PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus EEF1A2 UBXN6 22337587 biogrid exp G GP G P G P P G GP GP G P P G GP G GP G G UBXN6 RUVBL1 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P G GP GP GP G UBXN6 RUVBL2 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G APP UBXN6 21832049 innatedb,biogrid exp G P G G GP GP G P G G G GP GP G GP G P P G G GP G GP G UBXN2A UBXN6 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G PRKDC UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G ALPP UBXN6 18775313 biogrid exp P UBXN6 NXF1 22658674 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G TUBB6 UBXN6 22337587 biogrid exp GP P G G GP GP G P G GP P P P G GP GP GP GP G P GP G GP P GP GP G FAM104A UBXN6 26186194 biogrid exp P P P P P P P P P GP P P GP P P P GP P P GP G LMAN1 UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G FLOT1 UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G IRS4 UBXN6 22337587 biogrid exp GP P G G G GP G P P G GP P P P G GP GP G GP G P P GP GP GP P GP GP G DST UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP G G G GP GP GP GP GP G TRIM25 UBXN6 22939629 biogrid exp G P G G GP GP G P G GP P P G GP GP GP GP G P P GP G GP P GP GP G UBXN6 ZC3H7B 22939629 biogrid exp GP G G G GP G P G GP P G G GP G GP G P P G G G GP GP G SYVN1 UBXN6 18656546 intact exp G P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G UFD1L UBXN6 19275885 biogrid exp G P G G G GP G P P G GP P P G GP GP G GP G P P G GP GP G GP G UBXN6 VCPKMT 23349634,26186194 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP P G P P GP GP GP P GP GP G TUBA1C UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP G GP P GP GP G UBXN6 PLAA 18775313 intact exp GP P G G GP GP G P P G GP P P G GP GP GP GP G P P GP GP GP P GP GP G MAGEA4 UBXN6 25416956 biogrid,intact exp P P GP GSK3B UBXN6 21900206 biogrid,mint,intact exp G G G G GP G P G G G G GP G G G P G G G G G G UBXN6 UGGT1 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP G GP P GP GP G HERPUD1 UBXN6 18656546 intact exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G HSPA1A, HSPA1B UBXN6 22337587 biogrid exp P P P P P P P P P P P P P P P P P P P P P P FAF2 UBXN6 22337587 biogrid exp G G G G G G G G G G G G G G G G G G G G COPA UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP G GP P GP GP G POR UBXN6 26186194 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G VPS39 UBXN6 22939629 biogrid exp G G G GP G G G GP G G G G G G G GP G G GP G XPO6 UBXN6 22939629 biogrid exp G P G G GP GP G P P G GP P P G GP GP G GP G P GP GP GP P GP GP G CAV1 UBXN6 23335559 biogrid exp GP G G G GP G P P G GP P P G G GP GP G G P P G G G G G G CANX UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G UBXN6 LIMA1 22337587 biogrid exp GP P G G GP G G P G GP P G GP G G GP G P P GP GP GP GP GP G BAG3 UBXN6 23824909 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G ELAVL1 UBXN6 19322201 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP GP GP G RPS3 UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP G GP G P P GP G GP P GP GP G HNRNPU UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G CCT8 UBXN6 22337587 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G MCFD2 UBXN6 22337587 biogrid exp GP P G G GP GP G P G GP P P P G GP GP GP GP G P P GP G GP P GP GP G UBXN6 MOV10 22658674 biogrid exp G G G G G G G G G G G G G UBXN6 SEPT9 22337587 biogrid exp GP P G G GP GP G P G GP P P P G GP GP GP GP G P P GP G GP P GP GP G UBXN6 TRIM39 25416956 biogrid,intact exp P P P P P P P P P P P P P DERL1 UBXN6 19275885 biogrid exp GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G VCP UBXN6 19275885,19174149,18775313,23383273,26186194,21896481,22337587,21914798,18656546,16807242,22350894,25078495, 25402006 hprd,biogrid,intact exp, ortho, pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G