PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KMT2C ERP44 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EZH2 KMT2C 23238014 intact exp G G G G G G G G G G G G MEF2C KMT2C 20936779 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL4B KMT2C 23238014 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G JUN KMT2C 20936779 biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ELAVL1 KMT2C 19322201 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TSC22D1 KMT2C 21900206 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GRB2 KMT2C 20936779 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAPK14 KMT2C 20936779 biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H3F3A, H3F3B KMT2C 17403666 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APPL2 KMT2C 25814554 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AK1 KMT2C 17353931 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRKCZ KMT2C 20936779 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G CDC73 KMT2C 19136632 biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR82 KMT2C 20516061 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM4B KMT2C 21502505 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIST2H3A, HIST2H3C, HIST2H3D KMT2C 22266653,12482968 biogrid exp, ortho HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J KMT2C 23870121 biogrid exp, ortho G G G G G G G G KDM6A KMT2C 17761849, 25402006, 21836163 biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBBP5 KMT2C 17500065,12482968, 25402006, 21836163 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR5 KMT2C 22665483,22266653, 21836163 biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C ASH2L 20305087,17500065,12482968,23870121, 21836163 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C PAGR1 17500065, 21836163 biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C ASCL2 12482968, 25402006 biogrid exp, pred G G G G G G PAXIP1 KMT2C 17500065,17925232, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TP53 KMT2C 19433796, 25402006 dip exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMARCB1 KMT2C 19221051, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NCOA6 KMT2C 17021013,12482968,19047629,23870121, 25402006, 21836163 biogrid,intact,dip exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2E KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SS18 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C NSD1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RXRA KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RARA KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C BAZ1B 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C ESR2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G ESR1 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C SMARCC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MECP2 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SCGB1D1 KMT2C 23023127 pred G KMT2C CHD6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C SMARCE1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HMGB2 KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XPC KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NCOR1 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C WHSC1L1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARID2 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C L3MBTL3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C HIST1H2BN 23023127 pred G G KMT2A KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BRPF1 KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NR1H3 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C RHBDD3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H2AFX KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C HIST1H2BA 23023127 pred G RB1 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPP1R15A KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C