PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus gus SD10969p 16603075 intact exp gus koko 15575970 biogrid exp gus CG10348, isoform B, CG10348, isoform C 14605208 biogrid,intact exp G gus CG16890, isoform A, CG16890, isoform C 14605208 biogrid,intact exp G G G G G gus Oda 14605208 biogrid,intact exp G G G G G G G G G G gus RE42507p, Stumps, isoform C 12767830 intact exp G G G G G G G G G gus Cdc14, isoform A, Cdc14, isoform D 15575970 biogrid,intact exp G G G G G G gus Cyclin G, isoform A, Cyclin G, isoform B, Cyclin G, isoform C, Cyclin G, isoform D, Cyclin G, isoform F, LD46284p 15575970 biogrid,intact exp G G G G G G G G G G gus Cyclin-dependent kinase 4, isoform A, Cyclin-dependent kinase 4, isoform B, Cyclin-dependent kinase 4, isoform C, Cyclin-dependent kinase 4, isoform D, Cyclin-dependent kinase 4, isoform E, LD31205p 15575970 biogrid,intact exp G G G G gus RpL38 14605208 biogrid,intact exp G G G G G G G G G G gus vas 20123973,16498413,unassigned4 intact exp gus Eaf 16603075 intact exp G G G G G G G G G G gus Par-1, isoform P 14605208 intact exp G G G G G G G G G G gus Cyclin J, isoform A 15575970 biogrid,intact exp G gus GH14454p, Twin of eyeless, isoform A 14605208 biogrid,intact exp G G G gus RhoGAP68F 15575970 biogrid,intact exp G G G G G G G G G G gus Cyclin H, Cyclin H homolog 15575970 biogrid exp G G G G G G G G G G gus Cyp1 14605208 biogrid,intact exp G G G G G G G G G G gus CG6800 15575970 biogrid,intact exp ald gus 15575970 biogrid,intact exp G G gus DmREV7 15575970 biogrid,intact exp G G G G G G G G G G gus Cyclin H 15575970 intact exp gus CG13631-RA 14605208 biogrid,intact exp G G G G G G G G G gus Protein NASP homolog 14605208 biogrid,intact exp G G G G G G G G G gus Sirt2 15575970 biogrid,intact exp G G G G G G G G G G gus Sox15 14605208 biogrid,intact exp gus NetB 25294943 intact exp G G G G G gus mus304 14605208 biogrid,intact exp G G gus AF4/FMR2 family member 4 14605208 biogrid,intact exp G G G gus CG14589, isoform A 14605208 biogrid,intact exp G gus SAK 15575970 biogrid,intact exp G G gus cup 14605208 biogrid,intact exp gus CG7683 15575970 intact exp gus LP09464p, Nucleoporin 133kD 15710747 biogrid,intact exp G G G G G G G gus ftz-f1 14605208 biogrid,intact exp G G G G G G gus Klc 15575970 biogrid,intact exp G G G G G G G G G G gus rad201 14605208 biogrid,intact exp G G G G gus E2f2 15575970 biogrid,intact exp G G G G G G G G G G gus cdc2c 15575970 biogrid,intact exp G G G gus CycA 15575970 biogrid,intact exp G G gus SkpB 15575970 biogrid,intact exp G gus CG9248, isoform A, CG9248, isoform B, CG9248, isoform C, GM01519p 15575970 biogrid,intact exp G G G G G G G G G G gus CG9798 14605208 biogrid,intact exp G G G gus LD12022p, Pineapple eye, isoform A, Pineapple eye, isoform B 15575970 biogrid,intact exp G G gus P53 protein long form variant 1, p53, isoform B 20308539 biogrid exp G G G G G G G G G G gus l(3)00305 15575970 biogrid,intact exp G G G G G G G G G G gus CG5376 14605208 biogrid,intact exp G G gus RpS29 14605208 biogrid,intact exp G G G G G G G G G G gus Egfr 14605208 biogrid,intact exp G G G G G G gus Akt1 15575970 biogrid,intact exp G G G G G G G G G gus Adf1 14605208 biogrid,intact exp G G G G G G G G G G gus vas 16498413 biogrid exp, ortho gus Elongin C, isoform A, Elongin C, isoform B, RE05591p, RH71704p 14605208,22036573 biogrid,intact exp, ortho G G G G G G G G G G gus Cullin 5, FI20194p1 20123973 intact exp, ortho G G G G G G G G G G gus Roc2-RA ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A1Z6E0 anti bait coimmunoprecipitation 20123973 association C 3 A1Z6E0 P04412-2 two hybrid 14605208 physical association X 2 A1Z6E0 Q9VMA3 two hybrid 14605208 physical association X 2 A1Z6E0 P33244 two hybrid 14605208 physical association X 2 A1Z6E0 Q9VCZ7 two hybrid 14605208 physical association X 2 A1Z6E0 A1Z7R9 two hybrid 14605208 physical association X 2 A1Z6E0 P25007 two hybrid 14605208 physical association X 2 A1Z6E0 Q9VIF2 two hybrid 15575970 physical association X 2 A1Z6E0 Q7KJ69 two hybrid 15575970 physical association X 2 A1Z6E0 Q9VTU3 two hybrid 15575970 physical association X 2 A1Z6E0 Q95TJ9 two hybrid 15575970 physical association X 2 A1Z6E0 Q8MQJ7 two hybrid 15575970 physical association X 2 A1Z6E0 E1JGZ1 two hybrid array 16603075 physical association X 2 E1JIR3 A1Z6E0 two hybrid 15575970 physical association X 2 O17144 A1Z6E0 two hybrid 15575970 physical association X 2 Q9VZP3 A1Z6E0 two hybrid 15575970 physical association X 2 Q9W5N2 A1Z6E0 two hybrid 14605208 physical association X 2 Q9VLW7 A1Z6E0 two hybrid 15575970 physical association X 2 Q9VCW3 A1Z6E0 two hybrid fragment pooling approach 15710747 physical association X 2 Q9V3M2 A1Z6E0 two hybrid 14605208 physical association X 2 P09052 A1Z6E0 pull down 16498413 direct interaction X 2 P09052 A1Z6E0 isothermal titration calorimetry 16498413 direct interaction X 2 P09052 A1Z6E0 anti tag coimmunoprecipitation 20123973 physical association X 2 P09052 A1Z6E0 anti bait coimmunoprecipitation 20123973 physical association X 2 P09052 A1Z6E0 experimental interaction detection - physical association X 2 Q9V490 A1Z6E0 two hybrid 14605208 physical association X 2 Q9VH69 A1Z6E0 two hybrid 14605208 physical association X 2 P54361 A1Z6E0 two hybrid 14605208 physical association X 2 A1Z6E0 O96757 two hybrid 12767830 physical association X 2 A1Z6E0 O96757 two hybrid 12767830 physical association X 2 A1Z6E0 O96757 two hybrid 12767830 physical association X 2 A1Z6E0 Q9VJ55 two hybrid 14605208 physical association X 2 A1Z6E0 Q9VC43 two hybrid 14605208 physical association X 2 A1Z6E0 A1ZBL7 two hybrid 14605208 physical association X 2 A1Z6E0 P40657 two hybrid 14605208 physical association X 2 A1Z6E0 Q8SYZ4 two hybrid 15575970 