NPLOC4 UBXN6 22337587, 25402006 biogrid exp, pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G ASPSCR1 UBXN6 26186194,22337587, 25402006 biogrid exp, pred GP P G P GP G P P G GP P P P G GP GP P GP G P P GP GP GP GP GP VCPIP1 UBXN6 18775313, 25402006 biogrid,intact exp, pred G G G G G G P P G GP P P G GP G G P G P G GP GP GP G PSMD2 UBXN6 18656546, 21836163 biogrid exp, pred GP P G G GP GP G P P G GP P P G GP GP GP GP G P P GP GP GP P GP GP G MYH10 UBXN6 ortho GP P G G G GP G P P G GP P G GP GP GP GP G P P GP G GP GP GP G NEGR1 UBXN6 ortho G P G P GP G P G P P P G G GP G P G P GP P G GP P FZD5 UBXN6 ortho GP P G GP GP G G G GP GP G GP G P P GP G GP GP P G YWHAE UBXN6 ortho GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G RNMT UBXN6 ortho GP P G G GP GP G P P G GP P P G GP GP G GP G P P GP GP GP P GP GP G BTBD2 UBXN6 25402006 pred G G G G G G G G G G G G G G G G G G G UBE4B UBXN6 25402006 pred GP P G G GP GP G P P G GP P P G GP GP GP GP G P P GP G GP P GP GP G HIF1A UBXN6 25402006 pred GP P G G GP GP G P G GP P P G GP GP G GP G P GP G GP P GP GP G UBXN4 UBXN6 25402006 pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G FCHSD2 UBXN6 25402006 pred GP P G G GP GP G P P G GP P P G GP GP G GP G P P P GP GP P GP G G UBL7 UBXN6 23023127 pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP G GP P GP GP G UBXN6 NSFL1C 25402006 pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP G GP P GP GP G STX5 UBXN6 25402006 pred GP P G G GP GP G G GP P P P G G GP G GP G P P GP G G GP GP G PTPN3 UBXN6 25402006 pred GP P G G G GP G P P G GP P P P G GP GP G GP G P P GP GP GP P GP GP G UBXN8 UBXN6 25402006 pred G G G G G G G G G G G G G G G G G G G G CUL1 UBXN6 25402006 pred GP G G G GP G P P G GP P P G GP GP GP GP G P P GP GP GP P GP GP G TMUB2 UBXN6 23023127 pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G UBXN6 UBQLN2 23023127 pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G CD3D UBXN6 25402006 pred GP G GP G P GP P P G G G G G G G GP G P G G G SVIP UBXN6 25402006 pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G UBC UBXN6 23023127 pred CAPNS1 UBXN6 25402006 pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP G GP P GP GP G UBXN6 RNF19A 25402006 pred GP P G G GP GP G P P G GP P P P G GP GP GP GP G P P GP GP GP P GP GP G POLR2E UBXN6 25402006 pred G G G G G G G G G G G G G G G G G G G G UBXN10 UBXN6 25402006 pred GP P G G GP GP G P P G GP P P GP GP GP GP G P P GP GP GP GP GP G CUL2 UBXN6 25402006 pred GP P G G G GP G P G GP P P P G G GP GP GP G P P GP G G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96QU8 Q9BZV1 biochemical 22939629 colocalization X 2 A0A024R8R4 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q9UGR2-2 Q9BZV1 biochemical 22939629 colocalization X 2 A0A024R2A7 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 A0A024R2A7 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q9Y230 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q9BQE3 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q96JH7 Q9BZV1 affinity chromatography technology 18775313 physical association X 2 P05187 Q9BZV1 affinity chromatography technology 18775313 physical association X 2 Q9BZV1 pull down 19275885 direct interaction X 2 Q9BZV1 Q9UHB6 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 Q9UHD8-5 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 Q03001-11 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 Q05639 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 O75955 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 Q8NI22-3 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 P53621-2 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 Q7Z4F3 affinity chromatography technology 23335559 physical association X 2 Q9BZV1 Q7Z4F3 imaging technique 