PTM - CPLM Gene Name UniProt ID Type Position Code PHF2; CENP-35; KIAA0662 O75151 Acetylation 720 K PHF2; CENP-35; KIAA0662 O75151 Ubiquitination 175 K PHF2; CENP-35; KIAA0662 O75151 Ubiquitination 427 K PHF2; CENP-35; KIAA0662 O75151 Ubiquitination 412 K

PTM - dbPAF Gene Name UniProt ID Position Type Species PHF2; CENP-35; KIAA0662 O75151 1051 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 1056 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 1058 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 1059 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 1064 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 162 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 33 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 455 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 458 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 459 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 474 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 479 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 493 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 496 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 534 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 537 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 539 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 541 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 612 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 625 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 638 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 640 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 654 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 655 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 677 Y Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 679 Y Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 681 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 705 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 730 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 733 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 734 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 738 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 743 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 745 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 757 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 771 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 788 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 791 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 853 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 86 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 877 Y Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 879 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 882 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 899 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 904 Y Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 905 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 907 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 925 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 929 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 932 T Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 942 S Homo sapiens(Human) PHF2; CENP-35; KIAA0662 O75151 954 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O75151 K720-ac Acetylation VLPTPVTkPKLDSAA O75151 K1072-ac Acetylation AAKGKRTkKGMATAk O75151 K1079-ac Acetylation kKGMATAkQRLGKIL O75151 K631-m2 Methylation KsPLAGNkDNKFSFs O75151 K642-m2 Methylation FSFsFsNkKLLGSKA O75151 S86-p Phosphorylation VkPVQNGsQLFIKEL O75151 S458-p Phosphorylation PEVNTVAssDEVCDG O75151 S459-p Phosphorylation EVNTVAssDEVCDGD O75151 S474-p Phosphorylation REKEEPPsPIEAtPP O75151 T479-p Phosphorylation PPsPIEAtPPQsLLE O75151 S483-p Phosphorylation IEAtPPQsLLEKVSK O75151 S534-p Phosphorylation GKKKGKKsREsAsPt O75151 S537-p Phosphorylation KGKKsREsAsPtIPN O75151 S539-p Phosphorylation KKsREsAsPtIPNLD O75151 T541-p Phosphorylation sREsAsPtIPNLDLL O75151 S612-p Phosphorylation YKNSKPDsLLKMEEE O75151 S625-p Phosphorylation EEQKLEKsPLAGNkD O75151 S638-p Phosphorylation kDNKFSFsFsNkKLL O75151 S640-p Phosphorylation NKFSFsFsNkKLLGS O75151 T654-p Phosphorylation SKALRPPtsPGVFGA O75151 S655-p Phosphorylation KALRPPtsPGVFGAL O75151 S681-p Phosphorylation RDEYEYVsDDGELKI O75151 S705-p Phosphorylation NAPKRDLsFLLDKKA O75151 S730-p Phosphorylation LDSAAYKsDDssDEG O75151 S733-p Phosphorylation AAYKsDDssDEGsLH O75151 S734-p Phosphorylation AYKsDDssDEGsLHI O75151 S738-p Phosphorylation DDssDEGsLHIDtDt O75151 T743-p Phosphorylation EGsLHIDtDtKPGRN O75151 T745-p Phosphorylation sLHIDtDtKPGRNAR O75151 S757-p Phosphorylation NARVKKEsGSSAAGI O75151 S771-p Phosphorylation ILDLLQAsEEVGALE O75151 S788-p Phosphorylation PSSQPPAsPSTQEAI O75151 S853-p Phosphorylation LKRAAKNsVDLDDYE O75151 S879-p Phosphorylation DSDYVYPsLEsDEDN O75151 S882-p Phosphorylation YVYPsLEsDEDNPIF O75151 S899-p Phosphorylation RSKKRKGsDDAPYsP O75151 S905-p Phosphorylation GsDDAPYsPtARVGP O75151 T907-p Phosphorylation DDAPYsPtARVGPSV O75151 T925-p Phosphorylation DRPVREGtRVAsIET O75151 S929-p Phosphorylation REGtRVAsIETGLAA O75151 S942-p Phosphorylation AAAAAKLsQQEEQKS O75151 S954-p Phosphorylation QKSKKKKsAKRKLTP O75151 S1056-p Phosphorylation FLTQRRPsAssPNNN O75151 S1058-p Phosphorylation TQRRPsAssPNNNtA O75151 S1059-p Phosphorylation QRRPsAssPNNNtAA O75151 T1064-p Phosphorylation AssPNNNtAAKGKRT O75151 K80-sm Sumoylation PGQAPDVkPVQNGsQ O75151 K1087-sm Sumoylation QRLGKILkIHRNGKL O75151 K175-ub Ubiquitination KDCKMKLkEFVDYYY O75151 K412-ub Ubiquitination AFRSWTKkQALAEHE O75151 K427-ub Ubiquitination DELPEHFkPSQLIKD

