PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Dys eIF3-S5-1 i2d exp PAB-dependent poly(A)-specific ribonuclease subunit PAN2 eIF3-S5-1 14605208 biogrid,intact exp G G G G G G G G G G Sras eIF3-S5-1 19079254 intact exp G G G G G G G G G G Hip1 eIF3-S5-1 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G eIF3-S5-1 eIF3-S4-1 22036573 biogrid exp G G G G G G G G G G RH03791p eIF3-S5-1 i2d exp MED6 eIF3-S5-1 14605208 i2d,mint,intact exp G G G G G G G G G Dys eIF3-S5-1 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G eIF3-S5-1 CG4887-RA 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G eIF3-S5-1 sec10 15710747 biogrid,i2d,intact exp G G G G G G G G G G Cp38 eIF3-S5-1 14605208 biogrid,i2d,mint,intact exp G CG31731-RC eIF3-S5-1 14605208 biogrid exp G G G G G G G G G G CG3610-RA eIF3-S5-1 14605208 biogrid,i2d,mint,intact exp G Trc8 eIF3-S5-1 20068067 biogrid exp G G G G G G G G G G eIF3-S6 eIF3-S5-1 22036573 biogrid exp, ortho G G G G G G G G G G Tango7 eIF3-S5-1 14605208,22036573 biogrid,intact exp, ortho G G G G G G G G G G eIF3-S8 eIF3-S5-1 22036573 biogrid exp, ortho G G G G G G G G G G eIF3-S10 eIF3-S5-1 22036573 biogrid exp, ortho G G G G G G G G G G eIF3-S5-1 Eukaryotic translation initiation factor 3 subunit L, eIF3l 22036573 biogrid exp, ortho G G G G G G G G G G eIF3-S9 eIF3-S5-1 22036573 biogrid exp, ortho G G G G G G G G G G eIF3-S5-1 Eukaryotic translation initiation factor 3 subunit K, eIF3k 22036573 biogrid exp, ortho G G G G G G G G G G eIF-3p40 eIF3-S5-1 22036573 biogrid exp, ortho G G G G G G G G G G eIF3-S5-1 CG8184, isoform H ortho G G G G G G G G G G FI03211p, Spindle B eIF3-S5-1 ortho G MICOS complex subunit Mic60 eIF3-S5-1 ortho G G G G G G G G G G eIF3-S5-1 CG14270-PA, RE03721p ortho G G G G G G G G G G Klp10A eIF3-S5-1 ortho G G G G G G G G 14-3-3zeta eIF3-S5-1 ortho G G G G G G G Ubi-p63E eIF3-S5-1 ortho G G G G G G G G G G Sce eIF3-S5-1 ortho G G G G G G G eIF3-S5-1 GH01161p, TNF-receptor-associated factor 6 ortho G G G G G G G G G Bx42 eIF3-S5-1 ortho G G G G G G G G G G eIF-3p66 eIF3-S5-1 ortho G G G G G G G G G G bel eIF3-S5-1 ortho G G G G G G G G G G CG5205 eIF3-S5-1 ortho G G G G G G G G G G Vha68-1 eIF3-S5-1 ortho G G G G G G G G G eIF3-S5-1 Upf1 ortho G G G G G G G G G G Nop60B eIF3-S5-1 ortho G G G G G G G G G G slo eIF3-S5-1 ortho G G G G eIF3-S5-1 PMP34 ortho G G G G G G G G G G 14-3-3epsilon eIF3-S5-1 ortho G G G G G G G G G G Trip1 eIF3-S5-1 ortho G G G G G G G G G G eIF3-S5-1 mael ortho G G eIF3-S5-1 UQCR-Q ortho G G G G G G G G G G WD repeat-containing protein 48 homolog eIF3-S5-1 ortho G G G G G G G FI11703p, Rad21 mitotic cohesin, Verthandi, isoform A eIF3-S5-1 ortho G G G G G G G G G G N eIF3-S5-1 ortho G G G G eIF3-S5-1 Mitochondrial ribosomal protein L46, RE09091p ortho G G G G G G G G G G Tor eIF3-S5-1 ortho G G G G G G G G G G CkIIalpha eIF3-S5-1 ortho G G G G G G G G G G eIF3-S5-1 RpS10b ortho G G G G G G G G G G eIF3-S5-1 CG13708, isoform A, CG13708, isoform B ortho Adam eIF3-S5-1 ortho G G G G G G G G G G eIF3-S5-1 eIF3-S5-1 ortho G G G G G G G G G G eIF-4a eIF3-S5-1 ortho G G G G G G G G G G S6k-RA eIF3-S5-1 ortho G G G G G G G G G CkIIbeta eIF3-S5-1 ortho G G G G G G G G G G eIF3-S5-1 CSN5 ortho G G G G G G G G G G eIF3-S5-1 Pixie, isoform A, Pixie, isoform B, RE71924p ortho G G G G G G G G G G Tsp86D eIF3-S5-1 ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VN50 - 14605208 - X 2 Q9VN50 Q9VFF6 - 14605208 - X 2 Q9VN50 Q8MQJ8 - 