PHF21A 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C HIST1H2BM 23023127 pred G G G KMT2C PRDM5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C TGS1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C TXNRD2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOX15 KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C SMARCC2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LAMTOR5 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPP1CC KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C ZNF335 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G KLF1 KMT2C 25402006 pred G G G G G G G G G KMT2C SETD8 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOX12 KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMARCA2 KMT2C 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HNF4A KMT2C 25402006 pred G G G G G G G G G G G G G G G G G KMT2C RBM14 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BPTF KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C ASF1A 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CIT KMT2C 21836163 pred NPM1 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AR KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G PRKCB KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDYL2 KMT2C 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IL10 KMT2C 23023127 pred G KMT2C CHD5 23023127 pred G G G G G G KMT2C KMT2B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VDR KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G ARID1A KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NR1H2 KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C KAT6B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPP1CB KMT2C 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KMT2C SUV39H2 23023127 pred G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8NEZ4 affinity chromatography technology 12482968 physical association X 2 Q8NEZ4 biochemical 12482968 association X 2 Q8NEZ4 biochemical 12482968 association X 2 Q8NEZ4 affinity chromatography technology 12482968 physical association X 2 Q8NEZ4 affinity chromatography technology 12482968 physical association X 2 Q8NEZ4 Q9H836 pull down 19221051 direct interaction X 2 Q8NEZ4 Q9H836 two hybrid 19221051 direct interaction X 2 Q8NEZ4 Q16539-4 two hybrid 20936779 direct interaction X 2 Q8NEZ4 affinity chromatography technology 19047629 physical association X 2 Q8NEZ4 affinity chromatography technology 17021013 physical association X 2 Q8NEZ4 affinity chromatography technology 17500065 physical association X 2 Q8NEZ4 Q6P1J9 affinity chromatography technology 19136632 physical association X 2 Q9BTK6 Q8NEZ4 affinity chromatography technology 17500065 physical association X 2 A0A024R333 Q8NEZ4 affinity chromatography technology 20516061 physical association X 2 P00568 Q8NEZ4 affinity chromatography technology 17353931 physical association X 2 Q8NEZ4 P68431 enzymatic study 23870121 direct interaction X 2 Q8NEZ4 B4DPT1 pull down 12482968 direct interaction X 2 Q8NEZ4 O15550 affinity chromatography technology 17761849 physical association X 2 Q8NEZ4 P05412 two hybrid 20936779 direct interaction X 2 Q8NEZ4 Q6ZW49 affinity chromatography technology 17925232 physical association X 2 Q8NEZ4 B2R4P9 affinity chromatography technology 17403666 physical association X 2 Q8NEZ4 Q6ZW49 affinity chromatography technology 17500065 physical association X 2 Q8NEZ4 Q6ZW49 affinity chromatography technology 17500065 physical association X 2 Q8NEZ4 Q6ZW49 biochemical 17500065 association X 2 Q8NEZ4 Q6ZW49 affinity chromatography technology 17500065 physical association X 2 Q8NEZ4 B4DPT1 affinity chromatography technology 17500065 physical association X 2 Q8NEZ4 A0A024RDV8 two hybrid 21900206 direct interaction X 2 Q8NEZ4 affinity chromatography technology 21502505 physical association X 2 Q8NEZ4 B4DPT1 affinity chromatography technology 