23335559 colocalization X 2 Q9BZV1 A0A024RC12 two hybrid 25416956 direct interaction X 2 Q9BZV1 A0A024RCP5 two hybrid 25416956 direct interaction X 2 P0CG48 Q9BZV1 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9BZV1 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9BZV1 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9BZV1 biochemical 17623298 association X 2 P0CG48 Q9BZV1 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9BZV1 affinity chromatography technology 21906983 physical association X 2 O95817 Q9BZV1 affinity chromatography technology 23824909 physical association X 2 P50990 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 P27824 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q14258 Q9BZV1 biochemical 22939629 colocalization X 2 Q9BUF5 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 A0A024R9L9 Q9BZV1 biochemical 22939629 colocalization X 2 A8K5I0 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q96CS3 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q9Y265 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 Q13200 pull down 18656546 direct interaction X 2 Q9BZV1 Q13200 affinity chromatography technology 18656546 physical association X 2 Q9BZV1 Q13200 biochemical 18656546 colocalization X 2 Q9BZV1 Q9BZE9-4 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 P23396 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 P78527-2 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 O14654 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 Q96BA7 affinity chromatography technology 22337587 physical association X 2 Q9BZV1 P05067-7 pull down 21832049 direct interaction X 2 Q9BZV1 affinity chromatography technology 23349634 physical association X 2 Q9BZV1 two hybrid 21900206 direct interaction X 2 P55072 Q9BZV1 affinity chromatography technology 21914798 physical association X 2 P55072 Q9BZV1 pull down 21914798 direct interaction X 2 P55072 Q9BZV1 affinity chromatography technology 16807242 physical association X 2 P55072 Q9BZV1 pull down 19275885 direct interaction X 2 P55072 Q9BZV1 pull down 19275885 direct interaction X 2 P55072 Q9BZV1 affinity chromatography technology 22350894 physical association X 2 P55072 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 P55072 Q9BZV1 affinity chromatography technology 23383273 physical association X 2 P55072 Q9BZV1 pull down 19174149 direct interaction X 2 P55072 Q9BZV1 two hybrid 19174149 direct interaction X 2 P55072 Q9BZV1 affinity chromatography technology 19174149 physical association X 2 P55072 Q9BZV1 affinity chromatography technology 21896481 physical association X 2 P55072 Q9BZV1 pull down 21896481 direct interaction X 2 P55072 Q9BZV1 pull down 21896481 direct interaction X 2 P55072 Q9BZV1 affinity chromatography technology 18775313 physical association X 2 Q9NYU2 Q9BZV1 affinity chromatography technology 22337587 physical association X 2 Q9BUN8-2 Q9BZV1 pull down 19275885 direct interaction X 2 Q9BZV1 in vivo 18656546 - C 4 Q9BZV1 in vivo 18656546 - C 4 Q9BZV1 in vivo 18656546 - C 4 Q9BZV1 in vivo 18656546 - C 4 Q9BZV1 - 18656546 - C 3 Q9BZV1 - 18656546 - C 3 Q9BZV1 - 18656546 - C 3 P55072 Q9BZV1 two hybrid 18656546 - X 2 P55072 Q9BZV1 in vivo 18656546 - X 2 P55072 Q9BZV1 in vitro 18656546 - X 2 P55072 Q9BZV1 in vivo 18656546 - X 2 P55072 Q9BZV1 in vitro 18656546 - X 2 P55072 Q9BZV1 two hybrid 18656546 - X 2 Q9BZV1 P49841 two hybrid 21900206 physical association X 2 Q9BZV1 A0A024RCP5 two hybrid prey pooling approach 25416956 physical association X 2 Q9BZV1 A0A024RCP5 two hybrid array 25416956 physical association X 2 Q9BZV1 A0A024RCP5 validated two hybrid 25416956 physical association X 2 Q9BZV1 anti bait coimmunoprecipitation 18656546 physical association C 3 Q9BZV1 pull down 18656546 physical association C 3 Q9BZV1 anti