PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBC RNF114 19285159,18364390,16196087 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2E2 RNF114 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EWSR1 RNF114 24999758 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM52 RNF114 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G TRIM55 RNF114 22493164 biogrid,intact exp P P GP P P GP P P P P P P GP GP P GP TNFAIP3 RNF114 25165885 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UEVLD RNF114 19549727 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RPSA RNF114 21988832 biogrid,intact exp GP GP P P GP P P GP P P P P GP P GP P P GP P P P P G EVI2A RNF114 21988832 biogrid,intact exp G G G G G GP G GP G P G G G G G GP G GP G G G G G G G GP P G USO1 RNF114 26186194 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RNF2 RNF114 24457600 innatedb,biogrid exp P P P P GP P P P P P P P P P P P TRAIP RNF114 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P GP RNF114 AUP1 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2H RNF114 19549727 biogrid,intact exp GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DSTN RNF114 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RNF38 RNF114 22493164 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SUZ12 RNF114 24457600 innatedb,biogrid exp G G G G GP G G G GP G GP G G GP G GP G G G G GP G G G GP G GP G G UBE2DNL RNF114 19549727 intact exp BMI1 RNF114 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P UBE2K RNF114 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K1 RNF114 25260751 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF114 RNF114 21571784,23645206 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NUDCD2 RNF114 22939629 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2W RNF114 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CPLX1 RNF114 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G PARP11 RNF114 26186194,19615732 biogrid,intact exp G GP G G P G P GP P P P GP G P GP G P P GP P GP G GP GP UBE2U RNF114 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P GP XAF1 RNF114 25313037,23645206 biogrid exp G GP G G GP GP G GP GP G GP GP G G G GP GP GP P G GP G GP G GP G GP GP G DTX3 RNF114 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP G G G GP GP GP P G G G GP GP GP GP GP GP G TRAF4 RNF114 22493164 biogrid,intact exp G GP G GP G P GP G GP GP GP G G GP GP G GP G GP G GP P GP G GP GP G MAPK3 RNF114 21900206 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2E3 RNF114 19549727 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G LAGE3 RNF114 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF114 AK5 16169070 hprd,biogrid,i2d,mint,intact exp GP P G GP G GP GP G G G GP GP G G GP P P GP P GP GP G IDI2 RNF114 26186194 biogrid exp P P P P P P P P P P P P P P P GP GP P P P UBE2E1 RNF114 19549727 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G HSP90AA1 RNF114 21571784 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G HSPB1 RNF114 22939629 biogrid exp GP GP G G GP G G GP GP G GP GP GP G G GP G GP GP G GP GP GP GP GP G GP GP G UBE2D4 RNF114 19549727, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G TRAF6 RNF114 22493164, 23023127 biogrid,intact exp, pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G UBE2D3 RNF114 19549727, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2D2 RNF114 19549727,26186194, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBE2D1 RNF114 19549727,21571784, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G NDN RNF114 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ANKZF1 RNF114 23023127 pred GP P G GP GP P GP GP P GP GP G GP GP GP GP G P GP GP P GP GP GP P G UBE2B RNF114 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM56 RNF114 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G