20305087 physical association X 2 Q99929 Q8NEZ4 affinity chromatography technology 12482968 physical association X 2 P0CG48 Q8NEZ4 affinity chromatography technology 21139048 physical association X 2 P61964 Q8NEZ4 unspecified method 22665483 direct interaction X 2 P61964 Q8NEZ4 x-ray crystallography 22266653 association X 2 P61964 Q8NEZ4 unspecified method 22266653 direct interaction X 2 Q71DI3 Q8NEZ4 enzymatic study 22266653 direct interaction X 2 Q71DI3 Q8NEZ4 pull down 12482968 direct interaction X 2 Q8NEZ4 anti tag coimmunoprecipitation 17761849 association C 12 Q8NEZ4 molecular sieving 17500065 association C 10 Q8NEZ4 anti tag coimmunoprecipitation 17500065 association C 10 Q8NEZ4 cosedimentation through density gradient 12482968 association C 7 Q8NEZ4 anti bait coimmunoprecipitation 12482968 association C 7 Q8NEZ4 anti bait coimmunoprecipitation 19047629 - C 11 Q8NEZ4 anti bait coimmunoprecipitation 19136632 - C 12 Q8NEZ4 Q6P1J9 anti bait coimmunoprecipitation 19136632 physical association X 2 Q8NEZ4 K7PPA8 anti tag coimmunoprecipitation 19433796 physical association X 2 Q8NEZ4 K7PPA8 anti tag coimmunoprecipitation 19433796 physical association X 2 Q8NEZ4 anti tag coimmunoprecipitation 19433796 - C 8 Q8NEZ4 anti tag coimmunoprecipitation 19433796 - C 8 Q8NEZ4 anti bait coimmunoprecipitation 19433796 - C 11 Q14686 Q8NEZ4 anti bait coimmunoprecipitation 19047629 physical association X 2 Q14686 Q8NEZ4 anti bait coimmunoprecipitation 19433796 physical association X 2 Q8NEZ4 molecular sieving 12482968 association C 4 Q8NEZ4 anti bait coimmunoprecipitation 12482968 association C 4 Q8NEZ4 anti bait coimmunoprecipitation 23870121 association C 9 Q8NEZ4 anti bait coimmunoprecipitation 23870121 association C 6 Q8NEZ4 Q81UK1 two hybrid pooling approach 20711500 physical association X 2 Q8NEZ4 A0A024RD15 two hybrid pooling approach 20936779 physical association X 2 Q8NEZ4 anti bait coimmunoprecipitation 12482968 association C 6 Q14686 Q8NEZ4 anti bait coimmunoprecipitation 12482968 physical association X 2 Q14686 Q8NEZ4 anti bait coimmunoprecipitation 17021013 physical association X 2 Q15714 Q8NEZ4 two hybrid 21900206 physical association X 2 P00568 Q8NEZ4 anti bait coimmunoprecipitation 17353931 physical association X 2 Q3V8F5 Q8NEZ4 two hybrid pooling approach 20711500 physical association X 2 Q8NEZ4 Q81W18 two hybrid pooling approach 20711500 physical association X 2 Q8NEZ4 Q7CG44 two hybrid pooling approach 20711500 physical association X 2 Q8NEZ4 P05412 two hybrid pooling approach 20936779 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B H3F3A MLL3 MI:0004(affinity chromatography technology) 17403666 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_137045 bait prey TSC22D1 MLL3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_157690|BIOGRID_158517|UniProt_178288 bait|bait|bait prey|prey|prey HIST2H3A; MLL3 MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography) 12482968,22266653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_85547|BIOGRID_192522 prey|prey bait|bait WDR5 MLL3 MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation) 17500065,19047629,22266653,22665483 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|-|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|MI:0465(dip) BIOGRID_188855|BIOGRID_192517|BIOGRID_192511|HPRD_39584|DIP_55000 prey|bait|bait|-|- bait|prey|prey|-|- RBBP5 MLL3 MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 12482968,17500065,19047629,19136632 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0914(association)|MI:0914(association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|- MI:0468(hprd)|MI:0465(dip)|(intact)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|MI:0465(dip) HPRD_40436|DIP_55069|UniProt_69574|UniProt_69578|HPRD_39584|BIOGRID_137317|BIOGRID_85693|BIOGRID_83943|DIP_55000 -|-|neutral component|prey|-|prey|prey|bait|- -|-|neutral