PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus prp8 Histidyl-tRNA synthetase, isoform D 25294943 intact exp G G G G G G G G G G prp8 CG15308-RB 14605208 biogrid,intact exp G G G G G G prp8 Ald 25294943 intact exp G G G G G G G G G ps prp8 25294943 intact exp G G G G G G G G prp8 CG14353-RA 22036573 biogrid exp G G G G G prp8 CG6674, isoform A, LD44422p 22036573 biogrid exp G G G G G G G G prp8 CG14641, LD46870p 22036573 biogrid exp G G G G G G G G G G prp8 sgg 25294943 intact exp G G G prp8 CG5281-RA 25294943 intact exp G G prp8 CG6197-RA 22036573 biogrid exp G G G G G G G G prp8 CG1965, isoform A, LD29489p 22036573 biogrid exp G G G G G G G G G G prp8 Spinophilin, isoform J 25294943 intact exp G G G G G G prp8 CG9667, isoform A, RE31520p 22036573 biogrid exp, ortho G G G G G G G G G prp8 lethal(1)10Bb 22036573 biogrid exp, ortho G G G G G G G G G G prp8 l(3)72Ab 22036573 biogrid exp, ortho G G G G G G G G G G prp8 CG4849, LD28793p 22036573 biogrid exp, ortho G G G G G G G G G G prp8 CG6015, LD21931p 22036573 biogrid exp, ortho G G G G G G G G G G prp8 CG3436, isoform A, CG3436, isoform C, GM13767p 22036573 biogrid exp, ortho G G G G G G G G G G prp8 crn 22036573 biogrid exp, ortho G G G G G G G G G prp8 Bx42 22036573 biogrid exp, ortho G G G G G G G G G G prp8 ecd 22036573 biogrid exp, ortho G G G G G G G G G G prp8 CG4957 ortho G G G G G G G G G G prp8 Sep1 ortho G G G G G G G G G G prp8 mgr ortho G G G G G G G G G G prp8 faf ortho G G G G G G G G G prp8 RpS25 ortho prp8 BG:DS02740.2 ortho G G G G prp8 U2A ortho G prp8 bel ortho G G G G G G G G G G prp8 Phosphatidylinositol 5-phosphate 4-kinase, isoform A, Phosphatidylinositol 5-phosphate 4-kinase, isoform B, RH07911p ortho prp8 CG13277-PA, LSm7, isoform B, LSm7, isoform C, RH73529p ortho G G G G G G G G G G prp8 CG13900-RA ortho G G G G G G G G G G prp8 Probable 6-phosphogluconolactonase, 6PGL ortho G G G G G G G G G G prp8 hoip ortho prp8 14-3-3epsilon ortho G G G G G G G G G G prp8 ubl ortho G G G G G G G G G G prp8 N ortho G G G G prp8 Cbp20 ortho G G G G G G G G G G prp8 SmD3 ortho G G G G G G G G G G prp8 Splicing factor 3B subunit 6-like protein ortho G G G G G G G G G G prp8 LD24662p, Transport and golgi organization 4 ortho G G G G G G G G G prp8 Probable prefoldin subunit 5 ortho G G G G G G G G G G prp8 Ef1alpha-like factor, isoform A, Ef1alpha-like factor, isoform B, Ef1alpha-like factor, isoform D, RE07731p ortho G G G G G G G G G G prp8 Rpn11 ortho G G G G G G G G G G prp8 CG3018-PA, isoform A, Dorsal interacting protein 4, GM08377p, Lesswright, isoform A, Lesswright, isoform C, Lesswright, isoform D, RE25737p, Ubiquitin-conjugating enzyme, Ubiquitin-conjugating enzyme 9, Ubiquitin-conjugating enzyme 9 homolog ortho G G G G G G G G G G prp8 CG11839 ortho G G prp8 CG7433, isoform A, CG7433, isoform B, CG7433, isoform C, CG7433, isoform D ortho G G prp8 CG31368, isoform D ortho G G G G G prp8 LD41209p, Prp31 ortho G G G G G G G G G G prp8 CG6841-PA, LD04472p ortho G G G G G G G G G prp8 sbr ortho G G G G G G G G G G prp8 CG3542, LD24714p ortho G G G G G G prp8 abs ortho G G G G G G G G G prp8 E(z) ortho G G G G G G G prp8 NHP2 ortho G G G G G G G G G G prp8 dsh ortho G G G G G G G prp8 Hsc70Cb, isoform G, Hsc70Cb, isoform H ortho G G G G G G G G G G prp8 BcDNA.LD02793, Prp19 ortho G G G G G G G G G G prp8 holn1 ortho G G G G G G G G G G prp8 Epithelial membrane protein, isoform B ortho G G G G G G G G G G prp8 Sirt6 ortho G prp8 Dhx15 ortho G G G G G G G G G G prp8 Eukaryotic initiation factor 4A-III, eIF-4A-III, eIF4A-III ortho G G G G G G G G G G prp8 CG8184, isoform H ortho G G G G G G G G G G prp8 CG2807, isoform A, CG2807, isoform B ortho G G G G G G G G G G prp8 Nuclear GTP binding protein, Nucleostemin ortholog 2, SD10213p ortho G G SRPK prp8 ortho G G G G G G G G G prp8 mle ortho G G G G G G G prp8 skd ortho G G prp8 Nedd4 ortho G G G G G G G G G prp8 Cctgamma ortho G G G G G G G G G G prp8 Usp39 ortho G G G G G G G G G prp8 EG:BACR7A4.17 ortho G G G G G G G G G prp8 Slu7 ortho G G G G G G G G G prp8 CG16941, GH03554p ortho G G prp8 CG1375 ortho G G G G G G G G G prp8 CG10333, RH55640p ortho G G G G G G G G G G prp8 SD09427p, U4-U6 small nuclear riboprotein factor 60K ortho G G G G G G G G G prp8 Precursor RNA processing 3, isoform A ortho G G G G G G G G G G prp8 dod