PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CSNK1A1 FBXO3 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BMPR1B FBXO3 15761153 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G FBXO3 FBXL2 24123678 innatedb exp G G G G G G G G G G G G G G G G G G G G G EP300 FBXO3 18809579,24530506 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIPK2 FBXO3 18809579 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD3 FBXO3 15761153 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PML FBXO3 18809579 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD1 FBXO3 15761153 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNIP3 FBXO3 19615732 intact exp HSP90AB1 FBXO3 22939624 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G IDS FBXO3 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AXIN1 FBXO3 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G DCP2 FBXO3 24778252 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFAIP3 FBXO3 19615732 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS5 FBXO3 21145461 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NKD1 FBXO3 19888210 i2d exp G G G G G G G G G G TGFBR1 FBXO3 15761153 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CSNK1E FBXO3 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NEDD8 FBXO3 21145461 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMURF1 FBXO3 25721664 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO3 AXIN2 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD2 FBXO3 15761153 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL3 FBXO3 21145461 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSP90AA1 FBXO3 22939624 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DVL1 FBXO3 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBX1 FBXO3 18809579,12481031, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL1 FBXO3 18809579,21145461, 21836163 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SKP1 FBXO3 20596027,18809579,22632967,10531037,21516116, 23023127, 21836163 hprd,biogrid,mint,intact,dip exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXL6 FBXO3 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO3 BTRC 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO3 FBXL5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO6 FBXO3 21836163, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO3 FBXO3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO2 FBXO3 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW8 FBXO3 16082366 pred NCCRP1 FBXO3 21836163 pred BCR FBXO3 16082366 pred FBXW4 FBXO3 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO3 FBXW2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO3 FBXO7 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO3 FBXO5 16082366 pred G G G G G G G FBXO22 FBXO3 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO25 FBXO3 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P29590-5 Q9UK99 affinity chromatography technology 18809579 physical association X 2 P29590-5 Q9UK99 affinity chromatography technology 18809579 physical association X 2 P29590-5 Q9UK99 affinity chromatography technology 18809579 physical association X 2 O15205 Q9UK99 affinity chromatography technology 22797925 physical association X 2 Q09472 Q9UK99 affinity chromatography technology 18809579 physical association X 2 Q09472 Q9UK99 affinity chromatography technology 24530506 physical association X 2 A0A024R475 Q9UK99 affinity chromatography technology 21145461 physical association X 2 Q9H2X6-2 Q9UK99 affinity chromatography technology 18809579 physical association X 2 Q15843 Q9UK99 affinity chromatography technology 21145461 physical association X 2 P21580 Q9UK99 affinity chromatography technology 19615732 physical association X 2 Q9UK99 P07900-2 affinity chromatography technology 22939624 physical association X 2 A0A090N7U0 Q9UK99 affinity chromatography technology 21145461 physical association X 2 A0A090N7U0 Q9UK99 affinity chromatography technology 18809579 physical association X 2 P62877 Q9UK99 affinity chromatography technology 18809579 physical association X 2 P62877 Q9UK99 affinity chromatography technology 12481031 physical association X 2 A0A024R7W9 Q9UK99 affinity chromatography technology 21145461 physical association X 2 P0CG48 Q9UK99 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9UK99 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q9UK99 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9UK99 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9UK99 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9UK99 affinity chromatography technology 21906983 physical association X 2 P63208 Q9UK99 affinity chromatography technology 18809579 physical association X 2 Q9UK99 affinity chromatography technology 22190034 physical association X 2 Q8IU60 Q9UK99 affinity chromatography technology 24778252 physical association X 2 P63208 Q9UK99 anti tag coimmunoprecipitation 20596027 physical association X 2 Q9UK99 anti tag coimmunoprecipitation 22190034 association C 19 Q9UK99 tandem affinity purification 22810585 association C 27 Q9UK99 pull down 22190034 association C 15 Q9UK99 anti tag coimmunoprecipitation 19615732 physical association C 15 A0A024RD80 Q9UK99 luminescence based mammalian interactome mapping 22939624 physical association X 2 P63208 Q9UK99 two hybrid 21516116 physical association X 2 P63208 Q9UK99 anti tag coimmunoprecipitation 22632967 physical association X 2 P04608 Q9UK99 pull down 22190034 physical association X 2 Q99IB8 Q9UK99 two hybrid 24136289 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL3 FBXO3 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_202324 bait prey CUL1 FBXO3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18809579,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_204518|BIOGRID_208216 bait|prey prey|bait HSP90AB1 FBXO3 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_124996 prey bait UBC FBXO3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,21987572,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_166305|BIOGRID_268517|BIOGRID_181263|BIOGRID_173352|BIOGRID_163508|BIOGRID_172162 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey NEDD8 FBXO3 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_206781 bait prey RBX1 FBXO3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12481031,18809579 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_208215|BIOGRID_101967 prey|bait bait|prey FBXO3 HDAC9 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_193151 prey bait UBD FBXO3 MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226705 bait prey PML FBXO3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18809579 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_208270|BIOGRID_208283|BIOGRID_208212 prey|bait|bait bait|prey|prey EP300 FBXO3 MI:0004(affinity chromatography technology) 18809579 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208282 bait prey TNFAIP3 FBXO3 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_120382 bait prey HIPK2 FBXO3 MI:0004(affinity chromatography technology) 18809579 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208281 bait prey SKP1 FBXO3 MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 10531037,18809579,21516116,22632967 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|(intact)|MI:0468(hprd)|(biogrid) UniProt_114304|UniProt_122762|HPRD_31757|BIOGRID_208217 bait|prey|-|prey prey|bait|-|bait HSP90AA1 FBXO3 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255423 bait prey COPS5 FBXO3 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205205 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UK99 P22304 FBXO3 IDS 0.126 26186194 Q9UK99 Q9HCE7 FBXO3 SMURF1 0.702 25721664 Q9UK99 Q8IU60 FBXO3 DCP2 0.126 24778252 Q9UK99 Q9H2X6 FBXO3 HIPK2 0.21 18809579 Q9UK99 P07900 FBXO3 HSP90AA1 0.126 22939624 Q9UK99 P08238 FBXO3 HSP90AB1 0.126 22939624 Q9UK99 P04608 FBXO3 TAT 0.354 22190034 Q9UK99 Q09472 FBXO3 EP300 0.376 18809579,24530506 Q9UK99 P63208 FBXO3 SKP1 0.787 27705803,unassigned1304,18809579,21516116,22632967 Q9UK99 Q92905 FBXO3 COPS5 0.126 21145461 Q9UK99 P29590 FBXO3 PML 0.376 18809579 Q9UK99 Q96KP6 FBXO3 TNIP3 0.126 19615732 Q9UK99 P62877 FBXO3 RBX1 0.376 12481031,18809579 Q9UK99 Q13616 FBXO3 CUL1 0.309 18809579,21145461 Q9UK99 Q99IB8 FBXO3 Q99IB8 0.183 24136289 Q9UK99 Q13618 FBXO3 CUL3 0.126 21145461 Q9UK99 P49736 FBXO3 MCM2 0.126 25963833 Q9UK99 Q15843 FBXO3 NEDD8 0.126 21145461 Q9UK99 P21580 FBXO3 TNFAIP3 0.126 19615732 Q9UK99 P21698 FBXO3 NSS 0.126 22810585