RNF151 RNF114 23023127 pred P G G GP GP GP GP GP G P G GP G G P GP G P G GP UBE2L6 RNF114 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ILK RNF114 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BARD1 RNF114 23023127 pred P G GP P P GP P P P GP G GP P G P P GP P GP P GP GP GP G SOWAHC RNF114 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G UBE2A RNF114 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2C RNF114 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G STAU1 RNF114 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ASB6 RNF114 23023127 pred GP GP G G GP GP G P GP G GP P GP GP G GP GP GP GP G GP GP GP P GP G GP GP G UBE2I RNF114 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RNF114 NCOR2 21836163 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP G GP GP GP GP G UNC45A RNF114 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TTC14 RNF114 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G RAD18 RNF114 23023127 pred P P P P GP P P G P P GP P UBE2G1 RNF114 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM47 RNF114 23023127 pred GP P G P GP G GP GP G GP GP GP GP G GP GP G GP P GP GP GP GP GP G TRIM73 RNF114 23023127 pred GP G G G G GP G GP GP G GP GP G G G GP GP G P G P GP GP P GP G GP G G UBE2NL RNF114 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P21580 Q9Y508 two hybrid 25165885 direct interaction X 2 P21580 Q9Y508 pull down 25165885 direct interaction X 2 P21580 Q9Y508 affinity chromatography technology 25165885 physical association X 2 P21580 Q9Y508 affinity chromatography technology 25165885 physical association X 2 Q9Y508 P07900-2 biochemical 21571784 colocalization X 2 Q9Y508 O14810 biochemical 22939629 colocalization X 2 Q9Y508 Q14657 biochemical 22939629 colocalization X 2 Q9Y508 P60981-2 biochemical 22939629 colocalization X 2 Q9Y508 affinity chromatography technology 23645206 physical association X 2 Q9Y508 affinity chromatography technology 23645206 physical association X 2 Q9Y508 pull down 23645206 direct interaction X 2 Q9Y508 pull down 23645206 direct interaction X 2 Q9Y508 P35226 two hybrid 22493164 direct interaction X 2 Q9Y508 Q9BYV6-4 two hybrid 22493164 direct interaction X 2 Q9Y508 P61956-2 affinity chromatography technology 25027693 physical association X 2 Q9Y508 affinity chromatography technology 25313037 physical association X 2 Q9Y508 pull down 25313037 direct interaction X 2 Q9Y508 A0A087WW00 pull down 21571784 direct interaction X 2 Q9Y508 Q9Y6K8-2 two hybrid 16169070 direct interaction X 2 Q9Y508 two hybrid 19690564 direct interaction X 2 Q9Y508 A0A087WW00 two hybrid 19549727 direct interaction X 2 Q9Y508 P62837 two hybrid 19549727 direct interaction X 2 Q9Y508 A0A024R2K3 two hybrid 19549727 direct interaction X 2 Q9Y508 two hybrid 19549727 direct interaction X 2 Q9Y508 P61086 two hybrid 19549727 direct interaction X 2 Q9Y508 Q9BWJ1 two hybrid 21900206 direct interaction X 2 A0A024R2P0 Q9Y508 two hybrid 21988832 direct interaction X 2 P22794 Q9Y508 two hybrid 21988832 direct interaction X 2 Q9Y508 P04792 biochemical 22939629 colocalization X 2 Q9Y508 Q9Y508 enzymatic study 23645206 direct interaction X 2 Q9Y508 Q9H0F5 two hybrid 22493164 direct interaction X 2 Q9Y508 Q9Y4K3 two hybrid 22493164 direct interaction X 2 Q9Y508 Q9BWF2 two hybrid 22493164 direct interaction X 2 Q9Y508 Q9Y508 enzymatic study 21571784 direct interaction X 2 Q9Y508 Q99496 affinity chromatography technology 24457600 physical association X 2 Q9Y508 Q9NR21-4 affinity chromatography technology 19615732 physical association X 2 Q9Y508 P61077-3 two hybrid 19549727 direct interaction X 2 Q9Y508 A0A024RA90 two hybrid 19549727 direct interaction X 2 Q9Y508 A0A024R2Q2 two hybrid 19549727 direct interaction X 2 Q9Y508 Q8IX04-2 two hybrid 19549727 direct interaction X 2 Q9Y508 Q96FI0 two hybrid 19549727 direct