PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM28 TRIM6 11331580 biogrid exp G GP G G G GP GP G G G G G G GP G G G G G GP G MYC TRIM6 22328504 biogrid exp G GP G G G GP GP G G G G G GP G G G G G GP G TRIM23 TRIM6 11331580 biogrid exp G GP G G G GP GP G G G G G G GP G G G G G GP G IKBKE TRIM6 24882218 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G TRIM6 TRIM6 17156811,21680743,11331580 hprd,biogrid exp, ortho G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM6 TRIM5 16828831,16775307,11331580, 23023127, 21836163 hprd,biogrid exp, pred G GP G G G GP GP G G G G G G GP G G G G G P G TRIM6 TRIM4 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM6 AMFR 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRAF2 TRIM6 23023127 pred P P P P G G P SKI TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G BIRC2 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G FADD TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM21 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G NBR1 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM6 USP16 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM72 TRIM6 23023127 pred P P G G P ILK TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G SKIL TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM56 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM34 TRIM6 23023127 pred DTX3L TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM22 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G CASP8 TRIM6 23023127 pred G GP G G GP GP G G G G G GP G G G G G GP G RNF149 TRIM6 23023127 pred G GP G G G GP GP G G G G G G G G G G G G GP G RNF135 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TNFRSF1A TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G MDM2 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G BIRC3 TRIM6 23023127 pred G G G G GP P G G G G G P G G G G G GP TRIM27 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRAT1 TRIM6 21836163 pred G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9C030 Q9C030 in vivo 11331580 - X 2 Q9C030 Q9C030 two hybrid 11331580 - X 2 Q9C030 Q9C030 in vitro 11331580 - X 2 Q9C030 Q9C035 two hybrid 11331580 - X 2 Q9C030 Q9C035 two hybrid 11331580 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TRIM28 TRIM6 MI:0018(two hybrid) 11331580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association) (biogrid) BIOGRID_99610 prey bait TRIM23 TRIM6 MI:0018(two hybrid) 11331580 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association) (biogrid) BIOGRID_99609 prey bait TRIM6 TRIM5 MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 11331580,16775307,16828831 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_210315|BIOGRID_212745|HPRD_14563 bait|bait|- prey|prey|- MYC TRIM6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22328504 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_206951|BIOGRID_206950 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality TRIM6 TRIM6 17156811,21680743 0096,0004 LC TRIM6 TRIM6 17156811,21680743 0096,0004 LC MYC TRIM6 22328504,22328504 0004,0018 LC TRIM23 TRIM6 11331580 0401 LC TRIM28 TRIM6 11331580 0401 LC TRIM6 TRIM6 11331580 0018 LC TRIM6 TRIM5 16828831,11331580 0018,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9C030 Q0PF16 TRIM6 TRIM5 0.21 21680743 Q9C030 P01106 TRIM6 MYC 0.454 22328504 Q9C035 Q9C030 TRIM5 TRIM6 0.523 16775307,16828831 Q9C030 Q9C030 TRIM6 TRIM6 0.659 17156811,11331580,21680743 Q9C030 P36406 TRIM6 TRIM23 0.21 11331580 Q9C030 Q13263 TRIM6 TRIM28 0.21 11331580 Q9C030 Q14164 TRIM6 IKBKE 0.376 24882218

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYC TRIM6 MI:0045 experimental interaction detection MI:0461 interaction database UBC TRIM6 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 TRIM6 MI:0045 experimental interaction detection MI:0461 interaction database POLR2A TRIM6 MI:0045 experimental interaction detection MI:0461 interaction database TRIM23 TRIM6 MI:0045 experimental interaction detection MI:0461 interaction database TRIM28 TRIM6 MI:0045 experimental interaction detection MI:0461 interaction database IKBKE TRIM6 MI:0045 experimental interaction detection MI:0461 interaction database TRIM6 TRIM5 MI:0045 experimental interaction detection MI:0461 interaction database