PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KLHL2 WNK3 23838290 biogrid exp G G G G G GP GP G GP G G G G G GP G KLHL2 KLHL2 25416956,10397770 biogrid,intact exp G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 NACC1 19121354 biogrid exp G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 BCAM 25416956 biogrid,intact exp G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 DCTN2 26186194 biogrid exp G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 WNK2 23838290 biogrid exp G G G G G P P G P G G G GP G G GP P KLHL2 ACTC1 10397770 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL2 KEAP1 15383316 biogrid exp G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 TSPAN5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2C KLHL2 25416956 biogrid,intact exp G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 UBE2D1 23838290 biogrid exp G G G G G G G G G G GP GP G G G G G G G G G GP G G G G G GP G SDCBP KLHL2 25416956 biogrid,intact exp G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 WNK1 23838290,24641320 biogrid exp G G G G G G G G G G GP GP G G G G G G G G G G G G G G G GP G KLHL2 TMA16 25416956 biogrid,intact exp G G G G G G P G G G G G G G G GP G KLHL2 WNK4 23838290,24641320 biogrid exp G GP G GP G GP GP P KLHL2 ZFP36 21784977 biogrid exp G G G G G G G G G G GP GP G G G G G G G G G GP G G G G G GP G KLHL2 CLK2 25416956 biogrid,intact exp G G G G G G G G G G GP G G G G GP G G G G G GP G G GP G G GP G KLHL2 TXNDC12 25416956,21516116 biogrid,intact exp G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 CCDC43 25416956 biogrid,intact exp G G G G G G G G G G GP G G G G GP G G G G G GP G G GP G G GP G TNPO2 KLHL2 25416956 biogrid,intact exp G G G G G G G G G G GP GP G G G GP G G G G G G G G GP G G GP G KLHL2 KLHL12 15383316,16189514,21516116 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL2 ZNF114 25416956 biogrid,intact exp G G G P P P G G P P KLHL2 CUL3 25416956,23838290,21145461 biogrid,intact exp, ortho G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 NPTXR ortho G G G G G G P KLHL2 NUMA1 21836163 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 MAVS 21836163 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G ENC1 KLHL2 23023127 pred G G G G G G G G G G GP G G G G GP G G G G G GP G G GP G G GP G DAB1 KLHL2 21836163 pred G G G G G G G G G G GP G G G G G GP G KLHL2 STX1B 23023127 pred G G G G G KLHL2 BCL6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL2 KLHL26 23023127 pred G G G G G G GP P G G GP G G G GP G G GP G GP G PAK3 KLHL2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL2 UBQLN2 23023127 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 BTBD6 23023127 pred G G G G G G G G G G G G G G G GP G G G G G G G G GP G G G G KLHL2 BTBD10 23023127 pred G G G G G G G G G G GP G G G G G G G G G G GP G G G G G GP G KLHL2 PPP1R9A 21836163 pred G G G G G G G G GP G G G G GP G G G G G GP G G GP G G GP G KLHL2 KCNA2 23023127 pred G G G G G G P P G GP G G P G P G P KLHL18 KLHL2 23023127 pred G G G G G G G G G G GP GP G G G GP G G G G G G G GP G G GP G KLHL2 FAF1 23023127 pred G G G G G G G G G G GP G G G G GP G G G G G GP G G GP G G GP G KLHL2 KLHL4 23023127 pred G G G G P P G P G G P P DVL1 KLHL2 23023127 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G DCLK1 KLHL2 23023127 pred G G G G G G G G G G GP G G G G G G G GP G G P G KLHL2 DBN1 21836163 pred G G G G G G G G G G GP G G G G G G G G GP G G G G G GP G KLHL2 BTBD3 23023127 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 PRKCI 23023127 pred G G G G G G G G G G GP G G G G GP G G G G G GP G G GP G G GP G KLHL2 STX1A 23023127 pred G G G G G G G G G G GP G G G G G G G GP G G G KBTBD11 KLHL2 23023127 pred G G G G G G G G G GP GP G G G GP G G GP G GP G P