PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hmga2 Tollip 26045162 intact exp G G G G Ywhae Tollip 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Htt Tollip 21896309 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Tollip 14563850 i2d,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Il1rap Tollip 10854325 innatedb,intact exp, ortho G G Il1r1 Tollip 10854325 innatedb,intact exp, ortho G G G G G G G G G G G G G G G G G G G Irak1 Tollip 19273233,10854325 innatedb,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias2 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1l2 Tollip ortho P G G G G G G G G G Rbm38 Tollip ortho G G G G G G G G G G G G G G G G G G G G G Secisbp2l Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dzip3 Tollip ortho Cyhr1 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nucb1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irak2 Tollip ortho Diablo Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tlr3 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G Ptbp3 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cpsf6 Tollip ortho P Gnb2l1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csn2 Tollip ortho G G G G G G Traf6 Tollip ortho G G G G G G G G G G G G G G G G G G G G Atxn1 Tollip ortho Cstf1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Apeh Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dab1 Tollip ortho G G G G G G G G Wrnip1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nmi Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Maged1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tollip Trip6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zhx1 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pink1 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Oxr1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fam115a, Kiaa0738 Tollip ortho Tom1l1 Tollip ortho P G G G G G G G G G G G G G G G G G G G G G G G G Xrn2 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Itch Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uqcrb Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Odam Tollip ortho Gga1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gga3 Tollip ortho Rnf216 Tollip ortho Mapk14 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ldb1 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ing1 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tlr9 Tollip ortho G G Bhlhe40 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chd6 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbx3 Tollip ortho G G G G G G G G G G G G G G G G Tmem17 Tollip ortho Tlr2 Tollip ortho G G G G G G G G G G G G G G G G G Ankrd13a Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G 5'-nucleotidase domain containing 2, Protein Nt5dc2 Tollip ortho G G G G G G G G G G G G G G G Araf Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Flot1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fth1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 Tollip ortho G G G G G G G G G G G G G G G G G G Daxx Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Siah1a Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tollip Vps29 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Setdb1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eif2ak2 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G Cav1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gga2 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps35 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbr1 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tollip Rbpms ortho G G G G G G G G G G G G G G G G G G G G G G G Xiap Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tollip Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Leng8 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tlr4 Tollip ortho G G G G G G G G G G G G G G G G G Dazap2 Tollip ortho Rbfox2 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Snx8 Tollip ortho Xpo1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein N4bp2 Tollip ortho P Krt8 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G Sept1 Tollip ortho P G G G G G G G G Ube2i Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdyhv1 Tollip ortho P Rcan1 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd4l Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Herpud1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sun1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Abcb6 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Map1lc3a Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Larp4b Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lmnb2 Tollip ortho P G G Rac1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Peg10 Tollip ortho G Smad7 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tollip Rlim ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps25 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O88746 Q9QZ06 - 14563850 - X 2 Q9QZ06 B1AUW6 affinity chromatography technology 19273233 physical association X 2 Q9QZ06 imaging technique 21896309 colocalization X 2 Q9QZ06 Q61730 two hybrid 10854325 physical association X 2 Q9QZ06 Q61730 coimmunoprecipitation 10854325 physical association X 2 Q540G0 Q9QZ06 coimmunoprecipitation 10854325 physical association X 2 Q540G0 Q9QZ06 coimmunoprecipitation 10854325 physical association X 2 P13504 Q9QZ06 coimmunoprecipitation 10854325 physical association X 2 O88746 Q9QZ06 two hybrid 14563850 physical association X 2 O88746 Q9QZ06 coimmunoprecipitation 14563850 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9QZ06 P62259 TOLLIP YWHAE 0.081 16615898 Q9QZ06 P13504 TOLLIP IL1R1 0.21 10854325 Q9QZ06 Q61730 TOLLIP IL1RAP 0.454 10854325 Q9QZ06 Q62406 TOLLIP IRAK1 0.376 10854325,19273233 Q9QZ06 O88746 TOLLIP TOM1 0.454 14563850 Q9QZ06 P52927 TOLLIP HMGA2 0.126 26045162