PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Protein lingerer Rel 23749869 biogrid exp G G G G G G G G G G CG14490-RA Protein lingerer 14605208 biogrid,intact exp Iap2 Protein lingerer 23749869 biogrid exp G G G G G G G G G G sgg Protein lingerer 25294943 intact exp G G G Protein lingerer Fadd 23749869 biogrid exp G G G G G G Protein lingerer PGRP-LE 23749869 biogrid exp G G G G G G G G G G Tab2-RA Protein lingerer 23749869 biogrid exp G G G G G G G G BG5 Protein lingerer 23749869 biogrid exp G G G G G G G Serine-arginine protein kinase at 79D, isoform K Protein lingerer 14605208 biogrid,i2d,intact exp G G Protein lingerer ird5 23749869 biogrid exp G G G G G G G G Protein lingerer key 23749869 biogrid exp G G G G G G G G G G Protein lingerer PGRP-LC 23749869 biogrid exp G G G G G G Protein lingerer CG12521-RA 14605208 biogrid,i2d,intact exp G 14-3-3epsilon Protein lingerer 20818332 intact exp G G G G G G G G G G Protein lingerer Tak1 23749869 biogrid exp G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86S05 Q9VNV0 two hybrid 14605208 physical association X 2 Q86S05 Q9VTP8 two hybrid 14605208 physical association X 2 Q86S05 A1ZB08 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B lig PGRP-LC MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_76089 prey bait lig CG14490-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|(biogrid) DIP_14645|UniProt_47930|BIOGRID_40034 -|prey|prey -|bait|bait lig key MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75807 prey bait Tab2 lig MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_76303 bait prey lig BG4 MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_76694 prey bait lig Tak1 MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_76555 prey bait lig Wwox MI:0415(enzymatic study) 20489023 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_560760 bait prey lig srpk79D MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|(biogrid) DIP_9506|UniProt_63568|BIOGRID_36792 -|prey|prey -|bait|bait lig ird5 MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75911 prey bait lig CG12521-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip) UniProt_65423|BIOGRID_37956|DIP_11426 prey|prey|- bait|bait|- lig PGRP-LE MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75720 prey bait imd lig MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_76802 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9GNK5 Q86S05 PGRP-LC LIG 0.126 23749869 Q9GYV5 Q86S05 KEY LIG 0.126 23749869 Q9VNV0 Q86S05 SRPK79D LIG 0.183 14605208 Q86S05 P18431 LIG SGG 0.236 25294943 Q94527 Q86S05 REL LIG 0.126 23749869 Q9V3B4 Q86S05 FADD LIG 0.126 23749869 Q9V3Q6 Q86S05 TAK1 LIG 0.126 23749869 Q9VEZ5 Q86S05 IRD5 LIG 0.126 23749869 Q9VTP8 Q86S05 CG12521-RA LIG 0.21 14605208 Q9VXN9 Q86S05 PGRP-LE LIG 0.126 23749869 Q86S05 P92177 LIG 14-3-3EPSILON 0.081 20818332 Q86S05 Q24307 LIG IAP2 0.126 23749869 Q86S05 A1ZB08 LIG CG14490-RA 0.183 14605208