PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Lepr Socs6 16698021 mint,intact exp G G G G G G G G G Bcar1 Socs6 24284072 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Lck Socs6 20007709 biogrid exp G G G G G G G G G G G G G G Flt3 Socs6 22952242 biogrid exp G G G G G G G Socs6 Irs4 i2d exp G G Pik3r2 Socs6 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r1 Socs6 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul5 Socs6 19385048 biogrid exp, ortho Kit Socs6 14707129 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Frs3 Socs6 ortho G G G G G G G G G G G G Crk Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr89 Socs6 ortho Fam83h Socs6 ortho G G G G G G G G G G G G G G Zmiz2 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Socs6 Arih2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk5rap2 Socs6 ortho G G G G Hsp90ab1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmpr1b Socs6 ortho G G G Usp1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba1a Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Socs6 Plec ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Efemp1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Nkd1 Socs6 ortho G G G G G G Pola1 Socs6 ortho G G G G G G G G G G G G G G Acaca Socs6 ortho G G G G G Tubb4b Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sav1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Insr Socs6 ortho G G Met Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Madd Socs6 ortho G G G G G G G G G Tgfbr1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rela Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ar Socs6 ortho G G G G G G G G G G G G G G G G Axin1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm1a Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tceb1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irs2 Socs6 ortho G G G G G G G G G G G G G G G G G G G G Smurf2 Socs6 ortho Socs6 Clnk ortho Appl1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Socs6 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lnx1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G Kiaa0232 Socs6 ortho Egfr Socs6 ortho G G G G G G G G G G G G G G G G G G Socs6 Tubd1 ortho G G G G G G G G G G G G G G G G G G G G G Fbxo11 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r3 Socs6 ortho Socs6 Gab1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Socs6 Dcun1d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Acvr1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G Yap1 Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Amot Socs6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JLY0 - 12052866 - X 2 Q9JLY0 - 12052866 - X 2 Q80UI5 Q9JLY0 - 12052866 - X 2 P0CG48 Q9JLY0 affinity chromatography technology 16643902 physical association X 2 Q9JLY0 affinity chromatography technology 22952242 physical association X 2 Q9JLY0 affinity chromatography technology 22952242 physical association X 2 Q9JLY0 Q61140-2 affinity chromatography technology 24284072 physical association X 2 Q9JLY0 Q15369-2 biochemical 19385048 association X 2 Q9JLY0 Q15369-2 x-ray crystallography 19385048 association X 2 Q9JLY0 Q15369-2 pull down 19385048 direct interaction X 2 Q9JLY0 P05532 affinity chromatography technology 14707129 physical association X 2 Q9JLY0 P05532 affinity chromatography technology 14707129 physical association X 2 Q9JLY0 P05532 two hybrid 14707129 direct interaction X 2 Q9JLY0 two hybrid 16643902 direct interaction X 2 Q9JLY0 affinity chromatography technology 16643902 physical association X 2 Q9JLY0 affinity chromatography technology 16643902 physical association X 2 Q9JLY0 P06240 two hybrid 20007709 direct interaction X 2 Q9JLY0 P06240 pull down 20007709 direct interaction X 2 Q9JLY0 P06240 affinity chromatography technology 20007709 physical association X 2 Q9JLY0 Q15370-2 biochemical 19385048 association X 2 Q9JLY0 Q15370-2 x-ray crystallography 19385048 association X 2 Q9JLY0 Q15370-2 pull down 19385048 direct interaction X 2 Q9JLY0 Q9D5V5 pull down 19385048 direct interaction X 2 Q9JLY0 Q9BYM8 two hybrid array 16643902 physical association X 2 Q9JLY0 Q9BYM8 anti tag coimmunoprecipitation 16643902 physical association X 2 Q9JLY0 Q9BYM8 anti tag coimmunoprecipitation 16643902 physical association X 2 Q9JLY0 Q9BYM8 anti bait coimmunoprecipitation 16643902 physical association X 2 Q9JLY0 Q9BYM8 two hybrid array 16643902 physical association X 2 A0A024R7Y5 Q9JLY0 two hybrid array 16643902 physical association X 2 Q9JLY0 P48356 two hybrid 16698021 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JLY0 P05532 SOCS6 KIT 0.569 14707129 Q9JLY0 P48356 SOCS6 LEPR 0.309 16698021 Q9JLY0 Q00342 SOCS6 FLT3 0.569 22952242 Q9JLY0 Q61140 SOCS6 BCAR1 0.21 24284072 Q9JLY0 P06240 SOCS6 LCK 0.623 20007709 Q9JLY0 Q15370 SOCS6 TCEB2 0.416 19385048 Q9JLY0 Q15369 SOCS6 TCEB1 0.539 19385048,16643902 Q9JLY0 Q9BYM8 SOCS6 RBCK1 0.787 16643902 Q9JLY0 Q9D5V5 SOCS6 CUL5 0.183 19385048