvi-060360 Microbotryum violaceum 49.00 1.00e-23 99.80
IUUC-Mmr-061654 Microcebus murinus 27.59 5.00e-12 61.20
IUUC-Mdo-062649 Monodelphis domestica 27.59 4.00e-12 62.00
IUUC-Mmu-064105 Mus musculus 27.59 7.00e-12 61.20
IUUC-Mac-065532 Musa acuminata 42.53 1.00e-14 69.30
IUUC-Mpu-066269 Mustela putorius furo 28.74 2.00e-12 62.80
IUUC-Mlu-067631 Myotis lucifugus 27.59 5.00e-12 62.00
IUUC-Nfi-068468 Neosartorya fischeri 92.11 8.00e-60 219.00
IUUC-Ncr-068750 Neurospora crassa 52.90 8.00e-39 150.00
IUUC-Nle-069483 Nomascus leucogenys 27.59 5.00e-12 62.40
IUUC-Opr-070936 Ochotona princeps 27.59 7.00e-12 61.60
IUUC-Obr-076322 Oryza brachyantha 39.13 6.00e-15 70.10
IUUC-Ogl-077226 Oryza glaberrima 38.55 4.00e-13 64.30
IUUC-Oin-079220 Oryza indica 37.31 2.00e-09 52.80
IUUC-Olo-080688 Oryza longistaminata 38.55 4.00e-13 64.30
IUUC-Ome-081265 Oryza meridionalis 38.55 4.00e-13 64.30
IUUC-Oru-084342 Oryza rufipogon 40.23 6.00e-14 68.90
IUUC-Osa-086212 Oryza sativa 38.55 4.00e-13 64.30
IUUC-Ola-087277 Oryzias latipes 27.78 6.00e-11 57.40
IUUC-Olu-087780 Ostreococcus lucimarinus 32.97 3.00e-08 48.10
IUUC-Oga-088175 Otolemur garnettii 27.59 6.00e-12 61.20
IUUC-Oar-089477 Ovis aries 27.59 1.00e-11 60.80
IUUC-Ptr-091129 Pan troglodytes 27.59 1.00e-11 61.20
IUUC-Psi-093351 Pelodiscus sinensis 27.59 1.00e-11 60.50
IUUC-Pno-094948 Phaeosphaeria nodorum 56.64 5.00e-34 134.00
IUUC-Ppa-095788 Physcomitrella patens 40.23 7.00e-15 70.10
IUUC-Pfo-096993 Poecilia formosa 25.53 6.00e-10 54.30
IUUC-Pab-098502 Pongo abelii 27.59 9.00e-12 61.20
IUUC-Pop-098819 Populus trichocarpa 37.93 2.00e-13 65.50
IUUC-Pca-100144 Procavia capensis 16.09 4.00e-03 32.70
IUUC-Ppe-101560 Prunus persica 40.00 2.00e-12 61.60
IUUC-Pva-102810 Pteropus vampyrus 25.37 7.00e-07 45.10
IUUC-Pgr-103531 Puccinia graminis 46.49 6.00e-25 103.00
IUUC-Ptt-103753 Puccinia triticina 49.02 7.00e-24 100.00
IUUC-Pyt-104733 Pyrenophora triticirepentis 53.19 4.00e-40 154.00
IUUC-Rno-106072 Rattus norvegicus 28.74 3.00e-12 62.40
IUUC-Sce-106275 Saccharomyces cerevisiae 45.98 2.00e-18 84.00
IUUC-Sha-107554 Sarcophilus harrisii 28.74 3.00e-12 62.40
IUUC-Sja-107682 Schizosaccharomyces japonicus 38.71 4.00e-24 101.00
IUUC-Spo-108275 Schizosaccharomyces pombe 43.68 4.00e-18 81.60
IUUC-Smo-109151 Selaginella moellendorffii 39.53 1.00e-12 62.40
IUUC-Sit-110270 Setaria italica 41.38 1.00e-14 68.90
IUUC-Sly-111862 Solanum lycopersicum 40.22 5.00e-14 67.00
IUUC-Stu-112663 Solanum tuberosum 37.78 1.00e-03 33.50
IUUC-Sbi-114148 Sorghum bicolor 41.38 1.00e-14 68.90
IUUC-Sre-115216 Sporisorium reilianum 49.49 1.00e-24 103.00
IUUC-Ssc-116051 Sus scrofa 27.59 5.00e-12 61.60
IUUC-Tru-118466 Takifugu rubripes 26.74 3.00e-09 50.80
IUUC-Tsy-119334 Tarsius syrichta 24.46 1.00e-08 50.80
IUUC-Tni-119792 Tetraodon nigroviridis 26.74 7.00e-10 53.10
IUUC-Tca-121861 Theobroma cacao 39.62 8.00e-14 67.00
IUUC-Tvi-122499 Trichoderma virens 60.33 5.00e-35 137.00
IUUC-Tae-123431 Triticum aestivum 41.38 2.00e-14 68.20
IUUC-Tme-126934 Tuber melanosporum 48.54 2.00e-25 106.00
IUUC-Ttr-129001 Tursiops truncatus 26.44 2.00e-08 50.10
IUUC-Uma-129324 Ustilago maydis 48.48 2.00e-24 102.00
IUUC-Vda-129846 Verticillium dahliae 61.67 2.00e-37 145.00
IUUC-Vpa-130202 Vicugna pacos 42.50 4.00e-06 42.70
IUUC-Vvi-131474 Vitis vinifera 42.86 1.00e-09 53.90
IUUC-Xtr-132782 Xenopus tropicalis 29.89 2.00e-12 63.20
IUUC-Xma-134140 Xiphophorus maculatus 25.53 2.00e-09 53.10
IUUC-Yli-134517 Yarrowia lipolytica 42.22 2.00e-16 77.00
IUUC-Zma-134764 Zea mays 41.38 1.00e-14 69.30
Created Date 25-Jun-2017

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