PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CUL1 FBXO22 22268729,21145461 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G FBXO22 NCOR2 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G FBXO22 CENPJ 26638075 biogrid,intact exp G G G G G G G G G G G G G G G G G G COPS6 FBXO22 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G JUN FBXO22 25609649 intact exp G G G G G G G G G G G G G G G G G G G G G FBXO22 COPS5 19615732,21145461 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G SKP1 FBXO22 26496610,17463251 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G RBX1 FBXO22 12481031 biogrid exp G G G G G G G G G G G G G G G G G G G G G FBXO22 SRR 25336657 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G GBP7 FBXO22 ortho BCR FBXO22 16082366 pred FBXW8 FBXO22 16082366 pred FBXO22 FBXL21 16082366 pred FBXO22 FBXL3 16082366 pred G G G G G G G G G G G G G G G G G G G G G PSMA4 FBXO22 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 FBXW11 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 FBXL5 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 FBXO2 16082366 pred G G G G G G G G G G G G G G G G G G G G FBXL6 FBXO22 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 BTRC 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 FBXW2 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 FBXO10 16082366 pred G G G G G G G G G G G G G G G G G G G G FBXO22 FBXO6 16082366 pred G G G G G G G G G G G G G G G G G G G G FBXW4 FBXO22 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 FBXO7 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 FBXO3 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO22 FBXO25 16082366 pred G G G G G G G G G G G G G G G G G G G G G FBXO24 FBXO22 16082366 pred G FBXO22 FBXO5 16082366 pred G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL1 FBXO22 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21145461,22268729 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_292050|BIOGRID_204523 prey|bait bait|prey RBX1 FBXO22 MI:0004(affinity chromatography technology) 12481031 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_101968 bait prey NEDD8 FBXO22 MI:0004(affinity chromatography technology) 18247557 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_251576 bait prey SKP1 FBXO22 MI:0004(affinity chromatography technology) 17463251 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273745 prey bait UBC FBXO22 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,22053931,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_172170|BIOGRID_222178|BIOGRID_269998|BIOGRID_173378|BIOGRID_223880|BIOGRID_166416|BIOGRID_181270 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey FBXO22 COPS5 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_100632|BIOGRID_205203|BIOGRID_120380 prey|prey|prey bait|bait|bait COPS6 FBXO22 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120381|UniProt_100633 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality JUN FBXO22 25609649 0006 HT SKP1 FBXO22 26496610,26087183,17463251,26496610 0007,0004,0004,0004 HT,LC CUL1 FBXO22 21145461,22268729 0004,0004 HT,LC COPS6 FBXO22 19615732,19615732 0004,0007 HT FBXO22 COPS5 19615732,21145461,19615732 0004,0004,0007 HT FBXO22 CENPJ 26638075,26638075 1314,1313 HT FBXO22 NCOR2 26496610,26496610 0007,0004 HT JUN FBXO22 25609649 0006 HT SKP1 FBXO22 26496610,26496610 0007,0004 HT CUL1 FBXO22 21145461 0004 HT COPS6 FBXO22 19615732,19615732 0004,0007 HT FBXO22 COPS5 19615732,21145461,19615732 0004,0004,0007 HT FBXO22 CENPJ 26638075,26638075 1314,1313 HT FBXO22 NCOR2 26496610,26496610 0007,0004 HT SKP1 FBXO22 26087183,17463251 0004,0004 LC CUL1 FBXO22 22268729 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NEZ5 O43474 FBXO22 KLF4 0.376 26087183 Q8NEZ5 C9J0Q5 FBXO22 NCOR2 {ECO:0000313|ENSEMBL:ENSP00000400281} 0.126 26496610 Q9Y618 Q8NEZ5 NCOR2 FBXO22 0.126 26496610 Q8NEZ5 P05412 FBXO22 JUN 0.126 25609649 Q8NEZ5 O96017 FBXO22 CHEK2 0.126 23178491 Q9HC77 Q8NEZ5 CENPJ FBXO22 0.236 26638075 Q9GZT4 Q8NEZ5 SRR FBXO22 0.454 25336657 Q8NEZ5 Q7L5N1 FBXO22 COPS6 0.236 19615732 Q8NEZ5 P63208 FBXO22 SKP1 0.722 27705803,26087183,17463251,unassigned1304,26496610 Q92905 Q8NEZ5 COPS5 FBXO22 0.332 19615732,21145461 Q9QZX7 Q8NEZ5 SRR FBXO22 0.21 25336657 Q8NEZ5 Q13616 FBXO22 CUL1 0.236 22268729,21145461 Q8NEZ5 P62877 FBXO22 RBX1 0.21 12481031

