PTM - CPLM Gene Name UniProt ID Type Position Code OTUD5 Q96G74 Ubiquitination 385 K OTUD5 Q96G74 Ubiquitination 205 K OTUD5 Q96G74 Ubiquitination 343 K OTUD5 Q96G74 Ubiquitination 356 K OTUD5 Q96G74 Ubiquitination 386 K OTUD5 Q96G74 Ubiquitination 219 K OTUD5 Q96G74 Ubiquitination 245 K OTUD5 Q96G74 Ubiquitination 370 K

PTM - dbPAF Gene Name UniProt ID Position Type Species OTUD5 Q96G74 165 S Homo sapiens(Human) OTUD5 Q96G74 175 Y Homo sapiens(Human) OTUD5 Q96G74 177 S Homo sapiens(Human) OTUD5 Q96G74 181 Y Homo sapiens(Human) OTUD5 Q96G74 375 S Homo sapiens(Human) OTUD5 Q96G74 431 S Homo sapiens(Human) OTUD5 Q96G74 435 S Homo sapiens(Human) OTUD5 Q96G74 436 S Homo sapiens(Human) OTUD5 Q96G74 442 S Homo sapiens(Human) OTUD5 Q96G74 443 S Homo sapiens(Human) OTUD5 Q96G74 449 T Homo sapiens(Human) OTUD5 Q96G74 450 S Homo sapiens(Human) OTUD5 Q96G74 452 S Homo sapiens(Human) OTUD5 Q96G74 457 S Homo sapiens(Human) OTUD5 Q96G74 458 S Homo sapiens(Human) OTUD5 Q96G74 460 S Homo sapiens(Human) OTUD5 Q96G74 461 S Homo sapiens(Human) OTUD5 Q96G74 477 S Homo sapiens(Human) OTUD5 Q96G74 489 S Homo sapiens(Human) OTUD5 Q96G74 500 S Homo sapiens(Human) OTUD5 Q96G74 507 T Homo sapiens(Human) OTUD5 Q96G74 508 S Homo sapiens(Human) OTUD5 Q96G74 512 S Homo sapiens(Human) OTUD5 Q96G74 514 Y Homo sapiens(Human) OTUD5 Q96G74 527 S Homo sapiens(Human) OTUD5 Q96G74 529 S Homo sapiens(Human) OTUD5 Q96G74 54 S Homo sapiens(Human) OTUD5 Q96G74 64 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q96G74 R32-m1 Methylation PMPPAPRrGGGVGVG Q96G74 S64-p Phosphorylation VGARPRAsPPPQGPL Q96G74 S165-p Phosphorylation VGAVGGGsPEREEVG Q96G74 Y175-p Phosphorylation REEVGAGyNsEDEyE Q96G74 S177-p Phosphorylation EVGAGyNsEDEyEAA Q96G74 Y181-p Phosphorylation GyNsEDEyEAAAARI Q96G74 S375-p Phosphorylation AIkTSEEsWIEQQML Q96G74 S431-p Phosphorylation PSQPRKAsATCsSAT Q96G74 S435-p Phosphorylation RKAsATCsSATAAAs Q96G74 S442-p Phosphorylation sSATAAAsSGLEEWt Q96G74 T449-p Phosphorylation sSGLEEWtsRsPRQR Q96G74 S450-p Phosphorylation SGLEEWtsRsPRQRs Q96G74 S452-p Phosphorylation LEEWtsRsPRQRssA Q96G74 S457-p Phosphorylation sRsPRQRssAssPEH Q96G74 S458-p Phosphorylation RsPRQRssAssPEHP Q96G74 S460-p Phosphorylation PRQRssAssPEHPEL Q96G74 S461-p Phosphorylation RQRssAssPEHPELH Q96G74 S489-p Phosphorylation LALAKPPsPCAPGTS Q96G74 T507-p Phosphorylation SAGADRAtsPLVsLy Q96G74 S508-p Phosphorylation AGADRAtsPLVsLyP Q96G74 S512-p Phosphorylation RAtsPLVsLyPALEC Q96G74 Y514-p Phosphorylation tsPLVsLyPALECRA Q96G74 S527-p Phosphorylation RALIQQMsPSAFGLN Q96G74 K205-ub Ubiquitination QQEHWFEkALRDKKG Q96G74 K219-ub Ubiquitination GFIIKQMkEDGACLF Q96G74 K245-ub Ubiquitination DMHEVVRkHCMDYLM Q96G74 K253-ub Ubiquitination HCMDYLMkNADYFSN Q96G74 K343-ub Ubiquitination NSVVNPNkATIGVGL Q96G74 K356-ub Ubiquitination GLGLPSFkPGFAEQS Q96G74 K366-ub Ubiquitination FAEQSLMkNAIkTSE Q96G74 K370-ub Ubiquitination SLMkNAIkTSEEsWI Q96G74 K385-ub Ubiquitination EQQMLEDkkRATDWE Q96G74 K386-ub Ubiquitination QQMLEDkkRATDWEA