interaction X 2 Q969T4 Q9Y508 two hybrid 19549727 direct interaction X 2 A0A024QZ59 Q9Y508 two hybrid 22493164 direct interaction X 2 Q96A61 Q9Y508 two hybrid 22493164 direct interaction X 2 Q15022 Q9Y508 affinity chromatography technology 24457600 physical association X 2 P0CG48 Q9Y508 pull down 18364390 direct interaction X 2 P0CG48 Q9Y508 pull down 19285159 direct interaction X 2 P0CG48 Q9Y508 affinity chromatography technology 19285159 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 25015289 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 25165885 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 16196087 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9Y508 affinity chromatography technology 21906983 physical association X 2 Q8WVJ2 Q9Y508 biochemical 22939629 colocalization X 2 Q9Y508 Q9Y6K8-3 two hybrid 16169070 - X 2 Q9Y508 Q9Y6K8-3 two hybrid 16169070 - X 2 Q9Y508 P62837 two hybrid 19549727 physical association X 2 Q9Y508 P62837 two hybrid array 19549727 physical association X 2 Q9Y508 Q8IX04 two hybrid array 19549727 physical association X 2 Q9Y508 Q8IWF7 two hybrid array 19549727 physical association X 2 Q9Y508 B3KSH4 two hybrid array 19549727 physical association X 2 Q9Y508 A0A024R2K3 two hybrid array 19549727 physical association X 2 Q9Y508 A4D1L5 two hybrid array 19549727 physical association X 2 Q9Y508 Q5VVX9 two hybrid array 19690564 physical association X 2 Q9Y508 P35226 two hybrid array 22493164 physical association X 2 L7RXH5 Q9Y508 two hybrid 21900206 physical association X 2 Q9Y508 ubiquitinase assay 25260751 ubiquitination reaction C 5 Q9Y508 anti tag coimmunoprecipitation 19615732 physical association C 4 A0A024R2P0 Q9Y508 two hybrid array 21988832 physical association X 2 P22794 Q9Y508 two hybrid array 21988832 physical association X 2 Q9Y508 Q9Y6K8 two hybrid pooling approach 16169070 physical association X 2 Q9Y508 A0A024RA90 two hybrid 19549727 physical association X 2 Q9Y508 A0A024RDH2 two hybrid array 19549727 physical association X 2 Q9Y508 A0A024R2Q2 two hybrid array 19549727 physical association X 2 Q9Y508 Q9Y4K3 two hybrid array 22493164 physical association X 2 Q9Y508 Q9BWF2 two hybrid array 22493164 physical association X 2 Q9Y508 Q9H0F5 two hybrid array 22493164 physical association X 2 A0A024QZJ2 Q9Y508 two hybrid 19549727 physical association X 2 A0A024QZJ2 Q9Y508 two hybrid array 19549727 physical association X 2 Q969T4 Q9Y508 two hybrid array 19549727 physical association X 2 A0A024QZ59 Q9Y508 two hybrid array 22493164 physical association X 2 Q96A61 Q9Y508 two hybrid array 22493164 physical association X 2 Q9BYV6 Q9Y508 two hybrid array 22493164 physical association X 2 Q96B02 Q9Y508 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EVI2A RNF114 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288160|UniProt_117785 bait|unspecified role prey|unspecified role UBE2D2 RNF114 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_124085|UniProt_100814|UniProt_101035 bait|bait|bait prey|prey|prey CPLX1 RNF114 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239825 bait prey UBE2U RNF114 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123688|UniProt_102677 bait|bait prey|prey RNF114 AK5 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_156684|BIOGRID_94107|HPRD_29946 bait|bait|- prey|prey|- UBE2E1 RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124337|UniProt_101310 bait|bait prey|prey BMI1 RNF114 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122465|BIOGRID_284094 bait|bait prey|prey UBE2K RNF114 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124339 bait prey UBE2D4 RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124087|UniProt_100906 bait|bait prey|prey RPSA RNF114 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288354|UniProt_117953 prey|unspecified role