tag coimmunoprecipitation 18775313 association C 4 Q9BZV1 ubiquitinase assay 25260751 ubiquitination reaction C 5 Q1RN33 Q9BZV1 two hybrid prey pooling approach 25416956 physical association X 2 Q1RN33 Q9BZV1 two hybrid array 25416956 physical association X 2 Q1RN33 Q9BZV1 validated two hybrid 25416956 physical association X 2 Q9BZV1 Q15011 anti bait coimmunoprecipitation 18656546 physical association X 2 P55072 Q9BZV1 molecular sieving 18656546 physical association X 2 P55072 Q9BZV1 two hybrid 18656546 physical association X 2 P55072 Q9BZV1 pull down 18656546 direct interaction X 2 P55072 Q9BZV1 anti tag coimmunoprecipitation 18775313 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HSPA1A UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226201 prey bait APP UBXN6 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_227910 prey bait UBXN6 RUVBL2 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226197 bait prey UBXN6 RUVBL1 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226204 bait prey PRKDC UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226206 prey bait CANX UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226210 prey bait HERPUD1 UBXN6 MI:0018(two hybrid)|MI:0493(in vivo) 18656546 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (intact)|MI:0468(hprd) UniProt_96475|HPRD_40164 prey|- bait|- FAF2 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226199 prey bait VPS39 UBXN6 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240317 prey bait RPS3 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226205 prey bait UBC UBXN6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical) 17623298,21139048,21906983,21963094,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_177236|BIOGRID_225195|BIOGRID_167812|BIOGRID_265363|BIOGRID_269174|BIOGRID_161265 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey ASPSCR1 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226198 prey bait UFD1L UBXN6 MI:0096(pull down) 19275885 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_207891 bait prey DST UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226194 prey bait BAG3 UBXN6 MI:0004(affinity chromatography technology) 23824909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283147 bait prey UBXN6 VCPKMT MI:0004(affinity chromatography technology) 23349634 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_260395 prey bait HNRNPU UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226212 prey bait DERL1 UBXN6 MI:0096(pull down) 19275885 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_207889 prey bait TUBA1C UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226196 prey bait LMAN1 UBXN6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_221384|BIOGRID_226191 prey|prey bait|bait ALPP UBXN6 MI:0004(affinity chromatography technology) 18775313 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_148835 prey bait UBXN6 UGGT1 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226200 bait prey NPLOC4 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226209 prey bait GSK3B UBXN6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_156430|UniProt_158746|UniProt_179344 bait|bait|bait prey|prey|prey XPO6 UBXN6 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243048 prey bait COPA UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226214 prey bait FLOT1 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226211 prey bait UBXN6 LIMA1 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226192 bait prey UBXN6 SEPT9 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226193 bait prey UBXN6 ZC3H7B MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241277 bait prey TUBB6 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226203 prey bait EEF1A2 