PTM - dbPTM UniProt ID Position Code Type Resources References Q96G74 64 S Phosphorylation Swiss-Prot 1010711 17924679;18669648;18691976;22245969 Q96G74 165 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332;22245969 Q96G74 175 Y Phosphorylation Swiss-Prot 1010711 19413330;22245969 Q96G74 177 S Phosphorylation Swiss-Prot 1010711 18669648;19690332;22245969 Q96G74 452 S Phosphorylation Swiss-Prot 1010711 18669648 Q96G74 507 T Phosphorylation Swiss-Prot 1010711 19413330;22245969 Q96G74 508 S Phosphorylation Swiss-Prot 1010711 19413330 Q96G74 64 S Phosphorylation PhosphoELM.10011 18669648 Q96G74 165 S Phosphorylation PhosphoELM.10011 18669648 Q96G74 177 S Phosphorylation PhosphoELM.10011 18669648;15302935 Q96G74 452 S Phosphorylation PhosphoELM.10011 18669648 Q96G74 508 S Phosphorylation PhosphoELM.10011 18669648 Q96G74 512 S Phosphorylation PhosphoELM.10011 18669648 Q96G74 449 T Phosphorylation PhosphoELM.10011 18669648 Q96G74 507 T Phosphorylation PhosphoELM.10011 18669648;18220336 Q96G74 175 Y Phosphorylation PhosphoELM.10011 18669648 Q96G74 181 Y Phosphorylation PhosphoELM.10011 18669648 Q96G74 205 K Ubiquitylation Phosphositeplus.1010730 21890473 Q96G74 253 K Ubiquitylation Phosphositeplus.1010730 20972266 Q96G74 343 K Ubiquitylation Phosphositeplus.1010730 21890473 Q96G74 356 K Ubiquitylation Phosphositeplus.1010730 20972266;21890473;21906983 Q96G74 370 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96G74 385 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96G74 165 S Phosphorylation Phosphositeplus.1010730 18669648;19415658;19664994;19690332;20068231;20363803;21659604;22115753 Q96G74 177 S Phosphorylation Phosphositeplus.1010730 15302935;18669648;19690332;21659604;22115753;22245969 Q96G74 450 S Phosphorylation Phosphositeplus.1010730 19276368 Q96G74 452 S Phosphorylation Phosphositeplus.1010730 18669648 Q96G74 457 S Phosphorylation Phosphositeplus.1010730 20736484 Q96G74 461 S Phosphorylation Phosphositeplus.1010730 20736484 Q96G74 508 S Phosphorylation Phosphositeplus.1010730 16964243;19276368;19664995;21659604 Q96G74 64 S Phosphorylation Phosphositeplus.1010730 18669648;18691976;20068231;20230923;20363803;21659604 Q96G74 449 T Phosphorylation Phosphositeplus.1010730 19276368 Q96G74 507 T Phosphorylation Phosphositeplus.1010730 18220336;19276368;19664995;21659604 Q96G74 175 Y Phosphorylation Phosphositeplus.1010730 19415658 Q96G74 181 Y Phosphorylation Phosphositeplus.1010730 18669648 Q96G74 64 S Phosphorylation HPRD 9.0 18669648,18691976,19651622,17924679,20230923,20068231 Q96G74 165 S Phosphorylation HPRD 9.0 18669648,19413330,19415658,19651622,19664994,20068231 Q96G74 177 S Phosphorylation HPRD 9.0 15302935,18669648,18452278,20068231 Q96G74 452 S Phosphorylation HPRD 9.0 18669648,20068231 Q96G74 508 S Phosphorylation HPRD 9.0 18669648,19664995,20068231 Q96G74 512 S Phosphorylation HPRD 9.0 18669648 Q96G74 449 T Phosphorylation HPRD 9.0 18669648 Q96G74 507 T Phosphorylation HPRD 9.0 18669648,19413330,18691976,19664995,20068231 Q96G74 175 Y Phosphorylation HPRD 9.0 18669648,19413330,19415658,19651622,20068231 Q96G74 181 Y Phosphorylation HPRD 9.0 18669648 Q96G74 64 S Phosphorylation SysPTM 1.1 18691976;18669648 Q96G74 165 S Phosphorylation SysPTM 1.1 18669648 Q96G74 177 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References OTUD5 165 S Phosphorylation 18669648,19413330,19415658,19651622,19664994,20068231 OTUD5 