G KLHL2 CXXC1 21836163 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 APBA1 23023127 pred G G G G G G GP GP G G GP G G G P G G GP G G GP G KLHL2 LIN7B 23023127 pred G G G G G G G G G G G GP G G GP G G G G G G GP G G GP G KLHL2 KLHL3 23023127 pred G G G G G G G G G G GP GP G G G GP G G G G G G G G GP G G GP G CDC14B KLHL2 21836163 pred G G G G G G G G G G GP G G G G GP G G G G G G G G GP G G GP G KLHL2 KLHL32 23023127 pred G G G P P G KLHL2 SPTBN1 23023127 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G KLHL2 PICK1 23023127 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G STX7 KLHL2 23023127 pred G G G G G G G G G G GP G G G G G G G G G G G G G G G G GP G KLHL2 SHANK1 21836163 pred G P P P G P P P KLHL2 BTBD2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL2 KLHL1 23023127 pred G G P P G P KLHL2 ARHGEF2 21836163 pred G G G G G G G G G G GP G G G G GP G G G G G GP G G GP G G GP G KLHL2 TAOK1 21836163 pred G G G G G G G G G G GP GP G G G GP G G G G G GP G G GP G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q53G59 O95198 two hybrid 16189514 - X 2 Q53G59 O95198 two hybrid 16189514 - X 2 O95198 tandem affinity purification 20360068 physical association C 14 Q86WV7 O95198 mammalian protein protein interaction trap 25416956 physical association X 2 Q86WV7 O95198 bimolecular fluorescence complementation 25416956 physical association X 2 Q86WV7 O95198 two hybrid prey pooling approach 25416956 physical association X 2 Q86WV7 O95198 two hybrid array 25416956 physical association X 2 Q86WV7 O95198 validated two hybrid 25416956 physical association X 2 O14787 O95198 two hybrid prey pooling approach 25416956 physical association X 2 O14787 O95198 two hybrid array 25416956 physical association X 2 O14787 O95198 validated two hybrid 25416956 physical association X 2 O95881 O95198 two hybrid prey pooling approach 25416956 physical association X 2 O95881 O95198 two hybrid array 25416956 physical association X 2 O95881 O95198 validated two hybrid 25416956 physical association X 2 O95198 O95198 two hybrid array 25416956 physical association X 2 O95198 A8K7I0 two hybrid prey pooling approach 25416956 physical association X 2 O95198 P50895 two hybrid prey pooling approach 25416956 physical association X 2 O95198 A0A024R475 two hybrid prey pooling approach 25416956 physical association X 2 O95198 A8K7I0 two hybrid array 25416956 physical association X 2 O95198 P50895 two hybrid array 25416956 physical association X 2 O95198 A0A024R475 two hybrid array 25416956 physical association X 2 O95198 A8K7I0 validated two hybrid 25416956 physical association X 2 O95198 P50895 validated two hybrid 25416956 physical association X 2 O95198 A0A024R475 validated two hybrid 25416956 physical association X 2 Q8NC26 O95198 two hybrid prey pooling approach 25416956 physical association X 2 Q8NC26 O95198 two hybrid array 25416956 physical association X 2 Q8NC26 O95198 validated two hybrid 25416956 physical association X 2 A0A024R7Z5 O95198 two hybrid prey pooling approach 25416956 physical association X 2 A0A024R7Z5 O95198 two hybrid array 25416956 physical association X 2 A0A024R7Z5 O95198 validated two hybrid 25416956 physical association X 2 Q96EY4 O95198 two hybrid prey pooling approach 25416956 physical association X 2 Q96EY4 O95198 two hybrid array 25416956 physical association X 2 Q96EY4 O95198 validated two hybrid 25416956 physical association X 2 O95198 Q8D0W1 two hybrid pooling approach 20711500 physical association X 2 O00762 O95198 two hybrid prey pooling approach 25416956 physical association X 2 O00762 O95198 two hybrid array 25416956 physical association X 2 O00762 O95198 validated two hybrid 25416956 physical association X 2 Q53G59 O95198 two hybrid pooling approach 16189514 