PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8L746 P93002 protein complementation assay 22986789 direct interaction X 2 P93002 Q39163 two hybrid 10659709 direct interaction X 2 P93002 A8MQK5 two hybrid 10659709 direct interaction X 2 P93002 Q39163 two hybrid 12383081 direct interaction X 2 P93002 Q39163 pull down 12383081 direct interaction X 2 P93002 A8MQK5 two hybrid 12953119 direct interaction X 2 P93002 Q39163 two hybrid 10339621 direct interaction X 2 P93002 Q39163 pull down 10339621 direct interaction X 2 P93002 Q9FNZ5 two hybrid 11442055 direct interaction X 2 P93002 Q9LUA3 two hybrid 11442055 direct interaction X 2 P93002 Q9FNZ4 two hybrid 11442055 direct interaction X 2 P93002 Q39163 two hybrid 15634206 direct interaction X 2 P93002 Q9FNZ4 two hybrid 15634206 direct interaction X 2 P93002 Q9FNZ5 affinity chromatography technology 15749762 physical association X 2 P93002 Q9FNZ4 two hybrid 21798944 direct interaction X 2 P93002 Q9LUA3 two hybrid 21798944 direct interaction X 2 P93002 Q9FNZ5 two hybrid 21798944 direct interaction X 2 P93002 A1A6J5 two hybrid 10659709 direct interaction X 2 P93002 A1A6J5 two hybrid 10339621 direct interaction X 2 P93002 A1A6J5 two hybrid 15634206 direct interaction X 2 P93002 A1A6J5 two hybrid 15805484 direct interaction X 2 P93002 Q9LW20 two hybrid 21798944 direct interaction X 2 B2BDR5 P93002 protein complementation assay 22986789 direct interaction X 2 B2BDR5 P93002 two hybrid 10659709 direct interaction X 2 B2BDR5 P93002 two hybrid 12383081 direct interaction X 2 B2BDR5 P93002 pull down 12383081 direct interaction X 2 B2BDR5 P93002 pull down 18571510 direct interaction X 2 B2BDR5 P93002 two hybrid 12953119 direct interaction X 2 B2BDR5 P93002 two hybrid 10339621 direct interaction X 2 B2BDR5 P93002 pull down 10339621 direct interaction X 2 B2BDR5 P93002 two hybrid 10662863 direct interaction X 2 B2BDR5 P93002 pull down 10662863 direct interaction X 2 B2BDR5 P93002 biochemical 12084833 association X 2 B2BDR5 P93002 two hybrid 15634206 direct interaction X 2 B2BDR5 P93002 two hybrid 15805484 direct interaction X 2 Q147Q9 P93002 two hybrid 10659709 direct interaction X 2 Q147Q9 P93002 two hybrid 10662863 direct interaction X 2 Q147Q9 P93002 two hybrid 15634206 direct interaction X 2 Q147Q9 P93002 two hybrid 15805484 direct interaction X 2 Q8L746 P93002 two hybrid 22699612 direct interaction X 2 Q8L746 P93002 pull down 22699612 direct interaction X 2 Q9ZVH4 P93002 anti tag coimmunoprecipitation 22699612 physical association X 2 P93002 Q5ICL9 two hybrid 22699612 direct interaction X 2 P93002 Q5ICL9 two hybrid 22699612 direct interaction X 2 P93002 Q5ICL9 pull down 22699612 direct interaction X 2 Q9SZI3 P93002 two hybrid 22699612 direct interaction X 2 Q9SZI3 P93002 two hybrid 22699612 direct interaction X 2 P93002 two hybrid 17397508 physical association C 3 P93002 Q39163 two hybrid 10659709 physical association X 2 P93002 Q39163 two hybrid 10659709 physical association X 2 P93002 Q24JJ3 two hybrid 10659709 physical association X 2 P93002 Q39163 two hybrid 15634206 physical association X 2 P93002 Q9FNZ4 two hybrid 15634206 physical association X 2 P93002 Q9LUA3 pull down 21798944 direct interaction X 2 P93002 Q9FNZ4 two hybrid array 21798944 physical association X 2 P93002 Q9FNZ5 two hybrid array 21798944 physical association X 2 P93002 Q9LUA3 two hybrid array 21798944 physical association X 2 Q9ZVH4 P93002 anti bait coimmunoprecipitation 19490895 physical association X 2 Q9ZVH4 P93002 anti bait coimmunoprecipitation 19490895 physical association X 2 Q8L5U0 P93002 anti bait coimmunoprecipitation 19490895 physical association X 2 P43255 P93002 anti bait coimmunoprecipitation 19490895 physical association X 2 P93002 A1A6J5 two hybrid 10659709 physical association X 2 P93002 A1A6J5 two hybrid 15634206 physical association X 2 P93002 Q9LW20 two hybrid array 21798944 physical association X 2 B9DGG1 P93002 two hybrid 10659709 physical association X 2 