PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus H3f3a, H3f3b Ing2 16728977 biogrid exp Skil Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tmem71 Ing2 ortho G G G G G G G G G G Csnk1a1 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr5 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcc2 Ing2 ortho Arid4b Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hdac1 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ep300 Ing2 ortho Prmt5 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 Ing2 ortho G G G G G G G G G G G G G Dvl1 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pcna Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ing2 Smarcb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ing2 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spp1 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G Protein Arid4a Ing2 ortho Smurf2 Ing2 ortho Hdac2 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbbp7 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brms1l Ing2 ortho Rbbp4 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G Sap130 Ing2 ortho Smad2 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ing2 Actl6a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sap30 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxk2 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sirt1 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxk1 Ing2 ortho G G G Smad1 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcc1 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smurf1 Ing2 ortho Tp53 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sin3a Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sumo1 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Suds3 Ing2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9ESK4 Q9HAU4 affinity chromatography technology 15761153 physical association X 2 Q9ESK4 P84244 x-ray crystallography 16728977 association X 2 Q9ESK4 P84244 pull down 16728977 direct interaction X 2 Q9ESK4 affinity chromatography technology 15761153 physical association X 2 Q9ESK4 Q9HAU4 anti tag coimmunoprecipitation 15761153 physical association X 2 Q9ESK4 Q15797 anti tag coimmunoprecipitation 15761153 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ing2 H3f3a MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 16728977 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0914(association) (biogrid)|(biogrid) BIOGRID_314563|BIOGRID_314562 bait|bait prey|prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCE7 Q9ESK4 SMURF1 ING2 0.126 15761153 Q9HAU4 Q9ESK4 SMURF2 ING2 0.236 15761153 Q9ESK4 P84244 ING2 H3F3B 0.523 16728977 Q9ESK4 Q15797 ING2 SMAD1 0.126 15761153