PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ino80 HL01030p, Lost PHDs of trr, isoform A 25294943 intact exp G G G G G EcR HL01030p, Lost PHDs of trr, isoform A 22569554 biogrid exp G G G G usp HL01030p, Lost PHDs of trr, isoform A 22569554 biogrid exp G G G G G AT22559p, CG31802-PA HL01030p, Lost PHDs of trr, isoform A 15710747 biogrid,i2d,intact exp G Su(var)205 HL01030p, Lost PHDs of trr, isoform A 22569554 biogrid exp G G G G G G NetB HL01030p, Lost PHDs of trr, isoform A 25294943 intact exp G G G Gli-RA HL01030p, Lost PHDs of trr, isoform A 25294943 intact exp G G G G G Fas2 HL01030p, Lost PHDs of trr, isoform A 25294943 intact exp G G G G sgg HL01030p, Lost PHDs of trr, isoform A 25294943 intact exp G G G EG:BACR37P7.5 HL01030p, Lost PHDs of trr, isoform A 14605208 biogrid,i2d,mint,intact exp G GH01721p, Rau, isoform A, Rau, isoform B HL01030p, Lost PHDs of trr, isoform A 15710747 biogrid,i2d,intact exp G G G G trr HL01030p, Lost PHDs of trr, isoform A 22569554 biogrid exp G G G G G HL01030p, Lost PHDs of trr, isoform A Brinker, Brk, Putative transcription factor, RE18244p 14605208 biogrid,i2d,mint,intact exp

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9W1H0 Q9VML8 - 15710747 - X 2 Q9W1H0 Q9V3G9 - 14605208 - X 2 Q8T415 Q9W1H0 - 15710747 - X 2 Q9W1H0 Q8IRW8 affinity chromatography technology 22569554 physical association X 2 Q9W1H0 P05205 pull down 22569554 direct interaction X 2 Q9W1H0 P05205 pull down 22569554 direct interaction X 2 Q9W1H0 Q9VML8 two hybrid 15710747 direct interaction X 2 A4UZ51 Q9W1H0 affinity chromatography technology 22569554 physical association X 2 Q9W1H0 P20153 affinity chromatography technology 22569554 physical association X 2 Q9W1H0 Q9V3G9 two hybrid 14605208 direct interaction X 2 Q9XTN4 Q9W1H0 two hybrid 14605208 direct interaction X 2 Q8T415 Q9W1H0 two hybrid 15710747 direct interaction X 2 Q9W1H0 Q9VML8 two hybrid 15710747 physical association X 2 Q9W1H0 Q9V3G9 two hybrid 14605208 physical association X 2 Q9XTN4 Q9W1H0 two hybrid 14605208 physical association X 2 Q9W1H0 pull down 25294943 association C 15 Q9W1H0 Q9V3G9 two hybrid 14605208 physical association X 2 Q9XTN4 Q9W1H0 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B usp Lpt MI:0004(affinity chromatography technology) 22569554 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75245 prey bait Su(var)205 Lpt MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22569554 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_75247|BIOGRID_75248 prey|bait bait|prey Utx Lpt MI:0004(affinity chromatography technology) 22569554 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0794(synthetic genetic interaction defined by inequality) (biogrid) BIOGRID_75250 bait prey trr Lpt MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22569554 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0794(synthetic genetic interaction defined by inequality)|MI:0796(suppressive genetic interaction defined by inequality) (biogrid)|(biogrid)|(biogrid) BIOGRID_75246|BIOGRID_75249|BIOGRID_75251 prey|prey|bait bait|bait|prey Lpt brk MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact)|MI:0471(mint) DIP_24479|BIOGRID_46635|UniProt_62369|MINT_16185 -|bait|bait|bait -|prey|prey|prey CG31802 Lpt MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_62997 bait prey CG8965 Lpt MI:0018(two hybrid)|MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_62998|DIP_27900 bait|- prey|- EG:BACR37P7.5 Lpt MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0465(dip) UniProt_65283|BIOGRID_37873|MINT_26327|DIP_11263 prey|bait|prey|- bait|prey|bait|- EcR Lpt MI:0004(affinity chromatography technology) 22569554 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75244 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9XTN4 Q9W1H0 BRK LPT 0.183 14605208 Q9W1H0 Q7KT70 LPT GLI 0.126 25294943 Q9W1H0 Q24568 LPT NETB 0.236 25294943 Q9W1H0 P34082 LPT FAS2 0.126 25294943 Q9W1H0 Q9V3G9 LPT EG:BACR37P7.5 0.183 14605208 Q9W1H0 Q9VDY1 LPT INO80 0.126 25294943 Q9W1H0 P18431 LPT SGG 0.126 25294943