PTM - CPLM Gene Name UniProt ID Type Position Code Ubr4; Kiaa0462; Zubr1 A2AN08 Acetylation 3813 K Ubr4; Kiaa0462; Zubr1 A2AN08 Acetylation 3838 K Ubr4; Kiaa0462; Zubr1 A2AN08 Ubiquitination 187 K Ubr4; Kiaa0462; Zubr1 A2AN08 Ubiquitination 634 K Ubr4; Kiaa0462; Zubr1 A2AN08 Ubiquitination 1149 K Ubr4; Kiaa0462; Zubr1 A2AN08 Ubiquitination 1573 K Ubr4; Kiaa0462; Zubr1 A2AN08 Ubiquitination 4019 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Ubr4; Kiaa0462; Zubr1 A2AN08 152 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 157 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1633 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1646 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1651 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1732 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1736 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1759 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1760 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1761 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 178 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 181 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1876 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 1945 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 205 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 208 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 212 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2691 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2693 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2712 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2715 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2716 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2719 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2721 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2740 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2741 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2854 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2856 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2858 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2859 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2881 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2882 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2889 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2892 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2894 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2897 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2901 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2907 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2909 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2913 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2938 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 2949 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 360 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 362 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 363 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 364 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 365 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 370 Y Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 3776 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 3784 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 3857 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 3930 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 4002 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 4010 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 4083 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 4429 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 457 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 4685 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 4691 Y Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 473 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 4785 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 4847 T Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 619 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 620 