PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Psme2 Adrm1 23706739 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma8 Adrm1 23706739 intact exp P G Psmb9 Adrm1 23706739 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G Psme4 Adrm1 23706739 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo32 Adrm1 22673621 biogrid exp G G G G G G G G G G G G G G G G G G G G G G Ubc Adrm1 18497817 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb1 Adrm1 23706739 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd6 Adrm1 23706739 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc6 Adrm1 23706739 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb8 Adrm1 23706739 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Psmb5 Adrm1 23706739 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Psmb2 23706739 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Psma4 23706739 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma2 Adrm1 23706739 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psme3 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Psma1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfrkb Adrm1 ortho P Adrm1 Psma5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Psmd10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd4 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usmg5 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Psma7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ecm29 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Huwe1 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc4 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Psmd13 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc3 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Shfm1 Adrm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx1 Adrm1 ortho P Timm13 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc1 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd2 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jun Adrm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psme1 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc5 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd14 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Bub3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd12 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hbp1 Adrm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubqln1 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Uchl5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Psma6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Ubqln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd1 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lrrk2 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G Rps8 Adrm1 ortho P Psmd7 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb6 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbp8 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Park2 ortho G G G G Rad23a Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps21 Adrm1 ortho P Psmd5 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc2 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc92 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb7 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd3 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Txnl1 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Coiled-coil domain containing 95, isoform CRA_g, INO80 complex subunit E, Protein Ino80e Adrm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddi1 Adrm1 ortho P Egfr Adrm1 ortho GP G G G G G G G G G G G G G G G G G Snrnp200 Adrm1 ortho P Psmd8 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23b Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Adrm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd11 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bag1 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmb4 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6v0d2 Adrm1 ortho Rpn2 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nos2 Adrm1 ortho G Rpn1 Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube3a Adrm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Insig2 Adrm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc2a4 Adrm1 ortho G G G G G G G G G G G G G G G G G G G G Adrm1 Psmb3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Usp14 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adrm1 Timm8a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JKV1 Q9CPU7 affinity chromatography technology 22673621 physical association X 2 P55036 Q9JKV1 biochemical 17139257 colocalization X 2 Q9JKV1 P0CG50 affinity chromatography technology 18497817 physical association X 2 Q9JKV1 P0CG50 pull down 18497817 direct interaction X 2 Q9JKV1 P0CG50 two hybrid 18497817 direct interaction X 2 Q8WTU0 Q9JKV1 pull down 18497817 direct interaction X 2 Q9JKV1 P54727 pull down 18497817 direct interaction X 2 Q9JKV1 P62987 pull down 18497827 direct interaction X 2 Q9JKV1 P62987 pull down 18497817 direct interaction X 2 Q9JKV1 P62987 pull down 18497817 direct interaction X 2 Q9JKV1 P62987 two hybrid 18497817 direct interaction X 2 Q9JKV1 P62987 nuclear magnetic resonance 18497827 direct interaction X 2 Q9JKV1 Q99460 pull down 18497827 physical association X 2 Q9JKV1 Q99460 two hybrid 18497817 physical association X 2 Q9JKV1 A0A024R7G8 pull down 18497817 direct interaction X 2 Q9JKV1 cosedimentation through density gradient 23706739 colocalization C 14 Q9JKV1 cosedimentation through density gradient 23706739 colocalization C 9

PPI - HINT Gene A Gene B PMID Method Quality PSMB1 ADRM1 23706739 0029 LC PSMB5 ADRM1 23706739 0029 LC UBC ADRM1 18497817,18497817,18497817 0096,0018,0004 LC PSMB8 ADRM1 23706739 0029 LC PSMB9 ADRM1 23706739 0029 LC PSMA2 ADRM1 23706739 0029 LC PSMC6 ADRM1 23706739 0029 LC PSME2 ADRM1 23706739 0029 LC PSME4 ADRM1 23706739 0029 LC PSMD6 ADRM1 23706739 0029 LC PSMA8 ADRM1 23706739 0029 LC ADRM1 PSMA4 23706739 0029 LC ADRM1 PSMB2 23706739 0029 LC UBC ADRM1 18497817,18497817,18497817 0096,0018,0004 LC RAB39B ADRM1 26885862 0676 LC FBXO32 ADRM1 22673621 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JKV1 O09061 ADRM1 PSMB1 0.081 23706739 Q9JKV1 O55234 ADRM1 PSMB5 0.081 23706739 Q9JKV1 O60260 ADRM1 PARK2 0.623 25666615 Q9JKV1 P0CG48 ADRM1 UBC 0.523 25666615 Q9JKV1 P28063 ADRM1 PSMB8 0.081 23706739 Q9JKV1 P28076 ADRM1 PSMB9 0.081 23706739 Q9JKV1 P49722 ADRM1 PSMA2 0.081 23706739 Q9JKV1 P55036 ADRM1 PSMD4 0.081 17139257 Q9JKV1 P62334 ADRM1 PSMC6 0.081 23706739 Q9JKV1 P97372 ADRM1 PSME2 0.081 23706739 Q9JKV1 Q06323 ADRM1 PSME1 0.081 23706739 Q9JKV1 Q5SSW2 ADRM1 PSME4 0.081 23706739 Q9JKV1 Q99JI4 ADRM1 PSMD6 0.081 23706739 Q9JKV1 Q9CWH6 ADRM1 PSMA8 0.081 23706739 Q9R1P0 Q9JKV1 PSMA4 ADRM1 0.081 23706739 Q9R1P3 Q9JKV1 PSMB2 ADRM1 0.081 23706739 Q9Y5K5 Q9JKV1 UCHL5 ADRM1 0.21 25666615 Q9JKV1 Q8BHC1 ADRM1 RAB39B 0.126 26885862 Q9JKV1 P0CG50 ADRM1 UBC 0.523 18497817 Q9JKV1 Q99460 ADRM1 PSMD1 0.454 25666615 Q9JKV1 O43765 ADRM1 SGTA 0.794 26169395 Q9JKV1 Q9CPU7 ADRM1 FBXO32 0.126 22673621 Q9UHD9 Q9JKV1 UBQLN2 ADRM1 0.309 25666615