PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SKIL ING2 18334480 biogrid exp GP GP G G GP GP G G GP G GP GP GP G G GP GP G G G GP GP GP GP GP G GP GP APP ING2 21244100,21832049 innatedb,biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP PRMT5 ING2 22689669 biogrid exp GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP FOXK1 ING2 25609649 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP SPP1 ING2 20676127 intact exp G GP G G GP G G G GP G GP G GP GP G G G GP GP G GP G GP GP G GP COPS2 ING2 17929852 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP CSNK1A1 ING2 19888210 i2d exp G G G G G G G G G G G G G G G G G G GP G G G G G G G G G DVL1 ING2 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP HIST3H3 ING2 20953165,22595675 biogrid exp P P P P P P P P P P P P P P P P P P P P P P UBC ING2 20621832 mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP BRMS1L ING2 16387653 biogrid exp GP GP G G G GP G GP G G GP G GP G G G GP G G G G G G G G G GP GP ACTL6A ING2 16387653 biogrid exp GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 AXIN2 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP WDR5 ING2 22689669 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G FOXK2 ING2 25609649 intact exp GP GP G G GP GP G GP GP G GP GP G G G GP GP G GP G GP GP G GP GP G GP GP SUMO1 ING2 20676127 i2d,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP TMEM71 ING2 20676127 intact exp P G G P GP GP P P GP GP G P P P P P P G P P H3F3A, H3F3B ING2 20953165 mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 ING2 17884155 intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 SMURF1 15761153,20621832 hprd,biogrid,i2d,mint,intact exp, ortho G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G GP G GP HDAC2 ING2 16387653, 25402006 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP RBBP7 ING2 16387653,26186194, 25402006 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP PCNA ING2 19730436, 25402006 biogrid,mint,intact exp, ortho, pred GP GP G G GP G G G GP G GP G G GP G GP G G GP G GP GP GP G GP GP GP GP SMARCC1 ING2 16387653, 25402006 biogrid exp, ortho, pred GP G G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G G GP GP GP GP TP53 ING2 16024799,16782091, 25402006 biogrid,mint,intact exp, ortho, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP SMARCB1 ING2 16387653, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ARID4A ING2 16387653, 25402006, 21836163 biogrid exp, pred G P G GP G P G P GP G G P GP G P G P G G GP GP G G P SMAD2 ING2 18334480, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP SAP30 ING2 16387653,26496610, 25402006, 21836163 biogrid,intact exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G P GP G G GP G GP GP EP300 ING2 16782091,16024799, 25402006 hprd,biogrid,mint,intact,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP HDAC1 ING2 16728974,16387653,23752268,18193082, 25402006 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP ARID4B ING2 16387653, 25402006 biogrid exp, pred GP GP G G G GP G G GP G GP G G GP G G GP G GP G GP GP G G G G GP GP SMARCC2 ING2 16387653, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 SMURF2 15761153, 25402006 hprd,i2d,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SAP130 ING2 16387653, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G SIRT1 ING2 18193082, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 ING2 16782091, 25402006 hprd exp, pred P P P P P P P P P P P P P P P P P P P P P P SIN3A ING2 16728974,16387653,20676127, 25402006, 21836163 biogrid,i2d,intact exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP SMAD1 ING2 15761153, 25402006 hprd,i2d,bci exp, pred G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP RBBP4 ING2 16387653, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 SUDS3 16387653, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP KLF11 ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G ING2 DNMT3B 25402006 pred GP P G G GP GP G GP P GP GP GP P G GP GP GP GP G GP P GP GP GP GP GP GP NFKB1 ING2 25402006 pred GP G G G GP G G G GP G G G GP GP G GP G G G G GP GP GP G GP GP G GP RUNX1T1 ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G YY1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP OGT ING2 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP MNAT1 ING2 25402006 pred GP GP G P GP G G GP G GP GP GP G GP GP G P