PTM - CPLM Gene Name UniProt ID Type Position Code RYBP; DEDAF; YEAF1 Q8N488 Ubiquitination 208 K RYBP; DEDAF; YEAF1 Q8N488 Ubiquitination 119 K RYBP; DEDAF; YEAF1 Q8N488 Ubiquitination 136 K

PTM - dbPAF Gene Name UniProt ID Position Type Species RYBP; DEDAF; YEAF1 Q8N488 101 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 103 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 107 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 115 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 123 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 127 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 130 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 154 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 155 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 162 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 171 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 177 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 179 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 180 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 181 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 182 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 183 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 184 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 185 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 186 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 189 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 190 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 193 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 199 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 200 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 201 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 203 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 205 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 206 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 210 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 211 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 213 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 214 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 215 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 221 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 227 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 59 S Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 70 Y Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 72 T Homo sapiens(Human) RYBP; DEDAF; YEAF1 Q8N488 99 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8N488 K40-m1 Methylation RNSAEAFkCSICDVR Q8N488 S8-p Phosphorylation MTMGDKKsPtRPKRQ Q8N488 T10-p Phosphorylation MGDKKsPtRPKRQAK Q8N488 S59-p Phosphorylation TRKPRINsQLVAQQV Q8N488 Y70-p Phosphorylation AQQVAQQyAtPPPPK Q8N488 T72-p Phosphorylation QVAQQyAtPPPPKKE Q8N488 S99-p Phosphorylation PEKDKEIsPsVtKKN Q8N488 S101-p Phosphorylation KDKEIsPsVtKKNtN Q8N488 T103-p Phosphorylation KEIsPsVtKKNtNKK Q8N488 T107-p Phosphorylation PsVtKKNtNKKTKPK Q8N488 S115-p Phosphorylation NKKTKPKsDILkDPP Q8N488 S123-p Phosphorylation DILkDPPsEANsIQs Q8N488 S127-p Phosphorylation DPPsEANsIQsANAT Q8N488 S130-p Phosphorylation sEANsIQsANATTkT Q8N488 S154-p Phosphorylation RLKNVDRstAQQLAV Q8N488 T155-p Phosphorylation LKNVDRstAQQLAVt Q8N488 T162-p Phosphorylation tAQQLAVtVGNVTVI Q8N488 S179-p Phosphorylation DFKEKTRsSStSssT Q8N488 T182-p Phosphorylation EKTRsSStSssTVTs Q8N488 S184-p Phosphorylation TRsSStSssTVTssA Q8N488 S185-p Phosphorylation RsSStSssTVTssAG Q8N488 S189-p Phosphorylation tSssTVTssAGsEQQ Q8N488 S190-p Phosphorylation SssTVTssAGsEQQN Q8N488 S193-p Phosphorylation TVTssAGsEQQNQsS Q8N488 S199-p Phosphorylation GsEQQNQsSSGSEsT Q8N488 S205-p Phosphorylation QsSSGSEsTDKGSsR Q8N488 S211-p Phosphorylation EsTDKGSsRsstPKG Q8N488 S213-p Phosphorylation TDKGSsRsstPKGDM Q8N488 S214-p Phosphorylation DKGSsRsstPKGDMS Q8N488 T215-p Phosphorylation KGSsRsstPKGDMSA Q8N488 S227-p Phosphorylation MSAVNDEsF______ Q8N488 K119-ub Ubiquitination KPKsDILkDPPsEAN Q8N488 K136-ub Ubiquitination QsANATTkTSETNHT

PTM - dbPTM UniProt ID Position Code Type Resources References Q8N488 99 S Phosphorylation Swiss-Prot 1010711 19413330 Q8N488 127 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 Q8N488 130 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q8N488 227 S Phosphorylation Swiss-Prot 1010711 19690332 Q8N488 127 S Phosphorylation PhosphoELM.10011 18669648 Q8N488 130 S Phosphorylation PhosphoELM.10011 18669648 Q8N488 203 S Phosphorylation PhosphoELM.10011 18669648 Q8N488 215 T Phosphorylation PhosphoELM.10011 18669648 Q8N488 119 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q8N488 136 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8N488 123 S Phosphorylation Phosphositeplus.1010730 20363803 Q8N488 127 S Phosphorylation Phosphositeplus.1010730 19690332;20363803 Q8N488 130 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20363803 Q8N488 154 S Phosphorylation Phosphositeplus.1010730 20068231 Q8N488 214 S Phosphorylation Phosphositeplus.1010730 22115753 Q8N488 227 S Phosphorylation Phosphositeplus.1010730 19664995;19690332;20068231;20363803;21406692;22115753 Q8N488 99 S Phosphorylation Phosphositeplus.1010730 19664995;20068231;20363803;20815410;21406692 Q8N488 155 T Phosphorylation Phosphositeplus.1010730 20068231 Q8N488 162 T Phosphorylation Phosphositeplus.1010730 20068231 Q8N488 215 T Phosphorylation Phosphositeplus.1010730 22115753 Q8N488 99 S Phosphorylation HPRD 9.0 19413330,19664995,20068231 Q8N488 127 S Phosphorylation HPRD 9.0 18669648,19413330 Q8N488 130 S Phosphorylation HPRD 9.0 18669648 Q8N488 154 S Phosphorylation HPRD 9.0 20068231 Q8N488 203 S Phosphorylation HPRD 9.0 18669648 Q8N488 213 S Phosphorylation HPRD 9.0 20068231 Q8N488 214 S Phosphorylation HPRD 9.0 19651622,18452278 Q8N488 227 S Phosphorylation HPRD 9.0 19664995,20068231 Q8N488 155 T Phosphorylation HPRD 9.0 20068231 Q8N488 162 T Phosphorylation HPRD 9.0 20068231 Q8N488 171 T Phosphorylation HPRD 9.0 20068231 Q8N488 215 T Phosphorylation HPRD 9.0 18669648,19651622,18452278 Q8N488 127 S Phosphorylation SysPTM 1.1 18669648 Q8N488 130 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References RYBP 127 S Phosphorylation 18669648,19413330 RYBP 130 S Phosphorylation 18669648 RYBP 154 S Phosphorylation 20068231 RYBP 155 T Phosphorylation 20068231 RYBP 162 T Phosphorylation 20068231 RYBP 171 T Phosphorylation 20068231 RYBP 203 S Phosphorylation 18669648 RYBP 213 S Phosphorylation 20068231 RYBP 214 S Phosphorylation 19651622,18452278 RYBP 215 T Phosphorylation 18669648,19651622,18452278 RYBP 227 S Phosphorylation 19664995,20068231 RYBP 99 S Phosphorylation 19413330,19664995,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8N488 215 T 18669648 HTP Phosphorylation Q8N488 203 S 18669648 HTP Phosphorylation Q8N488 127 S 18669648 HTP Phosphorylation Q8N488 130 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8N488 99 Phosphoserine 20068231;21406692;23186163 Q8N488 123 Phosphoserine 23186163 Q8N488 127 Phosphoserine 19690332;23186163 Q8N488 130 Phosphoserine 18669648;19690332;23186163 Q8N488 227 Phosphoserine 21406692

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type RYBP IPI00296594 S 154 LKNVDRpSTAQQLA phosphorylation RYBP IPI00296594 S 227 SAVNDEpSF_____ phosphorylation RYBP IPI00296594 S 99 EKDKEIpSPSVTKK phosphorylation RYBP IPI00296594 T 155 KNVDRSpTAQQLAV phosphorylation RYBP IPI00296594 T 162 AQQLAVpTVGNVTV phosphorylation