PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus rap-1 vav-1 i2d exp G tra-1 vav-1 23549480 intact exp G vav-1 Y48G8AL.10a 23549480 intact exp cdc-42 vav-1 i2d exp G Y37A1B.17a vav-1 23549480 intact exp G T12D8.8 vav-1 23549480 intact exp G F09F7.5a vav-1 23549480 intact exp inx-12 vav-1 14704431 biogrid,i2d,mint,intact,dip exp G eft-3, eft-4 vav-1 14704431 biogrid,i2d,mint,intact,dip exp dhhc-6 vav-1 i2d exp G vav-1 Y44E3A.4 23549480 intact exp G C25A11.4a vav-1 23549480 intact exp G sqv-4 vav-1 23549480 intact exp G mig-6 vav-1 23549480 intact exp G pal-1 vav-1 14704431 biogrid,i2d,mint,intact exp unc-89 vav-1 23549480 intact exp G asp-3 vav-1 23549480 intact exp G vav-1 Y75B8A.1 14704431 biogrid,i2d,mint,intact,dip exp COLlagen structural, T28C6.4, T28C6.6 vav-1 23549480 intact exp gpb-1 vav-1 i2d exp G vav-1 Y63D3A.5 23549480 intact exp dyn-1 vav-1 23549480 intact exp G T28C6.7a vav-1 14704431 biogrid,i2d,mint,intact,dip exp G vav-1 Y4C6B.1 23549480 intact exp W10D9.4 vav-1 23549480 intact exp G ced-6 vav-1 23549480 intact exp G B0244.8 vav-1 14704431 biogrid,i2d,mint,intact,dip exp R03C1.1b vav-1 23549480 intact exp Eukaryotic translation initiation factor eIF5B, Y54F10BM.2 vav-1 23549480 intact exp T14G11.3 vav-1 23549480 intact exp G JC8.10b, Synaptojanin UNC-26A vav-1 23549480 intact exp vav-1 K11D12.10a 23549480 intact exp G Ceprp21 vav-1 23549480 intact exp G vav-1 T28F12.3 23549480 intact exp G Phosphoinositide 3-kinase adapter subunit, Y110A7A.10 vav-1 ortho G vav-1 daf-2 ortho G vav-1 Y39B6A.36 ortho G sem-5 vav-1 ortho G Phosphoinositide phospholipase C vav-1 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q45FX5 P34766-2 two hybrid 14704431 direct interaction X 2 Q45FX5 P53013 two hybrid 14704431 direct interaction X 2 Q45FX5 O01634 two hybrid 14704431 direct interaction X 2 Q45FX5 Q09967 two hybrid 14704431 direct interaction X 2 Q45FX5 two hybrid 14704431 direct interaction X 2 Q45FX5 Q9XW88 two hybrid 14704431 direct interaction X 2 G5EGT7 Q45FX5 two hybrid 23549480 physical association X 2 Q45FX5 P53013 two hybrid pooling approach 14704431 physical association X 2 Q45FX5 Q22847 two hybrid pooling approach 14704431 physical association X 2 Q45FX5 O01634 two hybrid pooling approach 14704431 physical association X 2 Q45FX5 Q19905 two hybrid 23549480 physical association X 2 Q45FX5 G5EDG6 two hybrid 23549480 physical association X 2 Q45FX5 V6CKC3 two hybrid 23549480 physical association X 2 Q45FX5 G5ECL3 two hybrid 23549480 physical association X 2 Q45FX5 Q22505 two hybrid 23549480 physical association X 2 Q45FX5 G5ECK4 two hybrid 23549480 physical association X 2 Q45FX5 Q6A573 two hybrid 23549480 physical association X 2 Q45FX5 P34708 two hybrid 23549480 physical association X 2 Q45FX5 Q9UB01 two hybrid 23549480 physical association X 2 Q45FX5 Q9U1W1 two hybrid 23549480 physical association X 2 P55956 Q45FX5 two hybrid 23549480 physical association X 2 Q45FX5 Q09967 two hybrid pooling approach 14704431 physical association X 2 Q45FX5 P34766 two hybrid pooling approach 14704431 physical association X 2 Q45FX5 Q9XW88 two hybrid pooling approach 14704431 physical association X 2 Q45FX5 P39055 two hybrid 23549480 physical association X 2 Q45FX5 B3CJ53 two hybrid 23549480 physical association X 2 Q45FX5 G5EE04 two hybrid 23549480 physical association X 2 Q45FX5 O76337 two hybrid 23549480 physical association X 2 Q45FX5 B7WNA3 two hybrid 23549480 physical association X 2 Q45FX5 O01761 two hybrid 23549480 physical association X 2 Q45FX5 G4RTG4 two hybrid 23549480 physical association X 2 Q45FX5 O76840 two hybrid 23549480 physical association X 2 Q45FX5 Q19275 two hybrid 23549480 physical association X 2 Q45FX5 O76337 two hybrid 23549480 physical association X 2 Q45FX5 Q8T7Z0 two hybrid 23549480 physical association X 2 Q45FX5 Q9N5D3 two hybrid 23549480 physical association X 2 Q45FX5 O17286 two hybrid 23549480 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B vav-1 tfg-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23558 bait prey mig-6 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23546 prey bait vav-1 unc-26 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24026 bait prey immt-1 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23550 