PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ACKR3 HECTD2 26496610 biogrid,intact exp G GP G GP G GP GP G GP GP GP GP G GP GP G P G GP G GP GP GP G GP GP G ELAVL1 HECTD2 19322201 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP G HECTD2 RNF166 26186194 biogrid exp GP GP G GP G G GP G GP G G G G GP GP G G G G G GP GP G GP GP G HECTD2 TSG101 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBE2M HECTD2 16082366 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP P G GP G GP GP GP GP GP GP G UBE2L3 HECTD2 16082366 pred GP G G GP G GP GP G GP G G G G GP GP G P G G G GP GP GP G GP GP G UBE2A HECTD2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G HECTD2 UBE2T 16082366 pred G GP G GP P P P GP GP P GP P G GP P GP G UBE2C HECTD2 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBE2B HECTD2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2N HECTD2 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G UBE2D2 HECTD2 16082366 pred GP G G P GP G G GP G GP GP GP GP G G GP GP P G GP GP G GP G GP GP GP G HECTD2 AKTIP 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBE2I HECTD2 16082366 pred GP GP G P GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP G GP GP GP GP G HECTD2 UBE2R2 16082366 pred G G G P G G G G G G G G GP G G G G G G G G G G GP GP G G UBE2H HECTD2 16082366 pred GP GP G P GP G GP G G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBE2D1 HECTD2 16082366 pred GP G G P GP G G GP G GP GP GP GP G G GP GP P G GP GP G GP G GP GP GP G HECTD2 UBE2E3 16082366 pred GP GP G GP G G GP G GP G G GP G GP GP GP G GP G G GP GP G GP GP G UBE2E1 HECTD2 16082366 pred GP GP G GP G G GP G GP G G GP G GP GP GP G GP G G GP GP G GP GP G CDC34 HECTD2 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G HECTD2 UBE2U 16082366 pred P P P P P P P P P P P P P P P P P P P P GP UBE2L6 HECTD2 16082366 pred GP GP G P GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP G HECTD2 16082366 pred HECTD2 UBE2Z 16082366 pred GP GP G P GP G G GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G UBE2S HECTD2 16082366 pred G G G G G G GP G G G GP G G G G G G G G G G GP G HECTD2 BIRC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G HECTD2 UFC1 16082366 pred GP GP G GP G GP GP G GP G GP G G GP GP G P G GP GP GP GP GP G GP GP G HECTD2 UBE2F 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G HECTD2 UBE2D4 16082366 pred GP G G P GP G G GP G GP GP GP GP G G GP GP P G GP GP G GP G GP GP GP G UBE2G1 HECTD2 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBE2V2 HECTD2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - HINT Gene A Gene B PMID Method Quality ACKR3 HECTD2 26496610,26496610 0007,0004 HT HECTD2 RNF166 26186194 0004 HT ACKR3 HECTD2 26496610,26496610 0007,0004 HT HECTD2 RNF166 26186194 0004 HT PIAS1 HECTD2 26157031,26157031 0415,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5U5R9 P25106 HECTD2 ACKR3 0.236 26496610 Q5U5R9 O75925 HECTD2 PIAS1 0.702 26157031 Q96A37 Q5U5R9 RNF166 HECTD2 0.126 26186194 Q5U5R9 Q15717 HECTD2 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SIAH2 HECTD2 MI:0362 inference MI:1106 pathways database PIAS1 HECTD2 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 HECTD2 MI:0362 inference MI:1106 pathways database UBB HECTD2 MI:0362 inference MI:1106 pathways database UBC HECTD2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 HECTD2 MI:0362 inference MI:1106 pathways database TAF1 HECTD2 MI:0045 experimental interaction detection MI:0461 interaction database ACKR3 HECTD2 MI:0045 experimental interaction detection MI:0461 interaction database CCNF HECTD2 MI:0362 inference MI:1106 pathways database UBE2A HECTD2 MI:0362 inference MI:1106 pathways database FBXW4 HECTD2 MI:0362 inference MI:1106 pathways database RBX1 HECTD2 MI:0362 inference MI:1106 pathways database RPS27A HECTD2 MI:0362 inference MI:1106 pathways database UBA52 HECTD2 MI:0362 inference MI:1106 pathways database SKP1 HECTD2 MI:0362 inference MI:1106 pathways database SKP2 HECTD2 MI:0362 inference MI:1106 pathways database CUL1 HECTD2 MI:0362 inference MI:1106 pathways database TRIP12 HECTD2 MI:0362 inference MI:1106 