PTM - dbPTM UniProt ID Position Code Type Resources References O75151 539 S Phosphorylation Swiss-Prot 1010711 18669648 O75151 882 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 O75151 899 S Phosphorylation Swiss-Prot 1010711 18220336 O75151 1056 S Phosphorylation Swiss-Prot 1010711 21532585 O75151 458 S Phosphorylation PhosphoELM.10011 17081983 O75151 537 S Phosphorylation PhosphoELM.10011 18669648 O75151 539 S Phosphorylation PhosphoELM.10011 18669648 O75151 655 S Phosphorylation PhosphoELM.10011 18669648 O75151 879 S Phosphorylation PhosphoELM.10011 18669648 O75151 882 S Phosphorylation PhosphoELM.10011 18669648 O75151 899 S Phosphorylation PhosphoELM.10011 18220336 O75151 541 T Phosphorylation PhosphoELM.10011 18669648 O75151 175 K Ubiquitylation Phosphositeplus.1010730 21890473 O75151 427 K Ubiquitylation Phosphositeplus.1010730 21890473 O75151 1056 S Phosphorylation Phosphositeplus.1010730 21532585;22115753 O75151 1058 S Phosphorylation Phosphositeplus.1010730 20363803 O75151 1059 S Phosphorylation Phosphositeplus.1010730 22115753 O75151 474 S Phosphorylation Phosphositeplus.1010730 20068231;20363803;22115753 O75151 537 S Phosphorylation Phosphositeplus.1010730 19276368 O75151 539 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;20815410;21659604 O75151 625 S Phosphorylation Phosphositeplus.1010730 20068231;20363803;21406692 O75151 640 S Phosphorylation Phosphositeplus.1010730 19276368 O75151 681 S Phosphorylation Phosphositeplus.1010730 20363803;21659604 O75151 705 S Phosphorylation Phosphositeplus.1010730 20068231;21406692;22115753 O75151 730 S Phosphorylation Phosphositeplus.1010730 20363803 O75151 733 S Phosphorylation Phosphositeplus.1010730 20363803 O75151 734 S Phosphorylation Phosphositeplus.1010730 20363803 O75151 738 S Phosphorylation Phosphositeplus.1010730 20363803 O75151 757 S Phosphorylation Phosphositeplus.1010730 21532585 O75151 879 S Phosphorylation Phosphositeplus.1010730 19690332;21659604;22115753 O75151 882 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;19690332;20068231;20363803;21406692;21659604;22115753 O75151 899 S Phosphorylation Phosphositeplus.1010730 18220336;20164059;21406692;21532585 O75151 905 S Phosphorylation Phosphositeplus.1010730 20363803 O75151 954 S Phosphorylation Phosphositeplus.1010730 21532585 O75151 479 T Phosphorylation Phosphositeplus.1010730 20068231;20363803;22115753 O75151 541 T Phosphorylation Phosphositeplus.1010730 18669648 O75151 458 S Phosphorylation HPRD 9.0 17081983 O75151 459 S Phosphorylation HPRD 9.0 17081983 O75151 474 S Phosphorylation HPRD 9.0 18452278,20068231 O75151 537 S Phosphorylation HPRD 9.0 18669648,20068231 O75151 539 S Phosphorylation HPRD 9.0 18669648,20068231 O75151 625 S Phosphorylation HPRD 9.0 20068231 O75151 655 S Phosphorylation HPRD 9.0 17081983,18669648,20068231 O75151 681 S Phosphorylation HPRD 9.0 17081983,20068231 O75151 705 S Phosphorylation HPRD 9.0 20068231 O75151 879 S Phosphorylation HPRD 9.0 18669648 O75151 882 S Phosphorylation HPRD 9.0 17081983,19413330,18452278,18669648,20068231 O75151 899 S Phosphorylation HPRD 9.0 18452278 O75151 905 S Phosphorylation HPRD 9.0 17081983 O75151 1059 S Phosphorylation HPRD 9.0 20068231 O75151 162 T Phosphorylation HPRD 9.0 20068231 O75151 479 T Phosphorylation HPRD 9.0 18452278,20068231 O75151 541 T Phosphorylation HPRD 9.0 17081983,18669648 O75151 654 T Phosphorylation HPRD 9.0 17081983,20068231 O75151 677 Y Phosphorylation HPRD 9.0 17081983 O75151 904 Y Phosphorylation HPRD 9.0 17081983 O75151 458 S Phosphorylation SysPTM 1.1 17081983 O75151 459 S Phosphorylation SysPTM 1.1 17081983 O75151 539 S Phosphorylation SysPTM 1.1 18669648 O75151 541 T Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References PHF2 1059 S Phosphorylation 20068231 PHF2 1064 S Phosphorylation 20068231 PHF2 162 T Phosphorylation 20068231 PHF2 458 S Phosphorylation 17081983 PHF2 459 S Phosphorylation 17081983 PHF2 474 S Phosphorylation 18452278,20068231 PHF2 479 T Phosphorylation 18452278,20068231 PHF2 537 S Phosphorylation 18669648,20068231 PHF2 539 S Phosphorylation 18669648,20068231 PHF2 541 T Phosphorylation 17081983,18669648 PHF2 625 S Phosphorylation 20068231 PHF2 654 T Phosphorylation 17081983,20068231 PHF2 655 S Phosphorylation 17081983,18669648,20068231 PHF2 677 Y Phosphorylation 17081983 PHF2 681 S Phosphorylation 17081983,20068231 PHF2 705 S Phosphorylation 20068231 PHF2 879 S Phosphorylation 18669648 PHF2 882 S Phosphorylation 17081983,19413330,18452278,18669648,20068231 PHF2 899 S Phosphorylation 18452278 PHF2 904 Y Phosphorylation 17081983 PHF2 905 S Phosphorylation 17081983