component|bait|-|bait|bait|prey|- NCOA6 MLL3 MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0030(cross-linking study)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 12482968,17021013,17500065,19047629,23870121 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|-|MI:0914(association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(intact)|(intact)|(intact)|(intact)|MI:0468(hprd)|(biogrid)|(intact)|MI:0465(dip)|(biogrid)|(biogrid)|(biogrid)|MI:0465(dip)|(intact)|(biogrid) HPRD_40436|UniProt_69572|UniProt_69574|UniProt_69578|UniProt_130744|HPRD_39584|BIOGRID_83942|UniProt_69575|DIP_55000|BIOGRID_127620|BIOGRID_85299|BIOGRID_129083|DIP_55034|UniProt_87380|BIOGRID_83940 -|bait|neutral component|prey|bait|-|bait|prey|-|bait|prey|prey|-|prey|bait -|prey|neutral component|bait|prey|-|prey|bait|-|prey|bait|bait|-|bait|prey WDR82 MLL3 MI:0004(affinity chromatography technology) 20516061 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_140132 bait prey ELAVL1 MLL3 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187117 bait prey UBC MLL3 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_169048 bait prey SMARCB1 MLL3 MI:0096(pull down)|MI:0096(pull down) 19221051 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_126006|BIOGRID_126008 bait|bait prey|prey AK1 MLL3 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_150543|BIOGRID_82498 bait|bait prey|prey MAPK14 MLL3 MI:0096(pull down)|MI:0018(two hybrid) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_110563|BIOGRID_127159 bait|bait prey|prey KDM6A MLL3 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17761849,19047629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0465(dip) BIOGRID_118771|DIP_55000 bait|- prey|- MLL3 ASH2L MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0030(cross-linking study)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation) 12482968,17500065,19047629,19136632,20305087,23870121 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|-|- MI:0468(hprd)|MI:0465(dip)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|MI:0468(hprd)|MI:0465(dip) HPRD_40436|DIP_55069|BIOGRID_137318|BIOGRID_83941|BIOGRID_182627|UniProt_69574|UniProt_69578|UniProt_130743|HPRD_39584|DIP_55000 -|-|bait|prey|prey|neutral component|bait|prey|-|- -|-|prey|bait|bait|neutral component|prey|bait|-|- c-Jun MLL3 MI:0096(pull down)|MI:0018(two hybrid) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_110515|BIOGRID_127160 bait|bait prey|prey KDM4B MLL3 MI:0004(affinity chromatography technology) 21502505 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_167286 bait prey PAXIP1 MLL3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation) 17500065,17925232,19047629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|-|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|MI:0465(dip) BIOGRID_137277|BIOGRID_137316|BIOGRID_137292|BIOGRID_137265|BIOGRID_136883|HPRD_39584|DIP_55000 bait|prey|bait|bait|bait|-|- prey|bait|prey|prey|prey|-|- MLL3 ASCL2 MI:0004(affinity chromatography technology) 12482968 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_85548 bait prey MLL3 PAGR1 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 17500065 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_137323|HPRD_39584 prey|- bait|- CDC73 MLL3 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 19136632 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0465(dip) DIP_55069|BIOGRID_145488|DIP_55135 -|bait|- -|prey|-