physical association X 2 Q53G59 O95198 two hybrid 21516116 physical association X 2 Q96MW1 O95198 two hybrid prey pooling approach 25416956 physical association X 2 Q96MW1 O95198 two hybrid array 25416956 physical association X 2 Q96MW1 O95198 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B KLHL2 WNK3 MI:0004(affinity chromatography technology) 23838290 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283841 bait prey KLHL2 UBE2D1 MI:0004(affinity chromatography technology) 23838290 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_283846 bait prey KLHL2 CUL3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21145461,23838290 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_201892|BIOGRID_283835 prey|prey bait|bait KLHL2 NACC1 MI:0018(two hybrid)|MI:0018(two hybrid) 19121354 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_211837|BIOGRID_211835 prey|prey bait|bait KLHL2 KEAP1 MI:0004(affinity chromatography technology) 15383316 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_210067 bait prey KLHL2 WNK4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23838290 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_283843|BIOGRID_283845 bait|bait prey|prey KLHL2 ACTC1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 10397770 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_213245|BIOGRID_213243|BIOGRID_213244 bait|bait|prey prey|prey|bait KLHL2 WNK1 MI:0004(affinity chromatography technology) 23838290 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283837 bait prey KLHL2 KLHL12 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 15383316,16189514,21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|(intact) MINT_67038|UniProt_114853|BIOGRID_79619|BIOGRID_210066|MINT_37855|HPRD_23340|UniProt_152465 bait|prey|bait|prey|bait|-|unspecified role prey|bait|prey|bait|prey|-|unspecified role KLHL2 WNK2 MI:0004(affinity chromatography technology) 23838290 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283839 bait prey

PPI - HINT Gene A Gene B PMID Method Quality KLHL2 KLHL2 10397770 0096 LC KLHL2 TSPAN5 26186194 0004 HT KLHL2 CUL3 21145461,23838290 0004,0004 HT,LC KLHL2 WNK4 23838290,23838290 0004,0415 LC KLHL2 HEL-S-77 26186194 0004 HT KLHL2 TSPAN5 26186194 0004 HT KLHL2 CUL3 21145461 0004 HT KLHL2 HEL-S-77 26186194 0004 HT KLHL2 KLHL2 10397770 0096 LC KLHL2 CUL3 23838290 0004 LC KLHL2 WNK4 23838290,23838290 0004,0415 LC SDCBP KLHL2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBE2C KLHL2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TNPO2 KLHL2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL2 KLHL2 23349464,24641320,25416956,25416956 0114,0114,0397,0018 LC,HT KLHL2 TXNDC12 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT KLHL2 CLK2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL2 BCAM 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL2 ACTC1 10397770,10397770 0047,0004 LC KLHL2 CUL3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL2 KLHL12 16189514,21516116,16189514 0398,0018,0018 HT KLHL2 ZNF114 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL2 TMA16 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL2 WNK4 23838290,23838290,24641320 0004,0415,0114 LC KLHL2 CCDC43 25416956,25416956,25416956,25416956,25416956,25416956 1112,0397,0018,0231,1356,0809 HT KLHL2 NACC1 19121354,19121354 0018,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P53202 O95198 CUL3 KLHL2 0.332 27107014 Q5TZN3 O95198 UBE2C {ECO:0000313|EMBL:CAG33269.1} KLHL2 0.332 25416956 P62079 O95198 TSPAN5 KLHL2 0.126 26186194 Q12208 O95198 USB1 KLHL2 0.332 27107014 Q08273 O95198 HRT1 KLHL2 0.332 27107014 Q04264 O95198 PDS5 KLHL2 0.332 27107014 P51668 O95198 UBE2D1 KLHL2 0.309 23838290 Q14145 O95198 KEAP1 KLHL2 0.396 