prey bait vav-1 CELE_Y48G8AL.10 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24029 bait prey vav-1 php-3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact)|MI:0471(mint) DIP_1525|BIOGRID_21795|UniProt_29908|MINT_7112 -|bait|bait|bait -|prey|prey|prey inx-12 vav-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_21796|DIP_1526|UniProt_29909|MINT_7113 prey|-|prey|prey bait|-|bait|bait T28C6.7 vav-1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(intact)|MI:0471(mint) DIP_1524|UniProt_29907|MINT_7111 -|prey|prey -|bait|bait egg-1 vav-1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0465(dip)|(intact) MINT_7108|DIP_1521|UniProt_29904 prey|-|prey bait|-|bait nfyb-1 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23551 prey bait dyn-1 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24023 prey bait vav-1 prp-21 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24116 bait prey vav-1 ajm-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23544 bait prey vav-1 CELE_Y37A1B.17 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23553 bait prey vav-1 hip-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24027 bait prey vav-1 col-117 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24028 bait prey vav-1 CELE_Y44E3A.4 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23555 bait prey sqv-4 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24024 prey bait vav-1 iffb-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23559 bait prey pal-1 vav-1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_21792|DIP_1522|UniProt_29905|MINT_7109 prey|-|prey|prey bait|-|bait|bait F09F7.5 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23549 prey bait vav-1 mlk-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23547 bait prey unc-89 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23545 prey bait vav-1 sos-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23552 bait prey vav-1 CELE_R03C1.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24115 bait prey ced-6 vav-1 MI:0018(two hybrid)|MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_24114|UniProt_23548 prey|prey bait|bait asp-3 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_24025 prey bait eft-3 vav-1 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14704431 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(intact)|(biogrid)|MI:0471(mint) DIP_1523|UniProt_29906|BIOGRID_21793|MINT_7110 -|prey|prey|prey -|bait|bait|bait tra-1 vav-1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23554 prey bait vav-1 CG9773 MI:0018(two hybrid) 14704431 taxid:6239(Caenorhabditis elegans) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_21791 bait prey vav-1 CELE_Y4C6B.1 MI:0018(two hybrid) 23549480 taxid:6239(Caenorhabditis elegans) taxid:6239(Caenorhabditis elegans) MI:0915(physical association) (intact) UniProt_23556 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q45FX5 Q09967 VAV-1 EGG-1 0.126 14704431 Q45FX5 Q22847 VAV-1 Q22847 0.126 14704431 Q45FX5 Q19905 VAV-1 SQV-4 0.183 23549480 Q9XW88 Q45FX5 PHP-3 VAV-1 0.126 14704431 Q6A573 Q45FX5 Q6A573 VAV-1 0.183 23549480 Q45FX5 P39055 VAV-1 DYN-1 0.183 23549480 Q45FX5 P34708 VAV-1 TRA-1 0.183 23549480 Q45FX5 P34766 VAV-1 PAL-1 0.286 14704431 Q45FX5 G5ECK4 VAV-1 G5ECK4 0.183 23549480 Q45FX5 G5ECL3 VAV-1 PRP-21 0.183 23549480 Q45FX5 G5EDG6 VAV-1 COL-3 0.183 23549480 Q45FX5 O01634 VAV-1 INX-12 0.286 14704431 Q45FX5 O01761 VAV-1 UNC-89 0.183 23549480 Q45FX5 Q22505 VAV-1 IMMT-1 0.183 23549480 Q45FX5 A0A0K3AV08 VAV-1 MLK-1 {ECO:0000312|EMBL:CTQ86850.1} 0.183 23549480 Q45FX5 B7WNA3 VAV-1 B7WNA3 0.183 23549480 Q45FX5 G4RTG4 VAV-1 AJM-1 0.183 23549480 Q45FX5 G5ECL2 VAV-1 UNC-26 {ECO:0000312|WORMBASE:JC8.10B} 0.183 23549480 Q45FX5 G5EE04 VAV-1 HIP-1 0.183 23549480 Q45FX5 G5EGT7 VAV-1 IFFB-1 0.183 23549480 Q45FX5 O17286 VAV-1 NFYB-1 0.183 23549480 Q45FX5 O76337 VAV-1 CED-6 0.183 23549480 Q45FX5 O76840 VAV-1 MIG-6 0.183 23549480 Q45FX5 P53013 VAV-1 EFT-4 0.286 14704431 Q45FX5 Q19275 VAV-1 Q19275 0.183 23549480 Q9N5D3 Q45FX5 SOS-1 VAV-1 0.183 23549480 Q9U1W1 Q45FX5 TFG-1 VAV-1 0.183 23549480 Q9UB01 Q45FX5 Q9UB01 VAV-1 0.183 23549480 V6CKC3 Q45FX5 V6CKC3 VAV-1 0.183 23549480 Q45FX5 P55956 VAV-1 ASP-3 0.183 23549480