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226202 prey bait VCP UBXN6 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0686(unspecified method)|MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0686(unspecified method)|MI:0686(unspecified method)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16807242,18656546,18775313,19174149,19275885,21896481,21914798,22337587,22350894,23383273 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|-|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd)|(intact)|(intact)|MI:0468(hprd)|(intact)|(intact)|(intact)|(intact) BIOGRID_195974|BIOGRID_207888|BIOGRID_145838|BIOGRID_193693|BIOGRID_116145|BIOGRID_249971|BIOGRID_116144|BIOGRID_193698|BIOGRID_221201|BIOGRID_145832|BIOGRID_145833|BIOGRID_116143|UniProt_97390|HPRD_33526|BIOGRID_148723|UniProt_96471|UniProt_96470|UniProt_96473|BIOGRID_226190|BIOGRID_207887|UniProt_183199|HPRD_40163|UniProt_182508|UniProt_96472|HPRD_40164|UniProt_183188|UniProt_168925|UniProt_97379|UniProt_96474 prey|prey|bait|bait|prey|bait|prey|bait|prey|prey|prey|prey|prey|-|prey|prey|bait|neutral component|prey|bait|prey|-|prey|prey|-|prey|prey|prey|prey bait|bait|prey|prey|bait|prey|bait|prey|bait|bait|bait|bait|bait|-|bait|bait|prey|neutral component|bait|prey|bait|-|bait|bait|-|bait|bait|bait|bait MCFD2 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226213 prey bait CCT8 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226207 prey bait TRIM25 UBXN6 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239381 bait prey IRS4 UBXN6 MI:0004(affinity chromatography technology) 22337587 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226208 prey bait ELAVL1 UBXN6 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186297 bait prey CAV1 UBXN6 MI:0428(imaging technique)|MI:0428(imaging technique) 23335559 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid) BIOGRID_247805|BIOGRID_247807 bait|bait prey|prey PSMD2 UBXN6 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18656546 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_207893|BIOGRID_207894|BIOGRID_207892 prey|prey|prey bait|bait|bait VCPIP1 UBXN6 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 18775313 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact)|(intact) BIOGRID_148836|UniProt_183188|UniProt_168925|UniProt_97379 prey|prey|prey|prey bait|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality POR UBXN6 26186194,26389662 0004,0004 HT,LC VCP UBXN6 18656546,18656546,18656546,19174149,18775313,16807242,18656546,18775313,21914798,21896481,19174149,21896481,19174149,21914798 0006,0071,0018,0004,0004,0004,0096,0007,0004,0004,0096,0096,0018,0096 LC UBXN2A UBXN6 26186194 0004 HT TRIM25 UBXN6 22939629 0401 HT FAM104A UBXN6 26186194 0004 HT VPS39 UBXN6 22939629 0401 HT XPO6 UBXN6 22939629 0401 HT ASPSCR1 UBXN6 22337587,26186194,26389662 0004,0004,0004 LC,HT UBXN6 VCPKMT 26186194,23349634 0004,0004 HT,LC UBXN6 ZC3H7B 22939629 0401 HT UBXN6 HEL-S-70 22350894,22337587,18775313,26475856,23383273,16807242,26186194,21914798,19174149,19275885,21896481,26389662,19174149,21914798,21896481,19174149 0004,0004,0004,0096,0004,0004,0004,0004,0018,0096,0004,0004,0096,0096,0096,0004 LC,HT POR UBXN6 26186194 0004 HT UBXN2A UBXN6 26186194 0004 HT TRIM25 UBXN6 22939629 0401 HT FAM104A UBXN6 26186194 0004 HT VPS39 UBXN6 22939629 0401 HT XPO6 UBXN6 22939629 0401 HT ASPSCR1 UBXN6 26186194 0004 HT UBXN6 VCPKMT 26186194 0004 HT UBXN6 ZC3H7B 22939629 0401 HT UBXN6 HEL-S-70 26186194 0004 HT POR UBXN6 26389662 0004 LC VCP UBXN6 18656546,18656546,18656546,19174149,18775313,16807242,18656546,18775313,21914798,21896481,19174149,21896481,19174149,21914798 0006,0071,0018,0004,0004,0004,0096,0007,0004,0004,0096,0096,0018,0096 LC ASPSCR1 UBXN6 22337587,26389662 0004,0004 LC UBXN6 VCPKMT 23349634 0004 LC UBXN6 