PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mapt Syvn1 23719816 biogrid exp G G G G G G G G G G G G G G G Pgls Syvn1 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Was Syvn1 15102471 mint,intact exp G G G G G G G G G Syvn1 Ern2 18369366 biogrid exp G G G G Syvn1 Hsd3b7 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Syvn1 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ncstn Syvn1 19725872 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bsg Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp7 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd7 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb4 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Psma1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa5 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Shh Syvn1 ortho G Cks1b Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Psmb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd14 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Htt Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mettl16 Syvn1 ortho Syvn1 Tmub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aup1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Naaa Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Derl1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Ern1 ortho G G G G G Hmox1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G Hfe Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Os9 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Amfr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Psma6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wfs1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csk Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myh9 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vimp Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tyr Syvn1 ortho G G G Asgr1 Syvn1 ortho G G G Svip Syvn1 ortho Psmd2 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp2cb Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rer1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Saraf Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Glra2 Syvn1 ortho Atf6 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Psmb3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fdft1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Hey1 ortho G G G G G G G G G G G G G G G G Pmp22 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubxn6 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein C78339 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wbp1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Sgk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb7 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atn1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Atp6ap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stxbp5l Syvn1 ortho Psma2 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mbtps2 Syvn1 ortho Psmd1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Gpr37 ortho G G G G G G G G G Syvn1 Herpud1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Sel1l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppargc1b Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Apob Syvn1 ortho G G G G G G G G Erlin2 Syvn1 ortho Usp19 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Derl2 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2u Syvn1 ortho Syvn1 Ube2j1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Yod1 Syvn1 ortho Erlec1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Asgr2 Syvn1 ortho G G Syvn1 Creb3l1 ortho G G G G G G G G G G G G G G G G G G G G G G Psmb1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hmgcr Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Por Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tmem129 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn3 Syvn1 ortho Creb3l2 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Erlin1 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb6 Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pdip Syvn1 ortho Syvn1 Hey2 ortho G G G Syvn1 Psma5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Syvn1 Psma7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clu Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2z Syvn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9DBY1 P10637-3 affinity chromatography technology 23719816 physical association X 2 Q9Z2E3 Q9DBY1 affinity chromatography technology 18369366 physical association X 2 P57716 Q9DBY1 affinity chromatography technology 19725872 physical association X 2 P57716 Q9DBY1 affinity chromatography technology 19725872 physical association X 2 P70315 Q9DBY1 two hybrid 15102471 physical association X 2 P57716 Q9DBY1 anti bait coimmunoprecipitation 19725872 physical association X 2 P57716 Q9DBY1 anti tag coimmunoprecipitation 19725872 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality YWHAE SYVN1 16615898 0027 LC WAS SYVN1 15102471 0018 LC PGLS SYVN1 16615898 0027 LC SYVN1 HSD3B7 16615898 0027 LC MAPT SYVN1 23719816 0004 LC NCSTN SYVN1 19725872,19725872,19725872 0006,0004,0007 LC SYVN1 B9D1 21763481 0676 LC SYVN1 ERN2 18369366 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9DBY1 P57716 SYVN1 NCSTN 0.61 19725872 Q9DBY1 P62259 SYVN1 YWHAE 0.081 16615898 Q9DBY1 P10637 SYVN1 MAPT 0.21 23719816 Q9DBY1 Q9CQ60 SYVN1 PGLS 0.081 16615898 Q9DBY1 P70315 SYVN1 WAS 0.183 15102471 Q9Z2E3 Q9DBY1 ERN2 SYVN1 0.21 18369366 Q9EQC1 Q9DBY1 HSD3B7 SYVN1 0.081 16615898