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 625 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 631 S Mus musculus(Mouse) Ubr4; Kiaa0462; Zubr1 A2AN08 924 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA A2AN08 K3038-ac Acetylation MDKKDVSkKNERSAL A2AN08 K5079-ac Acetylation GATRLTDkAVKDYSA A2AN08 S2577-gl O-GlcNAc RLVITARsIAVTRPN A2AN08 T152-p Phosphorylation RTEIITFtAMMKsAK A2AN08 S157-p Phosphorylation TFtAMMKsAKLPQTV A2AN08 S178-p Phosphorylation EDQKELAsPVsPELR A2AN08 S181-p Phosphorylation KELAsPVsPELRQkE A2AN08 T205-p Phosphorylation TSVFNPRtVPsPPIs A2AN08 S208-p Phosphorylation FNPRtVPsPPIsPQA A2AN08 S212-p Phosphorylation tVPsPPIsPQALVEG A2AN08 T360-p Phosphorylation GSAQQVRtGstssKE A2AN08 S362-p Phosphorylation AQQVRtGstssKEDD A2AN08 T363-p Phosphorylation QQVRtGstssKEDDy A2AN08 S364-p Phosphorylation QVRtGstssKEDDyE A2AN08 S365-p Phosphorylation VRtGstssKEDDyES A2AN08 Y370-p Phosphorylation tssKEDDyESDAATI A2AN08 S457-p Phosphorylation RTKEGVGsPKLGPGK A2AN08 S619-p Phosphorylation PPPPPLEssPRVKsP A2AN08 S620-p Phosphorylation PPPPLEssPRVKsPN A2AN08 S625-p Phosphorylation EssPRVKsPNKQAsG A2AN08 S631-p Phosphorylation KsPNKQAsGEkGNIL A2AN08 S924-p Phosphorylation NWSKHFSsDAAPQPR A2AN08 S1633-p Phosphorylation ERAIEVDsDWVEELA A2AN08 S1646-p Phosphorylation LAVEEEDsQAEDsDE A2AN08 S1651-p Phosphorylation EDsQAEDsDEDSLCN A2AN08 S1759-p Phosphorylation ESLVRHAstsPADKA A2AN08 T1760-p Phosphorylation SLVRHAstsPADKAK A2AN08 S1761-p Phosphorylation LVRHAstsPADKAKV A2AN08 S1945-p Phosphorylation LTLTRLAsAPVPFTV A2AN08 T2712-p Phosphorylation RNKRRHVtLPssPRs A2AN08 S2715-p Phosphorylation RRHVtLPssPRsNtP A2AN08 S2716-p Phosphorylation RHVtLPssPRsNtPM A2AN08 S2719-p Phosphorylation tLPssPRsNtPMGDK A2AN08 T2721-p Phosphorylation PssPRsNtPMGDKDD A2AN08 S2740-p Phosphorylation DADEKMQsSGIPDGG A2AN08 T2881-p Phosphorylation TDGSTLRtsPADHGG A2AN08 S2882-p Phosphorylation DGSTLRtsPADHGGs A2AN08 S2889-p Phosphorylation sPADHGGsVGsEsGG A2AN08 S2892-p Phosphorylation DHGGsVGsEsGGsAV A2AN08 S2894-p Phosphorylation GGsVGsEsGGsAVDS A2AN08 S2897-p Phosphorylation VGsEsGGsAVDSVAG A2AN08 S2909-p Phosphorylation VAGEHSVsGRSSAYG A2AN08 S3857-p Phosphorylation ASQYRALsVLGCGHT A2AN08 T3930-p Phosphorylation RQLMCLLtRDNPEAT A2AN08 T4002-p Phosphorylation LMAVNIKtPVVVENI A2AN08 T4010-p Phosphorylation PVVVENItLMCLRIL A2AN08 T4429-p Phosphorylation YKKVWCAtNEGEPMR A2AN08 T4685-p Phosphorylation LILQKGItQNALDyM A2AN08 Y4691-p Phosphorylation ItQNALDyMKKHIPS A2AN08 T4785-p Phosphorylation IDAARREtRAEKKRM A2AN08 T4847-p Phosphorylation EGYKFQPtKVLGIYT A2AN08 K187-ub Ubiquitination VsPELRQkEVQMNFL A2AN08 K634-ub Ubiquitination NKQAsGEkGNILASR A2AN08 K1149-ub Ubiquitination AAETDPHkSSEITkN A2AN08 K1155-ub Ubiquitination HkSSEITkNLLPATL A2AN08 K1573-ub Ubiquitination CKKYLSQkNVVEKLN A2AN08 K3731-ub Ubiquitination ENEEDRKkAVSNINT A2AN08 K4019-ub Ubiquitination MCLRILQkLIKPPAP

PTM - dbPTM UniProt ID Position Code Type Resources References A2AN08 178 S Phosphorylation Swiss-Prot 1010711 17242355 A2AN08 181 S Phosphorylation Swiss-Prot 1010711 17242355 A2AN08 365 S Phosphorylation Swiss-Prot 1010711 17242355 A2AN08 2712 T Phosphorylation Swiss-Prot 1010711 17242355 A2AN08 2716 S Phosphorylation Swiss-Prot 1010711 17242355 A2AN08 2719 S Phosphorylation Swiss-Prot 1010711 17242355 A2AN08 2721 T Phosphorylation Swiss-Prot 1010711 17242355 A2AN08 178 S Phosphorylation PhosphoELM.10011 17242355 A2AN08 181 S Phosphorylation PhosphoELM.10011 17242355 A2AN08 365 S Phosphorylation PhosphoELM.10011 17242355 A2AN08 2716 S Phosphorylation PhosphoELM.10011 17242355 A2AN08 2719 S Phosphorylation PhosphoELM.10011 17242355 A2AN08 2712 T Phosphorylation PhosphoELM.10011 17242355 A2AN08 2721 T Phosphorylation PhosphoELM.10011 17242355 A2AN08 1759 S Phosphorylation Phosphositeplus.1010730 18846507;19367708 A2AN08 178 S Phosphorylation Phosphositeplus.1010730 17242355;18056256;19854140;20415495;21183079 A2AN08 181 S Phosphorylation Phosphositeplus.1010730 17242355;19854140;20415495;21183079 A2AN08 208 S Phosphorylation Phosphositeplus.1010730 21183079 A2AN08 212 S Phosphorylation Phosphositeplus.1010730 21183079 A2AN08 2715 