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O75151 541 T 18669648 HTP Phosphorylation O75151 655 S 18669648 HTP Phosphorylation O75151 882 S 18669648 HTP Phosphorylation O75151 539 S 18669648 HTP Phosphorylation O75151 537 S 18669648 HTP Phosphorylation O75151 879 S 18669648 HTP Phosphorylation O75151 458 S 17081983 HTP Phosphorylation O75151 899 S 18220336 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O75151 474 Phosphoserine 20068231;24275569 O75151 479 Phosphothreonine 20068231 O75151 539 Phosphoserine 18669648;23186163 O75151 655 Phosphoserine 23186163 O75151 681 Phosphoserine 24275569 O75151 705 Phosphoserine 20068231;21406692;23186163 O75151 882 Phosphoserine 18669648;19690332;20068231;23186163;24275569 O75151 899 Phosphoserine 24275569 O75151 1056 Phosphoserine; by PKA 21532585

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type PHF2 IPI00260388 S 1064 RRPSASpSPNNNTA phosphorylation PHF2 IPI00260388 S 458 EVNTVApSSDEVCD phosphorylation PHF2 IPI00260388 S 655 ALRPPTpSPGVFGA phosphorylation PHF2 IPI00260388 S 681 DEYEYVpSDDGELK phosphorylation PHF2 IPI00260388 S 705 APKRDLpSFLLDKK phosphorylation PHF2 IPI00260388 S 899 SKKRKGpSDDAPYS phosphorylation PHF2 IPI00260388 T 654 KALRPPpTSPGVFG phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 5253 111272 - K Ubiquitination 21139048 5253 111272 - K Ubiquitination 21890473

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID PHF2 Homo sapiens (Human) 427; 175 "427,ELPEHFKPSQLIK; 175,DCKMKLKEFVDYY" 427:21890473; 175:21890473 PHF2 Homo sapiens (Human) 427; 175 "427,ELPEHFKPSQLIK; 175,DCKMKLKEFVDYY" 427:21890473; 175:21890473