B9DGG1 P93002 two hybrid 10659709 physical association X 2 B2BDR5 P93002 two hybrid 10659709 physical association X 2 B2BDR5 P93002 pull down 12084833 physical association X 2 B2BDR5 P93002 two hybrid 15634206 physical association X 2 B2BDR5 P93002 affinity chromatography technology 18571510 direct interaction X 2 B2BDR5 P93002 pull down 18571510 direct interaction X 2 B2BDR5 P93002 anti tag coimmunoprecipitation 19490895 direct interaction X 2 B2BDR5 P93002 two hybrid array 21798944 physical association X 2 Q93ZE2 P93002 two hybrid 15634206 physical association X 2 Q147Q9 P93002 two hybrid 10659709 physical association X 2 Q147Q9 P93002 two hybrid 15634206 physical association X 2 Q147Q9 P93002 two hybrid array 21798944 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B NPR1 TGA3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10659709,10662863,15634206,15805484 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_1913|UniProt_13485|BIOGRID_2646|BIOGRID_2591|BIOGRID_566|UniProt_17170 bait|bait|prey|bait|bait|bait prey|prey|bait|prey|prey|prey NPR1 TGA1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10659709,12953119 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid) UniProt_17166|UniProt_17164|BIOGRID_1586|BIOGRID_564 bait|bait|bait|bait prey|prey|prey|prey NPR1 NPR3 MI:0090(protein complementation assay) 22986789 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction) (biogrid) BIOGRID_16770 bait prey NPR1 CSN4 MI:0006(anti bait coimmunoprecipitation) 19490895 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_10396 prey bait NPR1 CUL3A MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19490895 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_10397|UniProt_10394 prey|prey bait|bait TGA2 NPR1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0401(biochemical)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0090(protein complementation assay)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 10339621,10659709,10662863,12084833,12383081,12953119,15634206,15805484,18571510,19490895,21798944,22986789 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid) BIOGRID_2645|BIOGRID_1587|UniProt_10755|UniProt_10756|BIOGRID_1843|BIOGRID_1215|BIOGRID_2099|BIOGRID_1844|BIOGRID_565|UniProt_2579|BIOGRID_584|UniProt_17171|BIOGRID_587|BIOGRID_16768|UniProt_13486|UniProt_10398|BIOGRID_1912|BIOGRID_2590|UniProt_16435|BIOGRID_1914 bait|prey|bait|bait|prey|bait|bait|prey|prey|prey|prey|prey|bait|prey|prey|prey|prey|prey|bait|prey prey|bait|prey|prey|bait|prey|prey|bait|bait|bait|bait|bait|prey|bait|bait|bait|bait|bait|prey|bait NPR1 TGA6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10339621,10659709,15634206,15805484 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid) UniProt_13483|BIOGRID_2593|BIOGRID_1841|UniProt_17168|BIOGRID_567|BIOGRID_2647 bait|bait|bait|bait|bait|prey prey|prey|prey|prey|prey|bait NPR1 TGA4 MI:0018(two hybrid) 10659709 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_17169 bait prey NPR1 TGA5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10339621,10659709,12383081,15634206 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_17165|UniProt_13484|BIOGRID_1842|BIOGRID_2592|UniProt_17167|BIOGRID_588|BIOGRID_563|BIOGRID_1845|BIOGRID_585 bait|bait|bait|bait|bait|prey|bait|bait|bait prey|prey|prey|prey|prey|bait|prey|prey|prey NPR1 NIMIN-2 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 11442055,21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(biogrid) UniProt_2583|BIOGRID_2050|UniProt_8722|BIOGRID_9510 bait|prey|prey|bait prey|bait|bait|prey NPR1 SKL1 MI:0397(two hybrid array)|MI:0018(two hybrid) 21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_4724|BIOGRID_8810 prey|bait bait|prey NPR1 uniprotkb:(gene name) MI:0397(two hybrid array) 21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_2580 bait prey NPR1 GRXC9 MI:0809(bimolecular fluorescence complementation) 17397508 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_15307 