PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bcl6 Gli2 25490446 intact exp G G G G G Bcl6 Gli1 25490446 intact exp G G G Bcl6 Sirt1 25490446 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Il5 Bcl6 12097386 intact exp Bcl6 Cdkn2a 15567177 biogrid exp Spp1 Bcl6 25436971 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Tbx21 22406686 biogrid,intact exp G G Bcl6 Bcl6 16331266,12097386 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6b Bcl6 16331266,9632807,20211142 biogrid,i2d exp, ortho G G G G G Bcl6 Bach2 16331266 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G Ppard Bcl6 20211142 biogrid,i2d exp, ortho Bcl6 Bcor 25490446 intact exp, ortho Bcl6 Fbxo11 22113614 dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Cutc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Mbd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jund Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Wdr35 ortho Bcl6 Hdac9 ortho Bcl6 Nkrf ortho Bcl6 Spen ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Ddx6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sp1 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Nacc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Jun Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Drosha ortho Bcl6 Smo ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Arhgap35 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Peli1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Ncor2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dynein, axonemal, heavy chain 9, Protein Dnah9 Bcl6 ortho Bcl6 Cdk8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Smarca4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Cacna1a ortho G G G G G G Bcl6 Yy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Ctnnb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Sae1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Sptlc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zbtb7a Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Wnt16 ortho G G Bcl6 Lsm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Diras1 ortho G G G G G G G G G Bcl6 Lpar4 ortho Bcl6 Zbtb17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Usp7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Zbtb6 ortho Bcl6 Pin1 ortho Hsp90aa1 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Bcl11a ortho G G G G G G G G G G G G G G G G G G G Bcl6 Csmd1 ortho Kmt2b Bcl6 ortho Bcl6 Siah1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Trib3 ortho G G G G G G G G G G G Bcl6 MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 ortho G G G G G G G G G G G G G G G G G G Junb Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Pml ortho G G G G G G G G G G G G G G G G G G G G G Bcl6 Blzf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Eif4enif1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Kifc1 ortho G G G G G G G G G G G G G Bcl6 Pikfyve ortho G G G G G G G Bcl6 Crebbp ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2f3 Bcl6 ortho G G G G G Bcl6 Raf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Ebf1 ortho G G G G G G G G G G G G G G G G G Bcl6 Mapk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Skp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppargc1a Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G Hnf1a Bcl6 ortho Bcl6 Atf7 ortho G G G G G G G G G G G Bcl6 Mta3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Wnk4 ortho G G G G G G G G G Bcl6 Irf4 ortho G G G G G G G G Bcl6 Arnt2 ortho G G G G Bcl6 Hdac7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Bcl6 ortho Bcl6 Kdm2a ortho Bcl6 Senp7 ortho Bcl6 BC021921 ortho G G G G Ercc5 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spi1 Bcl6 ortho G G G G G G G G G G G G G Bcl6 Ehmt1 ortho Traf1 Bcl6 ortho G G G Bcl6 Prkd3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ephb6 Bcl6 ortho G G G G G G G G G G Bcl6 Hdac5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arid1a Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Utp6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Traf3ip3 ortho Bcl6 Tbl1xr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Cdk19 ortho Bcl6 Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Aes ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Ola1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Protein Patz1, Transcription factor MAZR, Zinc finger protein 278, isoform CRA_d ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pou2f1 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Eif2ak3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Runx1t1 