PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KIT SOCS4 17997974 innatedb exp G G G G GP GP G G G G G GP G G G GP G G G G G G G G G G G SOCS4 SOCS4 25814554 intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G FRS3 SOCS4 25814554 biogrid,intact exp GP G G G GP G G G G G G G G G G G G G G G GP GP GP G G G GP G G LECT1 SOCS4 25814554 biogrid,intact exp GP G G G G GP G G GP G GP G GP G GP GP G G G GP GP GP GP GP GP GP G SOCS4 MDFIC 21988832 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP P G VWF SOCS4 21988832 biogrid,intact exp G G G G GP GP G G GP G G G G G G GP G G G G G G G G G G G G TCEB2 SOCS4 17997974,23990909 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNK2 SOCS4 25814554 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G MPP5 SOCS4 25814554 biogrid,intact exp GP G G G G GP G G GP G GP G GP GP G GP GP G G G G GP GP G GP G GP GP G TCEB1 SOCS4 17997974,23990909,16643902 innatedb,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS4 PIK3R3 25814554 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP G GP G GP GP GP GP G NR4A1 SOCS4 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS4 RBP7 25814554 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G P GP GP GP GP GP G GP G SOCS4 LDHAL6B 25814554 biogrid,intact exp P P P P P P P GP G JAK2 SOCS4 17997974 innatedb exp G GP G G GP GP G G GP G GP GP GP G P GP G P G GP G GP GP GP GP SOCS4 PINK1 25814554 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPRY1 SOCS4 21988832 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G PPAPDC2 SOCS4 25814554 biogrid exp GP GP G G G GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SOCS4 CUL5 21145461 biogrid exp, ortho GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G GRB2 SOCS4 25814554, 23023127 biogrid,intact exp, pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G EGFR SOCS4 16273093,17997974, 25402006 innatedb,biogrid,i2d exp, pred GP GP G GP G G GP G GP G G G G GP GP G G G GP GP G GP GP G GP GP G RAPGEF3 SOCS4 16082366 pred GP P G P GP G G GP G GP GP GP G P GP G G GP GP GP GP P GP GP P G RGL2 SOCS4 16082366 pred GP GP G G G GP G G GP G GP G G G G GP GP G G G G GP G GP GP G GP GP G SYK SOCS4 23023127 pred GP G G G GP GP G GP G GP G GP GP G GP GP G G G G G G GP GP GP GP G SOS2 SOCS4 16082366 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SOCS4 SPSB2 25402006 pred GP GP G G G GP G G P G GP G GP G GP GP G G G GP GP G GP GP GP GP G RAPGEF1 SOCS4 16082366 pred G GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP G GP GP GP GP GP G SOCS1 SOCS4 25402006, 23023127 pred GP GP P P G GP GP G GP GP G GP P G G G GP P GP P GP GP GP GP G GRAP2 SOCS4 23023127 pred P P P P P P P P P P P P P P SOCS4 SLA2 23023127 pred G G G G G G G G G G G G G G G G SOCS4 SPSB4 25402006 pred G NEDD9 SOCS4 23023127 pred GP GP G G GP GP G G GP GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SOCS6 SOCS4 23023127 pred GP GP G P GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP P GP GP G SOCS4 RAPGEFL1 16082366 pred G G GP P G P P P GP GP P P P P P KLHL24 SOCS4 23023127 pred G G G G G GP G G G G G G G G G GP GP G G G G G G G GP G G G G SOCS4 KLHL28 23023127 pred G G G G G G G G G G GP G G G G G G G G G GP G G G G G G G G SOCS4 IPP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS3 SOCS4 25402006, 23023127 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G G G GP G GP GP GP G GP GP G RALGPS2 SOCS4 16082366 pred GP GP G