PTM - CPLM Gene Name UniProt ID Type Position Code Sqstm1; A170; STAP Q64337 Ubiquitination 13 K Sqstm1; A170; STAP Q64337 Ubiquitination 141 K Sqstm1; A170; STAP Q64337 Ubiquitination 157 K Sqstm1; A170; STAP Q64337 Ubiquitination 165 K Sqstm1; A170; STAP Q64337 Ubiquitination 297 K Sqstm1; A170; STAP Q64337 Ubiquitination 314 K Sqstm1; A170; STAP Q64337 Ubiquitination 315 K Sqstm1; A170; STAP Q64337 Ubiquitination 422 K Sqstm1; A170; STAP Q64337 Ubiquitination 437 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Sqstm1; A170; STAP Q64337 148 Y Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 152 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 176 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 178 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 180 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 182 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 207 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 24 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 266 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 269 T Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 271 T Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 272 T Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 275 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 276 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 277 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 278 T Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 28 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 286 T Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 289 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 290 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 296 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 308 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 320 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 330 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 334 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 341 T Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 344 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 345 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 351 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 357 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 363 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 367 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 368 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 372 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 405 S Mus musculus(Mouse) Sqstm1; A170; STAP Q64337 409 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q64337 S24-p Phosphorylation TREIRRFsFCFsPEP Q64337 S28-p Phosphorylation RRFsFCFsPEPEAEA Q64337 Y148-p Phosphorylation kCSVCPDyDLCsVCE Q64337 S152-p Phosphorylation CPDyDLCsVCEGkGL Q64337 S178-p Phosphorylation PFGHLSDsFSHSRWL Q64337 S207-p Phosphorylation MGPPGNWsPRPPRAG Q64337 S249-p Phosphorylation ESVAAALsPLGIEVD Q64337 S266-p Phosphorylation VEHGGKRsRLtPttP Q64337 T269-p Phosphorylation GGKRsRLtPttPEss Q64337 T271-p Phosphorylation KRsRLtPttPEssst Q64337 T272-p Phosphorylation RsRLtPttPEssstG Q64337 S275-p Phosphorylation LtPttPEssstGTED Q64337 S276-p Phosphorylation tPttPEssstGTEDK Q64337 S277-p Phosphorylation PttPEssstGTEDKS Q64337 T278-p Phosphorylation ttPEssstGTEDKSN Q64337 T286-p Phosphorylation GTEDKSNtQPSSCSS Q64337 S296-p Phosphorylation SSCSSEVskPDGAGE Q64337 S308-p Phosphorylation AGEGPAQsLTEQMkk Q64337 S320-p Phosphorylation MkkIALEsVGQPEEQ Q64337 S330-p Phosphorylation QPEEQMEsGNCsGGD Q64337 S334-p Phosphorylation QMEsGNCsGGDDDWt Q64337 T341-p Phosphorylation sGGDDDWtHLSsKEV Q64337 S345-p Phosphorylation DDWtHLSsKEVDPsT Q64337 S351-p Phosphorylation SsKEVDPsTGELQsL Q64337 S357-p Phosphorylation PsTGELQsLQMPEsE Q64337 S363-p Phosphorylation QsLQMPEsEGPssLD Q64337 S367-p Phosphorylation MPEsEGPssLDPsQE Q64337 S368-p Phosphorylation PEsEGPssLDPsQEG Q64337 S372-p Phosphorylation GPssLDPsQEGPTGL Q64337 S405-p Phosphorylation ESLSQMLsMGFsDEG Q64337 S409-p Phosphorylation QMLsMGFsDEGGWLT Q64337 K13-ub Ubiquitination VKAYLLGkEEATREI Q64337 K91-ub Ubiquitination TMAMSYVkDDIFRIY Q64337 K141-ub Ubiquitination PVVGTRYkCSVCPDy Q64337 K157-ub Ubiquitination LCsVCEGkGLHREHS Q64337 K165-ub Ubiquitination GLHREHSkLIFPNPF Q64337 K297-ub Ubiquitination SCSSEVskPDGAGEG Q64337 K314-ub Ubiquitination QsLTEQMkkIALEsV Q64337 K315-ub Ubiquitination sLTEQMkkIALEsVG Q64337 K422-ub Ubiquitination LTRLLQTkNYDIGAA Q64337 K437-ub Ubiquitination LDTIQYSkHPPPL__