HEL-S-70 22350894,22337587,18775313,26475856,23383273,16807242,21914798,19174149,19275885,21896481,26389662,19174149,21914798,21896481,19174149 0004,0004,0004,0096,0004,0004,0004,0018,0096,0004,0004,0096,0096,0096,0004 LC UBC UBXN6 17623298 0401 LC MAGEA4 UBXN6 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT GSK3B UBXN6 21900206 0018 HT VCP UBXN6 18656546,18656546,18656546,19174149,18656546,19174149,19174149 0006,0071,0018,0004,0096,0096,0018 LC PSMD2 UBXN6 18656546,18656546,18656546 0401,0004,0096 LC TRIM25 UBXN6 22939629 0401 LC VPS39 UBXN6 22939629 0401 LC XPO6 UBXN6 22939629 0401 LC UBXN6 SMURF1 20804422 0415 LC UBXN6 TRIM39 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBXN6 NLGN3 25464930 0018 LC UBXN6 ZC3H7B 22939629 0401 LC UBXN6 HEL-S-70 25078495,18656546,19174149,19174149,19174149 0018,0018,0018,0096,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCE1 Q9BZV1 MOV10 UBXN6 0.126 22658674 Q9HCE7 Q9BZV1 SMURF1 UBXN6 0.183 20804422 Q9NZ94 Q9BZV1 NLGN3 UBXN6 0.183 25464930 Q9BZV1 Q62925 UBXN6 MAP3K1 0.033 25260751 Q9BZV1 O95817 UBXN6 BAG3 0.126 23824909 Q9HCM9 Q9BZV1 TRIM39 UBXN6 0.583 25416956,unassigned1304 Q9BZV1 Q96CS7 UBXN6 PLEKHB2 0.236 unassigned1304 Q9BZV1 Q14CS0 UBXN6 UBXN2B 0.236 unassigned1304 Q9BZV1 P16435 UBXN6 POR 0.236 26389662,26186194 Q9BZV1 Q92567 UBXN6 FAM168A 0.236 unassigned1304 Q9BZV1 Q15038 UBXN6 DAZAP2 0.236 unassigned1304 Q9BZV1 Q96JH7 UBXN6 VCPIP1 0.236 18775313 Q9BZV1 Q03135 UBXN6 CAV1 0.309 23335559 Q9BZV1 Q5VVQ6 UBXN6 YOD1 0.236 unassigned1304 Q9BZV1 Q1RN33 UBXN6 MAGEA4 {ECO:0000313|EMBL:AAY27261.1} 0.332 25416956 Q9BZV1 Q13200 UBXN6 PSMD2 0.523 18656546 Q9BZV1 Q9BZE9 UBXN6 ASPSCR1 0.396 22337587,26186194,26389662 Q9BZV1 P55072 UBXN6 VCP 0.997 22337587,16807242,26475856,26186194,26389662,21914798,22350894,19174149,25078495,18775313,23383273,21896481,19275885 Q9BZV1 Q92575 UBXN6 UBXN4 0.126 26389662 Q9BZV1 Q92890 UBXN6 UFD1L 0.309 19275885 Q9BZV1 Q96LJ8 UBXN6 UBXN10 0.332 unassigned1304,26389662 Q9BZV1 O14654 UBXN6 IRS4 0.21 22337587 Q9BZV1 O75955 UBXN6 FLOT1 0.21 22337587 Q9BZV1 P05067 UBXN6 APP 0.183 21832049 Q9BZV1 P05187 UBXN6 ALPP 0.126 18775313 Q9BZV1 P0DMV8 UBXN6 HSPA1A 0.21 22337587 Q9BZV1 P0DMV9 UBXN6 HSPA1B {ECO:0000312|HGNC:HGNC:5233} 0.21 22337587 Q9BZV1 P10398 UBXN6 ARAF 0.126 26389662 Q9BZV1 P23396 UBXN6 RPS3 0.21 22337587 Q9BZV1 P27824 UBXN6 CANX 0.21 22337587 Q9BZV1 P49257 UBXN6 LMAN1 0.21 22337587 Q9BZV1 P49841 UBXN6 GSK3B 0.332 21900206 Q9BZV1 P50990 UBXN6 CCT8 0.21 22337587 Q9BZV1 P53621 UBXN6 COPA 0.21 22337587 Q9BZV1 P68543 UBXN6 UBXN2A 0.332 unassigned1304,26186194 Q9BZV1 P78527 UBXN6 PRKDC 0.21 22337587 Q9BZV1 Q00839 UBXN6 HNRNPU 0.21 22337587 Q9BZV1 Q03001 UBXN6 DST 0.21 22337587 Q9BZV1 Q05639 UBXN6 EEF1A2 0.21 22337587 Q9BZV1 Q562R1 UBXN6 ACTBL2 0.126 26389662 Q9BZV1 Q8NI22 UBXN6 MCFD2 0.21 22337587 Q9BZV1 Q8TAT6 UBXN6 NPLOC4 0.21 22337587 Q9BZV1 Q969W3 UBXN6 FAM104A 0.126 26186194 Q9BZV1 Q96CS3 UBXN6 FAF2 0.21 22337587 Q9BZV1 Q96JC1 UBXN6 VPS39 0.081 22939629 Q9BZV1 Q96QU8 UBXN6 XPO6 0.081 22939629 Q9BZV1 Q9BQE3 UBXN6 TUBA1C 0.21 22337587 Q9BZV1 Q9BUF5 UBXN6 TUBB6 0.21 22337587 Q9BZV1 Q9BUN8 UBXN6 DERL1 0.309 19275885 Q9H867 Q9BZV1 VCPKMT UBXN6 0.236 23349634,26186194 Q9NYU2 Q9BZV1 UGGT1 UBXN6 0.21 22337587 Q9UGR2 Q9BZV1 ZC3H7B UBXN6 0.081 22939629 Q9UHB6 Q9BZV1 LIMA1 UBXN6 0.21 22337587 Q9UHD8 Q9BZV1 SEPT9 UBXN6 0.21 22337587 Q9UNZ2 Q9BZV1 NSFL1C UBXN6 0.126 26389662 Q9Y230 Q9BZV1 RUVBL2 UBXN6 0.21 22337587 Q9Y263 Q9BZV1 PLAA UBXN6 0.126 18775313 Q9Y265 Q9BZV1 RUVBL1 UBXN6 0.21 22337587 Q9UBU9 Q9BZV1 NXF1 UBXN6 0.126 22658674 Q9UNN5 Q9BZV1 FAF1 UBXN6 0.126 26389662 Q9BZV1 Q14258 UBXN6 TRIM25 0.081 22939629 Q9BZV1 P43358 UBXN6 MAGEA4 0.376 unassigned1304,25416956 Q9BZV1 Q15717 UBXN6 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 IRS4 