GP P G GP GP G P GP G GP P G GP P P GP GP GP GP VAV1 SOCS4 23023127 pred GP GP G GP GP G P G P G GP GP G GP GP G G G GP G GP P P GP GP GP G SHC4 SOCS4 23023127 pred G G G G G G G G G RASGRF2 SOCS4 16082366 pred GP GP G G GP GP G G GP G GP GP GP G GP GP G G G GP GP P GP GP GP GP GP G SOCS4 FEM1B 25402006 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G G G GP GP GP GP GP G GP GP G SOCS4 IRS2 21836163 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G KLHL40 SOCS4 23023127 pred GP G FER SOCS4 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G VAV2 SOCS4 23023127 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G G G GP GP GP GP GP GP GP G TNFAIP1 SOCS4 23023127 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G TYK2 SOCS4 21836163 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G G G GP GP GP GP GP GP GP GP G SOCS5 SOCS4 25402006, 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP G GP GP G RASGRP1 SOCS4 16082366 pred G G G G G G G G G G G G G G G G G G G EPOR SOCS4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOCS4 CSF3R 21836163 pred G G G G GP GP G G G G G G GP G G G GP G G GP G G G G G G GP G SOCS4 INPP5D 23023127 pred G GP G G GP GP G G G G GP G G GP G G GP G G G G G GP GP G GP G G G KLHL38 SOCS4 23023127 pred P P P P P P P P P P P P P P P P P P ABTB2 SOCS4 23023127 pred GP GP G G GP GP G G G G GP G GP G G GP GP G G G GP GP GP GP GP P GP GP G SOCS4 TNN 16082366 pred GP G G G G GP G G GP G P G GP G G GP GP G G G P P G GP GP GP GP P G GRB14 SOCS4 23023127 pred P GP P P G G GP GP G P GP P P G G GP P P GP P P GP SOCS4 KLHL14 23023127 pred P P G GP P P GP P GP P P P P P P P GP P P SH2D3C SOCS4 16082366 pred GP G G G GP G G G G G GP G G GP G G G G G GP G G G G GP GP GP G GRAP SOCS4 23023127 pred P P GP P GP GP G P G P P P P P GP P P BTBD17 SOCS4 23023127 pred P P P P P KLHL17 SOCS4 23023127 pred P G G G G G GP G P G GP G G GP G G G G GP GP G GP GP G SOCS4 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G IRS1 SOCS4 21836163 pred GP GP G P GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP P G SOCS4 RGL1 16082366 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G KLHL23 SOCS4 23023127 pred G G G G G P P G G G G P GP G G G KLHL18 SOCS4 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G G G G GP GP GP G GP GP G LRRC41 SOCS4 25402006 pred G G G G GP G G G GP G GP G GP GP G GP G G G G GP G G GP GP G GP GP G SOCS4 SHD 23023127 pred G G G G P G P G G G P P GRB10 SOCS4 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SHC1 SOCS4 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G RGL4 SOCS4 16082366 pred P G G P P P G P P P P P G P SH2B2 SOCS4 23023127 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G G G GP GP GP G GP GP GP GP G RASGEF1C SOCS4 16082366 pred P P G P GP P G P P P P GP G P P P P P P GP GHR SOCS4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB48 SOCS4 23023127 pred G GP G G GP P GP GP G G GP G G P G G P G GP P G GP G GP G SOCS4 KLHL8 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP GP GP GP GP G GP G G SOCS7 SOCS4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BCAR3 SOCS4 16082366 pred GP GP G P GP G G GP G GP G GP GP G GP GP G G GP GP GP GP GP G GP GP G KEAP1 SOCS4 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SOCS4 VAV3 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G IGFBP7 SOCS4 23023127 pred G G G G G G G G G G GP G G G G G G G G G G G G G G G G GP G SOS1 