PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus pcf-11 ape-1 23549480 intact exp figl-1 ape-1 23549480 intact exp G F38E9.1 ape-1 23549480 intact exp F49E2.2c ape-1 23549480 intact exp G F09E10.3 ape-1 23549480 intact exp G T23G11.7a ape-1 23549480 intact exp ape-1 C43G2.2a 23549480 intact exp C11E4.6 ape-1 23549480 intact exp G T08G5.5b ape-1 23549480 intact exp G alx-1 ape-1 23549480 intact exp G F08F8.3a ape-1 14704431 biogrid exp G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9XVN3 G5EEE6 two hybrid 14704431 direct interaction X 2 Q93203 Q9XVN3 two hybrid 23549480 physical association X 2 Q09345 Q9XVN3 two hybrid 23549480 physical association X 2 Q19246 Q9XVN3 two hybrid 23549480 physical association X 2 Q9XVN3 A6ZJ46 two hybrid 23549480 physical association X 2 Q9XVN3 P34552 two hybrid 23549480 physical association X 2 Q9XVN3 O45812 two hybrid 23549480 physical association X 2 Q9XVN3 A6ZJ46 two hybrid 23549480 physical association X 2 A8JJR1 Q9XVN3 two hybrid 23549480 physical association X 2 Q20177 Q9XVN3 two hybrid 23549480 physical association X 2 V6CJ04 Q9XVN3 two hybrid 23549480 physical association X 2 O16299 Q9XVN3 two hybrid 23549480 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ape-1 vps-39 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23642 bait prey alx-1 ape-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23638 prey bait ape-1 CELE_F49E2.2 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_24212|UniProt_23670 prey|prey bait|bait ape-1 bicd-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23636 bait prey CELE_T23G11.7 ape-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23641 prey bait C11E4.6 ape-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23633 prey bait pcf-11 ape-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23640 prey bait figl-1 ape-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23637 prey bait dhs-25 ape-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23635 prey bait F38E9.1 ape-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23639 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9XVN3 Q19246 APE-1 DHS-25 0.183 23549480 Q9XVN3 Q20177 APE-1 Q20177 0.183 23549480 Q9XVN3 O45812 APE-1 O45812 0.183 23549480 Q9XVN3 O16299 APE-1 FIGL-1 0.183 23549480 Q9XVN3 P34552 APE-1 ALX-1 0.183 23549480 V6CJ04 Q9XVN3 BICD-1 APE-1 0.183 23549480 Q9XVN3 Q93203 APE-1 Q93203 0.183 23549480 Q9XVN3 A6ZJ46 APE-1 A6ZJ46 0.183 23549480 Q9XVN3 A8JJR1 APE-1 VPS-39 0.183 23549480 Q9XVN3 Q09345 APE-1 PCF-11 0.183 23549480