physical association X 2 A1Z6E0 O77051 two hybrid 15575970 physical association X 2 A1Z6E0 P46824 two hybrid 15575970 physical association X 2 A1Z6E0 O77051 two hybrid 15575970 physical association X 2 A1Z6E0 Q9VNE1 two hybrid 15575970 physical association X 2 A1Z6E0 Q95R37 two hybrid array 16603075 physical association X 2 A1Z6E0 Q9VAQ0 anti tag coimmunoprecipitation 20123973 physical association X 2 Q9VEH1 A1Z6E0 two hybrid 15575970 physical association X 2 Q9I7K6 A1Z6E0 two hybrid 14605208 physical association X 2 Q9VCY7 A1Z6E0 two hybrid 14605208 physical association X 2 Q9VVN4 A1Z6E0 two hybrid 14605208 physical association X 2 Q9VQI9 A1Z6E0 two hybrid 14605208 physical association X 2 P83940 A1Z6E0 x-ray crystallography 16498413 direct interaction X 2 Q9VKW2 A1Z6E0 two hybrid 15575970 physical association X 2 P14785 A1Z6E0 two hybrid 15575970 physical association X 2 Q7JWD6 A1Z6E0 two hybrid 14605208 physical association X 2 Q7K306 A1Z6E0 two hybrid 15575970 physical association X 2 O97143 A1Z6E0 two hybrid 15575970 physical association X 2 C6SUW9 A1Z6E0 two hybrid 14605208 physical association X 2 Q961G6 A1Z6E0 two hybrid 15575970 physical association X 2 A1Z6K2 A1Z6E0 two hybrid 14605208 physical association X 2 Q9VD82 A1Z6E0 two hybrid 15575970 physical association X 2 Q8INB9 A1Z6E0 two hybrid 15575970 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CycA gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40428 bait prey Egfr gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_57748 null bait Cul-5 gus MI:0006(anti bait coimmunoprecipitation) 20123973 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44732 prey bait CG9248 gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40430 bait prey SAK gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39678 bait prey gus par-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25839 bait prey Akt1 gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39681 bait prey ald gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40431 bait prey Oda gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_60979 prey bait gus rad201 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25845 bait prey gus CG14589 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_48145 prey bait cup gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_54614 prey bait CG8223 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25846 prey bait E2f2 gus MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_41046|UniProt_39679 bait|bait prey|prey pie gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40604 bait prey RpS29 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25847 prey bait Elongin-C gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25850 prey bait Cyp1 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25851 prey bait CG13631-RA gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_52717 bait prey RpL38 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25840 prey bait koko gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39682 bait prey Nup133 gus MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_41845 bait prey CycG gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39680 bait prey toy gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_54656 prey bait CG6800 gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40434 bait prey Sirt2 gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40433 bait prey Eaf gus MI:0018(two hybrid) 16603075 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44495 bait prey CycJ gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40429 bait prey vas gus MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0006(anti bait coimmunoprecipitation)|MI:0045(experimental interaction detection) 16498413,20123973 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_44727|UniProt_44728|UniProt_43194|UniProt_43193|UniProt_44733|UniProt_45765 bait|bait|neutral component|bait|prey|unspecified role prey|prey|neutral component|prey|bait|unspecified role Adf1 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_60737 prey bait bond gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25843 prey bait rev7 gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39684 bait prey Atg1 gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39683 bait prey mus304 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25844 bait prey Cdk4 gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39676 bait prey CG12393 gus MI:0018(two hybrid) 16603075 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44483 bait prey Sox15 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25848 prey bait CycH gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40435 bait prey CG10348 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_58601 prey bait RhoGAP68F gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39674 bait prey cdc2c gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40436 bait prey Klc gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_41177 bait prey CG16890 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_61139 bait prey stumps gus MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12767830 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_38844|UniProt_38820|UniProt_38810 bait|bait|bait prey|prey|prey cdc14 gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_40432 bait prey CG5376 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25841 bait prey skpB gus MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_39673 bait prey lilli gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25849 prey bait ftz-f1 gus MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_25842 bait prey