bait|unspecified role HSP90AA1 RNF114 MI:0401(biochemical) 21571784 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_196795 prey bait LAGE3 RNF114 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240244 bait prey RNF114 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101204 prey bait DSTN RNF114 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241248 bait prey XAF1 RNF114 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23645206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_282428|BIOGRID_282425|BIOGRID_282426|BIOGRID_282424 prey|prey|bait|bait bait|bait|prey|prey UEVLD RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124090|UniProt_101179 bait|bait prey|prey TRAF6 RNF114 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122499|BIOGRID_284123 bait|bait prey|prey UBE2E3 RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124088|UniProt_101135 bait|bait prey|prey TRAF4 RNF114 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284137|UniProt_122516 bait|bait prey|prey UBE2D1 RNF114 MI:0401(biochemical)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,21571784 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(intact) BIOGRID_196796|UniProt_100798|BIOGRID_124084|UniProt_101009 bait|bait|bait|bait prey|prey|prey|prey uniprotkb:(gene name) RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_36479|MINT_65595 prey|prey bait|bait NUDCD2 RNF114 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240486 bait prey TRAIP RNF114 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284142|UniProt_122525 bait|bait prey|prey RNF2 RNF114 MI:0004(affinity chromatography technology) 24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_307037 bait prey HSPB1 RNF114 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243773 bait prey CDKN1A RNF114 MI:0004(affinity chromatography technology) 23645206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_282429 bait prey UBE2E2 RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101087|BIOGRID_124089 bait|bait prey|prey TRIM52 RNF114 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283981|UniProt_122570 prey|bait bait|prey UBE2H RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101347|BIOGRID_124338 bait|bait prey|prey PARP11 RNF114 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120564|UniProt_100647 bait|bait prey|prey MAPK3 RNF114 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_158992|UniProt_179590|BIOGRID_158645 bait|bait|bait prey|prey|prey UBE2D3 RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124086|UniProt_101061 bait|bait prey|prey UBE2W RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101488|BIOGRID_124340 bait|bait prey|prey UBC RNF114 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0401(biochemical)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 16196087,18364390,19285159,21139048,21571784,21890473,21906983,21963094,21987572,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_168844|BIOGRID_176526|BIOGRID_264979|BIOGRID_143225|BIOGRID_178182|BIOGRID_197795|BIOGRID_163071|BIOGRID_268765|BIOGRID_200685|BIOGRID_196798|BIOGRID_200668|BIOGRID_224603 bait|bait|bait|bait|bait|prey|bait|bait|bait|prey|bait|bait prey|prey|prey|prey|prey|bait|prey|prey|prey|bait|prey|prey SUZ12 RNF114 MI:0004(affinity chromatography technology) 24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_306092 bait prey RNF38 RNF114 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284012|UniProt_122571 prey|bait bait|prey UBE2DNL RNF114 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101189|BIOGRID_124091 bait|bait prey|prey TRIM55 RNF114 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122569|BIOGRID_284104 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality CPLX1 RNF114 22939629 0401 HT USO1 RNF114 26186194 0004 HT UBC RNF114 