SOCS4 16082366 pred GP G G G GP G G G GP G GP G GP GP G GP G G G G GP GP GP GP GP GP GP G G ARHGEF6 SOCS4 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP G G G G G G G GP G GP G G PRLR SOCS4 21836163 pred G G G G G G G G G G G G G G G G G G G CRKL SOCS4 23023127 pred GP G G G GP GP G G GP G G G GP GP G GP GP G G G GP GP G G GP GP GP G G SOCS2 SOCS4 25402006, 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G RALGDS SOCS4 16082366 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SOCS4 BTBD7 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G ZAP70 SOCS4 23023127 pred G G GP G G G GP G G GP G NCK2 SOCS4 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G RASGRP2 SOCS4 16082366 pred G GP G G GP GP G GP G GP G GP GP G GP GP GP G P GP GP GP GP P G BCL6 SOCS4 23023127 pred G G G G GP G G G G G G G G GP G G G G G G GP G G G G GP G G G CBLB SOCS4 23023127 pred GP GP G G G GP G G GP G GP G GP GP G GP GP G G G GP GP G G GP GP GP GP G CRK SOCS4 23023127 pred GP G G G G G G G GP G GP G G G G GP G G G G GP GP GP GP GP G GP G G SOCS4 RAB40C 25402006 pred G G G G GP GP G G GP G GP G GP G G GP GP G G G G G G GP GP G GP GP G SOCS4 SPSB1 25402006 pred GP GP G G GP GP G G G G GP G GP G G G GP G G G GP GP G GP G GP GP G IL10RA SOCS4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SH2D1A SOCS4 23023127 pred G G SOCS4 MAPK8IP1 23023127 pred P P G P GP G P G P P P P GP G P P P P P P P GP CCDC85B SOCS4 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP G GP G GP GP G SOCS4 KLHL25 23023127 pred GP GP G G G GP G GP G GP G GP GP G GP GP G G G P GP GP GP GP GP GP GP G RASGEF1B SOCS4 16082366 pred P P P P G P P P P P P P P CUL2 SOCS4 25402006 pred GP GP G G G GP G G GP G GP G GP GP G G GP G G G GP GP GP G G G GP GP G SOCS4 CISH 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G SOCS4 MYNN 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP GP GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B VWF SOCS4 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_120071|BIOGRID_288669 unspecified role|prey unspecified role|bait SPRY1 SOCS4 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_120181|BIOGRID_288783 unspecified role|prey unspecified role|bait SOCS4 MDFIC MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_120189|BIOGRID_288797 unspecified role|prey unspecified role|bait NR4A1 SOCS4 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288668|UniProt_120070 bait|unspecified role prey|unspecified role TCEB1 SOCS4 MI:0114(x-ray crystallography)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 16643902,17997974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact) DIP_53783|MINT_49821|UniProt_85142|MINT_82040|UniProt_167600 -|prey|prey|prey|prey -|bait|bait|bait|bait NRF1 SOCS4 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296143 bait prey SOCS4 SOCS4 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 17997974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip)|MI:0465(dip) DIP_53784|DIP_53785|DIP_53786|DIP_53787|DIP_53788|DIP_53789|DIP_53791|DIP_53790|DIP_53793|DIP_53792 -|-|-|-|-|-|-|-|-|- -|-|-|-|-|-|-|-|-|- CUL5 SOCS4 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203656 bait prey EGFR SOCS4 MI:0686(unspecified method) 17997974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_197467 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TCEB1 SOCS4 23990909 0004 LC TCEB2 SOCS4 23990909 0004 LC SOCS4 CUL5 21145461 