pathways database ELAVL1 HECTD2 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 HECTD2 MI:0362 inference MI:1106 pathways database HECTD2 FBXO31 MI:0362 inference MI:1106 pathways database HECTD2 FBXW9 MI:0362 inference MI:1106 pathways database HECTD2 FBXW10 MI:0362 inference MI:1106 pathways database HECTD2 RNF213 MI:0362 inference MI:1106 pathways database HECTD2 FBXL22 MI:0362 inference MI:1106 pathways database HECTD2 FBXL19 MI:0362 inference MI:1106 pathways database HECTD2 FBXW12 MI:0362 inference MI:1106 pathways database HECTD2 RNF19B MI:0362 inference MI:1106 pathways database HECTD2 RNF144B MI:0362 inference MI:1106 pathways database HECTD2 RBBP6 MI:0362 inference MI:1106 pathways database HECTD2 HUWE1 MI:0362 inference MI:1106 pathways database HECTD2 TRIM69 MI:0362 inference MI:1106 pathways database HECTD2 SIAH1 MI:0362 inference MI:1106 pathways database HECTD2 HERC6 MI:0362 inference MI:1106 pathways database HECTD2 UBR2 MI:0362 inference MI:1106 pathways database HECTD2 FBXL14 MI:0362 inference MI:1106 pathways database HECTD2 FBXW8 MI:0362 inference MI:1106 pathways database HECTD2 FBXL16 MI:0362 inference MI:1106 pathways database HECTD2 FBXO15 MI:0362 inference MI:1106 pathways database HECTD2 ZNRF1 MI:0362 inference MI:1106 pathways database HECTD2 FBXL13 MI:0362 inference MI:1106 pathways database HECTD2 FBXO22 MI:0362 inference MI:1106 pathways database HECTD2 ZNRF2 MI:0362 inference MI:1106 pathways database HECTD2 FBXO27 MI:0362 inference MI:1106 pathways database HECTD2 FBXO30 MI:0362 inference MI:1106 pathways database HECTD2 RNF217 MI:0362 inference MI:1106 pathways database HECTD2 DTX3L MI:0362 inference MI:1106 pathways database HECTD2 FBXO41 MI:0362 inference MI:1106 pathways database HECTD2 LMO7 MI:0362 inference MI:1106 pathways database HECTD2 MYLIP MI:0362 inference MI:1106 pathways database HECTD2 FBXW7 MI:0362 inference MI:1106 pathways database HECTD2 FBXO32 MI:0362 inference MI:1106 pathways database HECTD2 FBXW5 MI:0362 inference MI:1106 pathways database HECTD2 RNF166 MI:0045 experimental interaction detection MI:0461 interaction database HECTD2 MIB2 MI:0362 inference MI:1106 pathways database HECTD2 SPSB1 MI:0362 inference MI:1106 pathways database HECTD2 FBXL8 MI:0362 inference MI:1106 pathways database HECTD2 FBXO17 MI:0362 inference MI:1106 pathways database HECTD2 FBXL20 MI:0362 inference MI:1106 pathways database HECTD2 FBXL18 MI:0362 inference MI:1106 pathways database HECTD2 NEDD4L MI:0362 inference MI:1106 pathways database HECTD2 RBCK1 MI:0362 inference MI:1106 pathways database HECTD2 FBXL15 MI:0362 inference MI:1106 pathways database HECTD2 FBXO44 MI:0362 inference MI:1106 pathways database HECTD2 UNKL MI:0362 inference MI:1106 pathways database HECTD2 SMURF2 MI:0362 inference MI:1106 pathways database HECTD2 TRIM36 MI:0362 inference MI:1106 pathways database HECTD2 FBXO6 MI:0362 inference MI:1106 pathways database HECTD2 RNF19A MI:0362 inference MI:1106 pathways database HECTD2 RLIM MI:0362 inference MI:1106 pathways database HECTD2 FBXL12 MI:0362 inference MI:1106 pathways database HECTD2 FBXO40 MI:0362 inference MI:1106 pathways database HECTD2 HERC5 MI:0362 inference MI:1106 pathways database HECTD2 FBXL7 MI:0362 inference MI:1106 pathways database HECTD2 FBXO2 MI:0362 inference MI:1106 pathways database HECTD2 FBXO10 MI:0362 inference MI:1106 pathways database HECTD2 FBXO9 MI:0362 inference MI:1106 pathways database HECTD2 FBXL5 MI:0362 inference MI:1106 pathways database HECTD2 FBXL4 MI:0362 inference MI:1106 pathways database HECTD2 FBXW11 MI:0362 inference MI:1106 pathways database HECTD2 FBXO4 MI:0362 inference MI:1106 pathways database HECTD2 FBXL21 MI:0362 inference MI:1106 pathways database HECTD2 FBXL3 MI:0362 inference MI:1106 pathways database HECTD2 FBXW2 MI:0362 inference MI:1106 pathways database HECTD2 BTRC MI:0362 inference MI:1106 pathways database HECTD2 FBXO7 MI:0362 inference MI:1106 pathways database HECTD2 RNF115 MI:0362 inference MI:1106 pathways database HECTD2 RNF114 MI:0362 inference MI:1106 pathways database HECTD2 WSB1 MI:0362 inference MI:1106 pathways database