G P GP GP G GP G GP P ING2 MBD2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP CHAF1B ING2 25402006 pred P P P GP G P P GP HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J ING2 25402006 pred P GP G GP P GP P P P P P P P P P P GP GP GP P GP P P VDR ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G KAT5 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP AR ING2 25402006 pred GP G G G G G G G G G G G G G G G G G G G G G G G GP ESR1 ING2 25402006 pred GP G G G G G G G G G G G G G G G G G G G G G G G G G G G HABP2 ING2 21836163 pred G GP G G G G G G GP G GP GP GP G G GP G G G G G GP G G GP GP GP SIN3B ING2 25402006 pred GP GP G G G GP G GP GP G GP G GP G G G GP G GP G GP GP G G G G GP GP AEBP2 ING2 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP BCL6 ING2 25402006 pred G G G G GP G G G G G G G G GP G G G G G G GP G G G G GP G G BCL3 ING2 25402006 pred G G G GP G GP GP G G G GP G GP G G GP G G G GP G 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GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP ATR ING2 25402006 pred G GP G G G GP G GP GP G GP GP GP G G G GP G GP G GP G G G G G G GP CTBP1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP TAL1 ING2 25402006, 21836163 pred G G G G GP GP G G G G G G G G G G GP G G G G G G G G G G MAML1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP PIAS4 ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G TCF3 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP SMARCA4 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP CHFR ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G GTF2H1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP E4F1 ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CTNNB1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP ING2 SATB2 25402006 pred G G G GP GP GP G GP G G G CREBBP ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP CHEK1 ING2 25402006 pred G G G GP ING2 ASH2L 25402006 pred GP GP G G GP GP G GP GP G GP G G G G GP GP GP GP G GP GP G G GP G GP GP BLM ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP HCFC1 ING2 25402006 pred GP GP G G GP GP G GP G G GP GP GP G G G GP G G G G GP GP GP G G GP GP ING2 DNMT3A 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GLI1 ING2 25402006 pred GP G G G P G G GP P P P G GP GP GP P P G P GP GP GP MAPK9 ING2 25402006 pred G GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ZP3 ING2 21836163 pred P P P P P P P P P P P P P P P P ETS1 ING2 25402006 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP G G HR ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PML ING2 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP E2F5 ING2 25402006 pred G G G G G G G G G MDM2 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 CDYL 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP RELA ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 RCOR1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP HIF1A ING2 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP GP GP GP ING5 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP TP53INP1 ING2 25402006 pred GP GP G G G GP G G GP G GP G GP G G G GP G GP G GP GP GP G G G GP G PIAS1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP WT1 ING2 25402006 pred G P GP P GP P P P GP P GP P P P G P GP MAF ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP BRCA1 ING2 25402006 pred P P G GP P P P P P P P GP P P P P P P P P P P GP ING2 NR2E3 25402006 pred MECP2 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP CSNK2A1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP BAP18 ING2 25402006 pred P P P P P P P P P P P P P P P P P P P P P P ING2 MBD1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP RBL2 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP SMAD7 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P HNRNPUL1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP CREB1 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP MTA1 ING2 25402006 pred G GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP G GP G GP GP WHSC1 ING2 25402006 pred P GP G G GP GP G GP GP G P P GP GP GP GP G GP G GP GP GP GP GP P GP GP SMAD4 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP SUV39H1 ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ETS2 ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G SMARCA2 ING2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP ING2 APPL1 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP GATA4 ING2 25402006 pred P P P P GP P P GP P P GP P GP GP GP P P P GP P GP GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P38429 Q9H160 affinity chromatography technology 16728974 physical association X 2 P0CG48 Q9H160 affinity chromatography technology 24821572 physical association X 2 P0CG48 Q9H160 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q9H160 affinity chromatography technology 20621832 physical association X 2 Q92922 Q9H160 affinity chromatography technology 16387653 physical association X 2 Q9H160 P05067-7 pull down 21832049 direct interaction X 2 Q9H160 Q16695 pull down 20953165 direct interaction X 2 Q9H160 Q16695 unspecified method 22595675 direct interaction X 2 Q9H160 B4DV00 biochemical 22689669 colocalization X 2 Q9H160 Q9H7L9 affinity chromatography technology 16387653 physical association X 2 Q9H160 affinity chromatography technology 16387653 physical association X 2 Q9H160 A0A024R3R1 affinity chromatography technology 16387653 physical association X 2 Q9H160 affinity chromatography technology 16387653 physical association X 2 Q9H160 O75446 affinity chromatography technology 16387653 physical association X 2 Q9H160 P61830 affinity chromatography technology 16728974 physical association X 2 Q9H160 P61830 affinity chromatography technology 16728974 physical association X 2 Q9H160 P61830 affinity chromatography technology 16728974 physical association X 2 Q9H160 P61830 affinity chromatography technology 16728974 physical association X 2 Q9H160 P12757-5 affinity chromatography technology 18334480 physical association X 2 Q9H160 B0QZ35 affinity chromatography technology 18193082 physical association X 2 Q9H160 enzymatic study 20621832 direct interaction X 2 Q9H160 pull down 20621832 direct interaction X 2 Q9H160 affinity chromatography technology 20621832 physical association X 2 Q9H160 affinity chromatography technology 20621832 physical association X 2 Q09472 Q9H160 affinity chromatography technology 16782091 physical association X 2 Q92769 Q9H160 affinity chromatography technology 16387653 physical association X 2 P61201-2 Q9H160 affinity chromatography technology 17929852 physical association X 2 P61201-2 Q9H160 pull down 17929852 direct interaction X 2 P12004 Q9H160 affinity chromatography technology 19730436 physical association X 2 P61964 Q9H160 affinity chromatography technology 22689669 physical association X 2 Q9H160 Q96ST3 affinity chromatography technology 16387653 physical association X 2 Q9H160 Q16576 affinity chromatography technology 16387653 physical association X 2 Q9H160 Q09028-4 affinity chromatography technology 16387653 physical association X 2 Q9H160 Q5PSV4 affinity chromatography technology 16387653 physical association X 2 Q9H160 Q96ST3 affinity chromatography technology 16387653 physical association X 2 Q9H160 Q16576 affinity chromatography technology 16387653 physical association X 2 Q9H160 Q09028-4 affinity chromatography technology 16387653 physical association X 2 Q9H160 affinity chromatography technology 16387653 physical association X 2 Q9H160 O96019-2 affinity chromatography technology 16387653 physical association X 2 Q9H160 Q9H836 affinity chromatography technology 16387653 physical association X 2 Q9H160 Q96ST3 affinity chromatography technology 16728974 physical association X 2 Q9H160 P04637-7 affinity chromatography technology 16024799 physical association X 2 Q9H160 Q15796-2 affinity chromatography technology 18334480 physical association X 2 Q9H160 A0A024R3Z2 pull down 20676127 direct interaction X 2 Q13547 Q9H160 affinity chromatography technology 23752268 physical association X 2 Q13547 Q9H160 affinity chromatography technology 16387653 physical association X 2 Q13547 Q9H160 affinity chromatography technology 16387653 physical association X 2 Q13547 Q9H160 affinity chromatography technology 16728974 physical association X 2 Q13547 Q9H160 affinity chromatography technology 18193082 physical association X 2 Q9H160 mass spectrometry studies of complexes 16387653 association C 12 Q9H160 affinity chromatography technology 16387653 association C 12 Q9H160 in vivo 16782091 - C 3 Q9H160 in vivo 16782091 - C 3 Q9H160 in vivo 16782091 - C 3 B2R4R0 Q9H160 in vivo 16782091 - X 2 B2R4R0 Q9H160 in vivo 16782091 - X 2 Q09472 Q9H160 in vitro 16024799,16782091 - X 