0004 HT SOCS4 CUL5 21145461 0004 HT TCEB1 SOCS4 23990909 0004 LC TCEB2 SOCS4 23990909 0004 LC FRS3 SOCS4 25814554,25814554,25814554,25814554 0729,0397,0018,0004 HT SPRY1 SOCS4 21988832 0018 HT LECT1 SOCS4 25814554,25814554,25814554 0397,0018,1356 HT VWF SOCS4 21988832 0018 HT NR4A1 SOCS4 21988832 0018 HT GRB2 SOCS4 25814554,25814554,25814554,25814554,25814554 0729,1356,0397,0018,0004 HT TNK2 SOCS4 25814554,25814554,25814554 0397,0018,1356 HT TCEB1 SOCS4 16643902,17997974 0397,0114 LC TCEB2 SOCS4 17997974 0114 LC Q6ZMM6 SOCS4 21988832 0018 HT PLPP6 SOCS4 25814554 0018 HT MPP5 SOCS4 25814554,25814554,25814554 0397,0018,1356 HT SOCS4 PIK3R3 25814554,25814554,25814554,25814554,25814554 0729,1356,0397,0018,0004 HT SOCS4 RBP7 25814554,25814554,25814554,25814554,25814554 0729,1356,0397,0018,0004 HT SOCS4 PINK1 25814554,25814554,25814554,25814554,25814554 0729,1356,0397,0018,0004 HT SOCS4 LDHAL6B 25814554,25814554,25814554 0397,0018,1356 HT SOCS4 MDFIC 21988832 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WXH5 Q8N3R9 SOCS4 MPP5 0.376 25814554 Q9P1T7 Q8WXH5 MDFIC SOCS4 0.332 21988832 Q8WXH5 Q8WW24 SOCS4 TEKT4 0.236 unassigned1304 Q8WXH5 O43559 SOCS4 FRS3 0.454 25814554 Q8WXH5 P04275 SOCS4 VWF 0.332 21988832 Q8WXH5 P62993 SOCS4 GRB2 0.523 25814554 Q92569 Q8WXH5 PIK3R3 SOCS4 0.523 25814554 Q96R05 Q8WXH5 RBP7 SOCS4 0.523 25814554 Q9BXM7 Q8WXH5 PINK1 SOCS4 0.523 25814554 Q8WXH5 P22736 SOCS4 NR4A1 0.332 21988832 Q93034 Q8WXH5 CUL5 SOCS4 0.126 21145461 Q8WXH5 O43609 SOCS4 SPRY1 0.332 21988832 Q8WXH5 P98083 SOCS4 SHC1 0.21 23990909 Q8WXH5 O75829 SOCS4 LECT1 0.376 25814554 Q8WXH5 P00533 SOCS4 EGFR 0.309 17997974 Q8WXH5 Q8IY26 SOCS4 PPAPDC2 0.183 25814554 Q8WXH5 Q15369 SOCS4 TCEB1 0.376 16643902,23990909 Q8WXH5 Q15370 SOCS4 TCEB2 0.21 23990909 Q9WTZ1 Q8WXH5 RNF7 SOCS4 0.21 23990909 Q9D5V5 Q8WXH5 CUL5 SOCS4 0.21 23990909 Q9BYZ2 Q8WXH5 LDHAL6B SOCS4 0.376 25814554 Q8WXH5 Q07912 SOCS4 TNK2 0.376 25814554

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 FRS3 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database SPRY1 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database LECT1 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database EGFR SOCS4 MI:0362 inference MI:0461 interaction database VWF SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database NR4A1 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database SHC1 SOCS4 MI:0362 inference MI:0461 interaction database GRB2 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database TNK2 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database TCEB1 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database TCEB2 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database PLPP6 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database MPP5 SOCS4 MI:0045 experimental interaction detection MI:0461 interaction database SOCS4 PIK3R3 MI:0045 experimental interaction detection MI:0461 interaction database SOCS4 CUL5 MI:0045 experimental interaction detection MI:0461 interaction database SOCS4 RBP7 MI:0045 experimental interaction detection MI:0461 interaction database SOCS4 PINK1 MI:0045 experimental interaction detection MI:0461 interaction database SOCS4 LDHAL6B MI:0045 experimental interaction detection MI:0461 interaction database SOCS4 MDFIC MI:0045 experimental interaction detection MI:0461 interaction database SOCS4 RNF7 MI:0362 inference MI:0461 interaction database