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database RNMT UBXN6 MI:0362 inference MI:0461 interaction database EIF4EBP3 UBXN6 MI:0362 inference MI:0461 interaction database FLOT1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database BAG3 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database APP UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database ALPP UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database UBC UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1A UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database ARAF UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database POR UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database RPS3 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database CANX UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database SPR UBXN6 MI:0362 inference MI:0461 interaction database MAGEA4 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database LMAN1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database GSK3B UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database CCT8 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database COPA UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database VCP UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database UBXN2A UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database PRKDC UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database HNRNPU UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database DST UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database CAV1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database EEF1A2 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database PSMD2 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 UBXN6 MI:0362 inference MI:0461 interaction database FZD5 UBXN6 MI:0362 inference MI:0461 interaction database EIF4EBP1 UBXN6 MI:0362 inference MI:0461 interaction database EIF4EBP2 UBXN6 MI:0362 inference MI:0461 interaction database UBXN2B UBXN6 MI:0362 inference MI:0461 interaction database HERPUD1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database ACTBL2 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database SYVN1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database MCFD2 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database NPLOC4 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database UBXN4 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database UFD1L UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database FAM104A UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database FAF2 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database VCPIP1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database UBXN10 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database TUBA1C UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database TUBB6 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database DERL1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database ASPSCR1 UBXN6 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 FZD8 MI:0362 inference MI:0461 interaction database UBXN6 VCPKMT MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 TRIM39 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 UGGT1 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 LIMA1 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 SEPT9 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 FAF1 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 NSFL1C MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 RUVBL2 MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 PLAA MI:0045 experimental interaction detection MI:0461 interaction database UBXN6 RUVBL1 MI:0045 experimental interaction detection MI:0461 interaction database