175 Y Phosphorylation 18669648,19413330,19415658,19651622,20068231 OTUD5 177 S Phosphorylation 15302935,18669648,18452278,20068231 OTUD5 181 Y Phosphorylation 18669648 OTUD5 449 T Phosphorylation 18669648 OTUD5 452 S Phosphorylation 18669648,20068231 OTUD5 507 T Phosphorylation 18669648,19413330,18691976,19664995,20068231 OTUD5 508 S Phosphorylation 18669648,19664995,20068231 OTUD5 512 S Phosphorylation 18669648 OTUD5 64 S Phosphorylation 18669648,18691976,19651622,17924679,20230923,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q96G74 512 S 18669648 HTP Phosphorylation Q96G74 449 T 18669648 HTP Phosphorylation Q96G74 452 S 18669648 HTP Phosphorylation Q96G74 165 S 18669648 HTP Phosphorylation Q96G74 64 S 18669648 HTP Phosphorylation Q96G74 175 Y 18669648 HTP Phosphorylation Q96G74 177 S 18669648 HTP Phosphorylation Q96G74 177 S 15302935 HTP Phosphorylation Q96G74 181 Y 18669648 HTP Phosphorylation Q96G74 507 T 18669648 HTP Phosphorylation Q96G74 507 T 18220336 HTP Phosphorylation Q96G74 508 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q96G74 64 Phosphoserine 18691976;20068231;23186163;22245969 Q96G74 165 Phosphoserine 18669648;19690332;23186163;24275569;22245969 Q96G74 175 Phosphotyrosine 22245969 Q96G74 177 Phosphoserine 18669648;19690332;23186163;22245969 Q96G74 452 Phosphoserine 18669648 Q96G74 507 Phosphothreonine 22245969

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type OTUD5 IPI00640364 S 452 EEWTSRpSPRQRSS phosphorylation OTUD5 IPI00640364 S 508 GADRATpSPLVSLY phosphorylation OTUD5 IPI00640364 S 64 GARPRApSPPPQGP phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 55593 120738 - K Ubiquitination 22118674 55593 120738 - K Ubiquitination 18781797 55593 120738 - K Ubiquitination 21987572 55593 120738 - K Ubiquitination 20972266 55593 120738 - K Ubiquitination 21963094 55593 120738 - K Ubiquitination 21139048 55593 120738 - K Ubiquitination 21890473 55593 120738 - K Ubiquitination 21906983 55593 120738 - K Ubiquitination 22505724 55593 120738 - K Ubiquitination 23000965 55593 120738 - K Ubiquitination 25147182 55593 120738 - K Ubiquitination 12938929

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID OTUD5 Homo sapiens (Human) 121; 134 "121,SVVNPNKATIGVG; 134,LGLPSFKPGFAEQ" 121:21890473; 134:21890473 OTUD5 Homo sapiens (Human) 121; 134 "121,SVVNPNKATIGVG; 134,LGLPSFKPGFAEQ" 121:21890473; 134:21890473 OTUD5 Homo sapiens (Human) 356; 370; 385 "356,LGLPSFKPGFAEQ; 370,LMKNAIKTSEESW; 385,QQMLEDKKRATDW" "356:21906983; 370:21906983; 385:21139048,21906983" OTUD5 Homo sapiens (Human) 205; 343; 356; 370; 385 "205,QEHWFEKALRDKK; 343,SVVNPNKATIGVG; 356,LGLPSFKPGFAEQ; 370,LMKNAIKTSEESW; 385,QQMLEDKKRATDW" "205:21890473; 343:21890473; 356:21890473,21906983; 370:21906983; 385:21906983" OTUD5 Homo sapiens (Human) 356; 327; 341; 314; 181 "356,QQMLEDKKRATDW; 327,LGLPSFKPGFAEQ; 341,LMKNAIKTSEESW; 314,SVVNPNKATIGVG; 181,QEHWFEKALRDKK" "356:21906983; 327:21890473,21906983; 341:21906983; 314:21890473; 181:21890473" OTUD5 Homo sapiens (Human) 205; 338; 351; 365; 380 "205,QEHWFEKALRDKK; 338,SVVNPNKATIGVG; 351,LGLPSFKPGFAEQ; 365,LMKNAIKTSEESW; 380,QQMLEDKKRATDW" "205:21890473; 338:21890473; 351:21890473,21906983; 365:21906983; 380:21906983"