PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus VHL RWDD3 25500545 biogrid exp G G G G G G G G G G GP G GP G G G G G G G G GP G G G G G G NXF1 RWDD3 22658674 biogrid exp G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G HIF1A RWDD3 25500545,17956732 hprd,biogrid,intact exp G G G G GP GP G G GP G GP G GP G G GP GP G G G G G GP G GP G GP G G NFKBIA RWDD3 17956732 hprd,biogrid,intact exp G G G G GP GP G GP GP G G G GP G G GP GP G G G G G GP GP GP G GP G G SUMO1 RWDD3 17956732, 25402006 biogrid,intact exp, pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G UBE2I RWDD3 17956732, 25402006 biogrid,intact exp, pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP G GP G GP G G SIAH2 RWDD3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G DAXX RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G AR RWDD3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G SREBF2 RWDD3 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G BRCA1 RWDD3 25402006 pred G GP P P P P P GP P P P P P G SAE1 RWDD3 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G TOP1 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G TFAP2A RWDD3 25402006 pred G G G G G G G G G GP G G G G G G G G G G G G G G G G SENP1 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G NUDCD3 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G BHLHE40 RWDD3 25402006 pred G G G G G GP G GP GP G GP G G G G G GP G G G G G GP G G G GP G G TFAP2C RWDD3 25402006 pred G P P G GP GP G P P G G G G GP G P P G SLC2A1 RWDD3 25402006 pred G G G G G GP G G G G G G G G G G GP G G G G G G G G G G G G ETV6 RWDD3 25402006 pred G G G G GP GP G GP GP G G G GP G G GP GP G G G G G GP GP GP G GP G G UBA2 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G RANGAP1 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G HDAC4 RWDD3 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G G G G GP GP GP G GP G G TDG RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G RANBP2 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G RWDD3 RAD54L2 25402006 pred G G G G G G G G CASP8AP2 RWDD3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SP100 RWDD3 25402006 pred G G G GP P G GP GP GP G GP G G GP P G G G G GP GP GP G GP G SMAD4 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP G GP G GP G G PIAS1 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G RAD51 RWDD3 25402006 pred G GP P G P GP P G P GP GP G G G P P GP GP G MEF2A RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G G G G TNFRSF1A RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G TFAP2B RWDD3 25402006 pred P P GP P G P GP P P SALL1 RWDD3 25402006 pred G P GP G P GP G GP G P P GP G G P P P GP G DNMT3B RWDD3 25402006 pred G G G GP GP G GP P GP G GP G GP GP G G G G GP GP GP G GP G JUN RWDD3 25402006 pred G G G G G GP G G GP G GP G GP G G GP GP G G G G G GP G GP G GP G G RWDD3 GMEB1 25402006 pred G G GP P P P P P G G GP P G G P P GP G GP G PIAS2 RWDD3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOX10 RWDD3 25402006 pred G G GP G GP GP G G G GP G G G GP G G G G RWDD3 ZNF451 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G SART1 RWDD3 25402006 pred G G G G G GP G G GP G GP G G G G P GP G G G G G G G P G P G G MITF RWDD3 25402006 pred G G G G GP G G GP G G GP G GP G G G G G G G G G G G G G G G G DACH1 RWDD3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G ELK1 RWDD3 25402006 pred G G G G G GP G GP GP G GP G GP G G GP GP G G G G G GP G GP G GP G G TOPORS RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G HIPK2 RWDD3 25402006 pred G G G G GP GP G GP GP G GP G GP G G GP GP G G G G G GP GP GP G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Y3V2 pull down 17956732 association C 3 Q9Y3V2 A0A024R3Z2 anti bait coimmunoprecipitation 17956732 direct interaction X 2 Q9Y3V2 A0A024R3Z2 anti bait coimmunoprecipitation 17956732 direct interaction X 2 Q9Y3V2 P25963 anti bait coimmunoprecipitation 17956732 direct interaction X 2 D0VY79 Q9Y3V2 anti tag coimmunoprecipitation 17956732 physical association X 2 Q9Y3V2 P63279 pull down 17956732 direct interaction X 2 Q9Y3V2 P63279 confocal microscopy 17956732 colocalization X 2 Q9Y3V2 P63279 confocal microscopy 17956732 colocalization X 2 Q9Y3V2 P63279 pull down 17956732 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y3V2 P40337 RWDD3 VHL 0.569 25500545 Q9Y3V2 P63279 RWDD3 UBE2I 0.82 17956732 Q9Y3V2 P25963 RWDD3 NFKBIA 0.454 17956732 Q9Y3V2 Q9UBU9 RWDD3 NXF1 0.126 22658674 Q9Y3V2 P63165 RWDD3 SUMO1 0.454 17956732 Q9Y3V2 Q16665 RWDD3 HIF1A 0.507 25500545,17956732