PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG1671, LD47550p GH01721p, Rau, isoform A, Rau, isoform B 15710747 biogrid,intact exp G G G G G G FK506-bp1 CG1671, LD47550p 25813344 biogrid exp G G G G G G G G G CG1671, LD47550p CG7191, isoform A, HL01609p 14605208 biogrid,intact exp G G G CG12325, isoform A, CG12325, isoform B, LD10780p CG1671, LD47550p 22036573 biogrid exp, ortho G G G G G G CG1671, LD47550p CG9799, LD47749p 22036573 biogrid exp, ortho G G G G G G G G CG1671, LD47550p CG8064, GH01043p 22036573 biogrid exp, ortho G G G G G G G CG1671, LD47550p LD17611p, U3 small nuclear riboprotein factor 55K ortho CG1440-RC CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p Ak6 ortho G G G G G G G G G CG1671, LD47550p Cbp20 ortho G G G G G G G G G CG1671, LD47550p CG2875-RB ortho G G G G G G Hsc70Cb, isoform G, Hsc70Cb, isoform H CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p Rrp46-RA ortho G G G G G G G CG1671, LD47550p dbe ortho G G G G G CG1671, LD47550p hlc ortho G G G G G G G G G Ca2+-channel-protein-beta-subunit, isoform L CG1671, LD47550p ortho G G G G ATPsyn-beta CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p CG7275-PA, LD28275p ortho G G G G G G G G G CG1671, LD47550p Ribosome production factor 2 homolog ortho G G G G G G G G G CG1671, LD47550p Sirt7 ortho G G G G Vha55 CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p Fib ortho G G G G G G G G G blw CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p Putative rRNA methyltransferase ortho G G G G CG1671, LD47550p BG:DS01068.6 ortho G G G G G G CG1671, LD47550p Adenylyl cyclase-associated protein ortho G G G G G G G G G CG1671, LD47550p CG3335 ortho G G G G G G G CG1671, LD47550p EG:25E8.3 ortho G G G G G G G G G CG1671, LD47550p Deoxyribonuclease II ortho G G G G G G G G CG1671, LD47550p l(1)G0022 ortho G G G G G G G G G CG1671, LD47550p porin ortho G G G G G G G G G CG1671, LD47550p GH24511p, Ubiquitin activating enzyme 1, isoform A ortho G G G G G G G G G CG1671, LD47550p GH10889p, Protein interacting with APP tail-1, isoform A, Protein interacting with APP tail-1, isoform C ortho G G G G G G G G G CG1671, LD47550p Probable nucleolar GTP-binding protein 1 ortho G G G G G G G G G CG1671, LD47550p Ubiquitin-related modifier 1 homolog ortho G G G G CG1671, LD47550p CG11920-RA ortho G G G G G G G G G bys CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p CG4554 ortho G CG1671, LD47550p CG10206-PA, LD32943p, Nop5 ortho G G G G G G G G G CG1671, LD47550p Nucleolar complex protein 3 homolog, NOC3 protein homolog ortho G G G G G G G G G CG1671, LD47550p CG5589 ortho G CG1671, LD47550p LD47396p, Tcp-1eta ortho G G G G G G G G G Atg18 CG1671, LD47550p ortho G G G G G G G G G CG9143, LD11580p CG1671, LD47550p ortho G G G G G RpI135 CG1671, LD47550p ortho G G G G CG1671, LD47550p CG11123, RH42110p ortho G G G G G G G CG1671, LD47550p CG7728-PA, LD38375p ortho G G G G G G CG1671, LD47550p CG8258, LD24495p ortho G G G G G G G G G CG1671, LD47550p Nop56-RA ortho G G G G G G G G G CG1671, LD47550p pit ortho G G G G G G G G G Pgi CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p CG2260, LD41718p ortho G Lethal (3) 72Dn, isoform B CG1671, LD47550p ortho G G G G G G G CG1671, LD47550p Nuclear migration protein NudC, NudC, isoform A, NudC, isoform B, RE55422p ortho G G G G G G G G G Vha68-1 CG1671, LD47550p ortho G G G G G G G G CG1671, LD47550p l(1)G0020 ortho G G CG1671, LD47550p Nucleolar complex protein 2 homolog, Protein NOC2 homolog ortho G G G G G G G CG1671, LD47550p CG1671, LD47550p ortho G G G G G G G G G Hsp60 CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p Probable U3 small nucleolar RNA-associated protein 11, U3 snoRNA-associated protein 11 ortho G G G G G G G G G CG1671, LD47550p CG6249-PA, RE36848p ortho G G G G 14-3-3epsilon CG1671, LD47550p ortho G G G G G G G G G Hr51-RC CG1671, LD47550p ortho G CG1671, LD47550p Mat89Ba ortho G Nop60B CG1671, LD47550p ortho G G G G G G G G G CG1671, LD47550p Coq2 ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7JQT9 Q9VML8 - 15710747 - X 2 Q7JQT9 - 14605208 - X 2 Q7JQT9 Q9VML8 two hybrid 15710747 direct interaction X 2 Q5U0X8 Q7JQT9 affinity chromatography technology 22036573 physical association X 2 Q9VFV8 Q7JQT9 affinity chromatography technology 22036573 physical association X 2 Q7JQT9 Q9VE98 affinity chromatography technology 22036573 physical association X 2 Q7JQT9 two hybrid 14605208 direct interaction X 2 Q7JQT9 Q9VML8 two hybrid 15710747 physical association X 2 Q7JQT9 two hybrid 14605208 physical association X 2 Q7JQT9 Q9VML8 two hybrid fragment pooling approach 15710747 physical association X 2 Q9VLX6 Q7JQT9 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CG12325 CG1671 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_73733 prey bait CG1671 CG7191 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact) DIP_16945|BIOGRID_32082|UniProt_60905 -|bait|prey -|prey|bait CG1671 CG8965 MI:0399(two hybrid fragment pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0465(dip) UniProt_42893|BIOGRID_62751|DIP_27942 prey|prey|- bait|bait|- CG1671 CG9799 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74348 bait prey CG1671 CG8064 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_73836 bait prey