PTM - dbPTM UniProt ID Position Code Type Resources References Q64337 24 S Phosphorylation Swiss-Prot 1010711 17242355 Q64337 178 S Phosphorylation Swiss-Prot 1010711 19131326 Q64337 269 T Phosphorylation Swiss-Prot 1010711 19131326 Q64337 272 T Phosphorylation Swiss-Prot 1010711 19131326 Q64337 334 S Phosphorylation Swiss-Prot 1010711 19144319 Q64337 367 S Phosphorylation Swiss-Prot 1010711 15345747 Q64337 24 S Phosphorylation PhosphoELM.10011 17242355 Q64337 334 S Phosphorylation PhosphoELM.10011 19144319 Q64337 357 S Phosphorylation PhosphoELM.10011 19144319 Q64337 363 S Phosphorylation PhosphoELM.10011 19144319 Q64337 271 T Phosphorylation PhosphoELM.10011 19144319 Q64337 272 T Phosphorylation PhosphoELM.10011 19144319 Q64337 178 S Phosphorylation Phosphositeplus.1010730 18846507;19854140 Q64337 24 S Phosphorylation Phosphositeplus.1010730 20139300;21183079;21659604;21659605 Q64337 266 S Phosphorylation Phosphositeplus.1010730 19854140 Q64337 275 S Phosphorylation Phosphositeplus.1010730 20415495;20531401;21659604 Q64337 276 S Phosphorylation Phosphositeplus.1010730 21659604 Q64337 277 S Phosphorylation Phosphositeplus.1010730 21659604 Q64337 28 S Phosphorylation Phosphositeplus.1010730 21659604 Q64337 330 S Phosphorylation Phosphositeplus.1010730 21183079;21659605 Q64337 334 S Phosphorylation Phosphositeplus.1010730 19144319;19367708;21183079;21659604;21659605 Q64337 345 S Phosphorylation Phosphositeplus.1010730 21183079;21659605 Q64337 357 S Phosphorylation Phosphositeplus.1010730 21659605 Q64337 363 S Phosphorylation Phosphositeplus.1010730 19144319;21183079;21659605 Q64337 367 S Phosphorylation Phosphositeplus.1010730 21183079;21659605 Q64337 368 S Phosphorylation Phosphositeplus.1010730 19367708;21659604 Q64337 269 T Phosphorylation Phosphositeplus.1010730 19367708;19854140;20139300;20415495;20531401;20974803;21183079;21659604;21659605 Q64337 271 T Phosphorylation Phosphositeplus.1010730 21659604;21659605 Q64337 272 T Phosphorylation Phosphositeplus.1010730 18779572;20139300;20415495;20531401;20974803;21183079;21659604;21659605 Q64337 278 T Phosphorylation Phosphositeplus.1010730 21659604 Q64337 341 T Phosphorylation Phosphositeplus.1010730 21183079 Q64337 145 C S-nitrosylation dbSNO 1.0 20925432 Q64337 24 S Phosphorylation SysPTM 1.1 17242355 Q64337 277 S Phosphorylation SysPTM 1.1 17242355 Q64337 269 T Phosphorylation SysPTM 1.1 17242355 Q64337 272 T Phosphorylation SysPTM 1.1 18779572

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q64337 24 S 17242355 HTP Phosphorylation Q64337 272 T 19144319 HTP Phosphorylation Q64337 271 T 19144319 HTP Phosphorylation Q64337 334 S 19144319 HTP Phosphorylation Q64337 363 S 19144319 HTP Phosphorylation Q64337 357 S 19144319 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q64337 24 Phosphoserine 21183079 Q64337 178 Phosphoserine 19131326 Q64337 269 Phosphothreonine 19131326;21183079 Q64337 272 Phosphothreonine 19131326;21183079 Q64337 330 Phosphoserine 21183079 Q64337 334 Phosphoserine 19144319;21183079 Q64337 363 Phosphoserine 21183079 Q64337 367 Phosphoserine 21183079

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Sqstm1 IPI00133374 S 178 FGHLSDpSFSHSRW phosphorylation Sqstm1 IPI00133374 S 182 SDSFSHpSRWLRKL phosphorylation Sqstm1 IPI00133374 S 24 REIRRFpSFCFSPE phosphorylation Sqstm1 IPI00133374 S 266 EHGGKRpSRLTPTT phosphorylation Sqstm1 IPI00133374 S 275 TPTTPEpSSSTGTE phosphorylation Sqstm1 IPI00133374 S 276 PTTPESpSSTGTED phosphorylation Sqstm1 IPI00133374 S 334 MESGNCpSGGDDDW phosphorylation Sqstm1 IPI00133374 S 367 PESEGPpSSLDPSQ phosphorylation Sqstm1 IPI00133374 S 368 ESEGPSpSLDPSQE phosphorylation Sqstm1 IPI00133374 T 269 GKRSRLpTPTTPES phosphorylation Sqstm1 IPI00133374 T 271 RSRLTPpTTPESSS phosphorylation Sqstm1 IPI00133374 T 272 SRLTPTpTPESSST phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID Sqstm1 Mus musculus (Mouse) 13; 157; 165; 422; 437; 141; 297; 315; 314 "13,KAYLLGKEEATRE; 157,CSVCEGKGLHREH; 165,LHREHSKLIFPNP; 422,TRLLQTKNYDIGA; 437,DTIQYSKHPPPL; 141,VVGTRYKCSVCPD; 297,CSSEVSKPDGAGE; 315,LTEQMKKIALESV; 314,SLTEQMKKIALES" 13:22790023; 157:22790023; 165:22790023; 422:22790023; 437:22790023; 141:22790023; 297:22790023; 315:22790023; 314:22790023