PPI - HINT Gene A Gene B PMID Method Quality AK1 KMT2C 17353931,17353931 0006,0004 HT WDR5 KMT2C 17500065,17500065,26324722 0006,0096,0096 LC NCOA6 KMT2C 12482968,12482968,19047629,17021013,19047629,12482968,19433796,17021013,23870121 0004,0006,0004,0004,0006,0401,0006,0006,0006 LC RBBP5 KMT2C 17500065,17500065,12482968,12482968,12482968,26324722 0006,0004,0006,0004,0401,0096 LC PAXIP1 KMT2C 17500065,17500065,17925232,17500065 0401,0006,0004,0004 LC KMT2C ERP44 26496610,26496610 0007,0004 HT KMT2C ASH2L 26886794,12482968,12482968,17500065,20305087,12482968,17500065,23870121,26324722 0096,0096,0071,0004,0004,0006,0096,0006,0096 LC AK1 KMT2C 17353931,17353931 0006,0004 HT KMT2C ERP44 26496610,26496610 0007,0004 HT WDR5 KMT2C 17500065,17500065,26324722 0006,0096,0096 LC NCOA6 KMT2C 12482968,12482968,19047629,17021013,19047629,12482968,19433796,17021013,23870121 0004,0006,0004,0004,0006,0401,0006,0006,0006 LC RBBP5 KMT2C 17500065,17500065,12482968,12482968,12482968,26324722 0006,0004,0006,0004,0401,0096 LC PAXIP1 KMT2C 17500065,17500065,17925232,17500065 0401,0006,0004,0004 LC KMT2C ASH2L 26886794,12482968,12482968,17500065,20305087,12482968,17500065,23870121,26324722 0096,0096,0071,0004,0004,0006,0096,0006,0096 LC JUN KMT2C 20936779,20936779 0398,0018 HT MTNR1B KMT2C 26514267 0018 LC WDR5 KMT2C 22266653,22665483 0114,0114 LC HIST1H3A|HIST1H3B|HIST1H3C|HIST1H3D|HIST1H3E|HIST1H3F|HIST1H3G|HIST1H3H|HIST1H3I|HIST1H3J KMT2C 23870121 0415 LC NCOA6 KMT2C 12482968,12482968,12482968 0004,0006,0401 LC RBBP5 KMT2C 12482968,12482968,12482968 0006,0004,0401 LC TSC22D1 KMT2C 21900206 0018 HT MAPK14 KMT2C 20936779,20936779 0398,0018 HT HIST3H3 KMT2C 26324722 0415 LC PAXIP1 KMT2C 17500065,17500065,17500065 0401,0006,0004 LC HIST2H3A|HIST2H3C|HIST2H3D KMT2C 22266653 0415 LC APPL2 KMT2C 25814554,25814554,25814554 0397,0018,1356 HT KMT2C Q9H836 19221051,19221051 0096,0018 LC KMT2C ASH2L 12482968,12482968,12482968 0096,0071,0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NEZ4 O15550 KMT2C KDM6A 0.21 17761849 Q8NEZ4 P68431 KMT2C HIST1H3J 0.183 23870121 Q8NEZ4 Q15714 KMT2C TSC22D1 0.183 21900206 Q8NEZ4 Q16695 KMT2C HIST3H3 0.309 26324722 Q8NEZ4 Q3V8F5 KMT2C FLHB 0.126 20711500 Q8NEZ4 Q6P1J9 KMT2C CDC73 0.376 19136632 Q8NEZ4 Q6ZW49 KMT2C PAXIP1 0.472 17925232,17500065 Q8NEZ4 Q81UK1 KMT2C ALSD 0.126 20711500 Q8NEZ4 Q8NEU8 KMT2C APPL2 0.376 25814554 Q99929 Q8NEZ4 ASCL2 KMT2C 0.21 12482968 Q9C005 Q8NEZ4 DPY30 KMT2C 0.309 26324722 Q8NEZ4 Q6UXN9 KMT2C WDR82 0.126 20516061 Q8NEZ4 Q7CG44 KMT2C FRWC 0.126 20711500 Q8NEZ4 Q81W18 KMT2C DNAX 0.126 20711500 Q8NEZ4 O94953 KMT2C KDM4B 0.21 21502505 Q8NEZ4 P00568 KMT2C AK1 0.236 17353931 Q8NEZ4 Q14686 KMT2C NCOA6 0.787 19047629,12482968,23870121,17021013 Q8NEZ4 P61964 KMT2C WDR5 0.801 27705803,22266653,26324722,22665483 Q9UBL3 Q8NEZ4 ASH2L KMT2C 0.78 17500065,23870121,26324722,26886794,20305087,12482968 Q8NEZ4 Q71DI3 KMT2C HIST2H3D 0.523 12482968,22266653 Q8NEZ4 P05412 KMT2C JUN 0.286 20936779 Q9BS26 Q8NEZ4 ERP44 KMT2C 0.236 26496610 Q8NEZ4 Q16539 KMT2C MAPK14 0.286 20936779 Q8NEZ4 Q12824 KMT2C SMARCB1 0.523 19221051 Q9BTK6 Q8NEZ4 PAGR1 KMT2C 0.126 17500065 Q8NEZ4 P84243 KMT2C H3F3B 0.21 17403666 Q8NEZ4 P49286 KMT2C MTNR1B 0.183 26514267 Q8NEZ4 Q15291 KMT2C RBBP5 0.623 17500065,12482968,26324722 Q8NEZ4 Q15717 KMT2C ELAVL1 0.126 19322201 Q8NEZ4 Q06587 KMT2C RING1 0.126 27705803

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MEIS1 KMT2C MI:0362 inference MI:1106 pathways database UTY KMT2C MI:0362 inference MI:0461 interaction database KMT2D KMT2C MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SETD1A KMT2C MI:0362 inference MI:1106 pathways database POLR2D KMT2C MI:0362 inference MI:1106 pathways database KDM6A KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KDM4B KMT2C MI:0045 experimental interaction detection MI:0461 interaction database ESRRB KMT2C MI:0362 inference MI:0461 interaction database AK1 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database TP53 KMT2C MI:0362 inference MI:0461 interaction database JUN KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBC KMT2C MI:0045 experimental interaction detection MI:0461 interaction database RARA KMT2C MI:0362 inference MI:1106 pathways database RARB KMT2C MI:0362 inference MI:1106 pathways database EGR2 KMT2C MI:0362 inference MI:1106 