2 Q09472 Q9H160 in vivo 16024799,16782091 - X 2 Q09472 Q9H160 in vitro 16024799,16782091 - X 2 Q09472 Q9H160 in vivo 16024799,16782091 - X 2 Q15797 Q9H160 in vivo 15761153 - X 2 Q15797 Q9H160 in vivo 15761153 - X 2 Q9HAU4 Q9H160 in vivo 15761153 - X 2 Q9HAU4 Q9H160 in vivo 15761153 - X 2 Q9H160 Q9HCE7-2 in vivo 15761153 - X 2 Q9H160 Q9HCE7-2 in vivo 15761153 - X 2 Q9H160 anti tag coimmunoprecipitation 23752268 association C 91 P0CG48 Q9H160 anti tag coimmunoprecipitation 20621832 physical association X 2 Q09472 Q9H160 anti bait coimmunoprecipitation 16782091 physical association X 2 B2R4P9 Q9H160 pull down 20953165 physical association X 2 Q9HCE7 Q9H160 anti bait coimmunoprecipitation 20621832 physical association X 2 P12004 Q9H160 anti bait coimmunoprecipitation 19730436 physical association X 2 P12004 Q9H160 anti bait coimmunoprecipitation 19730436 physical association X 2 P12004 Q9H160 pull down 19730436 direct interaction X 2 Q9H160 K7PPA8 anti bait coimmunoprecipitation 16782091 physical association X 2 Q9H160 Q9HCE7-2 anti tag coimmunoprecipitation 20621832 physical association X 2 Q9H160 Q9HCE7-2 anti tag coimmunoprecipitation 20621832 physical association X 2 Q9H160 Q9HCE7-2 pull down 20621832 direct interaction X 2 Q9H160 A0A024R3Z2 pull down 20676127 physical association X 2 Q9H160 Q96ST3 anti bait coimmunoprecipitation 20676127 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SMARCC1 ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118414 prey bait COPS2 ING2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17929852 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_137013|BIOGRID_137011 prey|prey bait|bait SKIL ING2 MI:0004(affinity chromatography technology) 18334480 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_134523 prey bait BRMS1L ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118407 prey bait SMARCC2 ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118413 prey bait ACTL6A ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118415 prey bait NRF1 ING2 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295740 bait prey SIN3A ING2 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16387653,16728974,20676127 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_108915|BIOGRID_118408|BIOGRID_119161|BIOGRID_118398 bait|prey|prey|prey prey|bait|bait|bait SAP30 ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118410 prey bait ING2 SMURF1 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0007(anti tag coimmunoprecipitation)|MI:0415(enzymatic study)|MI:0493(in vivo)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15761153,20621832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint) BIOGRID_153100|BIOGRID_153102|BIOGRID_153104|UniProt_109570|BIOGRID_153103|HPRD_17768|MINT_45963|MINT_45964|MINT_45965|MINT_76586|MINT_76584|UniProt_109566|MINT_76587|MINT_76588|UniProt_109568|UniProt_109567|MINT_45962 prey|bait|bait|bait|prey|-|prey|bait|bait|prey|bait|bait|bait|bait|bait|prey|bait bait|prey|prey|prey|bait|-|bait|prey|prey|bait|prey|prey|prey|prey|prey|bait|prey ING2 SMURF2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17769 - - ING2 SUDS3 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118401 bait prey HDAC2 ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118400 prey bait SMAD1 ING2 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17767 - - RBBP7 ING2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_118402|BIOGRID_118411 prey|prey bait|bait HIST1H4A ING2 MI:0493(in vivo) 16782091 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_31634 - - UBC ING2 MI:0415(enzymatic study)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 20621832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact)|MI:0471(mint) BIOGRID_153101|MINT_76583|UniProt_109565|MINT_45961 prey|prey|prey|prey bait|bait|bait|bait APP ING2 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228023 prey bait ARID4A ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118404 prey bait HIST3H3 ING2 MI:0004(affinity chromatography technology) 20953165 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_259610 bait prey RBBP4 ING2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_118403|BIOGRID_118412 prey|prey bait|bait p53 ING2 MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 16024799,16782091 