S Phosphorylation Phosphositeplus.1010730 17242355;19367708;19854140;20139300;20531401;21183079 A2AN08 2716 S Phosphorylation Phosphositeplus.1010730 17242355;19367708;19854140;20139300;20415495;20531401;21183079;21659604;21659605 A2AN08 2719 S Phosphorylation Phosphositeplus.1010730 17242355;19854140;20415495;20531401;21183079 A2AN08 2882 S Phosphorylation Phosphositeplus.1010730 20139300;21183079 A2AN08 2889 S Phosphorylation Phosphositeplus.1010730 21183079;21659605 A2AN08 2892 S Phosphorylation Phosphositeplus.1010730 21183079;21659605 A2AN08 365 S Phosphorylation Phosphositeplus.1010730 21659604 A2AN08 457 S Phosphorylation Phosphositeplus.1010730 20415495 A2AN08 619 S Phosphorylation Phosphositeplus.1010730 21183079;21659605 A2AN08 620 S Phosphorylation Phosphositeplus.1010730 21183079;21659604 A2AN08 205 T Phosphorylation Phosphositeplus.1010730 21183079 A2AN08 2712 T Phosphorylation Phosphositeplus.1010730 17242355;20531401;21183079;21659605 A2AN08 2721 T Phosphorylation Phosphositeplus.1010730 17242355;20531401;21183079 A2AN08 2881 T Phosphorylation Phosphositeplus.1010730 20139300 A2AN08 360 T Phosphorylation Phosphositeplus.1010730 21183079;21659604 A2AN08 4785 T Phosphorylation Phosphositeplus.1010730 20139300 A2AN08 370 Y Phosphorylation Phosphositeplus.1010730 21183079 A2AN08 178 S Phosphorylation SysPTM 1.1 18056256 A2AN08 619 S Phosphorylation SysPTM 1.1 18846507 A2AN08 620 S Phosphorylation SysPTM 1.1 18846507 A2AN08 1759 S Phosphorylation SysPTM 1.1 18846507 A2AN08 2715 S Phosphorylation SysPTM 1.1 17242355;18846507 A2AN08 2716 S Phosphorylation SysPTM 1.1 17242355 A2AN08 2719 S Phosphorylation SysPTM 1.1 17242355 A2AN08 2712 T Phosphorylation SysPTM 1.1 17242355 A2AN08 2721 T Phosphorylation SysPTM 1.1 17242355 A2AN08 2881 T Phosphorylation SysPTM 1.1 18846507

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type A2AN08 2716 S 17242355 HTP Phosphorylation A2AN08 2712 T 17242355 HTP Phosphorylation A2AN08 181 S 17242355 HTP Phosphorylation A2AN08 2721 T 17242355 HTP Phosphorylation A2AN08 178 S 17242355 HTP Phosphorylation A2AN08 2719 S 17242355 HTP Phosphorylation A2AN08 365 S 17242355 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs A2AN08 178 Phosphoserine 21183079 A2AN08 181 Phosphoserine 21183079 A2AN08 212 Phosphoserine 21183079 A2AN08 370 Phosphotyrosine 21183079 A2AN08 2719 Phosphoserine 21183079 A2AN08 2721 Phosphothreonine 21183079

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Ubr4 IPI00378681 S 1759 SLVRHApSTSPADK phosphorylation Ubr4 IPI00378681 S 1761 VRHASTpSPADKAK phosphorylation Ubr4 IPI00378681 S 2715 RHVTLPpSSPRSNT phosphorylation Ubr4 IPI00378681 S 2716 HVTLPSpSPRSNTP phosphorylation Ubr4 IPI00378681 S 2719 LPSSPRpSNTPMGD phosphorylation Ubr4 IPI00378681 S 2882 GSTLRTpSPADHGG phosphorylation Ubr4 IPI00378681 S 620 PPPLESpSPRVKSP phosphorylation Ubr4 IPI00378681 T 2712 NKRRHVpTLPSSPR phosphorylation Ubr4 IPI00378681 T 2721 SSPRSNpTPMGDKD phosphorylation Ubr4 IPI00378681 T 2881 DGSTLRpTSPADHG phosphorylation Ubr4 IPI00648709 S 1759 SLVRHApSTSPADK phosphorylation Ubr4 IPI00648709 S 1761 VRHASTpSPADKAK phosphorylation Ubr4 IPI00648709 S 178 DQKELApSPVSPEL phosphorylation Ubr4 IPI00648709 S 181 ELASPVpSPELRQK phosphorylation Ubr4 IPI00648709 S 2603 METDCFpSPRCACW phosphorylation Ubr4 IPI00648709 S 2743 RHVTLPpSSPRSNT phosphorylation Ubr4 IPI00648709 S 2744 HVTLPSpSPRSNTP phosphorylation Ubr4 IPI00648709 S 2747 LPSSPRpSNTPMGD phosphorylation Ubr4 IPI00648709 S 457 TKEGVGpSPKLGPG phosphorylation Ubr4 IPI00648709 S 619 PPPPLEpSSPRVKS phosphorylation Ubr4 IPI00648709 S 620 PPPLESpSPRVKSP phosphorylation Ubr4 IPI00648709 T 2749 SSPRSNpTPMGDKD phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID Ubr4 Mus musculus (Mouse) 1149; 634; 187; 1573; 4019 "1149,AETDPHKSSEITK; 634,KQASGEKGNILAS; 187,SPELRQKEVQMNF; 1573,KKYLSQKNVVEKL; 4019,CLRILQKLIKPPA" 1149:22790023; 634:22790023; 187:22790023; 1573:22790023; 4019:22790023 Ubr4 Mus musculus (Mouse) 1149; 634; 187; 1573; 4019 "1149,AETDPHKSSEITK; 634,KQASGEKGNILAS; 187,SPELRQKEVQMNF; 1573,KKYLSQKNVVEKL; 4019,CLRILQKLIKPPA" 1149:22790023; 634:22790023; 187:22790023; 1573:22790023; 4019:22790023