14605208 - X 2 Q9XTM1 Q9VN50 - 15710747 - X 2 Q9VDW3 Q9VN50 - 14605208 - X 2 E1JJF7 Q9VN50 - 14605208 - X 2 Q7JVI3 Q9VN50 - 14605208 - X 2 Q9VN50 A1Z7K9 - 14605208 - X 2 Q9VN50 Q9VPY4 - 14605208 - X 2 Q9VN50 E1JIH5 - 14605208 - X 2 Q9VN50 - 14605208 - X 2 E2QCG7 Q9VN50 affinity chromatography technology 22036573 physical association X 2 Q9VN50 Q8MQJ8 two hybrid 14605208 direct interaction X 2 Q9VN50 two hybrid 14605208 direct interaction X 2 Q9VN50 Q9VFF6 two hybrid 14605208 direct interaction X 2 Q9VN50 Q7KRW1 pull down 20068067 direct interaction X 2 Q9VN50 O77410 affinity chromatography technology 22036573 physical association X 2 Q9VN50 Q9VTU4 affinity chromatography technology 22036573 physical association X 2 Q9VN50 Q9W2D9 affinity chromatography technology 22036573 physical association X 2 Q9VN50 Q9U9Q4 affinity chromatography technology 22036573 physical association X 2 Q9VN50 Q9VN25 affinity chromatography technology 22036573 physical association X 2 Q9XTM1 Q9VN50 two hybrid 15710747 direct interaction X 2 E1JJF7 Q9VN50 two hybrid 14605208 direct interaction X 2 Q7JVI3 Q9VN50 two hybrid 14605208 direct interaction X 2 Q7JVI3 Q9VN50 affinity chromatography technology 22036573 physical association X 2 Q9VN50 Q0E8Q7 two hybrid 14605208 direct interaction X 2 Q9VN50 Q9VPY4 two hybrid 14605208 direct interaction X 2 Q9VN50 A1Z7K9 two hybrid 14605208 direct interaction X 2 Q9VN50 A1ZAX1 affinity chromatography technology 22036573 physical association X 2 Q9VN50 Q9W4X7 affinity chromatography technology 22036573 physical association X 2 Q9VDW6-1 Q9VN50 two hybrid 14605208 physical association X 2 Q9VN50 Q8MQJ8 two hybrid 14605208 physical association X 2 Q9VN50 two hybrid 14605208 physical association X 2 Q9VN50 Q9VFF6 two hybrid 14605208 physical association X 2 Q9XTM1 Q9VN50 two hybrid 15710747 physical association X 2 E1JJF7 Q9VN50 two hybrid 14605208 physical association X 2 Q7JVI3 Q9VN50 two hybrid 14605208 physical association X 2 Q9VN50 Q9VPY4 two hybrid 14605208 physical association X 2 Q9VN50 A1Z7K9 two hybrid 14605208 physical association X 2 Q9VN50 E1JIH5 two hybrid 14605208 physical association X 2 Q9VN50 two hybrid 14605208 physical association X 2 Q9VN50 Q8MQJ8 two hybrid 14605208 physical association X 2 Q9VN50 Q9VDW6 two hybrid 14605208 physical association X 2 Q9VN50 Q9VFF6 two hybrid 14605208 physical association X 2 Q9XTM1 Q9VN50 two hybrid fragment pooling approach 15710747 physical association X 2 E1JJF7 Q9VN50 two hybrid 14605208 physical association X 2 Q7JVI3 Q9VN50 two hybrid 14605208 physical association X 2 Q9VN50 Q9VPY4 two hybrid 14605208 physical association X 2 Q9VN50 E1JIH5 two hybrid 14605208 physical association X 2 Q9VN50 A1Z7K9 two hybrid 14605208 physical association X 2 Q9VN50 Q9U1H8 two hybrid array 19079254 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Hip1 eIF3-S5-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0465(dip)|(intact) MINT_23222|BIOGRID_35615|DIP_7891|UniProt_53966 bait|bait|-|bait prey|prey|-|prey CG31731 eIF3-S5-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_26856 bait prey Trc8 eIF3-S5-1 MI:0096(pull down) 20068067 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_64192 bait prey Dys eIF3-S5-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_12781|UniProt_26583 bait|bait prey|prey Q9V505 eIF3-S5-1 MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_17503 bait prey eIF3-S5-1 sec10 