19285159,19285159,18364390 0004,0096,0096 LC UBE2D2 RNF114 26186194 0004 HT LAGE3 RNF114 22939629 0401 HT XAF1 RNF114 25313037,23645206,25313037,23645206 0004,0004,0096,0096 LC DTX3 RNF114 26186194 0004 HT NUDCD2 RNF114 22939629 0401 HT IDI2 RNF114 26186194 0004 HT PARP11 RNF114 26186194,19615732,19615732 0004,0004,0007 HT RNF114 AUP1 26186194 0004 HT RNF114 HEL-S-102 22939629 0401 HT RNF114 HEL32 22939629 0401 HT CPLX1 RNF114 22939629 0401 HT USO1 RNF114 26186194 0004 HT UBE2D2 RNF114 26186194 0004 HT LAGE3 RNF114 22939629 0401 HT DTX3 RNF114 26186194 0004 HT NUDCD2 RNF114 22939629 0401 HT IDI2 RNF114 26186194 0004 HT PARP11 RNF114 26186194,19615732,19615732 0004,0004,0007 HT RNF114 AUP1 26186194 0004 HT RNF114 HEL-S-102 22939629 0401 HT RNF114 HEL32 22939629 0401 HT UBC RNF114 19285159,19285159,18364390 0004,0096,0096 LC XAF1 RNF114 25313037,23645206,25313037,23645206 0004,0004,0096,0096 LC HIP2 RNF114 19549727 0397 HT CPLX1 RNF114 22939629 0401 LC RPSA RNF114 21988832,21988832 0397,0018 HT UBC RNF114 21571784 0415 LC TNFAIP3 RNF114 25165885,25165885,25165885 0096,0018,0004 LC EVI2A RNF114 21988832,21988832 0397,0018 HT MAPK3 RNF114 21900206 0018 HT BMI1 RNF114 22493164,22493164 0018,0397 HT UBE2D1 RNF114 21571784,19549727,19549727,21571784 0096,0397,0018,0415 LC,HT UBE2E1 RNF114 19549727,19549727 0397,0018 HT UBE2D3 RNF114 19549727,19549727 0397,0018 HT UBE2K RNF114 19549727 0018 HT UBE2H RNF114 19549727,19549727 0397,0018 HT UBE2D2 RNF114 19549727,19549727 0397,0018 HT MAP3K1 RNF114 25260751 0415 LC LAGE3 RNF114 22939629 0401 LC UBE2U RNF114 19690564,19690564 0397,0018 HT Q86SX1 RNF114 21571784 0401 LC UBE2DNL RNF114 19549727,19549727 0397,0018 HT UEVLD RNF114 19549727,19549727 0397,0018 HT Q8N291 RNF114 16169070 0018 HT NUDCD2 RNF114 22939629 0401 LC UBE2E3 RNF114 19549727,19549727 0397,0018 HT TRIM52 RNF114 22493164,22493164 0018,0397 HT UBE2W RNF114 19549727,19549727 0397,0018 HT UBE2E2 RNF114 19549727,19549727 0397,0018 HT TRAF4 RNF114 22493164,22493164 0018,0397 HT TRAIP RNF114 22493164,22493164 0018,0397 HT TRIM55 RNF114 22493164,22493164 0018,0397 HT RNF38 RNF114 22493164,22493164 0018,0397 HT SMURF1 RNF114 20804422 0415 LC UBE2D4 RNF114 19549727 0018 HT TRAF6 RNF114 22493164,22493164 0018,0397 HT RNF114 RNF114 23645206,21571784 0415,0415 LC RNF114 AK5 16169070,16169070 0018,0398 HT RNF114 HEL-S-102 22939629 0401 LC RNF114 HEL32 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y508 B3KSH4 RNF114 HIP2 0.236 19549727 Q9Y508 O14810 RNF114 CPLX1 0.081 22939629 Q9Y508 P60981 RNF114 DSTN 0.081 22939629 Q9Y508 P61086 RNF114 UBE2K 0.183 19549727 Q9Y508 Q8N9I9 RNF114 DTX3 0.126 26186194 Q9Y508 Q9HCE7 RNF114 SMURF1 0.183 20804422 Q9Y508 Q9H0F5 RNF114 RNF38 0.286 22493164 Q9Y508 Q8IWF7 RNF114 UBE2DNL 0.126 19549727 Q9Y679 Q9Y508 AUP1 RNF114 0.126 26186194 Q9Y6K8 Q9Y508 AK5 RNF114 0.286 16169070 Q9Y508 P07900 RNF114 HSP90AA1 0.126 21571784 Q9Y508 Q9BXS1 RNF114 IDI2 0.126 26186194 Q9Y508 P08865 RNF114 RPSA 0.286 21988832 Q9Y508 O60763 RNF114 USO1 0.126 26186194 Q9Y508 Q96LR5 RNF114 UBE2E2 0.376 19549727 Q9Y508 P21580 RNF114 TNFAIP3 0.702 25165885 Q9Y508 P0CG48 RNF114 UBC 0.671 18364390,16196087,19285159 Q9Y508 Q96B02 RNF114 UBE2W 0.376 19549727 Q9Y508 P61077 RNF114 UBE2D3 0.376 19549727 Q9Y508 Q9Y508 RNF114 RNF114 0.332 23645206 Q9Y508 Q9Y2X8 RNF114 UBE2D4 0.454 19549727 Q9Y508 Q62925 RNF114 MAP3K1 0.033 25260751 Q9Y508 P04792 RNF114 HSPB1 0.081 22939629 Q9Y508 Q9Y4K3 RNF114 TRAF6 0.286 22493164 Q9Y508 Q96A61 RNF114 TRIM52 0.286 22493164 Q9Y508 P62837 RNF114 UBE2D2 0.636 19549727,26186194 Q9Y508 Q8IX04 RNF114 UEVLD 0.286 19549727 Q9Y508 Q969T4 RNF114 UBE2E3 0.286 19549727 Q9Y508 Q9BUZ4 RNF114 TRAF4 0.286 22493164 Q9Y508 Q9BWF2 RNF114 TRAIP 0.286 22493164 Q9Y508 P22794 RNF114 EVI2A 0.286 21988832 Q9Y508 Q5VVX9 RNF114 UBE2U 0.286 19690564 Q9Y508 P62256 RNF114 UBE2H 