pathways database RARG KMT2C MI:0362 inference MI:1106 pathways database HOXB1 KMT2C MI:0362 inference MI:1106 pathways database POLR2C KMT2C MI:0362 inference MI:1106 pathways database POLR2E KMT2C MI:0362 inference MI:1106 pathways database RXRA KMT2C MI:0362 inference MI:1106 pathways database POLR2A KMT2C MI:0362 inference MI:1106 pathways database YY1 KMT2C MI:0362 inference MI:1106 pathways database PAX6 KMT2C MI:0362 inference MI:1106 pathways database POLR2B KMT2C MI:0362 inference MI:1106 pathways database CSTF2 KMT2C MI:0362 inference MI:0461 interaction database POLR2I KMT2C MI:0362 inference MI:1106 pathways database PBX1 KMT2C MI:0362 inference MI:1106 pathways database MTNR1B KMT2C MI:0045 experimental interaction detection MI:0461 interaction database CTCF KMT2C MI:0362 inference MI:1106 pathways database POLR2H KMT2C MI:0362 inference MI:1106 pathways database POLR2J KMT2C MI:0362 inference MI:1106 pathways database POLR2K KMT2C MI:0362 inference MI:1106 pathways database PKNOX1 KMT2C MI:0362 inference MI:1106 pathways database ACTB KMT2C MI:0362 inference MI:0461 interaction database POLR2F KMT2C MI:0362 inference MI:1106 pathways database WDR5 KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database POLR2G KMT2C MI:0362 inference MI:1106 pathways database HIST1H4A KMT2C MI:0362 inference MI:1106 pathways database POLR2L KMT2C MI:0362 inference MI:1106 pathways database HIST1H3A KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database H3F3A KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KMT2A KMT2C MI:0362 inference MI:1106 pathways database EP300 KMT2C MI:0362 inference MI:1106 pathways database CPSF1 KMT2C MI:0362 inference MI:0461 interaction database SMARCB1 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database TP53BP1 KMT2C MI:0362 inference MI:0461 interaction database CSTF3 KMT2C MI:0362 inference MI:0461 interaction database CUL4B KMT2C MI:0045 experimental interaction detection MI:0461 interaction database RAB32 KMT2C MI:0362 inference MI:0461 interaction database NCOA6 KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RBBP5 KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TSC22D1 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database NCOA1 KMT2C MI:0362 inference MI:0461 interaction database EZH2 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database MAPK14 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database HIST3H3 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database CDC73 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database CTR9 KMT2C MI:0362 inference MI:0461 interaction database FIP1L1 KMT2C MI:0362 inference MI:0461 interaction database WDR82 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database PAXIP1 KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HIST2H3A KMT2C MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database APPL2 KMT2C MI:0045 experimental interaction detection MI:0461 interaction database KMT2C LEO1 MI:0362 inference MI:0461 interaction database KMT2C CREBBP MI:0362 inference MI:0461,MI:1106 interaction database,pathways database KMT2C SYMPK MI:0362 inference MI:0461 interaction database KMT2C ASCL2 MI:0045 experimental interaction detection MI:0461 interaction database KMT2C ERP44 MI:0045 experimental interaction detection MI:0461 interaction database KMT2C PAGR1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KMT2C DPY30 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KMT2C NANOG MI:0362 inference MI:0461 interaction database KMT2C CPSF2 MI:0362 inference MI:0461 interaction database KMT2C ASH2L MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KMT2C KMT2B MI:0362 inference MI:0461 interaction database KMT2C SETD1B MI:0362 inference MI:1106 pathways database KMT2C MAFB MI:0362 inference MI:1106 pathways database KMT2C NCOA3 MI:0362 inference MI:1106 pathways database