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint) HPRD_39771|MINT_81898|BIOGRID_132917|UniProt_86967|MINT_49687 -|null|bait|null|null -|prey|prey|prey|prey SMARCB1 ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118416 prey bait SAP130 ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118406 prey bait PCNA ING2 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 10,19730436 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint) MINT_74338|MINT_44055|UniProt_103644|MINT_44054|UniProt_103645|MINT_74339|BIOGRID_127744|UniProt_103646|MINT_44056|MINT_74340 bait|bait|bait|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey|prey|prey|prey H3F3A ING2 MI:0096(pull down) 20953165 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_111687 bait prey EP300 ING2 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0493(in vivo) 16024799,16782091 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|- (biogrid)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_129758|MINT_81900|MINT_49689|UniProt_86969|HPRD_26626|HPRD_39771 bait|bait|bait|bait|-|- prey|prey|prey|prey|-|- SMAD2 ING2 MI:0004(affinity chromatography technology) 18334480 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_134524 prey bait SUMO1 ING2 MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down) 20676127 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_108916|BIOGRID_138556 bait|prey prey|bait SIRT1 ING2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18193082,22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0799(additive genetic interaction defined by inequality) (biogrid)|(biogrid) BIOGRID_134852|BIOGRID_193223 bait|bait prey|prey ARID4B ING2 MI:0004(affinity chromatography technology) 16387653 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118405 prey bait HDAC1 ING2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 16387653,16728974,18193082,23752268 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_118409|BIOGRID_280519|BIOGRID_134850|BIOGRID_118399|BIOGRID_119160|UniProt_131412 prey|bait|bait|prey|prey|bait bait|prey|prey|bait|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality SAP30 ING2 26496610,16387653,26496610 0007,0004,0004 HT,LC TP53 ING2 16782091,16024799 0006,0004 LC APP ING2 21832049,21244100 0096,0096 LC FOXK1 ING2 25609649,25609649 0676,0004 HT FOXK2 ING2 25609649,25609649 0676,0004 HT HDAC1 ING2 23752268,23752268,18193082,16387653,16728974 0007,0004,0004,0004,0004 LC RBBP7 ING2 16387653,26186194 0004,0004 LC,HT SIN3A ING2 20676127,16728974,16387653 0006,0004,0004 LC SAP30 ING2 26496610,26496610 0007,0004 HT FOXK1 ING2 25609649,25609649 0676,0004 HT FOXK2 ING2 25609649,25609649 0676,0004 HT RBBP7 ING2 26186194 0004 HT SAP30 ING2 16387653 0004 LC TP53 ING2 16782091,16024799 0006,0004 LC APP ING2 21832049,21244100 0096,0096 LC HDAC1 ING2 23752268,23752268,18193082,16387653,16728974 0007,0004,0004,0004,0004 LC RBBP7 ING2 16387653 0004 LC SIN3A ING2 20676127,16728974,16387653 0006,0004,0004 LC PRMT5 ING2 22689669 0401 LC SMAD1 ING2 15761153 0019 HT ING2 SMURF2 15761153 0019 HT ING2 SMURF1 20621832,20621832,20621832,20621832,15761153,20621832 0096,0004,0007,0006,0019,0415 LC,HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H160 Q09472 ING2 EP300 0.376 16782091 Q9H160 O14744 ING2 PRMT5 0.126 22689669 Q9H160 P61830 ING2 HHT2 0.376 16728974 Q9H160 P61964 ING2 WDR5 0.21 22689669 Q9H9S0 Q9H160 NANOG ING2 0.126 26687479 Q9H160 Q8TAQ2 ING2 SMARCC2 0.126 16387653 Q9H160 Q5PSV4 ING2 BRMS1L 0.126 16387653 Q9H160 P12757 ING2 SKIL 0.21 18334480 Q9H160 Q4LE39 ING2 ARID4B 0.126 16387653 Q9H160 P04637 ING2 TP53 0.376 16782091,16024799 Q9H160 O75446 ING2 SAP30 0.332 26496610,16387653 Q9H160 O96019 ING2 ACTL6A 0.126 16387653 Q9H160 P12004 ING2 PCNA 0.659 19730436 Q9H160 P0CG48 ING2 UBC 0.21 20621832 Q9H160 P05067 ING2 APP 0.332 21244100,21832049 Q9H160 P29374 ING2 ARID4A 0.126 16387653 Q9H160 Q09028 ING2 RBBP4 0.126 16387653 Q9H160 P84243 ING2 H3F3B 0.21 20953165 Q9H160 P38429 ING2 SAP30 0.21 16728974 Q9H160 Q15796 ING2 SMAD2 0.21 18334480 Q9H160 Q12824 ING2 SMARCB1 0.126 16387653 Q9H160 Q9H0E3 ING2 SAP130 0.126 16387653 Q9H160 Q92769 ING2 HDAC2 0.126 16387653 Q9H160 Q92922 ING2 SMARCC1 0.126 16387653 Q9H7L9 Q9H160 SUDS3 ING2 0.126 16387653 Q9H160 Q16695 ING2 HIST3H3 0.523 22595675,20953165 Q9H160 P61201 ING2 COPS2 0.454 17929852 Q9H160 Q13547 ING2 HDAC1 0.583 18193082,23752268,16728974,16387653 Q9H160 