0.286 19549727 Q9Y508 P51668 RNF114 UBE2D1 0.416 19549727 Q9Y508 Q9NR21 RNF114 PARP11 0.332 19615732,26186194 Q9Y508 Q6GPH4 RNF114 XAF1 0.876 23645206,25313037,unassigned1304 Q9Y508 Q8WVJ2 RNF114 NUDCD2 0.081 22939629 Q9Y508 P35226 RNF114 BMI1 0.286 22493164 Q9Y508 Q9BYV6 RNF114 TRIM55 0.286 22493164 Q9Y508 Q99496 RNF114 RNF2 0.126 24457600 Q9Y508 P27361 RNF114 MAPK3 0.332 21900206 Q9Y508 Q14657 RNF114 LAGE3 0.081 22939629 Q9Y508 Q15022 RNF114 SUZ12 0.126 24457600 Q9Y508 Q01844 RNF114 EWSR1 0.126 24999758 Q9Y508 P51965 RNF114 UBE2E1 0.286 19549727 Q9Y508 Q13233 RNF114 MAP3K1 0.183 25260751

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SIAH2 RNF114 MI:0362 inference MI:1106 pathways database USO1 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 RNF114 MI:0362 inference MI:1106 pathways database RPSA RNF114 MI:0045 experimental interaction detection MI:0461 interaction database UBB RNF114 MI:0362 inference MI:1106 pathways database UBC RNF114 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 RNF114 MI:0362 inference MI:1106 pathways database TNFAIP3 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database EVI2A RNF114 MI:0045 experimental interaction detection MI:0461 interaction database MAPK3 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database BMI1 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database CCNF RNF114 MI:0362 inference MI:1106 pathways database UBE2A RNF114 MI:0362 inference MI:1106 pathways database UBE2D1 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 RNF114 MI:0362 inference MI:1106 pathways database UBE2D3 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K RNF114 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database UBE2H RNF114 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 RNF114 MI:0362 inference MI:1106 pathways database RPS27A RNF114 MI:0362 inference MI:1106 pathways database UBA52 RNF114 MI:0362 inference MI:1106 pathways database SKP1 RNF114 MI:0362 inference MI:1106 pathways database EWSR1 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 RNF114 MI:0362 inference MI:1106 pathways database CUL1 RNF114 MI:0362 inference MI:1106 pathways database TRIP12 RNF114 MI:0362 inference MI:1106 pathways database SUZ12 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 RNF114 MI:0362 inference MI:1106 pathways database HECTD2 RNF114 MI:0362 inference MI:1106 pathways database UBE2U RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 RNF114 MI:0362 inference MI:1106 pathways database FBXW9 RNF114 MI:0362 inference MI:1106 pathways database FBXW10 RNF114 MI:0362 inference MI:1106 pathways database RNF213 RNF114 MI:0362 inference MI:1106 pathways database XAF1 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXL22 RNF114 MI:0362 inference MI:1106 pathways database FBXL19 RNF114 MI:0362 inference MI:1106 pathways database FBXW12 RNF114 MI:0362 inference MI:1106 pathways database RNF19B RNF114 MI:0362 inference MI:1106 pathways database RNF144B RNF114 MI:0362 inference MI:1106 pathways database RBBP6 RNF114 MI:0362 inference MI:1106 pathways database HUWE1 RNF114 MI:0362 inference MI:1106 pathways database TRIM69 RNF114 MI:0362 inference MI:1106 pathways database SIAH1 RNF114 MI:0362 inference MI:1106 pathways database HERC6 RNF114 MI:0362 inference MI:1106 pathways database UBE2DNL RNF114 MI:0045 experimental interaction detection MI:0461 interaction database UBR2 RNF114 MI:0362 inference MI:1106 pathways database UEVLD RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXL14 RNF114 MI:0362 inference MI:1106 pathways database FBXW8 RNF114 MI:0362 inference MI:1106 pathways database FBXL16 RNF114 MI:0362 inference MI:1106 pathways database DTX3 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXO15 RNF114 MI:0362 inference MI:1106 pathways database ZNRF1 RNF114 MI:0362 