PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sh3yl1 Sh3d19 12615363 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sh3yl1 Helz 12615363 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sh3yl1 Gfap ortho G G G G G Sh3yl1 Vim ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sh3yl1 Khdrbs1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sh3yl1 Vps37b ortho G G G G G G G G G G G G G G G G G G G G G G G G Sh3yl1 Zbtb7b ortho G G G G G G G G G G G G G G G G G G G G Sh3yl1 Bag3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O08641 Q91X43 two hybrid 12615363 physical association X 2 O08641 Q6DFV5 two hybrid 12615363 physical association X 2 O08641 Q91X43 pull down 12615363 physical association X 2 O08641 Q91X43 pull down 12615363 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sh3yl1 Helz MI:0018(two hybrid) 12615363 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_161867 bait prey Sh3yl1 Sh3d19 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12615363 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_161866|UniProt_161868|UniProt_161869 bait|prey|bait prey|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality SH3YL1 HELZ 12615363 0018 LC SH3YL1 SH3D19 12615363,12615363 0096,0018 LC SH3YL1 SH3D19 12615363,12615363 0096,0018 LC