PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FKBP9 HERC4 22863883 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 NUF2 26496610 biogrid,intact exp G G G HSP90AA1 HERC4 22939624 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC4 UBE2E3 22496338 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G GP G G RAD23A HERC4 22863883 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G UBC HERC4 22496338 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 UBE2J2 22496338 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSP90AB1 HERC4 22939624 intact exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 DNAJC7 26496610 biogrid,intact exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G NT5C2 HERC4 22863883 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G BAG3 HERC4 26496610 biogrid,intact exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 HERC4 22496338 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G USP5 HERC4 22863883 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G LSM6 HERC4 26344197 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 H2AFV 22863883 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G GP G G GMNN HERC4 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G GP G G HERC4 NXF1 22658674 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 DCTPP1 22863883 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G UBE2D2 HERC4 22496338 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HEXA HERC4 22863883 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 NUBP2 22863883 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G SHMT2 HERC4 22658674 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G HERC4 C9orf78 22863883 biogrid exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G PCNA HERC4 22863883 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G GP G G RB1 HERC4 26496610 biogrid,intact exp G G G G G G G G G G G GP G G G G G G G G G G G G G G GP G G NTRK1 HERC4 25921289 biogrid exp G P P HERC4 HERC6 18535780 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G WARS HERC4 22863883 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CENPC HERC4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC4 RASL11A 23023127 pred G G G G G G G G G G G GP G G G G G G G G G G G G G GP G G HERC4 BOLL 23023127 pred G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5GLZ8 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HSP90AA1 HERC4 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255476 bait prey HSP90AB1 HERC4 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125014 prey bait UBE2D2 HERC4 MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226051 prey bait PCNA HERC4 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300143 bait prey RAD23A HERC4 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302864 prey bait HERC4 HERC6 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_33187|BIOGRID_117215 -|prey -|bait HEXA HERC4 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300141 bait prey HERC4 UBE2E3 MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226052 bait prey FKBP9 HERC4 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300139 bait prey USP5 HERC4 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300144 bait prey HERC4 H2AFV MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300140 prey bait NT5C2 HERC4 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300142 bait prey UBC HERC4 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18781797,21139048,21890473,21906983,21963094,21987572,22496338,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_176992|BIOGRID_211542|BIOGRID_162189|BIOGRID_163551|BIOGRID_167549|BIOGRID_268846|BIOGRID_223865|BIOGRID_265066|BIOGRID_174520 bait|prey|bait|bait|bait|bait|bait|bait|bait prey|bait|prey|prey|prey|prey|prey|prey|prey HERC4 UBE2J2 MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226053 bait prey HERC4 NUBP2 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301537 bait prey HERC4 DCTPP1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300138 prey bait NRF1 HERC4 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296475 bait prey WARS HERC4 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300145 bait prey HERC4 C9orf78 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300137 prey bait