Q96ST3 ING2 SIN3A 0.309 16728974,16387653 Q9H160 P85037 ING2 FOXK1 0.236 25609649 Q9H160 Q01167 ING2 FOXK2 0.236 25609649 Q9HCE7 Q9H160 SMURF1 ING2 0.899 20621832 Q9H160 Q96EB6 ING2 SIRT1 0.21 18193082 Q9H160 Q16576 ING2 RBBP7 0.236 16387653,26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PGRMC1 ING2 MI:0362 inference MI:0461 interaction database PGRMC2 ING2 MI:0362 inference MI:0461 interaction database SAP30 ING2 MI:0045 experimental interaction detection MI:0461 interaction database ACTL6A ING2 MI:0045 experimental interaction detection MI:0461 interaction database TP53 ING2 MI:0045 experimental interaction detection MI:0461 interaction database APP ING2 MI:0045 experimental interaction detection MI:0461 interaction database UBC ING2 MI:0045 experimental interaction detection MI:0461 interaction database SPP1 ING2 MI:0045 experimental interaction detection MI:0461 interaction database PCNA ING2 MI:0045 experimental interaction detection MI:0461 interaction database SKIL ING2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database POLR2A ING2 MI:0362 inference MI:0461 interaction database ARID4A ING2 MI:0045 experimental interaction detection MI:0461 interaction database ECHS1 ING2 MI:0362 inference MI:0461 interaction database PDIA3 ING2 MI:0362 inference MI:0461 interaction database RASSF2 ING2 MI:0362 inference MI:0461 interaction database COPS2 ING2 MI:0045 experimental interaction detection MI:0461 interaction database WDR5 ING2 MI:0045 experimental interaction detection MI:0461 interaction database RPS11 ING2 MI:0362 inference MI:0461 interaction database RPL39 ING2 MI:0362 inference MI:0461 interaction database SUMO1 ING2 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H3A ING2 MI:0362 inference MI:0461 interaction database SLC35B1 ING2 MI:0362 inference MI:0461 interaction database RPL19 ING2 MI:0362 inference MI:0461 interaction database H3F3A ING2 MI:0045 experimental interaction detection MI:0461 interaction database FOXK1 ING2 MI:0045 experimental interaction detection MI:0461 interaction database FOXK2 ING2 MI:0045 experimental interaction detection MI:0461 interaction database RBBP4 ING2 MI:0045 experimental interaction detection MI:0461 interaction database EP300 ING2 MI:0045 experimental interaction detection MI:0461 interaction database SMARCB1 ING2 MI:0045 experimental interaction detection MI:0461 interaction database HDAC1 ING2 MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 ING2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SMAD1 ING2 MI:0045 experimental interaction detection MI:0461 interaction database RBBP7 ING2 MI:0045 experimental interaction detection MI:0461 interaction database HIST3H3 ING2 MI:0045 experimental interaction detection MI:0461 interaction database ARID4B ING2 MI:0045 experimental interaction detection MI:0461 interaction database BRMS1L ING2 MI:0045 experimental interaction detection MI:0461 interaction database H3F3C ING2 MI:0362 inference MI:0461 interaction database TMEM71 ING2 MI:0045 experimental interaction detection MI:0461 interaction database GDPGP1 ING2 MI:0362 inference MI:0461 interaction database HIST2H3A ING2 MI:0362 inference MI:0461 interaction database SMARCC2 ING2 MI:0045 experimental interaction detection MI:0461 interaction database HDAC2 ING2 MI:0045 experimental interaction detection MI:0461 interaction database SMARCC1 ING2 MI:0045 experimental interaction detection MI:0461 interaction database SIRT1 ING2 MI:0045 experimental interaction detection MI:0461 interaction database RPL39L ING2 MI:0362 inference MI:0461 interaction database SCMH1 ING2 MI:0362 inference MI:0461 interaction database SIN3A ING2 MI:0045 experimental interaction detection MI:0461 interaction database SAP130 ING2 MI:0045 experimental interaction detection MI:0461 interaction database ING2 RASSF4 MI:0362 inference MI:0461 interaction database ING2 SUDS3 MI:0045 experimental interaction detection MI:0461 interaction database ING2 NANOG MI:0045 experimental interaction detection MI:0461 interaction database ING2 SMURF2 MI:0045 experimental interaction detection MI:0461 interaction database ING2 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database ING2 MED4 MI:0362 inference MI:0461 interaction database ING2 SCML2 MI:0362 inference MI:0461 interaction database ING2 PPME1 MI:0362 inference MI:0461 interaction database