ortho G G G G prp8 Pen ortho G G prp8 Cullin 3, isoform F, FI19425p1 ortho G G G G G G G G G G prp8 LD20211p, Tudor-SN, isoform A, Tudor-SN, isoform B ortho G G G G G G G G G G prp8 CG9273 protein, CG9273-PA, GM04951p, Replication protein A2, isoform A, Replication protein A2, isoform B ortho G G G prp8 CG3605, isoform A, CG3605, isoform B, LD45152p ortho G G G G G G G G G G prp8 prp8 ortho G G G G G G G G G G prp8 Su(z)12 ortho G G G G G G G G G G prp8 RE08669p, Ribosomal protein L6, isoform B ortho G G G G G G G G G G prp8 BCAS2 ortholog, LD24242p ortho G G G G prp8 RpL37A ortho G G G G G G G G G G prp8 SmD1 ortho G G G G G G G G G G Gcn2 prp8 ortho G G G G G G G G G G prp8 Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p ortho G G G G G G G prp8 Sirt7 ortho G G G G G prp8 Sce ortho G G G G G G G prp8 RpA-70 ortho G G G G G G G G G G prp8 pnut ortho G G G G G G G G G G prp8 Cyclin-dependent kinase 9, GH21935p, Positive transcription elongation factor b small subunit ortho G G G G G G G G G G prp8 LD41216p, SMU1 ortholog, isoform A, SMU1 ortholog, isoform B, SMU1 ortholog, isoform C ortho G G G G G G G prp8 CG12320 ortho G G G prp8 SmD2 ortho G G G G G G G G G G prp8 me31B ortho G G G G G G G G G G prp8 T-complex protein 1 subunit delta ortho G G G G G G G G G G prp8 Pglym87 ortho G prp8 Top1 ortho G G G G G G G G G prp8 Ubiquitin-related modifier 1 homolog ortho G G G G prp8 RpLP0 ortho G G G G G G G G G G prp8 CG10418-PA ortho G G G G G G G G G G prp8 Ubi-p63E ortho G G G G G G G G G G prp8 Wwox ortho G G G G G G G G prp8 SmE ortho G G G G G G G G G G prp8 dre4 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A1Z8U0 - 14605208 - X 2 Q9VVM7 A1Z8U0 affinity chromatography technology 22036573 physical association X 2 A1Z8U0 Q9W2X3 two hybrid 14605208 direct interaction X 2 A1Z8U0 Q9VUV9 affinity chromatography technology 22036573 physical association X 2 A1Z8U0 Q9VI54 affinity chromatography technology 22036573 physical association X 2 A1Z8U0 Q9VPL0 affinity chromatography technology 22036573 physical association X 2 A1Z8U0 affinity chromatography technology 22036573 physical association X 2 A1Z8U0 P39736 affinity chromatography technology 22036573 physical association X 2 Q9W032 A1Z8U0 affinity chromatography technology 22036573 physical association X 2 Q9VAX8 A1Z8U0 affinity chromatography technology 22036573 physical association X 2 P17886 A1Z8U0 affinity chromatography technology 22036573 physical association X 2 Q9VT74 A1Z8U0 affinity chromatography technology 22036573 physical association X 2 A1Z8U0 A1Z9G2 affinity chromatography technology 22036573 physical association X 2 A1Z8U0 Q95RB1 affinity chromatography technology 22036573 physical association X 2 Q9VD52 A1Z8U0 affinity chromatography technology 22036573 physical association X 2 Q9VHV6 A1Z8U0 affinity chromatography technology 22036573 physical association X 2 A1Z8U0 Q9W2X3 two hybrid 14605208 physical association X 2 A1Z8U0 Q9W2X3 two hybrid 14605208 physical association X 2 A1Z8U0 anti tag coimmunoprecipitation 25294943 association C 35

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CG5931 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65445 prey bait l(1)10Bb Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71339 bait prey CG14353-RA Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71501 prey bait crn Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71320 bait prey CG1965 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_69748 prey bait Bx42 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71617 bait prey ecd Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65368 bait prey CG14641 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_73711 prey bait CG6674 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66640 prey bait CG3436 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70464 bait prey CG4849 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65075 prey bait Prp8 CG6197-RA MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70877 bait prey CG6015 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70814 prey bait CG15308-RB Prp8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact) BIOGRID_40963|DIP_16006|UniProt_59980 bait|-|bait prey|-|prey CG9667 Prp8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74848 prey bait