inference MI:1106 pathways database FBXL13 RNF114 MI:0362 inference MI:1106 pathways database FBXO22 RNF114 MI:0362 inference MI:1106 pathways database ZNRF2 RNF114 MI:0362 inference MI:1106 pathways database FBXO27 RNF114 MI:0362 inference MI:1106 pathways database FBXO30 RNF114 MI:0362 inference MI:1106 pathways database RNF217 RNF114 MI:0362 inference MI:1106 pathways database DTX3L RNF114 MI:0362 inference MI:1106 pathways database FBXO41 RNF114 MI:0362 inference MI:1106 pathways database LMO7 RNF114 MI:0362 inference MI:1106 pathways database MYLIP RNF114 MI:0362 inference MI:1106 pathways database FBXW7 RNF114 MI:0362 inference MI:1106 pathways database FBXO32 RNF114 MI:0362 inference MI:1106 pathways database UBE2E3 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXW5 RNF114 MI:0362 inference MI:1106 pathways database TRIM52 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database MIB2 RNF114 MI:0362 inference MI:1106 pathways database UBE2W RNF114 MI:0045 experimental interaction detection MI:0461 interaction database SPSB1 RNF114 MI:0362 inference MI:1106 pathways database FBXL8 RNF114 MI:0362 inference MI:1106 pathways database FBXO17 RNF114 MI:0362 inference MI:1106 pathways database FBXL20 RNF114 MI:0362 inference MI:1106 pathways database UBE2E2 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXL18 RNF114 MI:0362 inference MI:1106 pathways database NEDD4L RNF114 MI:0362 inference MI:1106 pathways database RNF2 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database NDN RNF114 MI:0362 inference MI:0461 interaction database TRAF4 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database TRAIP RNF114 MI:0045 experimental interaction detection MI:0461 interaction database IDI2 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database RBCK1 RNF114 MI:0362 inference MI:1106 pathways database TRIM55 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database RNF38 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXL15 RNF114 MI:0362 inference MI:1106 pathways database FBXO44 RNF114 MI:0362 inference MI:1106 pathways database UNKL RNF114 MI:0362 inference MI:1106 pathways database SMURF2 RNF114 MI:0362 inference MI:1106 pathways database TRIM36 RNF114 MI:0362 inference MI:1106 pathways database PARP11 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXO6 RNF114 MI:0362 inference MI:1106 pathways database RNF19A RNF114 MI:0362 inference MI:1106 pathways database RLIM RNF114 MI:0362 inference MI:1106 pathways database FBXL12 RNF114 MI:0362 inference MI:1106 pathways database FBXO40 RNF114 MI:0362 inference MI:1106 pathways database HERC5 RNF114 MI:0362 inference MI:1106 pathways database FBXL7 RNF114 MI:0362 inference MI:1106 pathways database FBXO2 RNF114 MI:0362 inference MI:1106 pathways database FBXO10 RNF114 MI:0362 inference MI:1106 pathways database FBXO9 RNF114 MI:0362 inference MI:1106 pathways database FBXL5 RNF114 MI:0362 inference MI:1106 pathways database FBXL4 RNF114 MI:0362 inference MI:1106 pathways database FBXW11 RNF114 MI:0362 inference MI:1106 pathways database FBXO4 RNF114 MI:0362 inference MI:1106 pathways database FBXL21 RNF114 MI:0362 inference MI:1106 pathways database FBXL3 RNF114 MI:0362 inference MI:1106 pathways database FBXW2 RNF114 MI:0362 inference MI:1106 pathways database BTRC RNF114 MI:0362 inference MI:1106 pathways database UBE2D4 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database FBXO7 RNF114 MI:0362 inference MI:1106 pathways database TRAF6 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database RNF115 RNF114 MI:0362 inference MI:1106 pathways database RNF114 AUP1 MI:0045 experimental interaction detection MI:0461 interaction database RNF114 WSB1 MI:0362 inference MI:1106 pathways database RNF114 AK5 MI:0045 experimental interaction detection MI:0461 interaction database