PPI - HINT Gene A Gene B PMID Method Quality GMNN HERC4 26496610,26496610 0007,0004 HT FKBP9 HERC4 22863883 0401 HT BAG3 HERC4 26496610,26496610 0007,0004 HT RB1 HERC4 26496610,26496610 0007,0004 HT HEXA HERC4 22863883 0401 HT PCNA HERC4 22863883 0401 HT WARS HERC4 22863883 0401 HT USP5 HERC4 22863883 0401 HT NT5C2 HERC4 22863883 0401 HT RAD23A HERC4 22863883 0401 HT LSM6 HERC4 26344197 0401 HT HERC4 H2AFV 22863883 0401 HT HERC4 DNAJC7 26496610,26496610 0007,0004 HT HERC4 NUF2 26496610,26496610 0007,0004 HT HERC4 DCTPP1 22863883 0401 HT HERC4 C9ORF78 22863883 0401 HT HERC4 NUBP2 22863883 0401 HT GMNN HERC4 26496610,26496610 0007,0004 HT FKBP9 HERC4 22863883 0401 HT BAG3 HERC4 26496610,26496610 0007,0004 HT RB1 HERC4 26496610,26496610 0007,0004 HT HEXA HERC4 22863883 0401 HT PCNA HERC4 22863883 0401 HT WARS HERC4 22863883 0401 HT USP5 HERC4 22863883 0401 HT NT5C2 HERC4 22863883 0401 HT RAD23A HERC4 22863883 0401 HT LSM6 HERC4 26344197 0401 HT HERC4 H2AFV 22863883 0401 HT HERC4 DNAJC7 26496610,26496610 0007,0004 HT HERC4 NUF2 26496610,26496610 0007,0004 HT HERC4 DCTPP1 22863883 0401 HT HERC4 C9ORF78 22863883 0401 HT HERC4 NUBP2 22863883 0401 HT FKBP9 HERC4 22863883 0401 LC HEXA HERC4 22863883 0401 LC HSP90AB1 HERC4 22939624 0729 HT UBC HERC4 22496338 0415 LC PCNA HERC4 22863883 0401 LC WARS HERC4 22863883 0401 LC USP5 HERC4 22863883 0401 LC NT5C2 HERC4 22863883 0401 LC RAD23A HERC4 22863883 0401 LC LSM6 HERC4 26344197 0401 LC HERC4 HERC4 26949039,22496338 0415,0415 LC HERC4 H2AFV 22863883 0401 LC HERC4 DCTPP1 22863883 0401 LC HERC4 C9ORF78 22863883 0401 LC HERC4 NUBP2 22863883 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5GLZ8 P08238 HERC4 HSP90AB1 0.126 22939624 Q5GLZ8 P0CG48 HERC4 UBC 0.309 22496338 Q5GLZ8 P68036 HERC4 UBE2L3 0.309 26949039 Q9Y5Y2 Q5GLZ8 NUBP2 HERC4 0.081 22863883 Q5GLZ8 P23381 HERC4 WARS 0.081 22863883 Q5GLZ8 P62312 HERC4 LSM6 0.081 26344197 Q9HCE1 Q5GLZ8 MOV10 HERC4 0.126 22658674 Q9H773 Q5GLZ8 DCTPP1 HERC4 0.081 22863883 Q9NZ63 Q5GLZ8 C9ORF78 HERC4 0.081 22863883 Q8IVU3 Q5GLZ8 HERC6 HERC4 0.21 18535780 Q5GLZ8 P07900 HERC4 HSP90AA1 0.126 22939624 Q71UI9 Q5GLZ8 H2AFV HERC4 0.081 22863883 Q5GLZ8 P12004 HERC4 PCNA 0.081 22863883 Q5GLZ8 O95302 HERC4 FKBP9 0.081 22863883 Q5GLZ8 P04629 HERC4 NTRK1 0.126 25921289 Q5GLZ8 P06865 HERC4 HEXA 0.081 22863883 Q5GLZ8 P06400 HERC4 RB1 0.236 26496610 Q99615 Q5GLZ8 DNAJC7 HERC4 0.236 26496610 Q9BZD4 Q5GLZ8 NUF2 HERC4 0.236 26496610 Q9CQR6 Q5GLZ8 PPP6C HERC4 0.236 26496610 Q5GLZ8 Q5GLZ8 HERC4 HERC4 0.554 22496338,26949039 Q61539 Q5GLZ8 ESRRB HERC4 0.236 26496610 Q5GLZ8 O75496 HERC4 GMNN 0.236 26496610 Q5GLZ8 O95817 HERC4 BAG3 0.236 26496610 Q5GLZ8 O88952 HERC4 LIN7C 0.236 26496610 Q9UBU9 Q5GLZ8 NXF1 HERC4 0.126 22658674 Q5GLZ8 P34897 HERC4 SHMT2 0.126 22658674 Q5GLZ8 P45974 HERC4 USP5 0.081 22863883 Q5GLZ8 E9PZI6 HERC4 E9PZI6 0.126 26496610 Q5GLZ8 P49902 HERC4 NT5C2 0.081 22863883

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PPP6C HERC4 MI:0362 inference MI:0461 interaction database LIN7A HERC4 MI:0362 inference MI:0461 interaction database KATNA1 HERC4 MI:0362 inference MI:0461 interaction database GMNN HERC4 MI:0045 experimental interaction detection MI:0461 interaction database ESRRB HERC4 MI:0362 inference MI:0461 interaction database BAG3 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database RB1 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database UBC HERC4 MI:0045 experimental interaction detection MI:0461 interaction database SHMT2 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database UBE2L3 HERC4 MI:0045 experimental interaction detection MI:0461 interaction database CENPC HERC4 MI:0362 inference MI:0461 interaction database HERC4 HERC6 MI:0045 experimental interaction detection MI:0461 interaction database HERC4 UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database HERC4 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database HERC4 DNAJC7 MI:0045 experimental interaction detection MI:0461 interaction database HERC4 NUF2 MI:0045 experimental interaction detection MI:0461 interaction database HERC4 LIN7B MI:0362 inference MI:0461 interaction database HERC4 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database HERC4 LIN7C MI:0362 inference MI:0461 interaction database HERC4 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database