PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ufd1l Foxp3 22922362 biogrid exp Ufd1l Vcp 22773186,22232657,17491009,12529442,10811609 biogrid,mint,intact,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Itpr1 Ufd1l 16103111 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Ufd1l 12411482 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Ngfr ortho G G G G G G G G G Sprtn Ufd1l ortho Ufd1l Skp2 ortho G G G G G G G G G G G G G Ufd1l Asns ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Nfkbia ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Ufd1l ortho G G G G G G G G G G G G G G G G G G G G Ppp2cb Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Armc1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Mapre1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Faf2 ortho P Ufd1l Anapc2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Pphln1 ortho Ufd1l Ube4b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hmox1 Ufd1l ortho G G G G G G G G G G G G G G G G G G G Ufd1l Rae1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Flnb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Papola ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Tiam2 ortho G G G G G G G G G G G G G G Ufd1l Mtmr12 ortho Ufd1l Dcun1d1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Faf1 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctsa Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Nudt6 ortho G G G G G G G G G G G G G Ufd1l Nsfl1c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gzmk Ufd1l ortho G G G Ufd1l Ubxn10 ortho G G G G G G Cap1 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Vcpip1 ortho Ufd1l Suz12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Rtcb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Psmg2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nub1 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Plaa Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Gars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dhx15 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Yod1 ortho Degs1 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Vimp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k1 Ufd1l ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Unc45a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23b Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Taf1c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Txlna ortho P Ptprf Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cfl1 Ufd1l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Mad2l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps33b Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Rps6kb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Aspscr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ldha Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l A2mp ortho P G G G G G G G G G G Ufd1l Ubxn7 ortho P Shfm1 Ufd1l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Ufd1l ortho P Ufd1l Stip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspb1 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Papolg ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Ttc27 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Erlin2 ortho P Ufd1l Sept8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l F13a1 ortho GP G G G G G G G G G G G G G G G G G G G G Tp53 Ufd1l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Sh3kbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Snx1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Ubxn6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrb2 Ufd1l ortho G G G G G G G G G Ufd1l Arpc5l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Amfr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Lrrk2 ortho GP G G G G G G G G G G G G G G G G G G G G Ufd1l Btrc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Sumo3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG5959, isoform CRA_a, Protein Kcnk16 Ufd1l ortho Ufd1l Uba2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Tmem62 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3ca Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Ezh2 ortho G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Huwe1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc5 Ufd1l ortho G G G G G G G G G G G G G G Ufd1l Chmp2a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Pdcd4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd7 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Ubxn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Dph5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Tcp11l1 ortho Cav1 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Psmd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Usp13 ortho G G G G G G Ufd1l Hbs1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Svip ortho Ufd1l Chm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Ufd1l ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P70362 Q53Z59 affinity chromatography technology 22922362 physical association X 2 P70362 Q9ES54 biochemical 22232657 association X 2 P70362 Q9ES54 x-ray crystallography 22232657 association X 2 P70362 enzymatic study 25260751 direct interaction X 2 P70362 P11881 affinity chromatography technology 16103111 physical association X 2 P70362 P0CG48 affinity chromatography technology 12411482 physical association X 2 P70362 P0CG50 pull down 12411482 direct interaction X 2 P70362 Q01853 pull down 17491009 direct interaction X 2 P70362 Q01853 affinity chromatography technology 10811609 physical association X 2 P70362 Q01853 affinity chromatography technology 12529442 physical association X 2 P70362 Q01853 affinity chromatography technology 12529442 physical association X 2 P70362 anti bait coimmunoprecipitation 16103111 association C 4 P70362 transmission electron microscopy 17202270 physical association C 4 P70362 pull down 22232657 physical association C 3 P70362 molecular sieving 22232657 physical association C 3 P70362 molecular sieving 17202270 physical association C 3 P70362 electron tomography 22232657 physical association C 3 P70362 transmission electron microscopy 17202270 physical association C 3 P70362 transmission electron microscopy 22232657 physical association C 3 P70362 Q9ES54 molecular sieving 17202270 direct interaction X 2 P70362 Q9ES54 molecular sieving 22232657 direct interaction X 2 P70362 Q9ES54 electron tomography 17202270 direct interaction X 2 P70362 Q9ES54 mass spectrometry studies of complexes 17202270 direct interaction X 2 P70362 Q9ES54 transmission electron microscopy 22232657 direct interaction X 2 P70362 Q9ES54 pull down 22232657 direct interaction X 2 P70362 Q9ES54 transmission electron microscopy 17202270 direct interaction X 2 P70362 pull down 22232657 physical association X 2 P70362 P46462 pull down 20691684 physical association X 2 P70362 Q01853 anti bait coimmunoprecipitation 22773186 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubc Ufd1l MI:0004(affinity chromatography technology) 12411482 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_322260 bait prey Itpr1 Ufd1l MI:0004(affinity chromatography technology) 16103111 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319863 bait prey Ufd1l Foxp3 MI:0004(affinity chromatography technology) 22922362 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324917 prey bait Ufd1l Vcp MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 10811609,12529442,17491009,22773186 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid) BIOGRID_328569|UniProt_175231|BIOGRID_324234|BIOGRID_328567|BIOGRID_327822 bait|bait|bait|prey|prey prey|prey|prey|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality UFD1L VCP 10811609,10811609,10811609,10811609 0004,0047,0405,0096 LC UBC UFD1L 12411482 0096 LC ITPR1 UFD1L 16103111 0004 LC UFD1L VCP 22232657,17491009,10811609,10811609,10811609,22773186,10811609,12529442 0096,0096,0004,0047,0405,0006,0096,0004 LC UFD1L FOXP3 22922362 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P70362 P11881 UFD1L ITPR1 0.21 16103111 Q9ES54 P70362 NPLOC4 UFD1L 0.454 22232657 Q01853 P70362 VCP UFD1L 0.731 12529442,10811609,22773186,17491009 Q99JB6 P70362 FOXP3 UFD1L 0.126 22922362 P70362 P46462 UFD1L VCP 0.21 20691684