ortho G G G G G G G G G G G G Helz2 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Mtmr6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Tnfrsf8 ortho Bcl6 Hbegf ortho G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Med6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Chd3 Bcl6 ortho Bcl6 Cul3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Hdac2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Zmynd8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Med23 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Hdac4 ortho Bcl6 Med17 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Parp12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Pcdh9 Bcl6 ortho Ctbp1 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Mapk8ip3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Ncor1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxm1 Bcl6 ortho G G G G G G G Bcl6 Osbpl1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Sin3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Zbtb7b ortho G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Hsf4 ortho G G G G Bcl6 Ppap2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Panx3 ortho Twist1 Bcl6 ortho G G G Bcl6 Elf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Prkce Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kifc3 Bcl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcl6 Lpar2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P41183 P35396 - 12970571 - X 2 P41183 O88282 - 9632807 - X 2 P41183 P51480-2 affinity chromatography technology 15567177 physical association X 2 P41183 Q3U150 affinity chromatography technology 22406686 physical association X 2 P41183 P41183 two hybrid 16331266 direct interaction X 2 P41183 P35396 two hybrid 20211142 direct interaction X 2 P41183 Q8N726 affinity chromatography technology 15567177 physical association X 2 P41183 O88282 affinity chromatography technology 9632807 physical association X 2 P41183 O88282 affinity chromatography technology 9632807 physical association X 2 P41183 O88282 two hybrid 16331266 direct interaction X 2 P41183 P97303 two hybrid 16331266 direct interaction X 2 P41183 P97303 two hybrid 16331266 direct interaction X 2 P41183 O88282 two hybrid 20211142 direct interaction X 2 P41183 Q7TPD1 anti bait coimmunoprecipitation 22113614 physical association X 2 P41183 Q7TPD1 anti bait coimmunoprecipitation 22113614 physical association X 2 P41183 Q3U150 anti bait coimmunoprecipitation 22406686 physical association X 2 P41183 Q3U150 anti bait coimmunoprecipitation 22406686 physical association X 2 P41183 Q3U150 anti bait coimmunoprecipitation 22406686 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ppard Bcl6 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_312904 prey bait Bcl6b Bcl6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 20211142,9632807 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_324416|BIOGRID_324417|BIOGRID_312903 bait|prey|bait prey|bait|prey Bcl6 Tbx21 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 22406686 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_173879|UniProt_173881|UniProt_173880 bait|bait|prey prey|prey|bait Bcl6 Cdkn2a MI:0004(affinity chromatography technology) 15567177 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324174 bait prey

PPI - HINT Gene A Gene B PMID Method Quality BCL6B BCL6 20211142,16331266 0018,0018 HT,LC PPARD BCL6 20211142,12970571,12970571 0018,0019,0004 HT,LC BCL6 BCL6 16331266 0018 LC BCL6 BACH2 16331266 0018 LC BATF BCL6 21572431 0007 LC BCL6B BCL6 9632807 0004 LC IL1A BCL6 21106671 0007 LC GZMB BCL6 17125145 0007 LC CSF1 BCL6 21106671 0007 LC IL6 BCL6 21106671 0007 LC CCL2 BCL6 21106671 0007 LC SPP1 BCL6 25436971 0004 LC RPLP0 BCL6 21106671 0007 LC IRF8 BCL6 19648273,16380510 0007,0007 LC PPARD BCL6 12970571,12970571 0019,0004 LC BCL6 CDKN2A 15567177 0004 LC BCL6 FBXO11 22113614 0006 LC BCL6 BCOR 25490446 0006 LC BCL6 SIRT1 25490446 0006 LC BCL6 TBX21 22406686,22406686 0006,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P41183 O88282 BCL6 BCL6B 0.648 9632807,20211142,16331266 P51480 P41183 CDKN2A BCL6 0.21 15567177 P42771 P41183 CDKN2A BCL6 0.21 15567177 P41183 P41183 BCL6 BCL6 0.332 16331266 P41183 P35396 BCL6 PPARD 0.183 20211142 P41183 P10923 BCL6 SPP1 0.21 25436971 Q8CGN4 P41183 BCOR BCL6 0.376 25490446 P97303 P41183 BACH2 BCL6 0.523 16331266 Q64364 P41183 CDKN2A BCL6 0.21 15567177 Q9JKD8 P41183 TBX21 BCL6 0.376 22406686 Q8N726 P41183 CDKN2A BCL6 0.21 15567177 Q923E4 P41183 SIRT1 BCL6 0.21 25490446