unassigned1304,15383316 Q8D0W1 O95198 CSGG KLHL2 0.126 20711500 Q9Y3S1 O95198 WNK2 KLHL2 0.21 23838290 Q9BYP7 O95198 WNK3 KLHL2 0.21 23838290 Q9HCG8 O95198 CWC22 KLHL2 0.236 unassigned1304 Q9UH77 O95198 KLHL3 KLHL2 0.236 unassigned1304 Q96RE7 O95198 NACC1 KLHL2 0.454 19121354 Q96HA8 O95198 WDYHV1 KLHL2 0.236 unassigned1304 Q99KJ8 O95198 DCTN2 KLHL2 0.236 20360068 Q14241 O95198 TCEB3 KLHL2 0.236 unassigned1304 Q9BUI4 O95198 POLR3C KLHL2 0.236 unassigned1304 Q9H1P6 O95198 C20ORF85 KLHL2 0.236 unassigned1304 O95198 O00560 KLHL2 SDCBP 0.454 25416956 P49760 O95198 CLK2 KLHL2 0.583 25416956,unassigned1304 P55081 O95198 MFAP1 KLHL2 0.236 unassigned1304 Q13618 O95198 CUL3 KLHL2 0.623 25416956,23838290,21145461 Q13895 O95198 BYSL KLHL2 0.236 unassigned1304 Q16543 O95198 CDC37 KLHL2 0.236 unassigned1304 Q6TGC4 O95198 PADI6 KLHL2 0.236 unassigned1304 Q8NC26 O95198 ZNF114 KLHL2 0.583 25416956,unassigned1304 Q96EY4 O95198 TMA16 KLHL2 0.583 25416956,unassigned1304 Q9H4A3 O95198 WNK1 KLHL2 0.454 24641320,23838290 Q9ULW6 O95198 NAP1L2 KLHL2 0.236 unassigned1304 O95198 A0A087WUI6 KLHL2 PIBF1 {ECO:0000313|ENSEMBL:ENSP00000478697} 0.236 unassigned1304 Q86WV7 O95198 Q86WV7 KLHL2 0.49 25416956 Q86XT4 O95198 TRIM50 KLHL2 0.236 unassigned1304 O95881 O95198 TXNDC12 KLHL2 0.554 25416956,21516116 P38340 O95198 TAE1 KLHL2 0.332 27107014 Q53G59 O95198 KLHL12 KLHL2 0.712 16189514,unassigned1304,21516116,15383316 P43618 O95198 CNN1 KLHL2 0.332 27107014 P50895 O95198 BCAM KLHL2 0.636 25416956,25910212 O95198 O14787 KLHL2 TNPO2 0.454 25416956 Q96J92 O95198 WNK4 KLHL2 0.74 24641320,23838290 Q96MW1 O95198 CCDC43 KLHL2 0.454 25416956 O95198 O95198 KLHL2 KLHL2 0.681 25416956,10397770,unassigned1304 P26651 O95198 ZFP36 KLHL2 0.21 21784977 Q13561 O95198 DCTN2 KLHL2 0.126 26186194 P68032 O95198 ACTC1 KLHL2 0.569 10397770 O95198 O00762 KLHL2 UBE2C 0.183 25416956

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SDCBP KLHL2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2C KLHL2 MI:0045 experimental interaction detection MI:0461 interaction database TNPO2 KLHL2 MI:0045 experimental interaction detection MI:0461 interaction database KPNA6 KLHL2 MI:0362 inference MI:0461 interaction database KLHL2 TXNDC12 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 ZFP36 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 CLK2 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 BCAM MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 UBE2D1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 KPNA1 MI:0362 inference MI:0461 interaction database KLHL2 TSPAN5 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 RBX1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database KLHL2 ACTC1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 DCTN2 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 CUL3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KLHL2 KEAP1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 PDS5A MI:0362 inference MI:0461 interaction database KLHL2 KLHL12 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 ZNF114 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 TMA16 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 WNK4 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 CCDC43 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 NACC1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 NTMT1 MI:0362 inference MI:0461 interaction database KLHL2 WNK3 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 WNK1 MI:0045 experimental interaction detection MI:0461 interaction database KLHL2 PDS5B MI:0362 inference MI:0461 interaction database KLHL2 CXXC1 MI:0362 inference MI:0461 interaction database KLHL2 WNK2 MI:0045 experimental interaction detection MI:0461 interaction database