prey bait NPR1 TGA7 MI:0018(two hybrid) 15634206 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_13482 bait prey NPR1 NIMIN-3 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11442055,15634206,21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid)|(intact) UniProt_2581|BIOGRID_9508|BIOGRID_2051|BIOGRID_2594|UniProt_13487 bait|prey|prey|bait|bait prey|bait|bait|prey|prey NPR1 NIMIN-1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 11442055,15749762,21798944 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_2582|BIOGRID_2627|BIOGRID_12322|BIOGRID_2049 bait|prey|prey|prey prey|bait|bait|bait CSN8 NPR1 MI:0006(anti bait coimmunoprecipitation) 19490895 taxid:3702(Arabidopsis thaliana) taxid:3702(Arabidopsis thaliana) MI:0915(physical association) (intact) UniProt_10395 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CIPK11 NPR1 20621018,20621018,20621018 0004,0018,0415 LC TGA2 NPR1 12383081,10662863,10659709,12383081,15634206,12084833,15805484,10662863,11442055,10339621,12953119,22986789,12084833,10339621,10662863,15749762,21798944 0096,0007,0018,0018,0018,0401,0018,0018,0018,0096,0018,0090,0096,0018,0096,0588,0397 LC,HT NPR1 TGA6 15634206,15805484,10662863,15749762,11442055,10339621,10659709 0018,0018,0018,0588,0018,0018,0018 LC NPR1 TGA4 10659709 0018 LC NPR1 TGA5 12383081,15634206,10662863,10339621,10339621,12383081,10659709 0018,0018,0018,0096,0018,0096,0018 LC NPR1 TGA3 10662863,10659709,15805484,21798944,15634206 0018,0018,0018,0397,0018 LC,HT NPR1 TGA1 10662863,10659709,12953119 0018,0018,0018 LC NPR1 TRX5 25201412,25201412 0096,0415 LC NPR1 NPR4 22699612,22699612 0096,0018 LC NPR1 NPR3 22699612,22986789,22699612 0096,0090,0018 LC NPR1 TGA7 10662863,15634206 0018,0018 LC NPR1 NIMIN-3 11442055,21798944,11442055,21798944,15634206 0411,0018,0018,0397,0018 LC,HT NPR1 NIMIN-1 21798944,21798944,11442055 0018,0397,0018 HT,LC NPR1 NIMIN-2 21798944,11442055,20507508,11442055,21798944,21798944 0096,0018,0018,0411,0018,0397 HT,LC NPR1 SKL1 21798944,21798944 0018,0397 HT NPR1 GRXC9 17397508 0018 LC NPR1 NPR2 22699612 0018 LC CIPK11 NPR1 20621018,20621018,20621018 0004,0018,0415 LC CSN8 NPR1 19490895 0006 LC TGA2 NPR1 12383081,10662863,12383081,12084833,10662863,18571510,10339621,18571510,12084833,10339621,10662863,25482810,19490895 0096,0007,0018,0401,0018,0004,0096,0096,0096,0018,0096,0004,0007 LC NPR1 NPR1 25201412 0096 LC NPR1 UBQ3 19490895 0004 LC NPR1 TGA4 10662863 0007 LC NPR1 TGA5 12383081,10339621,10339621,12383081 0018,0096,0018,0096 LC NPR1 TRX5 25201412,25201412 0096,0415 LC NPR1 NPR4 22699612,22699612 0096,0018 LC NPR1 CSN4 19490895 0006 LC NPR1 NPR3 22699612,22699612 0096,0018 LC NPR1 NIMIN-1 15749762,15749762 0007,0004 LC NPR1 NIMIN-2 21798944,21798944,21798944 0096,0018,0397 LC NPR1 CUL3A 19490895,22699612,19490895 0006,0007,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9LUA3 P93002 NIMIN-2 NPR1 0.722 11442055,20507508,21798944 Q39140 P93002 TGA6 NPR1 0.891 15634206,10339621,10659709,15805484 Q39241 P93002 TRX5 NPR1 0.523 25201412 Q39234 P93002 TGA3 NPR1 0.891 15634206,10662863,10659709,15805484 Q39237 P93002 TGA1 NPR1 0.671 10659709,12953119 Q39163 P93002 TGA5 NPR1 0.964 15634206,10339621,12383081,10659709 Q9FNZ5 P93002 NIMIN-1 NPR1 0.61 11442055,15749762,21798944 P93002 P43273 NPR1 TGA2 0.999 15634206,10339621,19490895,12084833,10662863,22986789,15805484,25482810,18571510,12383081,21798944,12953119,10659709 Q93ZE2 P93002 TGA7 NPR1 0.309 15634206 Q9SGP6 P93002 GRXC9 NPR1 0.309 17397508 P93002 O22932 NPR1 CIPK11 0.623 20621018 P93002 P43255 NPR1 CSN8 0.21 19490895 P93002 P93002 NPR1 NPR1 0.332 25201412 Q1EC66 P93002 UBQ3 NPR1 0.21 19490895 Q8L5U0 P93002 CSN4 NPR1 0.21 19490895 Q8L746 P93002 NPR3 NPR1 0.309 22986789 Q9FNZ4 P93002 NIMIN-3 NPR1 0.765 11442055,15634206,21798944 Q9LW20 P93002 SKL1 NPR1 0.286 21798944 Q9ZVH4 P93002 CUL3A NPR1 0.507 19490895 Q147Q9 P93002 Q147Q9 NPR1 0.126 21798944 Q39162 P93002 TGA4 NPR1 0.309 10659709