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact) BIOGRID_63129|DIP_27541|UniProt_42517 prey|-|prey bait|-|bait Tango7 eIF3-S5-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 14605208,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(biogrid)|(intact) BIOGRID_47662|DIP_25883|BIOGRID_64846|UniProt_53134 bait|-|bait|bait prey|-|prey|prey Q9V6X8 eIF3-S5-1 MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_17532 bait prey eIF3-S9 eIF3-S5-1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66545 bait prey MED6 eIF3-S5-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0465(dip) UniProt_53393|MINT_17773|DIP_26125 bait|bait|- prey|prey|- Sras eIF3-S5-1 MI:0397(two hybrid array) 19079254 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_43354 bait prey Q9NKF0 eIF3-S5-1 MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_13036 bait prey eIF-3p40 eIF3-S5-1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65058 bait prey CG31731 eIF3-S5-1 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_44334|DIP_21137 bait|- prey|- Dys eIF3-S5-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_44168 bait prey eIF3-S6 eIF3-S5-1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64766 bait prey Cp38 eIF3-S5-1 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_8680|MINT_23929|BIOGRID_36233|UniProt_54762 -|bait|bait|bait -|prey|prey|prey eIF3-S5-1 CG8232 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|(biogrid) DIP_25856|UniProt_53105|BIOGRID_47646 -|prey|prey -|bait|bait eIF3-S5-1 CG5642 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64780 prey bait eIF3-S5-1 eIF3-S4-1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67409 prey bait CG3610 eIF3-S5-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_14282|BIOGRID_45139|UniProt_49677 bait|bait|bait prey|prey|prey eIF3-S5-1 CG4887 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|MI:0465(dip) MINT_15601|UniProt_61748|BIOGRID_46202|DIP_23869 prey|prey|prey|- bait|bait|bait|- eIF3-S5-1 CG10306 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64959 prey bait eIF3-S5-1 eIF3-S8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64835 prey bait eIF3-S10 eIF3-S5-1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68531 bait prey Q9VET8 eIF3-S5-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_25292|UniProt_64184 bait|bait prey|prey Dys eIF3-S5-1 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_20869 - -

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VN50 Q0E940 EIF3-S5-1 EIF3-S9 0.126 22036573 Q9VN50 Q0KI50 EIF3-S5-1 DYS 0.183 14605208 Q9XTM1 Q9VN50 SEC10 EIF3-S5-1 0.309 15710747 Q9VN50 O77410 EIF3-S5-1 EIF3-S6 0.126 22036573 Q9VN50 Q7KRW1 EIF3-S5-1 TRC8 0.309 20068067 Q9VN50 Q7YU29 EIF3-S5-1 DYS 0.183 14605208 Q9VN50 Q9U1H8 EIF3-S5-1 SRAS 0.236 19079254 Q9VN50 Q9U9Q4 EIF3-S5-1 EIF-3P40 0.126 22036573 Q9VN50 Q9VDW3 EIF3-S5-1 DYS 0.183 14605208 Q9VN50 Q9VDW6 EIF3-S5-1 DYS 0.332 14605208 Q9VN50 Q9VN25 EIF3-S5-1 EIF3-S10 0.126 22036573 Q9VN50 A1Z7K9 EIF3-S5-1 PAN2 0.183 14605208 Q9VN50 P07183 EIF3-S5-1 CP38 0.354 14605208 Q9VN50 Q7JVI3 EIF3-S5-1 TANGO7 0.416 22036573,14605208 Q9VN50 Q8MQJ8 EIF3-S5-1 HIP1 0.183 14605208 Q9VN50 Q8MSX2 EIF3-S5-1 MED6 0.183 14605208 Q9VN50 Q9VFF6 EIF3-S5-1 CG3610-RA 0.183 14605208 Q9VPY4 Q9VN50 CG4887-RA EIF3-S5-1 0.183 14605208 Q9VTU4 Q9VN50 Q9VTU4 EIF3-S5-1 0.126 22036573 Q9W2D9 Q9VN50 Q9W2D9 EIF3-S5-1 0.126 22036573 Q9W4X7 Q9VN50 EIF3-S4-1 EIF3-S5-1 0.126 22036573 Q9VN50 A1ZAX1 EIF3-S5-1 EIF3-S8 0.126 22036573