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SIAH2 FBXO22 MI:0362 inference MI:1106 pathways database KLF4 FBXO22 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 FBXO22 MI:0362 inference MI:1106 pathways database CHEK2 FBXO22 MI:0045 experimental interaction detection MI:0461 interaction database JUN FBXO22 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXO22 MI:0362 inference MI:1106 pathways database UBC FBXO22 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 FBXO22 MI:0362 inference MI:1106 pathways database CCNF FBXO22 MI:0362 inference MI:1106 pathways database UBE2A FBXO22 MI:0362 inference MI:1106 pathways database FBXW4 FBXO22 MI:0362 inference MI:1106 pathways database RBX1 FBXO22 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPS27A FBXO22 MI:0362 inference MI:1106 pathways database UBA52 FBXO22 MI:0362 inference MI:1106 pathways database SKP1 FBXO22 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKP2 FBXO22 MI:0362 inference MI:1106 pathways database CUL1 FBXO22 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIP12 FBXO22 MI:0362 inference MI:1106 pathways database NEDD8 FBXO22 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 FBXO22 MI:0362 inference MI:1106 pathways database HECTD2 FBXO22 MI:0362 inference MI:1106 pathways database FBXO31 FBXO22 MI:0362 inference MI:1106 pathways database FBXW9 FBXO22 MI:0362 inference MI:1106 pathways database FBXW10 FBXO22 MI:0362 inference MI:1106 pathways database RNF213 FBXO22 MI:0362 inference MI:1106 pathways database FBXL22 FBXO22 MI:0362 inference MI:1106 pathways database FBXL19 FBXO22 MI:0362 inference MI:1106 pathways database FBXW12 FBXO22 MI:0362 inference MI:1106 pathways database RNF19B FBXO22 MI:0362 inference MI:1106 pathways database COPS6 FBXO22 MI:0045 experimental interaction detection MI:0461 interaction database RNF144B FBXO22 MI:0362 inference MI:1106 pathways database RBBP6 FBXO22 MI:0362 inference MI:1106 pathways database HUWE1 FBXO22 MI:0362 inference MI:1106 pathways database TRIM69 FBXO22 MI:0362 inference MI:1106 pathways database SIAH1 FBXO22 MI:0362 inference MI:1106 pathways database HERC6 FBXO22 MI:0362 inference MI:1106 pathways database UBR2 FBXO22 MI:0362 inference MI:1106 pathways database FBXL14 FBXO22 MI:0362 inference MI:1106 pathways database FBXW8 FBXO22 MI:0362 inference MI:1106 pathways database FBXL16 FBXO22 MI:0362 inference MI:1106 pathways database FBXO15 FBXO22 MI:0362 inference MI:1106 pathways database ZNRF1 FBXO22 MI:0362 inference MI:1106 pathways database FBXL13 FBXO22 MI:0362 inference MI:1106 pathways database FBXO22 ZNRF2 MI:0362 inference MI:1106 pathways database FBXO22 FBXO27 MI:0362 inference MI:1106 pathways database FBXO22 FBXO30 MI:0362 inference MI:1106 pathways database FBXO22 RNF217 MI:0362 inference MI:1106 pathways database FBXO22 DTX3L MI:0362 inference MI:1106 pathways database FBXO22 FBXO41 MI:0362 inference MI:1106 pathways database FBXO22 LMO7 MI:0362 inference MI:1106 pathways database FBXO22 MYLIP MI:0362 inference MI:1106 pathways database FBXO22 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database FBXO22 FBXW7 MI:0362 inference MI:1106 pathways database FBXO22 FBXO32 MI:0362 inference MI:1106 pathways database FBXO22 FBXW5 MI:0362 inference MI:1106 pathways database FBXO22 MIB2 MI:0362 inference MI:1106 pathways database FBXO22 SPSB1 MI:0362 inference MI:1106 pathways database FBXO22 FBXL8 MI:0362 inference MI:1106 pathways database FBXO22 FBXO17 MI:0362 inference MI:1106 pathways database FBXO22 FBXL20 MI:0362 inference MI:1106 pathways database FBXO22 FBXL18 MI:0362 inference MI:1106 pathways database FBXO22 NEDD4L MI:0362 inference MI:1106 pathways database FBXO22 RBCK1 MI:0362 inference MI:1106 pathways database FBXO22 SRR MI:0045 experimental interaction detection MI:0461 interaction database FBXO22 FBXL15 MI:0362 inference MI:1106 pathways database FBXO22 FBXO44 MI:0362 inference MI:1106 pathways database FBXO22 UNKL MI:0362 inference MI:1106 pathways database FBXO22 SMURF2 MI:0362 inference MI:1106 pathways database FBXO22 CENPJ MI:0045 experimental interaction detection MI:0461 interaction database FBXO22 TRIM36 MI:0362 inference MI:1106 pathways database FBXO22 FBXO6 MI:0362 inference MI:1106 pathways database FBXO22 RNF19A MI:0362 inference MI:1106 pathways database FBXO22 RLIM MI:0362 inference MI:1106 pathways database FBXO22 FBXL12 MI:0362 inference MI:1106 pathways database FBXO22 FBXO40 MI:0362 inference MI:1106 pathways database FBXO22 HERC5 MI:0362 inference MI:1106 pathways database FBXO22 FBXL7 MI:0362 inference MI:1106 pathways database FBXO22 FBXO2 MI:0362 inference MI:1106 pathways database FBXO22 FBXO10 MI:0362 inference MI:1106 pathways database FBXO22 FBXO9 MI:0362 inference MI:1106 pathways database FBXO22 FBXL5 MI:0362 inference MI:1106 pathways database FBXO22 FBXL4 MI:0362 inference MI:1106 pathways database FBXO22 FBXW11 MI:0362 inference MI:1106 pathways database FBXO22 FBXO4 MI:0362 inference MI:1106 pathways database FBXO22 FBXL21 MI:0362 inference MI:1106 pathways database FBXO22 FBXL3 MI:0362 inference MI:1106 pathways database FBXO22 FBXW2 MI:0362 inference MI:1106 pathways database FBXO22 BTRC MI:0362 inference MI:1106 pathways database FBXO22 FBXO7 MI:0362 inference MI:1106 pathways database FBXO22 RNF115 MI:0362 inference MI:1106 pathways database FBXO22 RNF114 MI:0362 inference MI:1106 pathways database FBXO22 NCOR2 MI:0045 experimental interaction detection MI:0461 interaction database FBXO22 WSB1 MI:0362 inference MI:1106 pathways database